KEGG   ENZYME: 4.2.2.3Help
Entry
EC 4.2.2.3                  Enzyme                                 

Name
mannuronate-specific alginate lyase;
alginate lyase I;
alginate lyase;
alginase I;
alginase II;
alginase;
poly(beta-D-1,4-mannuronide) lyase;
poly(beta-D-mannuronate) lyase;
aly (gene name) (ambiguous);
poly[(1->4)-beta-D-mannuronide] lyase
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
BRITE hierarchy
Sysname
alginate beta-D-mannuronate---uronate lyase
Reaction(IUBMB)
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at their reducing end.
Reaction(KEGG)
(other) R03706
Show
Comment
The enzyme catalyses the degradation of alginate by a beta-elimination reaction. It cleaves the (1->4) bond between beta-D-mannuronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to four residues, with preference for shorter products. cf. EC 4.2.2.11, guluronate-specific alginate lyase.
History
EC 4.2.2.3 created 1965 as EC 4.2.99.4, transferred 1972 to EC 4.2.2.3, modified 1990, modified 2015
Pathway
Fructose and mannose metabolism
Orthology
K01729  
poly(beta-D-mannuronate) lyase
Genes
ENT: 
EAS: 
ENR: 
KSA: 
KIN: 
LAX: 
SML: 
SMT: 
BUJ: 
SMZ: 
PSUW: 
PGB: 
PAE: 
PA3547(algL)
PAEV: 
N297_3670(algL)
PAEI: 
N296_3670(algL)
PAU: 
PAP: 
PAG: 
PAF: 
PNC: 
PAEB: 
PDK: 
PSG: 
PRP: 
PAEP: 
PAER: 
PAEM: 
PAEL: 
PAES: 
PAEU: 
PAEG: 
PAEC: 
M802_3667(algL)
PAEO: 
M801_3535(algL)
PMY: 
PMK: 
PRE: 
PPU: 
PP_1281(algL)
PPF: 
PPG: 
PPW: 
PPT: 
PPB: 
PPI: 
PPX: 
T1E_3160(algL)
PPUH: 
PPUT: 
PPUN: 
PP4_07930(algL)
PPUD: 
PFV: 
PMON: 
PMOT: 
PMOS: 
PPJ: 
PST: 
PSB: 
Psyr_1056(algL)
PSYR: 
PSP: 
PCI: 
PFL: 
PFL_1017(algL)
PPRC: 
PPRO: 
PPC_1055(algL)
PFO: 
PFS: 
PFLU_0983(algL)
PFE: 
PFC: 
PFN: 
PFW: 
PFB: 
PFF: 
PPZ: 
PMAN: 
OU5_2454(algL)
PTV: 
PEN: 
PBA: 
PBC: 
PPUU: 
PDR: 
PSV: 
PVLB_04200(algL1) PVLB_15515(algL2)
PSK: 
PKC: 
PKB_0961(algL)
PCH: 
PCZ: 
PCP: 
PFZ: 
PALK: 
PPV: 
PSES: 
PSCI_0728(algL)
PSEM: 
PSEC: 
PPSY: 
PSOS: 
AVN: 
AVL: 
AVD: 
ACX: 
SFR: 
PHA: 
PAT: 
PIA: 
PBW: 
PTN: 
MSR: 
AMC: 
AMH: 
AMAL: 
AMAE: 
AMAO: 
AMAG: 
AMAC: 
AMB: 
ALT: 
AAL: 
AAUS: 
ASP: 
GAG: 
SDE: 
Sde_2478(alg7C) Sde_2547(alg7B) Sde_2839(ply7E) Sde_2873(alg6A) Sde_3274(ply6D) Sde_3275(ply6C) Sde_3285(ply6E) Sde_3286(ply7F)
SAGA: 
HHU: 
ABO: 
ABO_0393(algL)
ALN: 
GSN: 
TAU: 
RPI: 
RPF: 
BUR: 
BCEW: 
BPYR: 
BCON: 
PSPU: 
PAPI: 
POX: 
PNR: 
BAV: 
ADT: 
CARE: 
CPRA: 
AGE: 
SAMY: 
RHL: 
NGL: 
MNO: 
MEY: 
BSB: 
RED: 
MALG: 
MMR: 
HBA: 
SPHK: 
SPHP: 
STER: 
ERY: 
AMX: 
CNA: 
SVE: 
SVT: 
AOI: 
AORI_3483(algL)
ALU: 
KAL: 
VBA: 
ACM: 
GMA: 
TSA: 
RBA: 
BCEL: 
RMR: 
NKO: 
PEP: 
PSN: 
GFO: 
CAO: 
CLY: 
CLH: 
CBAL: 
CBAT: 
DOK: 
DDO: 
I597_0905(cslB)
LAN: 
ZGA: 
NDO: 
POM: 
WIN: 
SZE: 
AHZ: 
OHO: 
MRO: 
 » show all
Taxonomy
Reference
1  [PMID:13144]
  Authors
Davidson IW, Lawson CJ, Sutherland IW.
  Title
An alginate lysate from Azotobacter vinelandii phage.
  Journal
J. Gen. Microbiol. 98 (1977) 223-9.
Reference
2  [PMID:6020438]
  Authors
Nakada HI, Sweeny PC.
  Title
Alginic acid degradation by eliminases from abalone hepatopancreas.
  Journal
J. Biol. Chem. 242 (1967) 845-51.
Reference
3  [PMID:14488584]
  Authors
PREISS J, ASHWELL G.
  Title
Alginic acid metabolism in bacteria. I. Enzymatic formation of unsaturated oligosac-charides and 4-deoxy-L-erythro-5-hexoseulose uronic acid.
  Journal
J. Biol. Chem. 237 (1962) 309-16.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9024-15-1

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