KEGG   ENZYME: 4.1.2.51Help
Entry
EC 4.1.2.51                 Enzyme                                 

Name
2-dehydro-3-deoxy-D-gluconate aldolase;
Pto1279 (gene name);
KDGA;
KDG-specific aldolase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-lyase (pyruvate-forming)
Reaction(IUBMB)
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde [RN:R08570]
Reaction(KEGG)
R08570;
(other) R10616
Show
Substrate
2-dehydro-3-deoxy-D-gluconate [CPD:C00204]
Product
pyruvate [CPD:C00022];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. In the direction of aldol synthesis the enzyme catalyses the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate at a similar ratio. It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase.
History
EC 4.1.2.51 created 2013
Pathway
Pentose phosphate pathway
Galactose metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K18127  
2-dehydro-3-deoxy-D-gluconate aldolase
Genes
TAC: 
TVO: 
TVG1289977(TVG1289977)
PTO: 
Taxonomy
Reference
1  [PMID:20023024]
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J. Bacteriol. 192 (2010) 964-74.
  Sequence
[pto:PTO1279]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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