KEGG   ENZYME: 4.1.1.84Help
Entry
EC 4.1.1.84                 Enzyme                                 

Name
D-dopachrome decarboxylase;
phenylpyruvate tautomerase II;
D-tautomerase;
D-dopachrome tautomerase;
D-dopachrome carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming)
Reaction(IUBMB)
D-dopachrome = 5,6-dihydroxyindole + CO2 [RN:R07313]
Reaction(KEGG)
Substrate
D-dopachrome [CPD:C15566]
Product
5,6-dihydroxyindole [CPD:C05578];
CO2 [CPD:C00011]
Comment
This enzyme is specific for D-dopachrome as substrate and belongs to the MIF (macrophage migration inhibitory factor) family of proteins. L-Dopachrome, L- or D-alpha-methyldopachrome and dopaminochrome do not act as substrates (see also EC 5.3.3.12, L-dopachrome isomerase)
History
EC 4.1.1.84 created 2005
Orthology
K10028  
D-dopachrome decarboxylase
Genes
HSA: 
100037417(DDTL) 1652(DDT) 391322
PTR: 
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
699933(DDT)
MCF: 
CSAB: 
RRO: 
104667410(DDT) 104667424(DDTL)
CJC: 
SBQ: 
MMU: 
13202(Ddt)
RNO: 
29318(Ddt)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
AML: 
UMR: 
FCA: 
PTG: 
BTA: 
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
416937(DDT)
CJO: 
APLA: 
TGU: 
FAB: 
PHI: 
FCH: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
GJA: 
107108548(GekBS149P)
XLA: 
447275(ddt-a) 494727(ddt-b)
XTR: 
550015(ddt)
DRE: 
415237(ddt)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
106562836(DOPD) 106570496(DOPD)
LCM: 
CMK: 
BFO: 
SPU: 
DPX: 
ISC: 
HRO: 
LGI: 
 » show all
Taxonomy
Reference
1  [PMID:8267597]
  Authors
Odh G, Hindemith A, Rosengren AM, Rosengren E, Rorsman H.
  Title
Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole.
  Journal
Biochem. Biophys. Res. Commun. 197 (1993) 619-24.
  Sequence
[rno:29318]
Reference
2  [PMID:9285056]
  Authors
Yoshida H, Nishihira J, Suzuki M, Hikichi K.
  Title
NMR characterization of physicochemical properties of rat D-dopachrome tautomerase.
  Journal
Biochem. Mol. Biol. Int. 42 (1997) 891-9.
  Sequence
[rno:29318]
Reference
3  [PMID:10079069]
  Authors
Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J.
  Title
Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.
  Journal
Biochemistry. 38 (1999) 3268-79.
  Sequence
[hsa:1652]
Reference
4  [PMID:9480844]
  Authors
Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M.
  Title
Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation.
  Journal
Biochem. Biophys. Res. Commun. 243 (1998) 538-44.
  Sequence
[hsa:1652]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
184111-06-6

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