| Entry |
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| Name |
cystathionine gamma-lyase;
homoserine deaminase;
homoserine dehydratase;
cystine desulfhydrase;
cysteine desulfhydrase;
gamma-cystathionase;
cystathionase;
homoserine deaminase-cystathionase;
gamma-CTL;
cystalysin;
cysteine lyase;
L-cystathionine cysteine-lyase (deaminating);
CGL
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| Class |
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
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| Sysname |
L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
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| Reaction(IUBMB) |
L-cystathionine + H2O = L-cysteine + 2-oxobutanoate + NH3 (overall reaction) [RN: R01001];
(1a) L-cystathionine = L-cysteine + 2-aminobut-2-enoate [RN: R08632];
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A multifunctional pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-cysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. Also catalyses the conversion of L-homoserine to 2-oxobutanoate and ammonia, of L-cystine to thiocysteine, pyruvate and ammonia, and of L-cysteine to pyruvate, hydrogen sulfide and ammonia.
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| History |
EC 4.4.1.1 created 1961 (EC 4.2.1.15 created 1961, incorporated 1972)
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| Pathway |
| Glycine, serine and threonine metabolism | | Cysteine and methionine metabolism | | Selenocompound metabolism | | Metabolic pathways | | Biosynthesis of antibiotics |
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| Orthology |
| cystathionine gamma-lyase | | cystathionine gamma-lyase / homocysteine desulfhydrase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | BACU: | | LVE: | | ECB: | | MYB: | | MYD: | | HAI: | | PALE: | | LAV: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | TGU: | | GFR: | | FAB: | | PHI: | | CCW: | | FPG: | | FCH: | | CLV: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PBI: | | GJA: | | XLA: | | XTR: | | DRE: | | IPU: | | TRU: | | TNG: | | LCO: | | MZE: | | OLA: | | XMA: | | SASA: | | LCM: | | CMK: | | BFO: | | CIN: | | SPU: | | SKO: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | MDE: | | AGA: | | AAG: | | CQU: | | AME: | | BIM: | | BTER: | | SOC: | | AEC: | | HST: | | CFO: | | NVI: | | TCA: | | BMOR: | | DPL: | | PXY: | | API: | | PHU: | | DPX: | | ISC: | | CEL: | | CBR: | | BMY: | | LOA: | | TSP: | | HRO: | | LGI: | | CRG: | | OBI: | | SMM: | | NVE: | | ADF: | | HMG: | | TAD: | | AQU: | | CME: | | GSL: | | SCE: | | AGO: | | ERC: | | KLA: | | LTH: | | VPO: | | ZRO: | | CGR: | | NCS: | | NDI: | | TPF: | | TBL: | | TDL: | | KAF: | | PPA: | | DHA: | | PIC: | | PGU: | | SPAA: | | LEL: | | CAL: | | CTP: | | COT: | | CDU: | | CTEN: | | YLI: | | CLU: | | CAUR: | | NCR: | | NTE: | | SMP: | | PAN: | | TTT: | | MTM: | | CTHR: | | MGR: | | TMN: | | FGR: | | FPU: | | NHE: | | TRE: | | MAW: | | MAJ: | | CMT: | | VAL: | | VDA: | | ELA: | | SSL: | | BFU: | | MBE: | | ANI: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | NFI: | | PCS: | | PDP: | | CIM: | | CPW: | | PBL: | | PBN: | | URE: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | BZE: | | BSC: | | BOR: | | ZTR: | | PFJ: | | BCOM: | | NPA: | | TML: | | CNE: | | CNB: | | CGI: | | TMS: | | PPL: | | DSQ: | | PCO: | | SHS: | | HIR: | | PSQ: | | ADL: | | FME: | | GTR: | | LBC: | | MRR: | | CCI: | | SCM: | | ABP: | | ABV: | | CPUT: | | SLA: | | WSE: | | WIC: | | UMA: | | PFP: | | PGR: | | MLR: | | MBR: | | SRE: | | DDI: | | DPP: | | DFA: | | ACAN: | | TET: | | PTM: | | PTI: | | PIF: | | PSOJ: | | NGR: | | ENT: | | ENC: | | ENO: | | EEC: | | ENL: | | ECLG: | | ECLE: | | ECLN: | | ECLI: | | ECLX: | | ECLY: | | ECLA: | | ECLC: | | ESC: | | KLE: | | EAS: | | EAU: | | EHM: | | EKB: | | ELG: | | EXF: | | ENR: | | ENX: | | ENF: | | ESA: | | CSK: | | CSZ: | | CSI: | | CSJ: | | CCON: | | CDM: | | CMJ: | | CUI: | | CMW: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPK: | | KPH: | | KPZ: | | KPV: | | KPW: | | KPY: | | KPG: | | KPC: | | KPQ: | | KPT: | | KPE: | | KPO: | | KPJ: | | KPI: | | KPA: | | KPS: | | KPX: | | KPB: | | KPNE: | | KPNU: | | KVA: | | KVD: | | KVQ: | | KOX: | | KOE: | | KOY: | | KMI: | | KOK: | | KOC: | | KOM: | | KQU: | | EAE: | | EAR: | | CKO: | | ROR: | | RON: | | CNT: | | CEM: | | CEN: | | CED: | | KSA: | | KOR: | | KRD: | | KCO: | | KIN: | | YEN: | | YEP: | | YEY: | | YEL: | | YEW: | | YET: | | YEF: | | YEE: | | YAL: | | YFR: | | YIN: | | YKR: | | YRO: | | YRU: | | YRB: | | YAK: | | SPE: | | SRR: | | SRL: | | SRY: | | SPLY: | | SRS: | | SRA: | | SMAF: | | SMW: | | SMAR: | | SMAC: | | SLQ: | | SERF: | | SERS: | | SRZ: | | SFO: | | PCV: | | DDC: | | DSO: | | PLU: | | PAY: | | PTT: | | XBO: | | XBV: | | XNE: | | XNM: | | XDO: | | XPO: | | XHO: | | PRG: | | MMK: | | ETR: | | ETD: | | ETE: | | ETC: | | EDW: | | EDL: | | EHO: | | XCC: | | XCB: | | XCA: | | XCP: | | XCV: | | XAC: | | XCI: | | XCT: | | XCU: | | XCN: | | XCW: | | XCR: | | XCM: | | XCF: | | XCJ: | | XFU: | | XAX: | | XAO: | | XOO: | | XOM: | | XOP: | | XOY: | | XOR: | | XOZ: | | XAL: | | XSA: | | XTN: | | XFR: | | XVE: | | XPE: | | SML: | | SMT: | | BUJ: | | SMZ: | | SACZ: | | STEK: | | SRH: | | SLM: | | PSU: | | PSUW: | | PSD: | | LAB: | | LAQ: | | LCP: | | LGU: | | LEZ: | | LEM: | | FAU: | | RHD: | | DJI: | | DJA: | | DTX: | | DKO: | | LRZ: | | VSC: | | PAE: | | PAEV: | | PAEI: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PAEB: | | PDK: | | PSG: | | PRP: | | PAEP: | | PAER: | | PAEM: | | PAEL: | | PAES: | | PAEU: | | PAEG: | | PAEC: | | PAEO: | | PRE: | | PCQ: | | PPU: | | PPF: | | PPG: | | PPW: | | PPT: | | PPB: | | PPI: | | PPX: | | PPUH: | | PPUT: | | PPUN: | | PPUD: | | PMON: | | PMOT: | | PMOS: | | PPJ: | | PFO: | | PFE: | | PFC: | | PFB: | | PFX: | | PPZ: | | PMAN: | | PTV: | | PBC: | | PPUU: | | PDR: | | PSV: | | PSK: | | PKC: | | PCH: | | PCZ: | | PCP: | | PALK: | | PSW: | | PPV: | | PSEM: | | PSEC: | | PKR: | | PFK: | | PANR: | | ILO: | | ILI: | | GNI: | | LHA: | | LOK: | | WMA: | | KKO: | | KGE: | | KSD: | | SDF: | | CVI: | | CVC: | | POL: | | JAG: | | JAB: | | JAZ: | | JAL: | | CFU: | | CARE: | | CPRA: | | MNR: | | MASW: | | RGE: | | RBN: | | RDP: | | MIU: | | PBH: | | DSU: | | BBA: | | BBAT: | | BBW: | | BBAC: | | BEX: | | BMX: | | ADE: | | ACP: | | AFW: | | ANK: | | MXA: | | MFU: | | MSD: | | MYM: | | CCX: | | AGE: | | VIN: | | SCU: | | CCRO: | | SAMY: | | LLU: | | MRM: | | HOH: | | MLO: | | MLN: | | MCI: | | MOP: | | MAM: | | MAMO: | | MESO: | | AAK: | | OAH: | | OPS: | | RPA: | | BVR: | | AUA: | | PSIN: | | RBM: | | CAK: | | PZU: | | BSB: | | BRD: | | BNE: | | BRG: | | BRL: | | CBOT: | | SIL: | | PSF: | | LMD: | | HNE: | | RRU: | | RRF: | | RCE: | | RPM: | | HJO: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSUT: | | BSUL: | | BSUS: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSX: | | BSP: | | BLI: | | BLD: | | BLH: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAMA: | | BAMN: | | BAMB: | | BAMT: | | BAMY: | | BMP: | | BAO: | | BAZ: | | BQL: | | BXH: | | BAMI: | | BAMC: | | BAMF: | | BAE: | | BATR: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BANT: | | BANR: | | BANS: | | BANH: | | BANV: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BAL: | | BNC: | | BCF: | | BCER: | | BCEF: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTHR: | | BTHI: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BTHU: | | BTW: | | BTHY: | | BWE: | | BWW: | | BTY: | | BMYC: | | BMYO: | | BCL: | | BPU: | | BPUM: | | BPUS: | | BMQ: | | BMD: | | BMEG: | | BCK: | | BAG: | | BCOA: | | BJS: | | BACI: | | BIF: | | BLE: | | BMET: | | GST: | | BACW: | | BACP: | | BACB: | | BBY: | | BACY: | | BACL: | | BALM: | | BEO: | | BSM: | | BSJ: | | BON: | | BGY: | | BFX: | | BGI: | | OIH: | | GKA: | | GTE: | | GTK: | | GTN: | | GWC: | | GYC: | | GYA: | | GCT: | | GMC: | | GGH: | | GJF: | | GEA: | | GEL: | | GSE: | | GSR: | | GEJ: | | GTH: | | PTL: | | AFL: | | AGN: | | ANM: | | AAMY: | | ANL: | | HHD: | | HMN: | | TAP: | | VIR: | | VHL: | | FPN: | | FAR: | | SAU: | | SAV: | | SAW: | | SAH: | | SAJ: | | SAM: | | SAS: | | SAR: | | SAC: | | SAA: | | SAO: | | SAE: | | SAD: | | SUU: | | SUV: | | SUE: | | SUJ: | | SUK: | | SUC: | | SUT: | | SUQ: | | SUZ: | | SUD: | | SUX: | | SUW: | | SUG: | | SUF: | | SAUA: | | SAUE: | | SAUN: | | SAUS: | | SAUU: | | SAUG: | | SAUZ: | | SAUT: | | SAUJ: | | SAUK: | | SAUQ: | | SAUV: | | SAUW: | | SAUX: | | SAUY: | | SAB: | | SUY: | | SAUB: | | SAUM: | | SAUC: | | SAUR: | | SAUI: | | SAUD: | | SAUF: | | SAMS: | | SUH: | | SEP: | | SER: | | SEPP: | | SEPS: | | SHA: | | SHH: | | SSP: | | SCA: | | SLG: | | SLN: | | SSD: | | SDT: | | SWA: | | SPAS: | | SXY: | | SXL: | | SXO: | | SHU: | | SCAP: | | SSCH: | | SSCZ: | | SAGQ: | | SEQO: | | SSIF: | | SCV: | | MCL: | | MCAK: | | SBAC: | | ESI: | | EAT: | | EAN: | | EXM: | | EXU: | | BBE: | | BLR: | | PJD: | | PPY: | | PPM: | | PPO: | | PPOL: | | PPQ: | | PPOY: | | PTA: | | PBJ: | | PIH: | | PPEO: | | PBV: | | PXL: | | ANX: | | PLN: | | PKU: | | PRT: | | PLL: | | PANA: | | PDG: | | PHC: | | PMAR: | | PPLA: | | JEO: | | SPSY: | | RST: | | NTR: | | CRN: | | CAE: | | ROB: | | MPA: | | MAO: | | MAVI: | | MAVU: | | MAV: | | MAVD: | | MAVR: | | MAVA: | | MIT: | | MIA: | | MIE: | | MIR: | | MID: | | MYO: | | MSM: | | MSG: | | MSB: | | MSN: | | MSH: | | MSA: | | MVA: | | MGI: | | MSP: | | MAB: | | MABB: | | MMV: | | MAY: | | MABO: | | MABL: | | MAZ: | | MAK: | | MYS: | | MYC: | | MCHE: | | MIZ: | | MMC: | | MKM: | | MJL: | | MRH: | | MMM: | | MCB: | | MNE: | | MYV: | | MYE: | | MGO: | | MFT: | | MPHL: | | MVQ: | | RHA: | | RER: | | REY: | | REB: | | ROP: | | ROA: | | RPY: | | RAV: | | RHW: | | SRT: | | SCO: | | SMA: | | SGR: | | SGB: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | SALS: | | STRP: | | SFI: | | SCI: | | SRC: | | SALU: | | SALL: | | SLV: | | SGU: | | SVT: | | STRE: | | SCW: | | SLD: | | SXI: | | STRM: | | STRC: | | SAMB: | | SPRI: | | SCZ: | | SCX: | | SRW: | | STRF: | | SLE: | | SRN: | | SPAV: | | SLC: | | STRT: | | SCLF: | | SGS: | | STSI: | | SLS: | | SNR: | | SPLU: | | MLU: | | KFL: | | ACE: | | GOB: | | BSD: | | MMAR: | | SEN: | | PDX: | | PSEA: | | PSEE: | | PSEH: | | PSEQ: | | PECQ: | | PHH: | | AMI: | | SESP: | | KAL: | | KPHY: | | LED: | | AHM: | | ACTI: | | ACAD: | | ALL: | | STP: | | SAQ: | | MAU: | | MIL: | | VMA: | | AMS: | | ASE: | | ACTN: | | AFS: | | BLO: | | CWO: | | GLJ: | | AVA: | | FGI: | | RBA: | | PIR: | | GES: | | SACI: | | PBOR: | | ABA: | | ACM: | | GMA: | | TRS: | | ABAC: | | GAU: | | GPH: | | GBA: | | NIA: | | PHE: | | SLI: | | CHE: | | FPSZ: | | IAL: | | TPT: | | TLE: | | MBN: | | MPL: | | MEZ: | | METH: | | HAL: | | HSL: | | HDL: | | HHI: | | HHN: | | HAB: | | HVO: | | HME: | | HGI: | | HTU: | | NMG: | | HXA: | | NGE: | | HRU: | | TAC: | | PYN: | | PYA: | | TBA: | | TLT: | | THS: | | TPEP: | | PPAC: | | APE: | | ACJ: | | HAH: | |
» show all
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| Reference |
1 |
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| Authors |
Braunstein, A.E. and Azarkh, R.M. |
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| Title |
[Participation of vitamin B6 in enzymic formation of hydrogen sulfide from L-cysteine.]. |
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| Journal |
Dokl. Akad. Nauk S.S.S.R. 71 (1950) 93-96. |
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| Reference |
2 |
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| Authors |
Braunstein, A.E. and Azarkh, R.M. |
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| Title |
[Phosphopyridoxal in aerobic deamination of homoserine and serine.]. |
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| Journal |
Dokl. Akad. Nauk S.S.S.R. 85 (1952) 385-388. |
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| Reference |
|
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| Authors |
FLAVIN M, SEGAL A. |
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| Title |
PURIFICATION AND PROPERTIES OF THE CYSTATHIONINE GAMMA-CLEAVAGE ENZYME OF NEUROSPORA. |
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| Journal |
J. Biol. Chem. 239 (1964) 2220-7. |
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| Reference |
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| Authors |
MATSUO Y, GREENBERG DM. |
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| Title |
A crystalline enzyme that cleaves homoserine and cystathionine. III. Coenzyme resolution, activators, and inhibitors. |
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| Journal |
J. Biol. Chem. 234 (1959) 507-15. |
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| Reference |
|
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| Authors |
MATSUO Y, GREENBERG DM. |
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| Title |
A crystalline enzyme that cleaves homoserine and cystathionine. IV. Mechanism of action, reversibility, and substrate specificity. |
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| Journal |
J. Biol. Chem. 234 (1959) 516-9. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9012-96-8 |
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