KEGG   ENZYME: 4.1.1.84Help
Entry
EC 4.1.1.84                 Enzyme                                 

Name
D-dopachrome decarboxylase;
phenylpyruvate tautomerase II;
D-tautomerase;
D-dopachrome tautomerase;
D-dopachrome carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming)
Reaction(IUBMB)
D-dopachrome = 5,6-dihydroxyindole + CO2 [RN:R07313]
Reaction(KEGG)
Substrate
D-dopachrome [CPD:C15566]
Product
5,6-dihydroxyindole [CPD:C05578];
CO2 [CPD:C00011]
Comment
This enzyme is specific for D-dopachrome as substrate and belongs to the MIF (macrophage migration inhibitory factor) family of proteins. L-Dopachrome, L- or D-alpha-methyldopachrome and dopaminochrome do not act as substrates (see also EC 5.3.3.12, L-dopachrome isomerase)
History
EC 4.1.1.84 created 2005
Orthology
K10028  D-dopachrome decarboxylase
Genes
HSA: 100037417(DDTL) 1652(DDT) 391322
PTR: 112206708 747265(DDT) 747294
PPS: 100983429 100991346(DDT) 100992828 100994211 100995427
GGO: 101147498 109024612
PON: 100439570 100446092(DDT)
NLE: 100581919 100590066 100600991
MCC: 699933(DDT)
MCF: 102140262(DDT)
CSAB: 103217148 103223037(DDT)
RRO: 104667410(DDT) 104667424(DDTL)
RBB: 108513786 108524064(DDT)
CJC: 100389231(DDT)
SBQ: 101039109(DDT)
MMU: 13202(Ddt)
RNO: 29318(Ddt)
CGE: 100765163(Ddt)
NGI: 103738065(Ddt)
HGL: 101717732(Ddt)
OCU: 100337941 100359341(DDT)
TUP: 102483953(DDT)
CFA: 100856501(DDT)
AML: 100476910(DDT)
UMR: 103669207(DDT)
ORO: 101378457(DDT)
FCA: 101082852
PTG: 102959720(DDT)
AJU: 106979699
BTA: 101907022 615999(DDT)
BIU: 109571323
PHD: 102341338(DDT)
CHX: 102181889(DDT)
OAS: 101111911
SSC: 100155535(DDT)
CFR: 102504827(DDT)
CDK: 105095200(DDT)
BACU: 103004027
LVE: 103073649
OOR: 101276351(DDT)
ECB: 100053419
EPZ: 103561727(DDT)
EAI: 106847118
HAI: 109394876
RSS: 109433804
PALE: 102883548
LAV: 100655770
TMU: 101349989
MDO: 103106482(DDT)
SHR: 100921416(DDT)
OAA: 100092476
GGA: 416937(DDT)
CJO: 107321319(DDT)
APLA: 101797488(DDT)
TGU: 100223695(DDT) 100301489(DDT)
FAB: 101807708(DDT)
PHI: 102103009(DDT)
PMAJ: 107211467
FCH: 102050365(DDT)
ASN: 102382950(DDT)
AMJ: 102572983(DDT)
PSS: 102445420(DDT)
CMY: 102941960
CPIC: 101935886(DDT)
ACS: 100555560
GJA: 107108548(GekBS149P)
XLA: 447275(ddt.S) 494727(ddt.L)
XTR: 550015(ddt)
NPR: 108794802
DRE: 415237(ddt)
SGH: 107576985
IPU: 108279157
AMEX: 103025217(ddt)
TRU: 101067398
LCO: 104931754(ddt)
MZE: 101482690
OLA: 101166691
PRET: 103461849(ddt)
NFU: 107397169
CSEM: 103384276
LCF: 108873416
HCQ: 109521711
BPEC: 110167612(ddt)
SASA: 106562836(DOPD) 106570496(DOPD)
ELS: 105030824
SFM: 108933907(ddt)
LCM: 102345613(DDT)
CMK: 103189632(ddt)
SPU: 764606
LAK: 106153865
 » show all
Taxonomy
Reference
1  [PMID:8267597]
  Authors
Odh G, Hindemith A, Rosengren AM, Rosengren E, Rorsman H.
  Title
Isolation of a new tautomerase monitored by the conversion of D-dopachrome to 5,6-dihydroxyindole.
  Journal
Biochem. Biophys. Res. Commun. 197 (1993) 619-24.
  Sequence
[rno:29318]
Reference
2  [PMID:9285056]
  Authors
Yoshida H, Nishihira J, Suzuki M, Hikichi K.
  Title
NMR characterization of physicochemical properties of rat D-dopachrome tautomerase.
  Journal
Biochem. Mol. Biol. Int. 42 (1997) 891-9.
  Sequence
[rno:29318]
Reference
3  [PMID:10079069]
  Authors
Sugimoto H, Taniguchi M, Nakagawa A, Tanaka I, Suzuki M, Nishihira J.
  Title
Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.
  Journal
Biochemistry. 38 (1999) 3268-79.
  Sequence
[hsa:1652]
Reference
4  [PMID:9480844]
  Authors
Nishihira J, Fujinaga M, Kuriyama T, Suzuki M, Sugimoto H, Nakagawa A, Tanaka I, Sakai M.
  Title
Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation.
  Journal
Biochem. Biophys. Res. Commun. 243 (1998) 538-44.
  Sequence
[hsa:1652]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.84
IUBMB Enzyme Nomenclature: 4.1.1.84
ExPASy - ENZYME nomenclature database: 4.1.1.84
BRENDA, the Enzyme Database: 4.1.1.84
CAS: 184111-06-6

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