KEGG   ENZYME: 4.4.1.13Help
Entry
EC 4.4.1.13                 Enzyme                                 

Name
cysteine-S-conjugate beta-lyase;
cysteine conjugate beta-lyase;
glutamine transaminase K/cysteine conjugate beta-lyase;
L-cysteine-S-conjugate thiol-lyase (deaminating)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)
Reaction(IUBMB)
RS-CH2-CH(NH3+)COO- + H2O = RSH + NH3 + pyruvate [RN:R03528]
Reaction(KEGG)
R03528;
(other) R09366
Show
Substrate
RS-CH2-CH(NH3+)COO- [CPD:C02882];
H2O [CPD:C00001]
Product
RSH [CPD:C01336];
NH3 [CPD:C00014];
pyruvate [CPD:C00022]
Comment
A pyridoxal-phosphate protein. In the reaction, RH may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitrobenzene.
History
EC 4.4.1.13 created 1981
Pathway
Selenocompound metabolism
Orthology
K00816  
kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase
Genes
HSA: 
56267(CCBL2) 883(CCBL1)
PTR: 
456999(CCBL2) 473069(CCBL1)
PPS: 
100980672(CCBL1) 100993985(CCBL2)
GGO: 
101128027(CCBL2) 101137144(CCBL1)
PON: 
100436953(CCBL2) 100452866(CCBL1)
MCC: 
694023(CCBL2) 717142(CCBL1)
MCF: 
MMU: 
229905(Ccbl2) 70266(Ccbl1)
RNO: 
311844(Ccbl1) 541589(Kat3)
CGE: 
100769821(Ccbl1) 100771070(Ccbl2)
HGL: 
101701445(Ccbl2) 101714047(Ccbl1)
TUP: 
102484200(CCBL2) 102492301(CCBL1)
CFA: 
479959(CCBL2) 491310(CCBL1)
AML: 
FCA: 
101082171(CCBL2) 101082605(CCBL1)
PTG: 
102956075(CCBL1) 102960707(CCBL2)
BTA: 
508712(CCBL2) 528582(CCBL1) 781863
BOM: 
PHD: 
102319020(CCBL2) 102328319(CCBL1)
CHX: 
102180605(CCBL1) 102182368(CCBL2)
OAS: 
101117485(CCBL1) 101119265(CCBL2)
SSC: 
100157176(CCBL2) 100515071(CCBL1)
CFR: 
102514713(CCBL1) 102522240(CCBL2)
BACU: 
103001193(CCBL2) 103010164(CCBL1)
LVE: 
103073927(CCBL1) 103090268(CCBL2)
ECB: 
100052141(CCBL2) 100070151(CCBL1)
MYB: 
102246710(CCBL1) 102246937(CCBL2)
MYD: 
102770113(CCBL1) 102774189(CCBL2)
PALE: 
102885606(CCBL2) 102890346(CCBL1)
MDO: 
100013642(CCBL1) 100027687(CCBL2)
SHR: 
100925132(CCBL1) 100928200(CCBL2)
OAA: 
100074153(CCBL1) 100074828(CCBL2)
GGA: 
100859686 417202(CCBL1) 424517(CCBL2)
MGP: 
TGU: 
100223564(CCBL2) 100226378(CCBL1)
FAB: 
101809203(CCBL1) 101816765(CCBL2)
PHI: 
APLA: 
101796959(CCBL2) 101804188(CCBL1)
FPG: 
101923826(CCBL2) 101924602(CCBL1)
FCH: 
102052592(CCBL1) 102055107(CCBL2)
CLV: 
102092812(CCBL2) 102097970(CCBL1)
ASN: 
102377511(CCBL2) 102381063(CCBL1)
AMJ: 
102564187(CCBL1) 102574637(CCBL2)
PSS: 
102446036(CCBL1) 102459761(CCBL2)
CMY: 
102931085(CCBL1) 102947846(CCBL2)
ACS: 
100555601(ccbl2)
PBI: 
103054557(CCBL2) 103058068(CCBL1)
XLA: 
380432(ccbl2) 734936(ccbl1)
XTR: 
496736(ccbl1)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102348380(CCBL1) 102366870(CCBL2)
CMK: 
103171755(ccbl1) 103174679(ccbl2)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG07704(Cbr-nkat-3) CBG10259
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
CME: 
GSL: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_11928(ccbl)
ACAN: 
PTI: 
TPS: 
PIF: 
NGD: 
GTT: 
LBZ: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:721818]
  Authors
Tateishi M, Suzuki S, Shimizu H.
  Title
Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs.
  Journal
J. Biol. Chem. 253 (1978) 8854-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
68652-57-3

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