KEGG   ENZYME: 4.1.1.28Help
Entry
EC 4.1.1.28                 Enzyme                                 

Name
aromatic-L-amino-acid decarboxylase;
DOPA decarboxylase;
tryptophan decarboxylase;
hydroxytryptophan decarboxylase;
L-DOPA decarboxylase;
aromatic amino acid decarboxylase;
5-hydroxytryptophan decarboxylase;
aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
aromatic-L-amino-acid carboxy-lyase
Reaction(IUBMB)
(1) L-dopa = dopamine + CO2 [RN:R02080];
(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 [RN:R02701]
Reaction(KEGG)
Substrate
L-dopa [CPD:C00355];
5-hydroxy-L-tryptophan [CPD:C00643]
Product
dopamine [CPD:C03758];
CO2 [CPD:C00011];
5-hydroxytryptamine [CPD:C00780]
Comment
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
History
EC 4.1.1.28 created 1961 (EC 4.1.1.26 and EC 4.1.1.27 both created 1961 and incorporated 1972)
Pathway
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Indole alkaloid biosynthesis
Isoquinoline alkaloid biosynthesis
Betalain biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01593  
aromatic-L-amino-acid decarboxylase
Genes
HSA: 
1644(DDC)
PTR: 
463409(DDC)
PPS: 
GGO: 
PON: 
MCC: 
693677(DDC)
MCF: 
MMU: 
13195(Ddc)
RNO: 
24311(Ddc)
CGE: 
HGL: 
TUP: 
CFA: 
606852(DDC)
AML: 
FCA: 
PTG: 
BTA: 
280762(DDC)
BOM: 
PHD: 
CHX: 
SSC: 
396857(DDC)
CFR: 
ECB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
420947(DDC)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
PSS: 
CMY: 
ACS: 
XLA: 
XTR: 
496742(ddc)
DRE: 
406651(ddc)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
CIN: 
100101815(hdcl)
SPU: 
DME: 
DPO: 
Dpse_GA10503(Dpse_Ddc)
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsim_GD21778(Dsim_Ddc)
DWI: 
Dwil_GK24237(Dwil_Ddc)
DYA: 
DGR: 
DMO: 
DVI: 
Dvir_GJ17995(Dvir_Ddc)
AGA: 
AAG: 
CQU: 
AME: 
410638(Ddc) 410639(GB14019) 410948(Tdc2)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
CEL: 
CELE_C05D2.3(basl-1) CELE_K01C8.3(tdc-1) CELE_ZK829.2(hdl-1)
CBR: 
CBG00668(Cbr-tdc-1)
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
RCU: 
VVI: 
PPP: 
CRE: 
NCR: 
SMP: 
FGR: 
NHE: 
SSL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_88074(AO090038000057)
ANG: 
ANI_1_2316014(An01g02000)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
URE: 
ABE: 
TVE: 
PNO: 
PTE: 
TML: 
CNE: 
CNB: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
TET: 
PTM: 
NGR: 
YPE: 
YPK: 
y2996(dcd)
YPA: 
YPN: 
YPM: 
YP_0943(dcd1)
YPP: 
YPG: 
YPZ: 
YPT: 
YPD: 
YPX: 
YPH: 
YPS: 
YPI: 
YPY: 
YPB: 
PPU: 
PPG: 
PPW: 
PFC: 
PEN: 
NOC: 
BUR: 
DVU: 
DVL: 
DVM: 
DVG: 
DDE: 
AFW: 
SUR: 
MLO: 
MCI: 
MOP: 
MAM: 
RHI: 
SFH: 
EAD: 
ARA: 
RTR: 
NWI: 
XAU: 
MET: 
MNO: 
RVA: 
SIL: 
SIT: 
JAN: 
MMR: 
PGV: 
FRA: 
GOB: 
SEN: 
PDX: 
AMI: 
VMA: 
RXY: 
ABA: 
SUS: 
GAU: 
CYP: 
CYH: 
MTT: 
CAU: 
CAG: 
CHL: 
MRB: 
MSV: 
 » show all
Taxonomy
Reference
1  [PMID:4536745]
  Authors
Christenson JG, Dairman W, Udenfriend S.
  Title
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).
  Journal
Proc. Natl. Acad. Sci. U. S. A. 69 (1972) 343-7.
  Organism
Rattus norvegicus, Sus scofa, Oryctolagus cuniculus
Reference
2  [PMID:14466899]
  Authors
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
  Title
Aromatic L-amino acid decarboxylase.
  Journal
J. Biol. Chem. 237 (1962) 89-93.
  Organism
Cavia porcellus
Reference
3
  Authors
McGilvery, R.W. and Cohen, P.P.
  Title
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
  Journal
J. Biol. Chem. 174 (1948) 813-816.
Reference
4
  Authors
Sekeris, C.E.
  Title
Zur Tyrosinstoffwechsel der Insekten. XII. Reinigung, Eigenschaften und Substratspezifitat der DOPA-Decarboxylase.
  Journal
Hoppe-Seyler's Z. Physiol. Chem. 332 (1963) 70-78.
Reference
5  [PMID:13462983]
  Authors
WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S.
  Title
Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation.
  Journal
J. Biol. Chem. 227 (1957) 617-24.
  Organism
Cavia porcellus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9042-64-2

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