| Entry |
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| Name |
cystathionine beta-synthase;
serine sulfhydrase;
beta-thionase;
methylcysteine synthase;
cysteine synthase;
serine sulfhydrylase;
L-serine hydro-lyase (adding homocysteine)
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
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| Reaction(IUBMB) |
L-serine + L-homocysteine = L-cystathionine + H2O [RN: R01290]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A pyridoxal-phosphate protein. A multifunctional enzyme: catalyses beta-replacement reactions between L-serine, L-cysteine, cysteine thioethers, or some other beta-substituted alpha-L-amino acids, and a variety of mercaptans.
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| Pathway |
| Glycine, serine and threonine metabolism | | Cysteine and methionine metabolism | | Metabolic pathways |
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| Orthology |
| cystathionine beta-synthase | | cysteine synthase / O-phosphoserine sulfhydrylase / spermine synthase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | CME: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | CNE: | | CNB: | | CGI: | | LBC: | | MPR: | | CCI: | | SCM: | | UMA: | | PGR: | | MBR: | | NGR: | | DDI: | | DPP: | | TGO: | | TET: | | PTM: | | TBR: | | TCR: | | LMA: | | LIF: | | LDO: | | LMI: | | LBZ: | | PTI: | | PIF: | | YEN: | | YEP: | | YEY: | | ECA: | | PCT: | | PCC: | | PLU: | | PAY: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KVA: | | KOX: | | CKO: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | PMR: | | ETR: | | ETD: | | ETC: | | HDE: | | DDC: | | XBO: | | PSI: | | ROR: | | XFA: | | XFT: | | XFM: | | XFN: | | XFF: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XAL: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | PSU: | | PSD: | | FAU: | | RHD: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PPUU: | | PFO: | | PFS: | | PFC: | | PPZ: | | PDR: | | ILO: | | CBS: | | CBD: | | CBG: | | CBC: | | LLO: | | FTU: | | FTF: | | FTR: | | FTT: | | FTG: | | FTL: | | FTH: | | FTA: | | FTS: | | FTI: | | FTM: | | FTN: | | FCF: | | FCN: | | FPH: | | FRT: | | FNA: | | HCH: | | KKO: | | CVI: | | PSE: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPR: | | BPZ: | | BTE: | | BGL: | | POL: | | CFU: | | RGE: | | DSU: | | BBA: | | BBAT: | | BEX: | | BMX: | | ADE: | | ACP: | | AFW: | | ANK: | | MXA: | | MFU: | | MSD: | | CCX: | | SUR: | | SCL: | | HOH: | | MLO: | | MCI: | | MOP: | | MAM: | | SMK: | | RHI: | | SFH: | | SFD: | | RTR: | | BBT: | | RPA: | | RPT: | | RVA: | | CAK: | | PZU: | | BSB: | | RRU: | | RRF: | | RCE: | | RPM: | | MAG: | | TMO: | | SAY: | | SAP: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTG: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MBO: | | MBB: | | MBT: | | MBM: | | MBK: | | MAF: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MLE: | | MLB: | | MPA: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MSM: | | MSG: | | MSA: | | MUL: | | MVA: | | MGI: | | MSP: | | MAB: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | MMI: | | MRH: | | MMM: | | MCB: | | MLI: | | ASD: | | CJK: | | CKP: | | CPU: | | CPL: | | CPG: | | CPP: | | CPK: | | CPQ: | | CPX: | | CPZ: | | COR: | | COP: | | COD: | | COS: | | COI: | | COE: | | COU: | | CRD: | | CUL: | | CUC: | | CUE: | | NFA: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GBR: | | GPO: | | GOR: | | TPR: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | SFI: | | KSK: | | LXX: | | CMI: | | CMS: | | CMC: | | MTS: | | ART: | | AAU: | | ACH: | | AAI: | | APN: | | ARR: | | RSA: | | KRH: | | MLU: | | BCV: | | XCE: | | IVA: | | CFL: | | CFI: | | CGA: | | ICA: | | PAC: | | MPH: | | NCA: | | KFL: | | TFU: | | NDA: | | NAL: | | TCU: | | SRO: | | FRA: | | FRE: | | FRI: | | FAL: | | FSY: | | NML: | | GOB: | | BSD: | | MMAR: | | KRA: | | SEN: | | SVI: | | TBI: | | AMD: | | AMN: | | AMM: | | PDX: | | AMI: | | SESP: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | CAI: | | SNA: | | BLO: | | BLJ: | | BLN: | | BLON: | | BLF: | | BLL: | | BLB: | | BLM: | | BLK: | | BLG: | | BAD: | | BLA: | | BLC: | | BLT: | | BBB: | | BBC: | | BNM: | | BLV: | | BLW: | | BLS: | | BNI: | | BDE: | | BBI: | | BBP: | | BBF: | | BBV: | | BBRU: | | BTP: | | CWO: | | AYM: | | PUV: | | WCH: | | SRU: | | SRM: | | CPI: | | NKO: | | PHE: | | SHG: | | SCN: | | HHY: | | SGN: | | CMR: | | BBD: | | EVI: | | SLI: | | FLI: | | FAE: | | MTT: | | GFO: | | FJO: | | FPS: | | FBR: | | FCO: | | FIN: | | COC: | | CCM: | | RBI: | | ZPR: | | CAT: | | RAN: | | RAI: | | RAR: | | RAG: | | RAE: | | FBC: | | CAO: | | CLY: | | WVI: | | KDI: | | LAN: | | ZGA: | | MRS: | | ASL: | | ORH: | | PTQ: | | NDO: | | POM: | | FBA: | | FTE: | | OHO: | | GAU: | | SACI: | | AVA: | | CSG: | | CALO: | | CTE: | | CPC: | | CCH: | | CPB: | | CLI: | | PLT: | | PPH: | | PAA: | | IAL: | | HAU: | | STI: | | MPZ: | | MBN: | | MPL: | | HJE: | | HXA: | | PYN: | | PYA: | | TBA: | | APE: | | DMU: | | DFD: | | TAG: | | IAG: | | THG: | | HBU: | | PFM: | | PIS: | | TPE: | | ASC: | | CLG: | |
» show all
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| Reference |
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| Authors |
Braunstein AE, Goryachenkova EV, Tolosa EA, Willhardt IH, Yefremova LL. |
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| Title |
Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine -synthase. |
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| Journal |
Biochim. Biophys. Acta. 242 (1971) 247-60. |
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| Organism |
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| Reference |
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| Authors |
Nakagawa H, Kimura H. |
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| Title |
Purification and properties of cystathionine synthetase synthetase from rat liver: separation of cystathionine synthetase from serine dehydratase. |
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| Journal |
Biochem. Biophys. Res. Commun. 32 (1968) 209-14. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
SCHLOSSMANN K, BRUEGGEMANN J, LYNEN F. |
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| Title |
[Biosynthesis of cysteine. I. Detection and isolation of serine sulfhydrase from baker's yeast.] |
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| Journal |
Biochem. Z. 336 (1962) 258-73. |
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| Organism |
Saccharomyces cerevisiae [GN: sce] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9023-99-8 |
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