| Entry |
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| Name |
xenobiotic-transporting ATPase;
multidrug-resistance protein;
MDR protein;
P-glycoprotein;
pleiotropic-drug-resistance protein;
PDR protein;
steroid-transporting ATPase;
ATP phosphohydrolase (steroid-exporting)
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| Class |
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
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| Sysname |
ATP phosphohydrolase (xenobiotic-exporting)
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| Reaction(IUBMB) |
ATP + H2O + xenobioticin = ADP + phosphate + xenobioticout [RN: R00086]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. The enzyme from Gram-positive bacteria and eukaryotic cells export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione---drug conjugates. Some also show some 'flippase' (phospholipid-translocating ATPase; EC 3.6.3.1) activity.
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| Orthology |
| xenobiotic-transporting ATPase |
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| Genes |
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| Reference |
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| Authors |
Bellamy WT. |
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| Title |
P-glycoproteins and multidrug resistance. |
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| Journal |
Annu. Rev. Pharmacol. Toxicol. 36 (1996) 161-83. |
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| Organism |
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| Reference |
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| Authors |
Frijters CM, Ottenhoff R, Van Wijland MJ, Van Nieuwkerk C, Groen AK, Oude Elferink RP. |
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| Title |
Influence of bile salts on hepatic mdr2 P-glycoprotein expression. |
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| Journal |
Adv. Enzyme. Regul. 36 (1996) 351-63. |
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| Organism |
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| Reference |
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| Authors |
Keppler D, Konig J, Buchler M. |
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| Title |
The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes. |
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| Journal |
Adv. Enzyme. Regul. 37 (1997) 321-33. |
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| Organism |
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| Reference |
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| Authors |
Loe DW, Deeley RG, Cole SP. |
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| Title |
Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione. |
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| Journal |
Cancer. Res. 58 (1998) 5130-6. |
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| Organism |
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| Reference |
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| Authors |
van Veen HW, Konings WN. |
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| Title |
The ABC family of multidrug transporters in microorganisms. |
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| Journal |
Biochim. Biophys. Acta. 1365 (1998) 31-6. |
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| Organism |
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| Reference |
6 |
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| Authors |
Griffiths, J.K. and Sansom, C.E. |
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| Title |
The Transporter Factsbook, Academic Press, San Diego, 1998. |
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| Reference |
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| Authors |
Prasad R, De Wergifosse P, Goffeau A, Balzi E. |
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| Title |
Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals. |
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| Journal |
Curr. Genet. 27 (1995) 320-9. |
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| Organism |
Saccharomyces cerevisiae [GN: sce] |
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| Reference |
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| Authors |
Nagao K, Taguchi Y, Arioka M, Kadokura H, Takatsuki A, Yoda K, Yamasaki M. |
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| Title |
bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily. |
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| Journal |
J. Bacteriol. 177 (1995) 1536-43. |
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| Organism |
Schizosaccharomyces pombe [GN: spo] |
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| Reference |
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| Authors |
Mahe Y, Lemoine Y, Kuchler K. |
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| Title |
The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. |
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| Journal |
J. Biol. Chem. 271 (1996) 25167-72. |
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| Organism |
Saccharomyces cerevisiae [GN: sce] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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