KEGG   ENZYME: 4.1.1.25Help
Entry
EC 4.1.1.25                 Enzyme                                 

Name
tyrosine decarboxylase;
L-tyrosine decarboxylase;
L-(-)-tyrosine apodecarboxylase;
L-tyrosine carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
L-tyrosine carboxy-lyase (tyramine-forming)
Reaction(IUBMB)
L-tyrosine = tyramine + CO2 [RN:R00736]
Reaction(KEGG)
R00736;
(other) R02080
Show
Substrate
L-tyrosine [CPD:C00082]
Product
tyramine [CPD:C00483];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine.
History
EC 4.1.1.25 created 1961
Pathway
ec00350  Tyrosine metabolism
ec00680  Methane metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01592  tyrosine decarboxylase
K18933  tyrosine decarboxylase / aspartate 1-decarboxylase
K22329  tyrosine decarboxylase
K22330  tyrosine decarboxylase
Genes
APLC: 110976950 110976951 110977004 110986576
SKO: 100370006
DME: Dmel_CG30446(Tdc2)
DPO: Dpse_GA15851
DAN: Dana_GF13800 Dana_GF13801
DER: Dere_GG10812 Dere_GG10813
DPE: Dper_GL10988 Dper_GL10989
DSE: Dsec_GM20861 Dsec_GM20862
DSI: Dsimw501_GD10312(Dsim_GD10312) Dsimw501_GD10313(Dsim_GD10313)
DWI: Dwil_GK23145 Dwil_GK23146
AAG: 5578213
AME: 410947(Tdc1) 410948(Tdc2)
NVI: 100118460
BMOR: 101745224
PMAC: 106710721
PXY: 105380584
API: 100164582
DNX: 107166908
TUT: 107364473
CEL: CELE_K01C8.3(tdc-1)
CBR: CBG00668(Cbr-tdc-1)
BMY: Bm1_42020
CRG: 105343976
MYI: 110450166
OBI: 106872068
LAK: 106169254
SHX: MS3_02440
ATH: AT4G28680(TYRDC)
CSAT: 104722011
BRP: 103854232
BOE: 106301496
LBR: LVIS_2213
EFA: EF0634
EFL: EF62_1003
EFS: EFS1_0482
EFQ: DR75_2583(tdc)
ENE: ENT_24840
EFM: M7W_577
EHR: EHR_03460
EMU: EMQU_0384
EDU: LIU_00045
MPX: MPD5_1444
CML: BN424_2873(tdc)
CBV: U729_1871(tdc)
SHY: SHJG_8487
MJA: MJ_0050
MMP: MMP0131
MMD: GYY_00665
MAE: Maeo_1008
MVO: Mvol_1332
MAC: MA_0006
MBAR: MSBR2_3469
MBAK: MSBR3_3475
MMA: MM_1317
MMAC: MSMAC_3369
METM: MSMTP_3249
MTHE: MSTHC_1464
MTHR: MSTHT_1822
MHOR: MSHOH_4092
MBU: Mbur_1732
MMET: MCMEM_2203
MMH: Mmah_2032
MPY: Mpsy_1730
MTP: Mthe_1636
MCJ: MCON_2882
MHI: Mhar_0758
MHU: Mhun_2611
MLA: Mlab_1545
MBG: BN140_0541(mfnA)
MEMA: MMAB1_0678(mfnA)
MPI: Mpet_0341
MBN: Mboo_2166
MPL: Mpal_2080
MPD: MCP_0399(mfnA)
MEZ: Mtc_0699(mfnA)
RCI: RCIX1543(mfnA)
MTH: MTH_1116
MMG: MTBMA_c15000(mfnA)
METC: MTCT_1010
MWO: MWSIV6_1508(mfnA)
METE: tca_01072
MST: Msp_0329(mfnA)
MSI: Msm_0987
MRU: mru_1896(mfnA)
MEB: Abm4_1501(mfnA)
MMIL: sm9_1948(mfnA)
MEYE: TL18_09200
MOL: YLM1_1352
METH: MBMB1_1647(mfnA)
MFC: BRM9_0901(mfnA)
MFI: DSM1535_0868(mfnA)
MCUB: MCBB_1953(mfnA)
MFV: Mfer_0124
MKA: MK1500
AFU: AF_2004
FPL: Ferp_1624
GAC: GACE_1678
GAH: GAH_00469
HAL: VNG_0327G(gadD)
HSL: OE_1498R(mfnA)
HHB: Hhub_1472(mfnA)
HALH: HTSR_1425(gadD)
HHSR: HSR6_1497(mfnA)
HSU: HLASF_0642(gadD)
HSF: HLASA_0638(gadD)
HMA: rrnAC1798(gadD)
HHI: HAH_2325(gadB)
NPH: NP_1194A(panD)
NMO: Nmlp_3238(mfnA)
HUT: Huta_2743
HTI: HTIA_2492
HMU: Hmuk_2995
HARC: HARCEL1_05395(mfnA)
HVO: HVO_0811(mfnA)
HME: HFX_0780
HLA: Hlac_0591
HTU: Htur_0805
NMG: Nmag_2599
NAT: NJ7G_4186
SALI: L593_04020
PHO: PH0937(PH0937)
PAB: PAB1578
PFU: PF1159
PFI: PFC_05020
PYN: PNA2_1618
PYS: Py04_1152
TKO: TK1814
TON: TON_1710
TGA: TGAM_2137(mfnA)
TSI: TSIB_0460
THE: GQS_06765
THA: TAM4_357
THM: CL1_0978
TLT: OCC_10103
THS: TES1_1892
TNU: BD01_1348
TEU: TEU_02775
PPAC: PAP_09195
ABI: Aboo_1436
APE: APE_0412
ACJ: ACAM_0297
SMR: Smar_1292
DKA: DKAM_0021
TAG: Tagg_0191
HBU: Hbut_0224
ASC: ASAC_0977
BARB: AOA66_0496(mfnA)
LOKI: Lokiarch_04140(mfnA_1) Lokiarch_53170(mfnA_2)
 » show all
Taxonomy
Reference
1
  Authors
McGilvery, R.W. and Cohen, P.P.
  Title
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
  Journal
J. Biol. Chem. 174 (1948) 813-816.
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.25
IUBMB Enzyme Nomenclature: 4.1.1.25
ExPASy - ENZYME nomenclature database: 4.1.1.25
BRENDA, the Enzyme Database: 4.1.1.25
CAS: 9002-09-9

DBGET integrated database retrieval system