KEGG   ENZYME: 4.4.1.13Help
Entry
EC 4.4.1.13                 Enzyme                                 
Name
cysteine-S-conjugate beta-lyase;
cysteine conjugate beta-lyase;
glutamine transaminase K/cysteine conjugate beta-lyase;
L-cysteine-S-conjugate thiol-lyase (deaminating)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)
Reaction(IUBMB)
RS-CH2-CH(NH3+)COO- + H2O = RSH + NH3 + pyruvate [RN:R03528]
Reaction(KEGG)
Substrate
RS-CH2-CH(NH3+)COO- [CPD:C02882];
H2O [CPD:C00001]
Product
RSH [CPD:C01336];
NH3 [CPD:C00014];
pyruvate [CPD:C00022]
Comment
A pyridoxal-phosphate protein. In the reaction, RH may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitrobenzene.
Orthology
K00816  
kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase
Genes
HSA: 
56267(CCBL2) 883(CCBL1)
PTR: 
456999(CCBL2) 473069(CCBL1)
PPS: 
100980672(CCBL1) 100993985(CCBL2)
GGO: 
101128027(CCBL2) 101137144(CCBL1)
PON: 
100436953(CCBL2) 100452866(CCBL1)
MCC: 
694023(CCBL2) 717142(CCBL1)
MMU: 
229905(Ccbl2) 70266(Ccbl1)
RNO: 
311844(Ccbl1) 541589(Kat3)
CFA: 
479959(CCBL2) 491310(CCBL1)
AML: 
FCA: 
101082171(CCBL2) 101082605(CCBL1)
BTA: 
508712(CCBL2) 528582(CCBL1) 781863
SSC: 
100157176(CCBL2) 100515071(CCBL1)
ECB: 
100052141(CCBL2) 100070151(CCBL1)
MDO: 
100013642 100027687(CCBL2)
SHR: 
100925132(CCBL1) 100928200(CCBL2)
OAA: 
100074153(CCBL1) 100074828(CCBL2)
GGA: 
100859686 417202(CCBL1) 424517(CCBL2)
MGP: 
100545698 100546759(CCBL2)
TGU: 
100223564(CCBL2) 100226378(CCBL1)
ACS: 
100555601(ccbl2)
XLA: 
380432(ccbl2) 734936(ccbl1)
XTR: 
496736(ccbl1)
DRE: 
100332215 393315(ccbl2)
TRU: 
101064758 101066451
OLA: 
101164171 101173380
BFO: 
BRAFLDRAFT_118927
SPU: 
593717
DME: 
Dmel_CG6950
DPO: 
Dpse_GA19977
DAN: 
Dana_GF23062
DER: 
Dere_GG17186
DPE: 
Dper_GL12368
DSE: 
Dsec_GM26066
DSI: 
Dsim_GD20629
DWI: 
Dwil_GK12747
DYA: 
Dyak_GE10079
DGR: 
Dgri_GH19404
DMO: 
Dmoj_GI22608
DVI: 
Dvir_GJ23853
AGA: 
AgaP_AGAP011158
AAG: 
AaeL_AAEL004435
CQU: 
CpipJ_CPIJ008201
AME: 
100578495
NVI: 
100119206(NV15933)
TCA: 
655252
API: 
100160464 100164839
PHU: 
Phum_PHUM210690
ISC: 
IscW_ISCW012664
CEL: 
CELE_R03A10.4(nkat-3)
CBR: 
CBG07704(Cbr-nkat-3) CBG10259
BMY: 
Bm1_10490
TSP: 
Tsp_07645
SMM: 
Smp_123750
NVE: 
NEMVE_v1g173158
HMG: 
100208716
TAD: 
TRIADDRAFT_20976
AQU: 
100641141
MBR: 
MONBRDRAFT_33534
NGR: 
NAEGRDRAFT_32036
DPP: 
DICPUDRAFT_78310
LBZ: 
LBRM_33_1600
PTI: 
PHATRDRAFT_10073 PHATR_10257
TPS: 
THAPSDRAFT_460
PIF: 
PITG_03678
 » show all
Taxonomy
Reference
1  [PMID:721818]
  Authors
Tateishi M, Suzuki S, Shimizu H.
  Title
Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs.
  Journal
J. Biol. Chem. 253 (1978) 8854-9.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
68652-57-3
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