KEGG   ENZYME: 3.6.4.3Help
Entry
EC 3.6.4.3                  Enzyme                                 

Name
microtubule-severing ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (tubulin-dimerizing)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
History
EC 3.6.4.3 created 2000
Orthology
K07767  
microtubule-severing ATPase
K13254  
spastin
Genes
HSA: 
11104(KATNA1) 6683(SPAST) 84056(KATNAL1)
PTR: 
452517(KATNAL1) 459133(SPAST) 748379(KATNA1)
PPS: 
100969467(KATNAL1) 100983006(SPAST) 100991443(KATNA1)
GGO: 
101128946(KATNA1) 101141230(KATNAL1) 101142697(SPAST)
PON: 
100431635(KATNA1) 100461041(KATNAL1) 100939092
MCC: 
698291 706264(SPAST) 712636(KATNAL1)
MCF: 
101864950(KATNA1) 102124785(KATNAL1) 102143804(SPAST)
MMU: 
231912(Katnal1) 23924(Katna1) 50850(Spast)
RNO: 
100910196 288449(Katnal1) 292464(Katna1) 362700(Spast)
CGE: 
100755046(Katnal1) 100759022(Katna1) 100765919(Spast)
HGL: 
101706398(Katnal1) 101710272(Spast) 101726567(Katna1)
TUP: 
102474110(SPAST) 102474426(KATNA1) 102479506(KATNAL1)
CFA: 
476240(KATNA1) 486020(KATNAL1) 608582(SPAST)
AML: 
100465290 100467330(KATNA1) 100468053(KATNAL1)
FCA: 
101088156(SPAST) 101089567(KATNAL1) 101099465(KATNA1)
PTG: 
102953217(SPAST) 102960267(KATNA1) 102962289(KATNAL1)
BTA: 
506715(KATNA1) 521442(SPAST) 537739(KATNAL1)
BOM: 
102268274(KATNAL1) 102270181(SPAST) 102272801(KATNA1)
PHD: 
102317958(KATNA1) 102322121 102325579(SPAST) 102337789(KATNAL1)
CHX: 
102186493(KATNAL1) 102188222(KATNA1) 102190238(SPAST)
SSC: 
100156612(KATNAL1) 100518101 396584(SPAST)
CFR: 
102516712(KATNA1) 102523471(KATNAL1) 102524344(SPAST)
BACU: 
103006341(SPAST) 103012410(KATNAL1) 103020498(KATNA1)
LVE: 
103073133(KATNA1) 103074023(SPAST) 103077620(KATNAL1)
ECB: 
100054514(SPAST) 100063699(KATNAL1) 100064649(KATNA1)
MYB: 
102241435(SPAST) 102250104(KATNA1) 102262837(KATNAL1)
MYD: 
102756220(SPAST) 102765363(KATNA1) 102771741(KATNAL1)
PALE: 
102885491(SPAST) 102890118(KATNAL1) 102897531(KATNA1)
MDO: 
100020211(KATNAL1) 100026926(KATNA1) 100026979(SPAST)
SHR: 
100913468(SPAST) 100932256(KATNAL1) 100933587(KATNA1)
OAA: 
100074754(KATNA1) 100078093(SPAST) 100078117(KATNAL1)
GGA: 
418920(KATNAL1) 421481(SPAST) 421626(KATNA1)
MGP: 
TGU: 
100217690(KATNAL1) 100224472(SPAST) 100230482(KATNA1)
FAB: 
101808663(SPAST) 101815060(KATNA1) 101821227(KATNAL1)
PHI: 
102106285(KATNA1) 102109189(SPAST) 102109393(KATNAL1)
APLA: 
101791139(KATNA1) 101795600(SPAST) 101796302(KATNAL1)
FPG: 
101917785(KATNAL1) 101919693(KATNA1) 101924622(SPAST)
FCH: 
102046052(SPAST) 102047381(KATNA1) 102059034(KATNAL1)
CLV: 
102084097(SPAST) 102089637(KATNA1) 102093005(KATNAL1)
ASN: 
102371986(KATNAL1) 102380094(SPAST) 102381333(KATNA1)
AMJ: 
102558354(KATNAL1) 102568221(KATNA1) 102573812(SPAST)
PSS: 
102452286(KATNA1) 102453910(KATNAL1) 102457579(SPAST)
CMY: 
102935395(KATNAL1) 102935890(SPAST) 102940946(KATNA1)
ACS: 
PBI: 
103049559(KATNAL1) 103054469(KATNA1) 103067475(SPAST)
XLA: 
399380(katna1) 446560(spast)
XTR: 
100489961(katnal1) 549207(spast) 779887(katna1)
DRE: 
405851(spast) 492790(katnal1) 553631(katna1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103177613(spast) 103179275(katna1) 103183238(katnal1)
BFO: 
CIN: 
SPU: 
373368(KATNA1) 577727
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409576(spas) 413966(GB19861)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG04086(Cbr-mei-1) CBG19220(Cbr-spas-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G80350(ERH3)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
CSV: 
RCU: 
POP: 
POPTR_0001s17710g(POPTRDRAFT_548648) POPTR_0003s05650g(POPTRDRAFT_817088) POPTR_0014s06760g(POPTRDRAFT_244112) POPTR_0017s04530g
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os01t0683100-01(Os01g0683100) Os06t0130000-01(Os06g0130000)
OBR: 
BDI: 
SBI: 
SORBI_03g031360(SORBIDRAFT_03g031360) SORBI_10g001950(SORBIDRAFT_10g001950) SORBI_10g009910(SORBIDRAFT_10g009910)
ZMA: 
SITA: 
ATR: 
s00069p00187480(AMTR_s00069p00187480) s00122p00082000(AMTR_s00122p00082000)
SMO: 
PPP: 
CRE: 
VCN: 
MIS: 
MPP: 
CSL: 
CVR: 
GSL: 
MBR: 
DDI: 
DPP: 
DFA: 
TGO: 
TET: 
PTM: 
PIF: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:8221885]
  Authors
McNally FJ, Vale RD.
  Title
Identification of katanin, an ATPase that severs and disassembles stable microtubules.
  Journal
Cell. 75 (1993) 419-29.
  Organism
Strongylocentrotus purpuratus
  Sequence
[spu:373368]
Reference
2  [PMID:9568719]
  Authors
Hartman JJ, Mahr J, McNally K, Okawa K, Iwamatsu A, Thomas S, Cheesman S, Heuser J, Vale RD, McNally FJ.
  Title
Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.
  Journal
Cell. 93 (1998) 277-87.
  Organism
Strongylocentrotus purpuratus
  Sequence
[spu:373368]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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