KEGG   ENZYME: 4.1.2.55Help
Entry
EC 4.1.2.55                 Enzyme                                 

Name
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase;
2-keto-3-deoxygluconate aldolase (ambiguous);
KDGA (ambiguous)
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
2-dehydro-3-deoxy-6-phospho-D-gluconate/2-dehydro-3-deoxy-6-phospho-D-galactonate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)
Reaction(IUBMB)
(1) 2-dehydro-3-deoxy-6-phospho-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate [RN:R05605];
(2) 2-dehydro-3-deoxy-6-phospho-D-galactonate = pyruvate + D-glyceraldehyde 3-phosphate [RN:R01064]
Reaction(KEGG)
Substrate
2-dehydro-3-deoxy-6-phospho-D-gluconate [CPD:C04442];
2-dehydro-3-deoxy-6-phospho-D-galactonate [CPD:C01286]
Product
pyruvate [CPD:C00022];
D-glyceraldehyde 3-phosphate [CPD:C00118]
Comment
In the archaeon Sulfolobus solfataricus the enzyme is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. It utilizes 2-dehydro-3-deoxy-6-phosphate-D-gluconate and 2-dehydro-3-deoxy-6-phosphate-D-galactonate with similar catalytic efficiency. In vitro the enzyme can also catalyse the cleavage of the non-phosphorylated forms 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate with much lower catalytic efficiency. cf. EC 4.1.2.21, 2-dehydro-3-deoxy-6-phosphogalactonate aldolase, and EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase.
History
EC 4.1.2.55 created 2014
Pathway
Pentose phosphate pathway
Galactose metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K11395  
2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
Genes
HAL: 
VNG_0444G(dapA)
HSL: 
OE_1665R(kdgA)
TAC: 
TVO: 
TVG0663048(TVG0663048)
PTO: 
FAC: 
SSO: 
SSO3197(eda)
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
STK_24790(kdgA)
SAI: 
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
SULA: 
MSE: 
MCN: 
AHO: 
PAS: 
PYR: 
POG: 
TUZ: 
TTN: 
TTX_1156a(kdgA)
 » show all
Taxonomy
Reference
1  [PMID:10527934]
  Authors
Buchanan CL, Connaris H, Danson MJ, Reeve CD, Hough DW
  Title
An extremely thermostable aldolase from Sulfolobus solfataricus with specificity  for non-phosphorylated substrates.
  Journal
Biochem. J. 343 Pt 3 (1999) 563-70.
  Sequence
Reference
2  [PMID:16330030]
  Authors
Lamble HJ, Theodossis A, Milburn CC, Taylor GL, Bull SD, Hough DW, Danson MJ
  Title
Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon  Sulfolobus solfataricus.
  Journal
FEBS. Lett. 579 (2005) 6865-9.
  Sequence
Reference
3  [PMID:17176250]
  Authors
Wolterink-van Loo S, van Eerde A, Siemerink MA, Akerboom J, Dijkstra BW, van der Oost J
  Title
Biochemical and structural exploration of the catalytic capacity of Sulfolobus KDG aldolases.
  Journal
Biochem. J. 403 (2007) 421-30.
  Sequence
[sso:SSO3197] [sai:Saci_0225] [sto:STK_24790]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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