KEGG   ENZYME: 5.5.1.7Help
Entry
EC 5.5.1.7                  Enzyme                                 

Name
chloromuconate cycloisomerase;
muconate cycloisomerase II
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
Reaction(IUBMB)
2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate [RN:R04259]
Reaction(KEGG)
Substrate
2-chloro-2,5-dihydro-5-oxofuran-2-acetate [CPD:C04522]
Product
3-chloro-cis,cis-muconate [CPD:C03585]
Comment
Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts (in the reverse direction) on 2-chloro-cis,cis-muconate. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase).
History
EC 5.5.1.7 created 1983
Pathway
Chlorocyclohexane and chlorobenzene degradation
Fluorobenzoate degradation
Toluene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K01860  
chloromuconate cycloisomerase
Genes
REU: 
BXE: 
Bxe_A1129(clcB)
BPT: 
Bpet1535(catB2) Bpet3749(catB5)
AXY: 
SJP: 
Taxonomy
Reference
1  [PMID:7305906]
  Authors
Schmidt E, Knackmuss HJ.
  Title
Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid.
  Journal
Biochem. J. 192 (1980) 339-47.
  Organism
Pseudomonas sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
95990-33-3

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