| Entry |
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| Name |
17alpha-hydroxyprogesterone aldolase;
C-17/C-20 lyase;
17alpha-hydroxyprogesterone acetaldehyde-lyase;
CYP17;
CYP17A1 (gene name)
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| Class |
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
 |
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| Sysname |
17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)
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| Reaction(IUBMB) |
17alpha-hydroxyprogesterone = androstenedione + acetaldehyde [RN: R01841]
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| Reaction(KEGG) |
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| Substrate |
17alpha-hydroxyprogesterone [CPD: C01176]
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| Product |
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| Comment |
A microsomal hemeprotein that catalyses two independent reactions at the same active site - the 17-hydroxylation of pregnenolone and progesterone, which is part of glucocorticoid hormones biosynthesis (EC 1.14.99.9), and the conversion of the 17-hydroxylated products via a 17,20-lyase reaction to form androstenedione and dehydroepiandrosterone, leading to sex hormone biosynthesis. The enzymes from different organisms differ in their substrate specificity. While the enzymes from pig, hamster, and rat accept both 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone, the enzymes from human, bovine, sheep, goat, and bison do not accept the former, and the enzyme from guinea pig does not accept the latter [2].
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| Pathway |
| Steroid hormone biosynthesis | | Metabolic pathways |
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| Reference |
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| Authors |
Nowotny E, Sananez RD, Nattero G, Yantorno C, Faillaci MG. |
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| Title |
Bioconversion of steroids in vitro by testes from autoimmunized rabbits. |
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| Journal |
Hoppe. Seylers. Z. Physiol. Chem. 355 (1974) 716-20. |
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| Organism |
Oryctolagus cuniculus |
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| Reference |
|
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| Authors |
Gilep AA, Estabrook RW, Usanov SA |
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| Title |
Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species. |
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| Journal |
Biochemistry. (Mosc). 68 (2003) 86-98. |
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| Reference |
|
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| Authors |
Kolar NW, Swart AC, Mason JI, Swart P |
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| Title |
Functional expression and characterisation of human cytochrome P45017alpha in Pichia pastoris. |
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| Journal |
J. Biotechnol. 129 (2007) 635-44. |
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| Reference |
|
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| Authors |
Pechurskaya TA, Lukashevich OP, Gilep AA, Usanov SA |
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| Title |
Engineering, expression, and purification of "soluble" human cytochrome P45017alpha and its functional characterization. |
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| Journal |
Biochemistry. (Mosc). 73 (2008) 806-11. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 62213-24-5 |
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