Entry
Name
phosphatidylinositol diacylglycerol-lyase;
monophosphatidylinositol phosphodiesterase;
phosphatidylinositol phospholipase C;
1-phosphatidylinositol phosphodiesterase;
1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming);
1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)
Reaction(IUBMB)
1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol [RN:
R03364 ]
Reaction(KEGG)
Substrate
1-phosphatidyl-1D-myo-inositol [CPD:
C01194 ]
Product
1D-myo-inositol 1,2-cyclic phosphate [CPD:
C04299 ];
1,2-diacyl-sn-glycerol [CPD:
C00641 ]
Comment
This enzyme is bacterial. Activity is also found in animals, but this activity is due to the presence of EC
3.1.4.11 , phosphoinositide phospholipase C.
History
EC 4.6.1.13 created 1972 as EC 3.1.4.10, modified 1976, transferred 2002 to EC 4.6.1.13
Pathway
ec00562 Inositol phosphate metabolism
Orthology
K01771 1-phosphatidylinositol phosphodiesterase
Genes
PMUR : 107299456 107301572
CTIG : 120311159 120311160 120311194
MUO : 115473826 115473872 115474224 115474717 115474806 115474807 115474855 115474859 115474860 115474861 115474862 115474864 115475012
GSH : 117360316 117360317 117360591 117360796
DRE : 100000275 100000352(si:dkey-152b24.7) 100002310(si:dkey-152b24.6) 100006223(si:dkey-266f7.9)
SANH : 107688224 107693279
SGH : 107589506 107592133 107592465
CAUA : 113047372 113059667 113062220
CGIB : 127934934(si:dkey-266f7.9) 127953942 128030375
PTET : 122324015(si:dkey-266f7.9)
LROH : 127178961 127181386(si:dkey-266f7.9)
OMC : 131525428(si:dkey-266f7.9)
PPRM : 120481439 120481456 120483722
RKG : 130079372 130102371(si:dkey-266f7.9) 130106297
MAMB : 125243524 125243665 125244010 125244245 125275521(si:dkey-266f7.9)
CIDE : 127496729 127496901 127496902 127501678(si:dkey-266f7.9)
MASI : 127425630(si:dkey-266f7.9) 127453201 127454658
TROS : 130557713 130557747 130558215 130567352(si:dkey-266f7.9) 130568782
TDW : 130415863(si:dkey-266f7.9) 130433137
MANU : 129455690(si:dkey-266f7.9)
IPU : 108256182(si:dkey-152b24.7)
IFU : 128599929(si:dkey-152b24.7)
AMEX : 103030468 103041431
CMAO : 118799147 118805959(si:dkey-266f7.9)
CHAR : 105901465(si:dkey-266f7.9)
TFS : 130518608(si:dkey-266f7.9)
TBEN : 117477519(si:dkey-266f7.9) 117500496(si:dkey-152b24.7)
CGOB : 115015465 115020949
PGEO : 117455353(si:dkey-266f7.9) 117460675
GACU : 117542630(si:dkey-266f7.9) 117543253(si:dkey-152b24.7)
EMAC : 134861833 134875131(si:dkey-266f7.9)
ELY : 117263248(si:dkey-266f7.9) 117266370
EFO : 125892696 125904985(si:dkey-266f7.9)
PLEP : 121945209(si:dkey-152b24.7) 121958134(si:dkey-266f7.9)
SLUC : 116035966 116036094 116047362(si:dkey-266f7.9)
ECRA : 117946864 117957147(si:dkey-266f7.9)
ESP : 116675804 116691177 116701672
PFLV : 114556835 114568185
GAT : 120810372 120810373 120825948(si:dkey-266f7.9)
PPUG : 119197651 119218730(si:dkey-266f7.9)
AFB : 129097429(si:dkey-266f7.9) 129110188
CLUM : 117728154 117739140(si:dkey-266f7.9)
PSWI : 130195445(si:dkey-266f7.9) 130212632
MSAM : 119897129(si:dkey-152b24.7) 119907306(si:dkey-266f7.9)
SCHU : 122864918(si:dkey-266f7.9) 122881707
CUD : 121524371(si:dkey-266f7.9)
ALAT : 119006458(si:dkey-152b24.7) 119016458(si:dkey-266f7.9)
OAU : 116320040(si:dkey-266f7.9) 116327118
OML : 112162382(si:dkey-266f7.9)
CSAI : 133461038(si:dkey-266f7.9)
GAF : 122843109(si:dkey-266f7.9)
PPRL : 129375179(si:dkey-266f7.9) 129375668
CTUL : 119779680(si:dkey-266f7.9)
KMR : 108239495(si:dkey-266f7.9)
AOCE : 111565076 111578045
MCEP : 125016486 125020013(si:dkey-266f7.9)
HHIP : 117770858(si:dkey-266f7.9) 117776319
HSP : 118113716 118124973(si:dkey-266f7.9)
SMAU : 118292407(si:dkey-266f7.9) 118308150
LCF : 108879457(si:dkey-266f7.9) 108899480(si:dkey-152b24.7)
SLAL : 111655664 111657590
XGL : 120784697 120786563(si:dkey-266f7.9)
SSCV : 125986747(si:dkey-266f7.9)
PTAO : 133471545(si:dkey-266f7.9)
MALB : 109958561 109974696
SJO : 128366171 128373870 128373888(si:dkey-266f7.9)
STRU : 115175794 115178570
OTW : 112229698(si:dkey-266f7.9) 112242428
OMY : 110487536 110488237(si:dkey-266f7.9)
OGO : 123997724 124042781(si:dkey-266f7.9)
ONE : 115118467 115132727 115141089
OKE : 118364423 118398086(si:dkey-266f7.9)
SALP : 111955195 111958895
SNH : 120026712(si:dkey-266f7.9) 120040124 120040125 120047611 120047613 120047620 120047622 120048402
CCLU : 121543097 121585315 123487094 123491522
AANG : 118233155(si:dkey-266f7.9)
PSPA : 121309939(si:dkey-266f7.9)
ARUT : 117965047 117970765
PSEX : 120525668(si:dkey-266f7.9)
LCM : 102353481 102357360 106704972
SKO : 100378443 100378594 102805589
MDL : 103568655 103572022 103580584 106693414
CGLO : 123262139 123267193 123269201 123269745 123271301 123271533
HVI : 124356378 124361798 124361799 124363969
DPOL : 127836979 127875087
TBL : TBLA_0G03650(TBLA0G03650)
CAL : CAALFM_C202600CA(FGR22) CAALFM_C203040WA(PLC2)
CTP : CTRG_01321 CTRG_01371
CDU : CD36_17390(PLC22) CD36_17810
SLB : AWJ20_1356 AWJ20_281(PLC2)
NTE : NEUTE1DRAFT149986(NEUTE1DRAFT_149986) NEUTE1DRAFT63869(NEUTE1DRAFT_63869)
SMP : SMAC_01937 SMAC_04631
PGRI : PgNI_01820 PgNI_04685
TMN : UCRPA7_1358 UCRPA7_7184 UCRPA7_7913
SSCK : SPSK_00779 SPSK_10319
FGR : FGSG_00423 FGSG_05655
FPU : FPSE_00086 FPSE_06249
FPOA : FPOAC1_000444 FPOAC1_008084
FVN : FVRRES_00589 FVRRES_08649
FVR : FVEG_00884 FVEG_06828
FOX : FOXG_00628 FOXG_09227
NHE : NECHADRAFT_57455 NECHADRAFT_70960
FFC : NCS54_00108700 NCS54_01024500
FKR : NCS57_00106800 NCS57_01017700
FMU : J7337_001112 J7337_009491
TRE : TRIREDRAFT_111102 TRIREDRAFT_57975
TRR : M419DRAFT_133321 M419DRAFT_71841
MAW : MAC_02826 MAC_03182 MAC_05413
MAJ : MAA_04277 MAA_04887 MAA_10423
PCHM : VFPPC_00326 VFPPC_06941 VFPPC_07676
AMUS : LMH87_003807 LMH87_010040
PLJ : VFPFJ_01457 VFPFJ_05152
PTKZ : JDV02_001315 JDV02_003069
VAL : VDBG_01003 VDBG_06112
VDA : VDAG_00614 VDAG_03270
CFJ : CFIO01_03094 CFIO01_12060
CLUP : CLUP02_12289 CLUP02_17648
CHIG : CH63R_07894 CH63R_08759 CH63R_11685
SSL : SS1G_06145 SS1G_06734 SS1G_12385
BFU : BCIN_05g04370 BCIN_08g00150 BCIN_11g04660
PSCO : LY89DRAFT_690521 LY89DRAFT_691271 LY89DRAFT_708673
TMF : EYB26_005420 EYB26_005999
TRG : TRUGW13939_02909 TRUGW13939_05358
ZTR : MYCGRDRAFT_107761 MYCGRDRAFT_109874 MYCGRDRAFT_98925
PFJ : MYCFIDRAFT_189591 MYCFIDRAFT_29247 MYCFIDRAFT_75813
FFU : CLAFUR5_01060 CLAFUR5_01893 CLAFUR5_09162
CBET : CB0940_00369 CB0940_01076 CB0940_10508
BCOM : BAUCODRAFT_144753 BAUCODRAFT_71222
TASA : A1Q1_00715 A1Q1_03737
CCAC : CcaHIS019_0200340(CcaverHIS019_0200340) CcaHIS019_0212100(CcaverHIS019_0212100) CcaHIS019_0704310(CcaverHIS019_0704310)
SHS : STEHIDRAFT_102395 STEHIDRAFT_52122
ADL : AURDEDRAFT_112159 AURDEDRAFT_113803
LBC : LACBIDRAFT_308269 LACBIDRAFT_315813 LACBIDRAFT_318365 LACBIDRAFT_335698
CCI : CC1G_10832 CC1G_13081
ABP : AGABI1DRAFT104838(AGABI1DRAFT_104838) AGABI1DRAFT121976(AGABI1DRAFT_121976)
ABV : AGABI2DRAFT200290(AGABI2DRAFT_200290) AGABI2DRAFT210674(AGABI2DRAFT_210674)
MRR : Moror_14864 Moror_4204
SCM : SCHCO_02006100(SCHCODRAFT_02006100)
PGR : PGTG_06638 PGTG_22509
PTRC : PtA15_16A155 PtA15_18A111
PSTR : Pst134EA_026754 Pst134EA_026812 Pst134EA_028931
MLR : MELLADRAFT_116429 MELLADRAFT_84419
TET : TTHERM_000426139 TTHERM_00426140
TVA : TVAG_2v0041100 TVAG_2v0070310
YMO : HRD69_03690 HRD69_03695 HRD69_15995
YEG : PL78_06870 PL78_06875
TAMN : N4264_11055 N4264_11200
PPUU : PputUW4_02517 PputUW4_02518
PTZ : HU718_014460 HU718_014465
PAZE : KSS91_13800 KSS91_13805
MDH : AYM39_00650 AYM39_02300
MKO : MKLM6_0167 MKLM6_0502
MBD : MEBOL_004474 MEBOL_006196
BCG : BCG9842_B1438 BCG9842_B1713
BTHR : YBT1520_18545 YBT1520_19995
BTHI : BTK_18535 BTK_19900
BTC : CT43_CH3446 CT43_CH3702
BTM : MC28_1721 MC28_2930 MC28_C065 MC28_C068 MC28_E065 MC28_E071 MC28_E079 MC28_E158 MC28_F101
BTG : BTB_c35790(plcA) BTB_c38340
BTN : BTF1_14915 BTF1_16860 BTF1_32876
BTHT : H175_ch3502 H175_ch3764
BTHU : YBT1518_19170 YBT1518_20640
BTHY : AQ980_11120 AQ980_12515
BWE : BcerKBAB4_2347 BcerKBAB4_3532
BWW : bwei_1197(plcA2) bwei_2488(plcA)
BMYO : BG05_2262 BG05_3483
BBY : CY96_17890 CY96_29345
BWD : CT694_20260 CT694_29575 CT694_33035 CT694_33635
BALU : QRY64_01200 QRY64_21435(plcA)
SUX : SAEMRSA15_00670(plc)
SUF : SARLGA251_00750(plc)
SAUT : SAI1T1_2000520(plc)
SAUJ : SAI2T2_1000520(plc)
SAUK : SAI3T3_1000520(plc)
SAUQ : SAI4T8_1000520(plc)
SAUV : SAI7S6_1000520(plc)
SAUW : SAI5S5_1000520(plc)
SAUX : SAI6T6_1000520(plc)
SAUY : SAI8T7_1000520(plc)
SSH : NCTC13712_00046(plc)
SSTE : SAMEA4384403_1481(plc)
LMOC : LMOSLCC5850_0195(plcA)
LMW : LMOSLCC2755_0200(plcA)
LMX : LMOSLCC2372_0202(plcA)
LMZ : LMOSLCC2482_0201(plcA)
LMON : LMOSLCC2376_0172(plcA)
LMOO : LMOSLCC2378_0214(plcA)
LMOY : LMOSLCC2479_0201(plcA)
LMOT : LMOSLCC2540_0204(plcA)
LMOA : LMOATCC19117_0209(plcA)
FSA : C5Q98_00040 C5Q98_00045
NWL : NWFMUON74_53710(plcA)
RHW : BFN03_07585 BFN03_07590
SQZ : FQU76_06180 FQU76_08485
SXT : KPP03845_104116(plcA)
SHAU : K9S39_00445 K9S39_04865
SSPI : I6J01_02440 I6J01_19965
CHZ : CHSO_1681 CHSO_4603(plc)
CNK : EG343_12135 EG343_22920
CGLE : NCTC11432_02913(plc)
CCAO : H5J24_00105 H5J24_14025
» show all
Taxonomy
Reference
Authors
Allan D, Michell RH.
Title
Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0.
Journal
Reference
Authors
Friedel RO, Brown JD, Durell.
Title
Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain.
Journal
Reference
Authors
Irvine RF.
Title
The enzymology of stimulated inositol lipid turnover.
Journal
Reference
Authors
Michell RH, Allan D.
Title
Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus).
Journal
Reference
Authors
Low MG, Finean JB.
Title
Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C.
Journal
Reference
Authors
Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG
Title
Sequence of the Bacillus thuringiensis phosphatidylinositol specific phospholipase C.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.6.1.13
ExPASy - ENZYME nomenclature database: 4.6.1.13