| Entry |
|
|---|
| Name |
chloromuconate cycloisomerase;
muconate cycloisomerase II |
|---|
| Class |
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
 |
|---|
| Sysname |
2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing) |
|---|
| Reaction(IUBMB) |
2-chloro-2,5-dihydro-5-oxofuran-2-acetate =
3-chloro-cis,cis-muconate [RN:R04259] |
|---|
| Reaction(KEGG) |
R04259;
(other) R05391 R05392 R06834 R06840 R08119
 |
|---|
| Substrate |
2-chloro-2,5-dihydro-5-oxofuran-2-acetate [CPD:C04522] |
|---|
| Product |
3-chloro-cis,cis-muconate [CPD:C03585] |
|---|
| Cofactor |
Manganese [CPD:C00034] |
|---|
| Comment |
Requires Mn2+. The product of cycloisomerization of
3-chloro-cis,cis-muconate spontaneously eliminates chloride to
produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts (in the
reverse direction) on 2-chloro-cis,cis-muconate. Not identical with
EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.11
(dichloromuconate cycloisomerase). |
|---|
| Pathway |
PATH: ec00361 gamma-Hexachlorocyclohexane degradation
PATH: ec00364 Fluorobenzoate degradation
PATH: ec00627 1,4-Dichlorobenzene degradation
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01860 chloromuconate cycloisomerase |
|---|
| Genes |
DDI: DDBDRAFT_0186151
XCC: XCC3807(tcbD)
XCB: XC_3879
XCA: xccb100_3991
XCV: XCV3980(tcbD)
XAC: XAC3862(tcbD)
XOO: XOO4102(tcbD)
XOM: XOO_3878
BXE: Bxe_A1129(clcB)
SUN: SUN_1179
BTL: BALH_0330
CGB: cg2635(catB)
CHU: CHU_2140(tfdD) CHU_2415(clcB)
RBA: RB11118 RB8686(ykfB)
SAI: Saci_2196
 |
|---|
| Structures |
PDB: 1NU5 2CHR 3I4K |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7305906]
Schmidt E, Knackmuss HJ.
Chemical structure and biodegradability of halogenated aromatic
compounds. Conversion of chlorinated muconic acids into
maleoylacetic acid.
Biochem. J. 192 (1980) 339-47.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 5.5.1.7
IUBMB Enzyme Nomenclature: 5.5.1.7
ExPASy - ENZYME nomenclature database: 5.5.1.7
UM-BBD (Biocatalysis/Biodegradation Database): 5.5.1.7
BRENDA, the Enzyme Database: 5.5.1.7
CAS: 95990-33-3 |
|---|
