| Entry |
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| Name |
squalene---hopene cyclase
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| Class |
Isomerases;
Intramolecular transferases;
Transferring other groups
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| Sysname |
squalene mutase (cyclizing, hop-22(29)-ene-forming)
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| Reaction(IUBMB) |
squalene = hop-22(29)-ene [RN: R07322]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme also produces the cyclization product hopan-22-ol by addition of water (cf. EC 4.2.1.129, squalene-hopanol cyclase). Hopene and hopanol are formed at a constant ratio of 5:1.
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| Pathway |
| Sesquiterpenoid and triterpenoid biosynthesis |
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| Orthology |
| squalene-hopene/tetraprenyl-beta-curcumene cyclase |
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| Genes |
MGR: | | NFI: | | AFM: | | AFV: | | ACT: | | PCS: | | AJE: | | PNO: | | TET: | | PTM: | | FAU: | | AVN: | | AVL: | | AVD: | | TTU: | | MCA: | | MMT: | | MAH: | | NOC: | | NHL: | | NWA: | | AFE: | | AFR: | | ACU: | | AFI: | | REU: | | REH: | | RME: | | CTI: | | CNC: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPZ: | | BPQ: | | BTE: | | BTD: | | BVI: | | BUR: | | BCN: | | BCH: | | BCM: | | BCJ: | | BAM: | | BAC: | | BMU: | | BMJ: | | BCT: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGF: | | BRH: | | BGD: | | BYI: | | BUK: | | BPX: | | NEU: | | NET: | | NIT: | | NII: | | NMU: | | GSU: | | GSK: | | GME: | | GUR: | | GLO: | | GBM: | | GEO: | | GEM: | | GEB: | | PCA: | | PPD: | | DSA: | | DAF: | | DHY: | | DAL: | | AFW: | | DAO: | | SFU: | | RHI: | | SFH: | | SFD: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | NWI: | | NHA: | | OCA: | | OCG: | | OCO: | | AOL: | | MEX: | | MEA: | | MDI: | | MCH: | | MRD: | | MET: | | MPO: | | MNO: | | BID: | | MSL: | | HDN: | | HDT: | | HMC: | | RVA: | | MSC: | | ZMO: | | ZMN: | | ZMM: | | ZMB: | | ZMP: | | SPHM: | | GOX: | | GOH: | | GBE: | | ACR: | | AMV: | | GDI: | | GDJ: | | GXY: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | RRU: | | RRF: | | RPM: | | MAG: | | ABS: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSUB: | | BSX: | | BLI: | | BLD: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAMI: | | BAE: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BWE: | | BPU: | | BMQ: | | BMD: | | BMH: | | BCO: | | BJS: | | BACI: | | GTN: | | GYC: | | GYA: | | GCT: | | GGH: | | BBE: | | PJD: | | PTA: | | AAC: | | AAD: | | DAE: | | SGY: | | SCO: | | SMA: | | SGR: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | STRP: | | SFI: | | KSK: | | FRA: | | FRE: | | FRI: | | FAL: | | FSY: | | ACE: | | BSD: | | SEN: | | SVI: | | PDX: | | AMI: | | MAU: | | MIL: | | CAI: | | RXY: | | ABA: | | ACA: | | ACM: | | GMA: | | TSA: | | TRS: | | SUS: | | CTM: | | MIN: | | AMU: | | RBA: | | PSL: | | PLM: | | PBS: | | IPA: | | SACI: | | PHM: | | SYN: | | SYZ: | | SYY: | | SYT: | | SYS: | | SYQ: | | SYNE: | | SYNP: | | TEL: | | MAR: | | CYT: | | CYP: | | CYC: | | CYN: | | CYH: | | CYJ: | | AMR: | | CAN: | | CYU: | | GVI: | | ANA: | | NPU: | | NOS: | | NOP: | | AVA: | | ANB: | | ACY: | | CSG: | | CALO: | | CALT: | | TER: | | MIC: | | PLP: | | SCS: | | STI: | | NDE: | | LFC: | | LFI: | | MOX: | | IHO: | |
» show all
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| Reference |
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| Authors |
Hoshino T, Sato T. |
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| Title |
Squalene-hopene cyclase: catalytic mechanism and substrate recognition. |
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| Journal |
Chem. Commun. (Camb). (2002) 291-301. |
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| Organism |
Alicyclobacillus acidocaldarius [GN: aac] |
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| Reference |
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| Authors |
Hoshino T, Nakano S, Kondo T, Sato T, Miyoshi A |
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| Title |
Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring. |
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| Journal |
Org. Biomol. Chem. 2 (2004) 1456-70. |
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| Reference |
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| Authors |
Sato T, Kouda M, Hoshino T |
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| Title |
Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius. |
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| Journal |
Biosci. Biotechnol. Biochem. 68 (2004) 728-38. |
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| Reference |
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| Authors |
Reinert DJ, Balliano G, Schulz GE |
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| Title |
Conversion of squalene to the pentacarbocyclic hopene. |
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| Journal |
Chem. Biol. 11 (2004) 121-6. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 76600-69-6 |
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