KEGG   ENZYME: 4.1.3.16Help
Entry
EC 4.1.3.16                 Enzyme                                 

Name
4-hydroxy-2-oxoglutarate aldolase;
2-oxo-4-hydroxyglutarate aldolase;
hydroxyketoglutaric aldolase;
4-hydroxy-2-ketoglutaric aldolase;
2-keto-4-hydroxyglutaric aldolase;
4-hydroxy-2-ketoglutarate aldolase;
2-keto-4-hydroxyglutarate aldolase;
2-oxo-4-hydroxyglutaric aldolase;
DL-4-hydroxy-2-ketoglutarate aldolase;
hydroxyketoglutarate aldolase;
2-keto-4-hydroxybutyrate aldolase;
4-hydroxy-2-oxoglutarate glyoxylate-lyase;
KHGA
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
Reaction(IUBMB)
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate [RN:R00470]
Reaction(KEGG)
Substrate
4-hydroxy-2-oxoglutarate [CPD:C01127]
Product
pyruvate [CPD:C00022];
glyoxylate [CPD:C00048]
Comment
The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, L-4-hydroxy-2-oxoglutarate aldolase.
History
EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)
Pathway
Arginine and proline metabolism
Glyoxylate and dicarboxylate metabolism
Metabolic pathways
Orthology
K18123  
4-hydroxy-2-oxoglutarate aldolase
Genes
HSA: 
112817(HOGA1)
PTR: 
742884(HOGA1)
GGO: 
101154009(HOGA1)
PON: 
100171598(HOGA1)
MCF: 
102126728(HOGA1)
MMU: 
67432(Hoga1)
RNO: 
293949(Hoga1)
CGE: 
100759109(Hoga1)
HGL: 
101700602(Hoga1)
TUP: 
102486364(HOGA1)
CFA: 
608755(HOGA1)
AML: 
FCA: 
101101417(HOGA1)
PTG: 
102965487(HOGA1)
BTA: 
506001(HOGA1)
BOM: 
102265621(HOGA1)
PHD: 
102342808(HOGA1)
CHX: 
102173994(HOGA1)
SSC: 
100153961(HOGA1)
CFR: 
102512614(HOGA1)
ECB: 
100070689(HOGA1)
MYB: 
102246939(HOGA1)
MYD: 
102768587(HOGA1)
PALE: 
102884382(HOGA1)
MDO: 
100021876(HOGA1)
SHR: 
100929176(HOGA1)
OAA: 
100088274(HOGA1)
GGA: 
770036(C10ORF65)
MGP: 
TGU: 
100231472(HOGA1)
FAB: 
101806953(HOGA1)
PHI: 
102112987(HOGA1)
FPG: 
101920952(HOGA1)
FCH: 
102052298(HOGA1)
CLV: 
102097409(HOGA1)
ASN: 
102382587(HOGA1)
ACS: 
XLA: 
495193(hoga1)
XTR: 
496669(hoga1)
DRE: 
405806(hoga1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362318(HOGA1)
BFO: 
CIN: 
SPU: 
API: 
ISC: 
NVE: 
HMG: 
LIR: 
LAW_00107(dapA_1)
DOR: 
TLI: 
AMO: 
 » show all
Taxonomy
Reference
1  [PMID:14089442]
  Authors
KURATOMI K, FUKUNAGA K.
  Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.
  Journal
Biochim. Biophys. Acta. 78 (1963) 617-28.
  Organism
Rattus norvegicus
Reference
2  [PMID:5780845]
  Authors
Kobes RD, Dekker EE
  Title
2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties.
  Journal
J. Biol. Chem. 244 (1969) 1919-25.
  Organism
Bos taurus
Reference
3  [PMID:5580656]
  Authors
Lane RS, Shapley A, Dekker EE.
  Title
2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine.
  Journal
Biochemistry. 10 (1971) 1353-64.
  Organism
Bos taurus
Reference
4  [PMID:3942759]
  Authors
Scholtz JM, Schuster SM
  Title
Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase.
  Journal
Biochim. Biophys. Acta. 869 (1986) 192-6.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-81-3

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