KEGG   ENZYME: 3.6.4.4Help
Entry
EC 3.6.4.4                  Enzyme                                 
Name
plus-end-directed kinesin ATPase;
kinesin
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
kinesin ATP phosphohydrolase (plus-end-directed)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
Microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (alpha) chains (110 kDa) and two or more light (beta) chains (65-75 kDa). Also hydrolyses GTP.
Orthology
K06026  
Genes
DME: 
CGR: 
CHU: 
Taxonomy
Reference
1  [PMID:3926325]
  Authors
Vale RD, Reese TS, Sheetz MP.
  Title
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility.
  Journal
Cell. 42 (1985) 39-50.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:9335494]
  Authors
Howard J.
  Title
Molecular motors: structural adaptations to cellular functions.
  Journal
Nature. 389 (1997) 561-7.
Reference
3  [PMID:9275178]
  Authors
Nakagawa T, Tanaka Y, Matsuoka E, Kondo S, Okada Y, Noda Y, Kanai Y, Hirokawa N.
  Title
Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 9654-9.
  Organism
Mus musculus [GN:mmu]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system