| Entry |
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| Name |
cystathionine gamma-lyase;
homoserine deaminase;
homoserine dehydratase;
cystine desulfhydrase;
cysteine desulfhydrase;
gamma-cystathionase;
cystathionase;
homoserine deaminase-cystathionase;
gamma-CTL;
cystalysin;
cysteine lyase;
L-cystathionine cysteine-lyase (deaminating)
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| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
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| Sysname |
L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
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| Reaction(IUBMB) |
L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate (overall reaction) [RN: R01001];
(1a) L-cystathionine = L-cysteine + 2-ammoniobut-2-enoate [RN: R08632];
(1b) 2-ammoniobut-2-enoate + H2O = 2-oxobutanoate + NH3 (spontaneous) [RN: R08637]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A multifunctional pyridoxal-phosphate protein. Also catalyses elimination reactions of L-homoserine to form H2O, NH3 and 2-oxobutanoate, of L-cystine, producing thiocysteine, pyruvate and NH3, and of L-cysteine producing pyruvate, NH3 and H2S.
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| History |
EC 4.4.1.1 created 1961 (EC 4.2.1.15 created 1961, incorporated 1972)
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| Pathway |
| Glycine, serine and threonine metabolism | | Cysteine and methionine metabolism | | Selenocompound metabolism | | Metabolic pathways |
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| Orthology |
| cystathionine gamma-lyase | | cystathionine gamma-lyase / homocysteine desulfhydrase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MCF: | | MMU: | | RNO: | | CGE: | | HGL: | | TUP: | | CFA: | | AML: | | FCA: | | BTA: | | BOM: | | PHD: | | CHX: | | SSC: | | CFR: | | ECB: | | MYB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | TGU: | | FAB: | | PHI: | | APLA: | | FPG: | | FCH: | | CLV: | | ASN: | | PSS: | | ACS: | | XLA: | | XTR: | | DRE: | | TRU: | | MZE: | | OLA: | | XMA: | | LCM: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | BMOR: | | API: | | PHU: | | CEL: | | CBR: | | BMY: | | LOA: | | TSP: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | CME: | | GSL: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | DHA: | | PIC: | | PGU: | | LEL: | | CAL: | | CTP: | | CDU: | | COT: | | YLI: | | CLU: | | NCR: | | SMP: | | PAN: | | TTT: | | MTM: | | MGR: | | FGR: | | NHE: | | VAL: | | SSL: | | BFU: | | ANI: | | NFI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | PCS: | | CIM: | | CPW: | | PBL: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | ZTR: | | TML: | | CNE: | | CNB: | | CGI: | | PPL: | | LBC: | | CCI: | | SCM: | | UMA: | | PGR: | | MBR: | | DDI: | | DPP: | | DFA: | | ACAN: | | TET: | | PTM: | | PTI: | | PIF: | | NGR: | | YEP: | | YEY: | | PLU: | | PAY: | | ENT: | | ENC: | | ENO: | | ESC: | | EEC: | | ENL: | | EAS: | | EAE: | | EAR: | | ENR: | | ESA: | | CSK: | | CSZ: | | CSI: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPE: | | KPO: | | KPJ: | | KPI: | | KVA: | | KOX: | | KOE: | | CKO: | | SPE: | | SRR: | | SRL: | | SRY: | | SRS: | | SRA: | | SMAF: | | SMW: | | SLQ: | | SFO: | | ETR: | | ETD: | | ETC: | | DDC: | | XBO: | | XNE: | | MMK: | | ROR: | | XCC: | | XCB: | | XCA: | | XCV: | | XCP: | | XAC: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOR: | | XAL: | | XCI: | | SML: | | SMT: | | BUJ: | | SMZ: | | PSU: | | PSD: | | FAU: | | RHD: | | PAE: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PDK: | | PSG: | | PRP: | | PAEP: | | PAER: | | PAEM: | | PAEL: | | PAES: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUT: | | PPUN: | | PPUU: | | PFO: | | PFC: | | PPZ: | | PDR: | | PRE: | | PSV: | | PSK: | | PMON: | | PMOT: | | ILO: | | ILI: | | GNI: | | KKO: | | NGO: | | CVI: | | POL: | | CFU: | | RGE: | | DSU: | | BBA: | | BBAT: | | BEX: | | BMX: | | ADE: | | ACP: | | AFW: | | ANK: | | MXA: | | MFU: | | MSD: | | CCX: | | SCU: | | HOH: | | MLO: | | MCI: | | MOP: | | MAM: | | RPA: | | CAK: | | PZU: | | BSB: | | SIL: | | PSF: | | LMD: | | HNE: | | RRU: | | RRF: | | RCE: | | RPM: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BSX: | | BSP: | | BLI: | | BLD: | | BLH: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAMA: | | BAMN: | | BAMB: | | BAZ: | | BQL: | | BXH: | | BAMI: | | BAMC: | | BAMF: | | BAE: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BANT: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BTHU: | | BWE: | | BTY: | | BCL: | | BPU: | | BMQ: | | BMD: | | BCK: | | BAG: | | BJS: | | BACI: | | BIF: | | OIH: | | GKA: | | GTN: | | GTH: | | GTE: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | GJF: | | AFL: | | HHD: | | SAU: | | SAV: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAS: | | SAR: | | SAC: | | SAA: | | SAO: | | SAE: | | SAD: | | SUU: | | SUV: | | SUH: | | SUE: | | SUJ: | | SUK: | | SUC: | | SUT: | | SUQ: | | SUZ: | | SUD: | | SUX: | | SUW: | | SUG: | | SUF: | | SAUA: | | SAUE: | | SAUN: | | SAUS: | | SAUU: | | SAUZ: | | SAB: | | SUY: | | SAUB: | | SAUM: | | SAUC: | | SAUR: | | SEP: | | SER: | | SHA: | | SSP: | | SCA: | | SLG: | | SLN: | | SSD: | | SDT: | | SWA: | | SPAS: | | ESI: | | EAT: | | EAN: | | EXM: | | MCL: | | BBE: | | PJD: | | PPY: | | PPM: | | PPO: | | PPOL: | | PTA: | | CRN: | | CAE: | | ROB: | | MPA: | | MAO: | | MAV: | | MIT: | | MIR: | | MIA: | | MID: | | MYO: | | MSM: | | MSG: | | MSA: | | MVA: | | MGI: | | MSP: | | MAB: | | MABB: | | MMV: | | MMC: | | MKM: | | MJL: | | MRH: | | MMM: | | MCB: | | MNE: | | RHA: | | RER: | | REY: | | ROP: | | RPY: | | SRT: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | SFI: | | SCI: | | SRC: | | MLU: | | KFL: | | ACE: | | GOB: | | BSD: | | MMAR: | | SEN: | | PDX: | | AMI: | | SESP: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | ACTN: | | AFS: | | BLO: | | CWO: | | ABA: | | ACM: | | GMA: | | TRS: | | GAU: | | RBA: | | SACI: | | GLJ: | | AVA: | | PHE: | | SLI: | | CHE: | | IAL: | | TPT: | | TLE: | | MBN: | | MPL: | | MEZ: | | METH: | | HAL: | | HSL: | | HHI: | | HHN: | | HTU: | | NMG: | | HVO: | | HME: | | HXA: | | NGE: | | HRU: | | TAC: | | TVO: | | PYN: | | PYA: | | TBA: | | TLT: | | THS: | | APE: | | ACJ: | | HAH: | |
» show all
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| Reference |
1 |
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| Authors |
Braunstein, A.E. and Azarkh, R.M. |
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| Title |
[Participation of vitamin B6 in enzymic formation of hydrogen sulfide from L-cysteine.]. |
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| Journal |
Dokl. Akad. Nauk. S.S.S.R. 71 (1950) 93-96. |
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| Reference |
2 |
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| Authors |
Braunstein, A.E. and Azarkh, R.M. |
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| Title |
[Phosphopyridoxal in aerobic deamination of homoserine and serine.]. |
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| Journal |
Dokl. Akad. Nauk. S.S.S.R. 85 (1952) 385-388. |
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| Reference |
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| Authors |
FLAVIN M, SEGAL A. |
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| Title |
PURIFICATION AND PROPERTIES OF THE CYSTATHIONINE GAMMA-CLEAVAGE ENZYME OF NEUROSPORA. |
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| Journal |
J. Biol. Chem. 239 (1964) 2220-7. |
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| Organism |
Neurospora sp. |
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| Reference |
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| Authors |
MATSUO Y, GREENBERG DM. |
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| Title |
A crystalline enzyme that cleaves homoserine and cystathionine. III. Coenzyme resolution, activators, and inhibitors. |
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| Journal |
J. Biol. Chem. 234 (1959) 507-15. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
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| Authors |
MATSUO Y, GREENBERG DM. |
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| Title |
A crystalline enzyme that cleaves homoserine and cystathionine. IV. Mechanism of action, reversibility, and substrate specificity. |
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| Journal |
J. Biol. Chem. 234 (1959) 516-9. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9012-96-8 |
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