KEGG   ENZYME: 4.4.1.13Help
Entry
EC 4.4.1.13                 Enzyme                                 

Name
cysteine-S-conjugate beta-lyase;
cysteine conjugate beta-lyase;
glutamine transaminase K/cysteine conjugate beta-lyase;
L-cysteine-S-conjugate thiol-lyase (deaminating)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)
Reaction(IUBMB)
an L-cysteine-S-conjugate + H2O = a thiol + NH3 + pyruvate (overall reaction) [RN:R03528];
(1a) an L-cysteine-S-conjugate = a thiol + 2-aminoprop-2-enoate;
(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);
(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous)
Reaction(KEGG)
R03528;
(other) R09366
Show
Substrate
L-cysteine-S-conjugate [CPD:C02882];
H2O [CPD:C00001];
2-aminoprop-2-enoate [CPD:C02218];
2-iminopropanoate [CPD:C20904]
Product
thiol [CPD:C01336]
Comment
A pyridoxal-phosphate protein. The enzyme can act on a broad range of L-cysteine-S-conjugates, including aromatic conjugates such as 4-bromobenzene and 2,4-dinitrobenzene. The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase.
History
EC 4.4.1.13 created 1981
Pathway
Selenocompound metabolism
Orthology
K00816  
kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase
Genes
HSA: 
56267(KYAT3) 883(KYAT1)
PTR: 
456999(KYAT3) 473069(KYAT1)
PPS: 
100980672(KYAT1) 100993985(KYAT3)
GGO: 
101128027(CCBL2) 101137144(CCBL1)
PON: 
100436953(KYAT3) 100452866(KYAT1)
NLE: 
100579800(KYAT3) 100598335(KYAT1)
MCC: 
694023(KYAT3) 717142(KYAT1)
MCF: 
101925086(KYAT3) 102142392(KYAT1)
CSAB: 
103224481(KYAT3) 103239781(KYAT1)
RRO: 
104660517(KYAT1) 104664603(KYAT3)
CJC: 
100390682(KYAT1) 100392205(KYAT3)
SBQ: 
101034905(CCBL1) 101049363(CCBL2)
MMU: 
229905(Kyat3) 70266(Kyat1)
RNO: 
311844(Kyat1) 541589(Kyat3)
CGE: 
100769821(Kyat1) 100771070(Kyat3)
NGI: 
103730106(Kyat3) 103742867(Kyat1)
HGL: 
101701445(Kyat3) 101714047(Ccbl1)
OCU: 
100351221(KYAT1) 100358799(KYAT3)
TUP: 
102484200(KYAT3) 102492301(KYAT1)
CFA: 
479959(KYAT3) 491310(KYAT1)
AML: 
100466080(KYAT3) 100484335(KYAT1)
UMR: 
103662922(KYAT3) 103670433(KYAT1)
FCA: 
101082171(KYAT3) 101082605(KYAT1)
PTG: 
102956075(KYAT1) 102960707(KYAT3)
BTA: 
104968656(KYAT1) 508712(KYAT3) 528582(CCBL1)
BOM: 
PHD: 
102319020(KYAT3) 102328319(KYAT1)
CHX: 
102180605(KYAT1) 102182368(KYAT3)
OAS: 
101117485(KYAT1) 101119265(KYAT3)
SSC: 
100157176(KYAT3) 100515071(KYAT1)
CFR: 
102514713(KYAT1) 102522240(KYAT3)
BACU: 
103001193(KYAT3) 103010164(KYAT1)
LVE: 
103073927(KYAT1) 103090268(KYAT3)
ECB: 
100052141(KYAT3) 100070151(KYAT1)
MYB: 
102246710(KYAT1) 102246937(KYAT3)
MYD: 
102770113(KYAT1) 102774189(KYAT3)
PALE: 
102885606(KYAT3) 102890346(KYAT1)
LAV: 
100674418(KYAT1) 100676040(KYAT3)
MDO: 
100013642(KYAT1) 100027687(KYAT3)
SHR: 
100925132(KYAT1) 100928200(KYAT3)
OAA: 
100074153(CCBL1) 100074828(KYAT3)
GGA: 
417202(CCBL1) 424517(CCBL2)
MGP: 
100545698(KYAT1) 100546759(KYAT3)
CJO: 
107317420(KYAT3) 107321728(KYAT1)
APLA: 
101796959(KYAT3) 101804188(KYAT1)
TGU: 
100223564(KYAT3) 100226378(KYAT1)
GFR: 
102043066(KYAT3) 102045568(KYAT1)
FAB: 
101809203(KYAT1) 101816765(KYAT3)
PHI: 
102108384(KYAT3) 102109435(KYAT1)
CCW: 
104688281(KYAT1) 104695321(KYAT3)
FPG: 
101923826(KYAT3) 101924602(KYAT1)
FCH: 
102052592(KYAT1) 102055107(KYAT3)
CLV: 
102092812(KYAT3) 102097970(KYAT1)
AAM: 
106490298(KYAT1) 106499802(KYAT3)
ASN: 
102377511(KYAT3) 102381063(KYAT1)
AMJ: 
102564187(KYAT1) 102574637(KYAT3)
PSS: 
102446036(KYAT1) 102459761(KYAT3)
CMY: 
102931085(KYAT1) 102947846(KYAT3)
ACS: 
100555601(kyat3)
PBI: 
103054557(KYAT3) 103058068(KYAT1)
GJA: 
107115481(KYAT1) 107126241(KYAT3)
XLA: 
380432(ccbl2.L) 734936(ccbl1.L)
XTR: 
496736(ccbl1)
DRE: 
100332215 393315(ccbl2) 791592(ccbl1)
TRU: 
101064758(kyat1) 101066451(kyat3)
TNG: 
MZE: 
101466800(kyat1) 101486988(ccbl2)
OLA: 
101164171(kyat1) 101173380(kyat3)
XMA: 
SASA: 
LCM: 
102348380(KYAT1) 102366870(KYAT3)
CMK: 
103171755(kyat1) 103174679(kyat3)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD20629(Dsim_GD20629)
DWI: 
DYA: 
Dyak_GE10079(dyak_GLEANR_10037)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
724811(GB15834)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG07704(Cbr-nkat-3) CBG10259
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CME: 
GSL: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
DFA_11928(ccbl)
ACAN: 
TET: 
SMIN: 
v1.2.018754.t1(symbB.v1.2.018754.t1)
PTI: 
TPS: 
AAF: 
NGD: 
PIF: 
PSOJ: 
SPAR: 
GTT: 
TBR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:721818]
  Authors
Tateishi M, Suzuki S, Shimizu H.
  Title
Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs.
  Journal
J. Biol. Chem. 253 (1978) 8854-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
68652-57-3

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