KEGG   ENZYME: 4.1.2.30Help
Entry
EC 4.1.2.30                 Enzyme                                 

Name
17alpha-hydroxyprogesterone aldolase;
C-17/C-20 lyase;
17alpha-hydroxyprogesterone acetaldehyde-lyase;
CYP17;
CYP17A1 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)
Reaction(IUBMB)
17alpha-hydroxyprogesterone = androstenedione + acetaldehyde [RN:R01841]
Reaction(KEGG)
R01841;
(other) R08516
Show
Substrate
17alpha-hydroxyprogesterone [CPD:C01176]
Product
androstenedione [CPD:C00280];
acetaldehyde [CPD:C00084]
Comment
A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.99.9), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter [2].
History
EC 4.1.2.30 created 1976
Pathway
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K00512  
steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone aldolase
Genes
HSA: 
1586(CYP17A1)
PTR: 
450141(CYP17A1)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
678693(CYP17A1)
MCF: 
CJC: 
100400572(CYP17A1)
MMU: 
13074(Cyp17a1)
RNO: 
25146(Cyp17a1)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
477807(CYP17A1)
AML: 
UMR: 
FCA: 
493967(CYP17A1)
PTG: 
BTA: 
BOM: 
PHD: 
CHX: 
OAS: 
101105226 493968(CYP17A1)
SSC: 
403330(CYP17A1)
CFR: 
BACU: 
LVE: 
ECB: 
100034232(CYP17A1)
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
425056(CYP17A1)
MGP: 
APLA: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
102567971(CYP17A1)
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
100036774(cyp17a1)
XTR: 
100145650(cyp17a1)
DRE: 
399692(cyp17a1)
TRU: 
100125766(cyp17a2) 100125798(cyp17a1)
MZE: 
OLA: 
100125816(cyp17) 101170547(cyp17a2)
XMA: 
LCM: 
CMK: 
BFO: 
LGI: 
CIT: 
CIC: 
PVU: 
FVE: 
CSV: 
SOT: 
 » show all
Taxonomy
Reference
1  [PMID:4435747]
  Authors
Nowotny E, Sananez RD, Nattero G, Yantorno C, Faillaci MG.
  Title
Bioconversion of steroids in vitro by testes from autoimmunized rabbits.
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 355 (1974) 716-20.
Reference
2  [PMID:12693981]
  Authors
Gilep AA, Estabrook RW, Usanov SA
  Title
Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species.
  Journal
Biochemistry. (Mosc). 68 (2003) 86-98.
  Sequence
Reference
3  [PMID:17386955]
  Authors
Kolar NW, Swart AC, Mason JI, Swart P
  Title
Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris.
  Journal
J. Biotechnol. 129 (2007) 635-44.
  Sequence
[hsa:1586]
Reference
4  [PMID:18707589]
  Authors
Pechurskaya TA, Lukashevich OP, Gilep AA, Usanov SA
  Title
Engineering, expression, and purification of "soluble" human cytochrome P45017alpha and its functional characterization.
  Journal
Biochemistry. (Mosc). 73 (2008) 806-11.
  Sequence
[hsa:1586]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62213-24-5

DBGET integrated database retrieval system