KEGG ENZYME: 3.7.1.8

ENZYME: 3.7.1.8

Entry

EC 3.7.1.8                  Enzyme

Name

2,6-dioxo-6-phenylhexa-3-enoate hydrolase;
HOHPDA hydrolase

Class

Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances

Sysname

2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase

Reaction(IUBMB)

2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate [RN:R02606]

Reaction(KEGG)

R02606;
(other) R05359

Substrate

2,6-dioxo-6-phenylhexa-3-enoate [CPD:C01273];
H2O [CPD:C00001]

Product

benzoate [CPD:C00180];
2-oxopent-4-enoate [CPD:C00596]

Comment

Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.

History

EC 3.7.1.8 created 1989

Pathway

ec00621

Dioxin degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K10222

2,6-dioxo-6-phenylhexa-3-enoate hydrolase

Genes

PSD:

DSC_09385

PNT:	G5B91_07370(bphD)

PCAV:

D3880_11795

PIZ:	LAB08_R28810

PPHA:

BVH74_16335

BAEN:

L3V59_23200(bphD)

BXE:	Bxe_C1186(bphD)

BXB:	DR64_8619(bphD)

PPAI:

E1956_45905(bphD)

PNA:

Pnap_4141

ACK:	C380_15950(bphD)

CTES:

O987_08230

AZI:	AzCIB_4408

JCR:	O9K63_12450

NMAR:

HPC71_10545 HPC71_13590

AWN:	NQV15_16540

» show all

Reference

Authors

Omori, T., Sugimura, K., Ishigooka, H. and Minoda, Y.

Title

Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl.

Journal

Agric Biol Chem 50:931-937 (1986)

Other DBs

ExplorEnz - The Enzyme Database:

3.7.1.8

IUBMB Enzyme Nomenclature:

3.7.1.8

ExPASy - ENZYME nomenclature database:

3.7.1.8

UM-BBD (Biocatalysis/Biodegradation Database):

3.7.1.8

BRENDA, the Enzyme Database:

3.7.1.8

CAS:	102925-38-2

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