KEGG   ENZYME: 4.2.1.116Help
Entry
EC 4.2.1.116                Enzyme                                 

Name
3-hydroxypropionyl-CoA dehydratase;
3-hydroxypropionyl-CoA hydro-lyase;
3-hydroxypropanoyl-CoA dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
3-hydroxypropanoyl-CoA hydro-lyase
Reaction(IUBMB)
3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O [RN:R03045]
Reaction(KEGG)
Substrate
3-hydroxypropanoyl-CoA [CPD:C05668]
Product
acryloyl-CoA [CPD:C00894];
H2O [CPD:C00001]
Comment
Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA [2].
History
EC 4.2.1.116 created 2009
Pathway
Carbon fixation pathways in prokaryotes
Microbial metabolism in diverse environments
Orthology
K14469  
acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase
K15019  
3-hydroxypropionyl-coenzyme A dehydratase
Genes
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
CTM: 
ZGA: 
CTS: 
FAC: 
SSO: 
SSO0654(paaF-2)
SOL: 
SSOA: 
SSOL: 
SSOF: 
STO: 
SAI: 
Saci_1633(paaF)
SACN: 
SACR: 
SACS: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
NMR: 
NIR: 
NID: 
NIN: 
NKR: 
CSY: 
NGA: 
NVN: 
NEV: 
TAA: 
NMY3_00896(echA8_1) NMY3_01290(echA8_2)
NBV: 
TAH: 
 » show all
Taxonomy
Reference
1  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science. 318 (2007) 1782-6.
  Sequence
[mse:Msed_2001]
Reference
2  [PMID:19429610]
  Authors
Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G
  Title
3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.
  Journal
J. Bacteriol. 191 (2009) 4572-81.
  Sequence
[mse:Msed_2001]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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