| Entry |
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| Name |
cystathionine gamma-lyase;
homoserine deaminase;
homoserine dehydratase;
cystine desulfhydrase;
cysteine desulfhydrase;
gamma-cystathionase;
cystathionase;
homoserine deaminase-cystathionase;
gamma-CTL;
cystalysin;
cysteine lyase;
L-cystathionine cysteine-lyase (deaminating)
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| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
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| Sysname |
L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
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| Reaction(IUBMB) |
L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate (overall reaction) [RN: R01001];
(1a) L-cystathionine = L-cysteine + 2-ammoniobut-2-enoate [RN: R08632];
(1b) 2-ammoniobut-2-enoate + H2O = 2-oxobutanoate + NH3 (spontaneous) [RN: R08637]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A multifunctional pyridoxal-phosphate protein. Also catalyses elimination reactions of L-homoserine to form H2O, NH3 and 2-oxobutanoate, of L-cystine, producing thiocysteine, pyruvate and NH3, and of L-cysteine producing pyruvate, NH3 and H2S.
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| Pathway |
| Glycine, serine and threonine metabolism | | Cysteine and methionine metabolism | | Selenocompound metabolism | | Metabolic pathways |
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| Orthology |
| cystathionine gamma-lyase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DAN: | | DER: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | CEL: | | CBR: | | BMY: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | CME: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | MGR: | | FGR: | | NHE: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | URE: | | ABE: | | PNO: | | PTE: | | TML: | | CNE: | | CNB: | | PPL: | | LBC: | | CCI: | | SCM: | | UMA: | | MBR: | | NGR: | | DDI: | | DPP: | | TET: | | PTM: | | PTI: | | PIF: | | PLU: | | PAY: | | ENT: | | ENC: | | ENO: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | KPM: | | KPE: | | KVA: | | KOX: | | SPE: | | SRR: | | SRS: | | SRA: | | DDC: | | XCC: | | XCB: | | XCA: | | XCV: | | XAC: | | XAX: | | XOO: | | XOM: | | XOP: | | XAL: | | SML: | | SMT: | | PSU: | | FAU: | | PAE: | | PAU: | | PAP: | | PAG: | | PDK: | | PPU: | | PPF: | | PPG: | | PPW: | | PFO: | | KKO: | | NGO: | | CVI: | | POL: | | CFU: | | DSU: | | BBA: | | ADE: | | ACP: | | AFW: | | ANK: | | MXA: | | MFU: | | CCX: | | HOH: | | MLO: | | RPA: | | CAK: | | PZU: | | BSB: | | SIL: | | HNE: | | RRU: | | RCE: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BSX: | | BLI: | | BLD: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAZ: | | BQL: | | BXH: | | BAMI: | | BAE: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BCL: | | BPU: | | BMQ: | | BMD: | | BMH: | | BCK: | | BAG: | | BJS: | | BACI: | | OIH: | | GKA: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | AFL: | | SAU: | | SAV: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAS: | | SAR: | | SAC: | | SAA: | | SAO: | | SAE: | | SAD: | | SUU: | | SUV: | | SUH: | | SUE: | | SUJ: | | SUK: | | SUC: | | SUT: | | SUQ: | | SUZ: | | SUD: | | SUX: | | SUW: | | SUG: | | SUF: | | SAB: | | SUY: | | SAUB: | | SAUM: | | SEP: | | SER: | | SHA: | | SSP: | | SCA: | | SLG: | | SLN: | | SSD: | | SDT: | | SWA: | | HHD: | | ESI: | | EAT: | | EAN: | | MCL: | | BBE: | | PJD: | | PPY: | | PPM: | | PPO: | | PTA: | | LLA: | | LLK: | | LLT: | | LLS: | | LLC: | | LLM: | | LLR: | | LLN: | | LLI: | | LGR: | | LGV: | | STC: | | STL: | | STE: | | STN: | | STU: | | STW: | | LPL: | | LPJ: | | LPT: | | LPS: | | LSL: | | LSI: | | LDB: | | LBU: | | LDE: | | LDL: | | LCS: | | LCE: | | LCW: | | LRE: | | LRF: | | LRU: | | LHE: | | LHR: | | LFE: | | LFR: | | LRL: | | LRA: | | EFA: | | EFL: | | EFI: | | EFD: | | EFS: | | EFC: | | EFU: | | EFM: | | EHR: | | ENE: | | ECAS: | | THL: | | OOE: | | LME: | | LMM: | | LKI: | | LGS: | | LEC: | | LCN: | | LGE: | | CRN: | | CML: | | CAC: | | CAE: | | CAY: | | CPE: | | CPF: | | CPR: | | CBO: | | CBA: | | CBH: | | CBY: | | CBL: | | CBK: | | CBB: | | CBI: | | CBF: | | CBM: | | CBJ: | | CBE: | | CKL: | | CKR: | | CPY: | | CLJ: | | CLB: | | CSR: | | CPAS: | | AOE: | | CLE: | | EHA: | | RAL: | | TOC: | | TTM: | | TTO: | | SRI: | | MPA: | | MAV: | | MSM: | | MVA: | | MGI: | | MSP: | | MAB: | | MMC: | | MKM: | | MJL: | | RHA: | | RER: | | ROP: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | MLU: | | KFL: | | ACE: | | GOB: | | SEN: | | PDX: | | AMI: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | BLO: | | CWO: | | ABA: | | ACM: | | PHE: | | SLI: | | FJO: | | WVI: | | FSU: | | FSC: | | GAU: | | RBA: | | AVA: | | TPT: | | TLE: | | MBN: | | MPL: | | MEZ: | | HAL: | | HSL: | | HTU: | | NMG: | | HVO: | | HXA: | | TAC: | | TVO: | | PYN: | | PYA: | | TBA: | | MAX: | | APE: | |
» show all
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| Reference |
1 |
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| Authors |
Braunstein, A.E. and Azarkh, R.M. |
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| Title |
[Participation of vitamin B6 in enzymic formation of hydrogen sulfide from L-cysteine.]. |
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| Journal |
Dokl. Akad. Nauk. S.S.S.R. 71 (1950) 93-96. |
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| Reference |
2 |
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| Authors |
Braunstein, A.E. and Azarkh, R.M. |
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| Title |
[Phosphopyridoxal in aerobic deamination of homoserine and serine.]. |
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| Journal |
Dokl. Akad. Nauk. S.S.S.R. 85 (1952) 385-388. |
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| Reference |
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| Authors |
FLAVIN M, SEGAL A. |
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| Title |
PURIFICATION AND PROPERTIES OF THE CYSTATHIONINE GAMMA-CLEAVAGE ENZYME OF NEUROSPORA. |
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| Journal |
J. Biol. Chem. 239 (1964) 2220-7. |
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| Organism |
Neurospora sp. |
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| Reference |
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| Authors |
MATSUO Y, GREENBERG DM. |
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| Title |
A crystalline enzyme that cleaves homoserine and cystathionine. III. Coenzyme resolution, activators, and inhibitors. |
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| Journal |
J. Biol. Chem. 234 (1959) 507-15. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
MATSUO Y, GREENBERG DM. |
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| Title |
A crystalline enzyme that cleaves homoserine and cystathionine. IV. Mechanism of action, reversibility, and substrate specificity. |
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| Journal |
J. Biol. Chem. 234 (1959) 516-9. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9012-96-8 |
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