KEGG   ENZYME: 4.1.3.4Help
Entry
EC 4.1.3.4                  Enzyme                                 
Name hydroxymethylglutaryl-CoA lyase;
hydroxymethylglutaryl coenzyme A-cleaving enzyme;
hydroxymethylglutaryl coenzyme A lyase;
3-hydroxy-3-methylglutaryl coenzyme A lyase;
3-hydroxy-3-methylglutaryl CoA cleaving enzyme;
3-hydroxy-3-methylglutaryl-CoA lyase;
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase
Class Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase
(acetyl-CoA-forming)
Reaction(IUBMB) (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate
[RN:R01360]
Reaction(KEGG) R01360
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Substrate (S)-3-hydroxy-3-methylglutaryl-CoA [CPD:C00356]
Product acetyl-CoA [CPD:C00024];
acetoacetate [CPD:C00164]
Pathway ec00072  Synthesis and degradation of ketone bodies
ec00280  Valine, leucine and isoleucine degradation
ec00281  Geraniol degradation
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology K01640  hydroxymethylglutaryl-CoA lyase
Genes HSA: 3155(HMGCL)
PTR: 456624(HMGCL)
MCC: 710833(HMGCL) 714982(HMGCLL1)
MMU: 15356(Hmgcl)
RNO: 79238(Hmgcl)
CFA: 478187(HMGCL)
BTA: 317658(HMGCL)
ECB: 100057686
MDO: 100010594
OAA: 100082402
GGA: 396316(HMGCL)
TGU: 100217934
XLA: 432233(hmgcl)
DRE: 394190(hmgcl)
BFO: BRAFLDRAFT_270381
CIN: 100184013
SPU: 756856
DME: Dmel_CG10399
DPO: Dpse_GA10298
DAN: Dana_GF15438
DER: Dere_GG10447
DPE: Dper_GL26197
DSE: Dsec_GM16259
DWI: Dwil_GK18282
DYA: Dyak_GE14242
DGR: Dgri_GH13343
DMO: Dmoj_GI17729
DVI: Dvir_GJ17557
AGA: AgaP_AGAP008717
AAG: AaeL_AAEL002065
CQU: CpipJ_CPIJ001976
AME: 726494(GB18444)
NVI: 100120133(NV11699)
TCA: 661818
API: 100160586(ACYPI001872)
PHU: Phum_PHUM454550
ISC: IscW_ISCW015386
CEL: Y71G12B.10
CBR: CBG22170
SMM: Smp_185140
NVE: NEMVE_v1g89324
TAD: TRIADDRAFT_61193
ATH: AT2G26800
POP: POPTR_833174
RCU: RCOM_1635180
VVI: 100243192 100264975
OSA: 4326266(Os01g0269000)
SBI: SORBI_05g002170
ZMA: 100193689
PPP: PHYPADRAFT_58979
CRE: CHLREDRAFT_195057
CME: CMA068C
YLI: YALI0B22550g
NCR: NCU05419
PAN: PODANSg6798
MGR: MGG_09181(MG09181.4)
FGR: FG00638.1
ANI: AN5273.2
AFM: AFUA_2G12450 AFUA_7G01720
AOR: AO090026000392 AO090038000541
ANG: An02g04640
AFV: AFLA_070820 AFLA_135360
ACT: ACLA_065820 ACLA_071350
PCS: Pc20g14670 Pc21g09480
NFI: NFIA_087590 NFIA_114450
CIM: CIMG_05209
URE: UREG_06412
SSL: SS1G_10681
BFU: BC1G_04231
PNO: SNOG_07488
CNE: CNC00210
CNB: CNBC7020
PPL: POSPLDRAFT_33879
LBC: LACBIDRAFT_247997
UMA: UM02001.1
MBR: MONBRDRAFT_33622
NGR: NAEGRDRAFT_80885
DDI: DDB_G0283813(hmgL)
TGO: TGME49_004460
TET: TTHERM_00686100
PTM: GSPATT00029666001
TBR: Tb927.4.2700
TCR: 506635.80 508027.129 508029.10
PTI: PHATRDRAFT_13643(HCL1)
EIC: NT01EI_1368 NT01EI_2169
ETR: ETAE_2032
XCC: XCC1832(mvaB)
XCB: XC_2357
XCA: xccb100_2120
XCV: XCV1897(mvaB)
XAC: XAC1851(mvaB)
XOO: XOO2903(mvaB)
XOM: XOO_2753
XOP: PXO_00102
XAL: XALc_1332(mvaB)
SML: Smlt2207(hmgcL)
SMT: Smal_1800
VVU: VV2_0499 VV2_0500
VVY: VVA1049
VPA: VPA0615 VPA1129
VHA: VIBHAR_05477
VEX: VEA_000381 VEA_001540
PPR: PBPRB1119
PAE: PA2011(liuE)
PAU: PA14_38490(gnyL)
PAP: PSPA7_3278
PAG: PLES_33121(liuE)
PPU: PP_3394 PP_3540(mvaB)
PPF: Pput_2234 Pput_5024
PPG: PputGB1_2384
PPW: PputW619_1943 PputW619_2559
PST: PSPTO_2742(mvaB)
PSB: Psyr_2471
PSP: PSPPH_2629(mvaB)
PFL: PFL_3934(mvaB)
PFO: Pfl01_1315 Pfl01_3654
PFS: PFLU1417 PFLU3887
PEN: PSEEN2983(mvaB)
PMY: Pmen_2029
PSA: PST_1716(mvaB) PST_3217
CJA: CJA_2967
AVN: Avin_25990 Avin_49510
PAR: Psyc_0312(mvaB)
PCR: Pcryo_0343
PRW: PsycPRwf_2063
ACI: ACIAD2820
ACD: AOLE_09400 AOLE_11865 AOLE_12735
ACB: A1S_1372
ABY: ABAYE2292 ABAYE2344
ABC: ACICU_01407
ABN: AB57_1547 AB57_1597
ABB: ABBFA_002122 ABBFA_002172
SON: SO_1893(mvaB)
SDN: Sden_2250
SFR: Sfri_2731
SAZ: Sama_1358
SBL: Sbal_2832
SBM: Shew185_2850
SBN: Sbal195_2977
SBP: Sbal223_1526
SLO: Shew_2574
SPC: Sputcn32_1715
SSE: Ssed_1454
SPL: Spea_2802
SHE: Shewmr4_2326
SHM: Shewmr7_2398
SHN: Shewana3_1668
SHW: Sputw3181_2310
SHL: Shal_2907
SWD: Swoo_3227
SWP: swp_3448
SVO: SVI_1276(mvaB)
ILO: IL0878
CPS: CPS_1599(mvaB)
PHA: PSHAa1448(hmgcL)
PAT: Patl_2762 Patl_2929
MAQ: Maqu_2126
AMC: MADE_02416
CBU: CBU_0520(leuA)
CBS: COXBURSA331_A0633(leuA)
CBD: CBUD_1542(leuA)
CBG: CbuG_1475(leuA)
CBC: CbuK_1317(leuA)
LPN: lpg1830(mvaB)
LPF: lpl1794
LPP: lpp1793
LPC: LPC_1274(mvaB)
LPA: lpa_02643(leuA)
LLO: LLO_1073(mvaB)
NOC: Noc_1888
NHL: Nhal_2501
HCH: HCH_03947
ABO: ABO_2665(mvaB)
MMW: Mmwyl1_1472
AHA: AHA_2074
ASA: ASA_1908
KKO: Kkor_1055
CVI: CV_1759(mvaB)
LHK: LHK_02058
RSO: RSc0261
RPI: Rpic_0114 Rpic_1378 Rpic_2061
RPF: Rpic12D_0121 Rpic12D_1442
REU: Reut_A0153 Reut_A1462 Reut_A2107 Reut_B4194 Reut_C6248
REH: H16_A0186 H16_A1235(mvaB) H16_A1547 H16_A2385(hmgL1) H16_B0615
     H16_B2494(hmgL2)
RME: Rmet_0607 Rmet_2124
CTI: RALTA_A0129 RALTA_A1930 RALTA_B2209
BPS: BPSL0333
BPM: BURPS1710b_0543
BPL: BURPS1106A_0367
BPD: BURPS668_0353
BPR: GBP346_A0272
BTE: BTH_I0313
BVI: Bcep1808_3048
BUR: Bcep18194_A4853 Bcep18194_A6309 Bcep18194_C6961
BCN: Bcen_1213 Bcen_2345 Bcen_5396
BCH: Bcen2424_1692 Bcen2424_2959 Bcen2424_5465
BCM: Bcenmc03_1664 Bcenmc03_2980 Bcenmc03_4804
BCJ: BCAL0631 BCAL1750 BCAM2661
BAM: Bamb_1600 Bamb_3007 Bamb_4807 Bamb_6280
BAC: BamMC406_1622 BamMC406_2870 BamMC406_5348 BamMC406_5984
BMU: Bmul_1554 Bmul_2955
BMJ: BMULJ_00279(hmgL) BMULJ_01690(hmgL)
BXE: Bxe_A2729 Bxe_A4270
BPH: Bphy_0165 Bphy_4250 Bphy_6613
BPY: Bphyt_0440 Bphyt_0806 Bphyt_6976
BGL: bglu_1g32590
BGE: BC1002_0184 BC1002_0581 BC1002_5140 BC1002_5817 BC1002_7090
PNU: Pnuc_0873
BPE: BP0556(hmgcL) BP3695
BPA: BPP0239(hmgcL) BPP0508 BPP2803(hmgL)
BBR: BB0243(hmgcL) BB0714(hmgL) BB3124(hmgL)
BPT: Bpet2783 Bpet4318 Bpet4729
BAV: BAV0197(hmgcL)
RFR: Rfer_3824 Rfer_4199
POL: Bpro_2353 Bpro_4037 Bpro_4155
PNA: Pnap_0477 Pnap_1123 Pnap_3506
AAV: Aave_1652 Aave_4349
AJS: Ajs_2871 Ajs_3143 Ajs_3757
DIA: Dtpsy_2358 Dtpsy_2490 Dtpsy_3038
VEI: Veis_0293 Veis_0514
DAC: Daci_2875 Daci_2967 Daci_3137 Daci_5964
VAP: Vapar_0455 Vapar_1756 Vapar_2773 Vapar_3267 Vapar_4710
CTT: CtCNB1_0509 CtCNB1_1672 CtCNB1_1781 CtCNB1_3122
MPT: Mpe_A3354
HAR: HEAR0103
MMS: mma_0124(hmgL)
HSE: Hsero_4694
LCH: Lcho_0036 Lcho_0438 Lcho_0445 Lcho_2115
TIN: Tint_2717
EBA: ebA4662(hmgL)
AZO: azo3065(mvaB)
DAR: Daro_0086
TMZ: Tmz1t_0753
APP: CAP2UW1_4325
GME: Gmet_3293
BBA: Bd3576(mvaB)
DAL: Dalk_3796
DAT: HRM2_21340(mvaB)
ADE: Adeh_1644
ACP: A2cp1_2302
AFW: Anae109_2166
ANK: AnaeK_2214
MXA: MXAN_3753
SCL: sce4321(mvaB)
HOH: Hoch_3592
SME: SM_b21125(hmgL)
SMD: Smed_4536
ATU: Atu3480(hmgL)
ATC: AGR_L_2702
ARA: Arad_1377(pyc)
AVI: Avi_7692(hmgL)
RHI: NGR_b11640
BME: BMEI1926
BMI: BMEA_A0017
BMF: BAB1_0017
BMB: BruAb1_0017(mvaB)
BMC: BAbS19_I00140
BMT: BSUIS_A0018
BOV: BOV_0014(mvaB)
BMR: BMI_I17(mvaB)
OAN: Oant_0040
BJA: bll6364 blr0698 blr4422(hmgL)
BRA: BRADO3681(hmgL)
BBT: BBta_4049(hmgL)
RPA: RPA2540(hmgL)
RPB: RPB_2932
RPC: RPC_2780
RPD: RPD_2536
RPE: RPE_2910
RPT: Rpal_2810
XAU: Xaut_1854
AZC: AZC_1996
SNO: Snov_3532
MRD: Mrad2831_3870
MET: M446_1232 M446_1922 M446_5092
MNO: Mnod_2776 Mnod_4905
CCR: CC_0467
CCS: CCNA_00500
CAK: Caul_4523
CSE: Cseg_0532
PZU: PHZ_c0425(mvaB)
SIL: SPO2788(mvaB)
SIT: TM1040_0739
RSP: RSP_2510(hmgL)
RSH: Rsph17029_1172
RSQ: Rsph17025_2009
RSK: RSKD131_0825
RCP: RCAP_rcc01515(hmgL)
JAN: Jann_1149 Jann_3783
RDE: RD1_3295(mvaB)
PDE: Pden_3641 Pden_4878
DSH: Dshi_1303(mvaB)
MMR: Mmar10_2390
HNE: HNE_1080 HNE_3374
HBA: Hbal_1509
NAR: Saro_0177
SWI: Swit_2317
ACR: Acry_2695
RRU: Rru_A1940
RCE: RC1_0377
MAG: amb0673
AZL: AZL_a02290(hmgL)
BSU: BSU18230(yngG)
BHA: BH1134
BAN: BA_2550(mvaB)
BAR: GBAA_2550(mvaB)
BAA: BA_3052
BAT: BAS2372
BAH: BAMEG_2050(mvaB)
BAI: BAA_2609(mvaB)
BCE: BC2486
BCA: BCE_2551(mvaB)
BCZ: BCZK2288(mvaB)
BCR: BCAH187_A2606(mvaB)
BCB: BCB4264_A2514(mvaB)
BCU: BCAH820_2563(mvaB)
BCG: BCG9842_B2809(mvaB)
BCQ: BCQ_2428(mvaB)
BCX: BCA_2634(mvaB)
BCY: Bcer98_1805
BTK: BT9727_2330(mvaB)
BTL: BALH_2291
BTB: BMB171_C2245(mvaB)
BWE: BcerKBAB4_2358
BLI: BL01990(yngG)
BLD: BLi02141(yngG)
BCL: ABC0547
BAY: RBAM_018350(yngG)
BPU: BPUM_1782(yngG)
BPF: BpOF4_11300
BMQ: BMQ_0977 BMQ_4408
BMD: BMD_0978 BMD_4394
OIH: OB1343 OB3230
GKA: GK1601
GTN: GTNG_1450
GWC: GWCH70_1838
GYC: GYMC61_2443 GYMC61_3564
GCT: GC56T3_1907
AFL: Aflv_0183
LSP: Bsph_0901
BBE: BBR47_38570(yngG)
AAC: Aaci_2053
BTS: Btus_1269 Btus_1869 Btus_2163
CDF: CD0797
CDC: CD196_0747
CDL: CDR20291_0728
AOE: Clos_0815
MPA: MAP3194
MAV: MAV_4025
MSM: MSMEG_2024 MSMEG_2072
MUL: MUL_2447
MVA: Mvan_1894
MGI: Mflv_4466
MAB: MAB_4650c
MMC: Mmcs_1588
MKM: Mkms_1612
MJL: Mjls_1558
MMI: MMAR_1493
NFA: nfa46700
RHA: RHA1_ro04924 RHA1_ro05078
RER: RER_04250 RER_34990(hmgL)
ROP: ROP_45850(hmgL) ROP_49950 ROP_51390
GBR: Gbro_2863
SCO: SCO2778(hmgL)
SMA: SAV_5276(hmgL)
SGR: SGR_4757
SCB: SCAB_58011(hmgL)
AAU: AAur_4148
ACH: Achl_0192
KSE: Ksed_21580
NCA: Noca_0149
KFL: Kfla_0141
NDA: Ndas_0968
TCU: Tcur_0961 Tcur_1975
SRO: Sros_6411 Sros_6617
FRE: Franean1_3719 Franean1_4049
ACE: Acel_0401
NML: Namu_0348 Namu_4266
GOB: Gobs_5035
SEN: SACE_3041 SACE_4360 SACE_6499(hmgL)
SVI: Svir_05920
TBI: Tbis_2152
AMI: Amir_6387
STP: Strop_0026
SAQ: Sare_0032
CAI: Caci_0816
SNA: Snas_0124
RXY: Rxyl_1697
CWO: Cwoe_0233 Cwoe_3976 Cwoe_4125
AFO: Afer_1146
LIL: LA_0845
LIC: LIC12782
LBL: LBL_2733(leuA-4)
LBI: LEPBI_I1932(mvaB)
LBF: LBF_1877
ABA: Acid345_1427
ACA: ACP_1662
SRU: SRU_1246
SRM: SRM_01435(mvaB)
RMR: Rmar_2658
CHU: CHU_1436(leuA)
DFE: Dfer_4398
SLI: Slin_3023
CPI: Cpin_2930
PHE: Phep_1418
GFO: GFO_2517(mvaB)
FJO: Fjoh_2213
FPS: FP1821(mvaB)
FBA: FIC_00098
RBI: RB2501_11347
ZPR: ZPR_0863
CAT: CA2559_08456
ACO: Amico_1324
RRS: RoseRS_0049 RoseRS_4162
RCA: Rcas_0594 Rcas_3494 Rcas_3515
CAU: Caur_0371 Caur_2265
CAG: Cagg_1303 Cagg_3092
CHL: Chy400_0397 Chy400_2438
HAU: Haur_0762
TRO: trd_A0543
STI: Sthe_0007
TRA: Trad_2936
TTH: TTC1162
TTJ: TTHA1526
MRB: Mrub_2263
MSV: Mesil_2180 Mesil_3280
HLA: Hlac_1101
HVO: HVO_A0568
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13271348]
BACHHAWAT BK, ROBINSON WG, COON MJ.
The enzymatic cleavage of beta-hydroxy-beta-methylglutaryl coenzyme
A to acetoacetate and acetyl coenzyme A.
J. Biol. Chem. 216 (1955) 727-36.
Sus scofa [GN:ssc]
Other DBs ExplorEnz - The Enzyme Database: 4.1.3.4
IUBMB Enzyme Nomenclature: 4.1.3.4
ExPASy - ENZYME nomenclature database: 4.1.3.4
BRENDA, the Enzyme Database: 4.1.3.4
CAS: 9030-83-5
DBGET integrated database retrieval system