| Entry |
|
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| Name |
haloalkane dehalogenase;
1-chlorohexane halidohydrolase;
1-haloalkane dehalogenase |
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| Class |
Hydrolases;
Acting on halide bonds;
In carbon-halide compounds
 |
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| Sysname |
1-haloalkane halidohydrolase |
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| Reaction(IUBMB) |
1-haloalkane + H2O = a primary alcohol + halide [RN:R02337] |
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| Reaction(KEGG) |
R02337 > R05284 R05367 R05368 R07669 R07670;
(other) R05369 R05370
 |
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| Substrate |
1-haloalkane [CPD:C01872];
H2O [CPD:C00001] |
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| Product |
primary alcohol [CPD:C00226];
halide [CPD:C00462] |
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| Comment |
Acts on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and
some haloaromatic compounds. |
|---|
| Pathway |
PATH: ec00361 gamma-Hexachlorocyclohexane degradation
PATH: ec00626 Naphthalene and anthracene degradation
PATH: ec00631 1,2-Dichloroethane degradation
PATH: ec00641 3-Chloroacrylic acid degradation
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01563 haloalkane dehalogenase |
|---|
| Genes |
PIC: PICST_39941
XFA: XF1965
XFT: PD0836(dhaA)
XCC: XCC0216(dhaA)
XCB: XC_0226
XCA: xccb100_0235(dhaA)
XCV: XCV0241
XAC: XAC0235(dhaA)
XOO: XOO4213(dhaA)
XOM: XOO_3982
SML: Smlt0206(dhaA)
PPR: PBPRA1463
PCR: Pcryo_1253
SON: SO_1743
SDN: Sden_1370
SFR: Sfri_1366 Sfri_2056
SAZ: Sama_1183
SBL: Sbal_1551
SBM: Shew185_1547
SLO: Shew_1714
SPC: Sputcn32_1446
SSE: Ssed_1511 Ssed_1777
SHN: Shewana3_2714
CPS: CPS_2154
PAT: Patl_1915
MAQ: Maqu_2428
PIN: Ping_1998
CBU: CBU_1225
HCH: HCH_05560
ABO: ABO_2415(dhmA)
RPI: Rpic_3885
RPF: Rpic12D_3998
BUR: Bcep18194_A4031 Bcep18194_A5407 Bcep18194_A6488 Bcep18194_B1849
AZO: azo3045
GUR: Gura_2009
DAT: HRM2_23490(dhaA)
MLO: mlr5354
PLA: Plav_1611
ATU: Atu6064(dha)
ATC: AGR_pTi_130
RET: RHE_PE00174(ype00077)
RLE: pRL110536
BJA: blr1087
BRA: BRADO6133
BBT: BBta_1660 BBta_3409
CCR: CC_1175
CCS: CCNA_01233
JAN: Jann_2620
HNE: HNE_0985(dhlA)
ELI: ELI_03475
MTU: Rv1833c Rv2296 Rv2579(dhaA)
MTC: MT2353 MT2656(linB)
MRA: MRA_1844 MRA_2313 MRA_2608(dhaA)
MTF: TBFG_12319 TBFG_12599
MBO: Mb1864c Mb2318 Mb2610(dhaA)
MBB: BCG_1868c BCG_2312 BCG_2602(dhaA)
MBT: JTY_2306 JTY_2596(dhaA)
MPA: MAP0345c MAP2057
MAV: MAV_0357 MAV_2130
MSM: MSMEG_6314 MSMEG_6837
MUL: MUL_3052 MUL_3979(dhaA)
MVA: Mvan_2384
MGI: Mflv_4004
MMC: Mmcs_4949
MKM: Mkms_5037
MJL: Mjls_5330
NFA: nfa26230
RHA: RHA1_ro01411 RHA1_ro02879 RHA1_ro05164
SMA: SAV_4779
SEN: SACE_3906 SACE_5821
STP: Strop_2973
SRU: SRU_0874
RBA: RB10245(dhlA)
SYF: Synpcc7942_0901
AVA: Ava_0656 Ava_1799 Ava_2037 Ava_3113 Ava_5038 Ava_C0108
CAU: Caur_3533
CHL: Chy400_3810
 |
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| Structures |
PDB: 1B6G 1BE0 1BEE 1BEZ 1BN6 1BN7 1CIJ 1CQW 1CV2 1D07
1EDB 1EDD 1EDE 1HDE 1K5P 1K63 1K6E 1MJ5 2BFN 2DHC
2DHD 2DHE 2EDA 2EDC 2O2H 2O2I 2PKY 2QVB 2V9Z 2YXP
3FBW |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:4019411]
Keuning S, Janssen DB, Witholt B.
Purification and characterization of hydrolytic haloalkane
dehalogenase from Xanthobacter autotrophicus GJ10.
J. Bacteriol. 163 (1985) 635-9.
Xanthobacter autotrophicus [GN:xau] |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:3667524]
Scholtz R, Leisinger T, Suter F, Cook AM.
Characterization of 1-chlorohexane halidohydrolase, a dehalogenase
of wide substrate range from an Arthrobacter sp.
J. Bacteriol. 169 (1987) 5016-21.
Arthrobacter sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:3624201]
Yokota T, Omori T, Kodama T.
Purification and properties of haloalkane dehalogenase from
Corynebacterium sp. strain m15-3.
J. Bacteriol. 169 (1987) 4049-54.
Corynebacterium sp. |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.8.1.5
IUBMB Enzyme Nomenclature: 3.8.1.5
ExPASy - ENZYME nomenclature database: 3.8.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.5
BRENDA, the Enzyme Database: 3.8.1.5
CAS: 95990-29-7 |
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