KEGG   ENZYME: 3.6.3.51Help
Entry
EC 3.6.3.51                 Enzyme                                 

Name
mitochondrial protein-transporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (mitochondrial protein-importing)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. (TIM is the protein transport machinery of the inner mitochondrial membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.)
History
EC 3.6.3.51 created 2000
Orthology
K10836  
mitochondrial protein-transporting ATPase
Genes
DME: 
Taxonomy
Reference
1  [PMID:9171336]
  Authors
Bomer U, Meijer M, Maarse AC, Honlinger A, Dekker PJ, Pfanner N, Rassow J.
  Title
Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane.
  Journal
EMBO. J. 16 (1997) 2205-16.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
2  [PMID:7600576]
  Authors
Berthold J, Bauer MF, Schneider HC, Klaus C, Dietmeier K, Neupert W, Brunner M.
  Title
The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system.
  Journal
Cell. 81 (1995) 1085-93.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
3  [PMID:10548718]
  Authors
Voos W, Martin H, Krimmer T, Pfanner N.
  Title
Mechanisms of protein translocation into mitochondria.
  Journal
Biochim. Biophys. Acta. 1422 (1999) 235-54.
  Organism
Saccharomyces cerevisiae [GN:sce], Caenorhabditis elegans [GN:cel]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system