| Entry |
|
|---|
| Name |
4-chlorobenzoate---CoA ligase |
|---|
| Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
 |
|---|
| Sysname |
4-chlorobenzoate:CoA ligase |
|---|
| Reaction(IUBMB) |
4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP +
diphosphate [RN:R03932] |
|---|
| Reaction(KEGG) |
R03932;
(other) R08117
 |
|---|
| Substrate |
4-chlorobenzoate [CPD:C02370];
CoA [CPD:C00010];
ATP [CPD:C00002] |
|---|
| Product |
4-chlorobenzoyl-CoA [CPD:C06387];
AMP [CPD:C00020];
diphosphate [CPD:C00013] |
|---|
| Cofactor |
Magnesium [CPD:C00305] |
|---|
| Comment |
Requires Mg2+. This enzyme is part of the bacterial
2,4-dichlorobenzoate degradation pathway. |
|---|
| Pathway |
PATH: ec00364 Fluorobenzoate degradation
PATH: ec00623 2,4-Dichlorobenzoate degradation
PATH: ec01100 Metabolic pathways |
|---|
| Structures |
PDB: 1T5D 1T5H 2QVX 2QVY 2QVZ 2QW0 3CW8 3CW9 3DLP |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:7765837]
Dunaway-Mariano D, Babbitt PC.
On the origins and functions of the enzymes of the 4-chlorobenzoate
to 4-hydroxybenzoate converting pathway.
Biodegradation. 5 (1994) 259-76.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1418673]
Loffler F, Muller R, Lingens F.
Purification and properties of 4-halobenzoate-coenzyme A ligase from
Pseudomonas sp. CBS3.
Biol. Chem. Hoppe. Seyler. 373 (1992) 1001-7.
Pseudomonas sp. |
|---|
Reference
Authors
Title
Journal
Organism
Sequence
|
3 [PMID:1610806]
Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D.
Isolation and characterization of the three polypeptide components
of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3.
Biochemistry. 31 (1992) 5605-10.
Pseudomonas sp.
NCBI-GI: 146761193 |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.2.1.33
IUBMB Enzyme Nomenclature: 6.2.1.33
ExPASy - ENZYME nomenclature database: 6.2.1.33
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.33
BRENDA, the Enzyme Database: 6.2.1.33
CAS: 141583-20-2 |
|---|
