| Entry |
|
|---|
| Name |
aromatic-L-amino-acid decarboxylase;
DOPA decarboxylase;
tryptophan decarboxylase;
hydroxytryptophan decarboxylase;
L-DOPA decarboxylase;
aromatic amino acid decarboxylase;
5-hydroxytryptophan decarboxylase;
aromatic-L-amino-acid carboxy-lyase (tryptamine-forming) |
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
 |
|---|
| Sysname |
aromatic-L-amino-acid carboxy-lyase |
|---|
| Reaction(IUBMB) |
(1) 3,4-dihydroxy-L-phenylalanine = dopamine + CO2 [RN:R02080];
(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 [RN:R02701] |
|---|
| Reaction(KEGG) |
R02080 R02701;
(other) R00685 R00699 R00736 R01167 R04909
 |
|---|
| Substrate |
3,4-dihydroxy-L-phenylalanine [CPD:C00355];
5-hydroxy-L-tryptophan [CPD:C00643] |
|---|
| Product |
dopamine [CPD:C03758];
CO2 [CPD:C00011];
5-hydroxytryptamine [CPD:C00780] |
|---|
| Cofactor |
Pyridoxal phosphate [CPD:C00018];
PQQ [CPD:C00113] |
|---|
| Comment |
A pyridoxal-phosphate protein. The enzyme also acts on some other
aromatic L-amino acids, including L-tryptophan. |
|---|
| Pathway |
PATH: ec00340 Histidine metabolism
PATH: ec00350 Tyrosine metabolism
PATH: ec00360 Phenylalanine metabolism
PATH: ec00380 Tryptophan metabolism
PATH: ec00901 Indole alkaloid biosynthesis
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec00965 Betalain biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01593 aromatic-L-amino-acid decarboxylase |
|---|
| Genes |
HSA: 1644(DDC)
PTR: 463409(DDC)
MCC: 693677(DDC)
MMU: 13195(Ddc)
RNO: 24311(Ddc)
CFA: 606852(DDC)
BTA: 280762(DDC)
SSC: 396857(DDC)
ECB: 100052557
MDO: 100030001
GGA: 420947(DDC)
TGU: 100226623
XLA: 100126640
XTR: 496742
DRE: 406651(ddc)
BFO: BRAFLDRAFT_102098 BRAFLDRAFT_99569
CIN: 100101815(hdcl)
SPU: 577767 593847 759472 764126
DME: Dmel_CG10697(Ddc)
DPO: Dpse_GA10503(Dpse_Ddc)
DAN: Dana_GF15210
DER: Dere_GG21650
DPE: Dper_GL21129
DSE: Dsec_GM17029
DYA: Dyak_GE12670
DGR: Dgri_GH13483
DMO: Dmoj_GI17235
AGA: AgaP_AGAP009091
AAG: AaeL_AAEL014238
CQU: CpipJ_CPIJ013307
AME: 410638
NVI: 100119990
TCA: 662962(Ddc)
API: 100160466
CEL: C05D2.3 K01C8.3(tdc-1) ZK829.2(hdl-1)
CBR: CBG00668
BMY: Bm1_42020
NVE: NEMVE_v1g98001
HMG: 100208951 100212300
TAD: TRIADDRAFT_21756
ATH: AT2G20340
POP: POPTR_816969
VVI: 100251450
OSA: 4343080(Os07g0437500)
SBI: SORBI_02g010470(SORBIDRAFT_02g010470)
PPP: PHYPADRAFT_187205
CRE: CHLREDRAFT_116869(DDC1)
NCR: NCU08275
FGR: FG05295.1
ANI: AN2357.2
AFM: AFUA_3G02240
AOR: AO090038000057
ANG: An01g02000
NFI: NFIA_003370
SSL: SS1G_02607
BFU: BC1G_01168
CNE: CND00950
CNB: CNBD5350
LBC: LACBIDRAFT_190337
UMA: UM06083.1
MGL: MGL_3372
TET: TTHERM_00929550
PTM: GSPATT00035189001
YPE: YPO1193
YPK: y2996(dcd)
YPM: YP_0943(dcd1)
YPA: YPA_0905
YPN: YPN_2783
YPG: YpAngola_A1334
YPP: YPDSF_2502
YPS: YPTB1234
YPI: YpsIP31758_2788
YPY: YPK_2867
YPB: YPTS_1322
PPU: PP_2552
PPF: Pput_3163
PPG: PputGB1_3364
PPW: PputW619_2223
PEN: PSEEN2370
NOC: Noc_2983
BUR: Bcep18194_B2911
DVU: DVU0867
DVL: Dvul_2115
DDE: Dde_1124
AFW: Anae109_1428
MLO: mll0712
ARA: Arad_0017
RHI: NGR_b20140
NWI: Nwi_1102
XAU: Xaut_0071
MET: M446_1957
MNO: Mnod_1238
SIL: SPO3687
SIT: TM1040_3466
JAN: Jann_3501
MMR: Mmar10_1409
FRA: Francci3_2867
SEN: SACE_2888
RXY: Rxyl_1038
ABA: Acid345_2160
SUS: Acid_1182
GAU: GAU_3087
CYP: PCC8801_0883
CAU: Caur_2842
CAG: Cagg_1126
CHL: Chy400_3078
 |
|---|
| Structures |
PDB: 1JS3 1JS6 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4536745]
Christenson JG, Dairman W, Udenfriend S.
On the identity of DOPA decarboxylase and 5-hydroxytryptophan
decarboxylase (immunological titration-aromatic L-amino acid
decarboxylase-serotonin-dopamine-norepinephrine).
Proc. Natl. Acad. Sci. U. S. A. 69 (1972) 343-7.
Rattus norvegicus [GN:rno], Sus scofa [GN:ssc], Oryctolagus
cuniculus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14466899]
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
Aromatic L-amino acid decarboxylase.
J. Biol. Chem. 237 (1962) 89-93.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
|
3
McGilvery, R.W. and Cohen, P.P.
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
J. Biol. Chem. 174 (1948) 813-816. |
|---|
Reference
Authors
Title
Journal
|
4
Sekeris, C.E.
Zur Tyrosinstoffwechsel der Insekten. XII. Reinigung, Eigenschaften
und Substratspezifitat der DOPA-Decarboxylase.
Hoppe-Seyler's Z. Physiol. Chem. 332 (1963) 70-78. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:13462983]
WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S.
Studies on the effect of vitamin B6 on 5-hydroxytryptamine
(serotonin) formation.
J. Biol. Chem. 227 (1957) 617-24.
Cavia porcellus |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 4.1.1.28
IUBMB Enzyme Nomenclature: 4.1.1.28
ExPASy - ENZYME nomenclature database: 4.1.1.28
BRENDA, the Enzyme Database: 4.1.1.28
CAS: 9042-64-2 |
|---|
