KEGG   ENZYME: 4.1.1.6Help
Entry
EC 4.1.1.6                  Enzyme                                 

Name
aconitate decarboxylase;
cis-aconitic decarboxylase;
CAD;
cis-aconitate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
cis-aconitate carboxy-lyase (itaconate-forming)
Reaction(IUBMB)
cis-aconitate = itaconate + CO2 [RN:R02243]
Reaction(KEGG)
Substrate
cis-aconitate [CPD:C00417]
Product
itaconate [CPD:C00490];
CO2 [CPD:C00011]
History
EC 4.1.1.6 created 1961
Pathway
C5-Branched dibasic acid metabolism
Orthology
K17724  
aconitate decarboxylase
Genes
HSA: 
730249(ACOD1)
PTR: 
452753(IRG1)
PPS: 
100991677(IRG1)
GGO: 
101139986(IRG1)
PON: 
100453492(IRG1)
NLE: 
100580880(IRG1)
MCC: 
695991(IRG1)
MCF: 
102125305(IRG1)
RRO: 
104671179(IRG1)
CJC: 
100406137(IRG1)
MMU: 
16365(Acod1)
RNO: 
306127(Irg1)
CGE: 
100764165(Acod1)
NGI: 
103724871(Irg1)
HGL: 
101714481(Irg1)
OCU: 
100343808(IRG1)
TUP: 
102484215(IRG1)
CFA: 
485496(IRG1)
AML: 
100469289(IRG1)
UMR: 
103659173(IRG1)
FCA: 
101088973(IRG1)
PTG: 
102971647(IRG1)
BTA: 
504806(IRG1)
BOM: 
102266999(IRG1)
PHD: 
102331628(IRG1)
CHX: 
102183801(IRG1)
OAS: 
101102743(IRG1)
SSC: 
CFR: 
102510611(IRG1)
BACU: 
103015984(IRG1)
LVE: 
103073823(IRG1)
ECB: 
100052594(IRG1)
MYB: 
102253704(IRG1)
MYD: 
102758508(IRG1)
PALE: 
102890891(IRG1)
MDO: 
100012559(ACOD1)
SHR: 
100930346(IRG1)
OAA: 
GGA: 
418812(IRG1) 422307(IRG1L)
MGP: 
CJO: 
107308047(IRG1)
APLA: 
TGU: 
GFR: 
102032832(IRG1)
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
106491683(IRG1)
ASN: 
AMJ: 
PSS: 
102460085(IRG1)
CMY: 
ACS: 
PBI: 
103049799(IRG1)
GJA: 
107120147(IRG1)
XLA: 
398116(irg1)
XTR: 
DRE: 
562007(irg1l) 795305(irg1)
TRU: 
101063714(irg1)
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103177413(irg1)
BFO: 
LGI: 
CRG: 
PIC: 
BFU: 
ANI: 
AOR: 
AOR_1_286024(AO090010000161)
ANG: 
ANI_1_1536084(An09g06220) ANI_1_2952014(An01g09950)
AFV: 
PNO: 
PTE: 
 » show all
Taxonomy
Reference
1  [PMID:13438855]
  Authors
BENTLEY R, THIESSEN CP.
  Title
Biosynthesis of itaconic acid in Aspergillus terreus.  III.  The properties and reaction mechanism of cis-aconitic acid decarboxylase.
  Journal
J. Biol. Chem. 226 (1957) 703-20.
Reference
2  [PMID:23610393]
  Authors
Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, Buttini M, Linster CL, Medina E, Balling R, Hiller K
  Title
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 7820-5.
  Sequence
[hsa:730249] [mmu:16365]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9025-01-8

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