Entry
Name
dihydrofolate synthase;
dihydrofolate synthetase;
7,8-dihydrofolate synthetase;
H2-folate synthetase;
7,8-dihydropteroate:L-glutamate ligase (ADP);
dihydropteroate:L-glutamate ligase (ADP-forming);
DHFS
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate [RN:
R02237 ]
Reaction(KEGG)
Substrate
Product
Comment
In some bacteria, a single protein catalyses both this activity and that of EC
6.3.2.17 , tetrahydrofolate synthase [2], the combined activity of which leads to the formation of the cofactor polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates. In contrast, the activities are located on separate proteins in most eukaryotes studied to date [3]. This enzyme is responsible for attaching the first glutamate residue to dihydropteroate to form dihydrofolate and is present only in those organisms that have the ability to synthesize tetrahydrofolate de novo, e.g. plants, most bacteria, fungi and protozoa [3].
History
EC 6.3.2.12 created 1972, modified 2005
Pathway
Orthology
K11754 dihydrofolate synthase / folylpolyglutamate synthase
K22099 dihydrofolate synthase / folylpolyglutamate synthase
K24102 dihydrofolate synthase / dihydropteroate synthase
Genes
CSAT : 104719816 104724515 104730143
GHI : 107942305 107947263 121224364
HSYR : 120184056 120207495
LJA : Lj2g3v3340810.2(Lj2g3v3340810.2) Lj2g3v3340810.3(Lj2g3v3340810.3) Lj2g3v3340810.4(Lj2g3v3340810.4)
PCIN : 129294203 129294548
CANN : 107875563 124894944
SSPL : 121794663 121799883
ECAD : 122602959 122610729
PSOM : 113321187 113340246
TAES : 123110173 123119219
PVIR : 120658521 120694175
SMO : SELMODRAFT_428477 SELMODRAFT_90954
APRO : F751_4069 F751_6837
OLU : OSTLU_13191 OSTLU_29778
SCE : YKL132C(RMA1) YMR113W(FOL3)
SEUB : DI49_3247 DI49_4202
SPAO : SPAR_K00850 SPAR_M02290
NCS : NCAS_0A04290(NCAS0A04290)
NDI : NDAI_0E02020(NDAI0E02020)
TPF : TPHA_0G02400(TPHA0G02400)
TBL : TBLA_0I00690(TBLA0I00690)
TDL : TDEL_0A02110(TDEL0A02110)
KAF : KAFR_0D02970(KAFR0D02970)
KNG : KNAG_0A06220(KNAG0A06220)
CAL : CAALFM_C701280CA(CaO19.6908)
NTE : NEUTE1DRAFT115854(NEUTE1DRAFT_115854)
PBEL : QC761_203045(FOL3_1)
PPSD : QC762_203045(FOL3_1)
SHS : STEHIDRAFT_152355 STEHIDRAFT_98452
ABP : AGABI1DRAFT109678(AGABI1DRAFT_109678)
ABV : AGABI2DRAFT187126(AGABI2DRAFT_187126)
SCM : SCHCO_01269092(SCHCODRAFT_01269092)
PMAL : PMUG01_12039900(DHFS-FPGS)
PREL : PRELSG_1203500(DHFS-FPGS)
FCY : FRACYDRAFT_216117 FRACYDRAFT_267244
TPS : THAPSDRAFT_9534(FGS1)
ECOO : ECRM13514_3073(folC)
ECOH : ECRM13516_3016(folC)
ECW : EcE24377A_2609(folC)
EDJ : ECDH1ME8569_2253(folC)
ECOI : ECOPMV1_02474(folC)
KMI : VW41_06380 VW41_15800
REE : electrica_01435(folC)
RTG : NCTC13098_01939(folC_2)
CNT : JT31_05820 JT31_19290
CEM : LH23_12105 LH23_21800
CEN : LH86_11515 LH86_20385
CLAP : NCTC11466_01270(folC)
KIE : NCTC12125_00358(folC)
AHN : NCTC12129_01493(folC)
PTF : PROFFT_A_06130(folC)
PSHI : SAMEA2665130_0937(folC)
YPG : YpAngola_A0358(folC)
YPI : YpsIP31758_1423(folC)
SMW : SMWW4_v1c34460(folC)
SFJ : SAMEA4384070_3456(folC)
SOF : NCTC11214_03339(folC)
EAME : GXP68_00640(folC) GXP68_06545(folC)
PAQU : DMB82_0007310(folC)
DIC : Dpoa569_001119(folC)
EHD : ERCIPSTX3056_364(folC)
ETP : LU633_17525(folC) LU633_21140(folC)
BAPF : BUMPF009_CDS00427(folc)
BAPG : BUMPG002_CDS00428(folc)
BAPU : BUMPUSDA_CDS00426(folc)
BAPW : BUMPW106_CDS00427(folc)
TPTY : NCTC11468_02526(folC)
PHEI : NCTC12003_01535(folC)
PRJ : NCTC6933_02362(folC)
LRI : NCTC12151_02323(folC)
HIC : NTHIC486_01398(folC)
HPIT : NCTC13334_01547(folC)
HHZ : NCTC10839_01674(folC)
HAEG : NCTC8502_01774(folC)
PDAG : 4362423_00772(folC)
ADP : NCTC12871_01693(folC)
ALIG : NCTC10568_00823(folC)
ASEG : NCTC10977_01365(folC)
AVT : NCTC3438_01486(folC)
RPNE : NCTC8284_01913(folC_1) NCTC8284_01914(folC_2)
PAET : NCTC13378_00652(folC)
XFU : XFF4834R_chr10330(folC)
XPH : XppCFBP6546_06325(folC)
XHD : LMG31886_33170(folC)
LLZ : LYB30171_02016(folC)
VAU : VANGNB10_cI0872(folC)
VPL : SA104470976_01771(folC)
PAEB : NCGM1900_3188(folC)
PVD : CFBP1590__3794(folC)
PPRC : PFLCHA0_c21210(folC)
PMUD : NCTC8068_03449(folC)
PFW : PF1751_v1c36920(folC)
PTRT : HU722_0019405(folC)
PTW : TUM18999_17130(folC)
PTAE : NCTC10697_02593(folC)
MSHE : MAALD49_19080(folC)
PSYC : DABAL43B_0547(folC)
MCAT : MC25239_01375(folC)
MCUN : NCTC10297_00748(folC)
SCAA : TUM17387_16870(folC)
SALH : HMF8227_01950(folC)
CBS : COXBURSA331_A1053(folC)
LLG : 44548918_01103(folC)
LJR : NCTC11533_01557(folC)
LCJ : NCTC11976_02005(folC)
LWA : SAMEA4504053_1519(folC)
LSS : NCTC12082_00577(folC)
LADL : NCTC12735_01835(folC)
LANT : TUM19329_16400(folC)
MISZ : MishRS11D_24000(folC)
TIB : THMIRHAM_15130(folC)
TSE : THMIRHAS_17500(folC)
TZO : THMIRHAT_16990(folC)
TFRI : Thiofri_02413(folC)
TNI : TVNIR_1223(folC_[H])
GAI : IMCC3135_26375(folC)
THIC : TspCOW1_10790(folC)
HAXI : HAALTHF_34510n(folC)
ALCA : ASALC70_04326(folC)
AEL : NCTC12917_02507(folC)
CHJ : NCTC10426_00163(folC)
SALN : SALB1_1032 SALB1_3252
CDIZ : CEDIAZO_02077(folC)
NMQ : NMBM04240196_1473(folC)
NMZ : NMBNZ0533_0740(folC)
NMX : NMA510612_1004(folC)
NWE : SAMEA3174300_0404(folC)
NZO : SAMEA4504057_1628(folC)
NCI : NCTC10296_02007(folC)
NCZ : NCTC10294_00333(folC)
NANI : NCTC12227_00582(folC)
ECOR : SAMEA4412678_1359(folC)
NBA : CUN60_03295 CUN60_07945
BMN : BMA10247_A0533(folC)
BPM : BURPS1710b_A0765(folC)
BPL : BURPS1106A_A2303(folC)
BPD : BURPS668_A2441(folC)
BPZ : BP1026B_II1813(folC)
BUE : BRPE67_BCDS15480(folC)
PDIO : PDMSB3_0175.1(folC)
PLG : NCTC10937_01727(folC)
LMIR : NCTC12852_01518(folC)
BUO : BRPE64_BCDS12770(folC)
VTR : MYVALT_F_02150(folC)
BTRM : SAMEA390648703425(dedC)
AXX : ERS451415_02471(folC)
LIM : L103DPR2_02339(folC)
LIH : L63ED372_00761(folC)
METP : C1M51_05950 C1M51_16910
URU : DSM104443_01585(folC)
UPL : DSM104440_01491(folC)
APET : ToN1_37670(folC1) ToN1_44950(folC2)
AZA : AZKH_3105(folC) AZKH_p0178(folC)
AZD : CDA09_11095 CDA09_16410
FPHO : SHINM1_008500(folC)
WEJ : L2227_00640 L2227_05295
ERU : Erum3680(probable_folC)
ERW : ERWE_CDS_03790(folC)
ERG : ERGA_CDS_03740(folC)
RBS : RHODOSMS8_03339(fgs)
SMEL : SM2011_c02763(folC)
SFD : USDA257_c58930(folC)
SAME : SAMCFNEI73_Ch0033(folC)
AGR : AGROH133_02827(folC)
AVV : RvVAT039_16870(folC)
AVF : RvVAR031_03990(folC)
REC : RHECIAT_CH0000025(folC)
REL : REMIM1_CH00024(folC)
REP : IE4803_CH00023(folC)
REI : IE4771_CH00024(folC)
RTR : RTCIAT899_CH00140 RTCIAT899_CH10395
RGA : RGR602_CH00022(folC)
RPHA : AMC79_CH00024(folC)
RHR : CKA34_02975 CKA34_13805
RLS : HB780_17050 HB780_25945
RAW : NE851_09850 NE851_15375
ARA : Arad_0031(folC) Arad_2739(folC)
RIF : U5G49_000718 U5G49_004407
NGL : RG1141_CH40080(folC)
NEN : NCHU2750_37450(folC)
LAS : CLIBASIA_03560(folC)
BIO : BR141012304_10635(folC)
BIC : LMTR13_00580 LMTR13_02075
BRK : CWS35_05590 CWS35_08185
BBET : F8237_14860 F8237_18130
BROS : QUH67_00445 QUH67_32995
RBK : E0H22_01855 E0H22_23370
TRB : HB776_24740 HB776_26905
TALZ : RPMA_01570 RPMA_04340
BHS : BM1374165_00037(folC)
BBK : BARBAKC583_1352(folC)
BTX : BM1374166_00032(folC)
BEZ : NCTC12898_01651(fgs)
MAQU : Maq22A_c15210(folC) Maq22A_c24990(folC)
MEE : DA075_15310 DA075_23450
MTEA : DK419_05425 DK419_27605
MIND : mvi_24610(folC_1) mvi_33800(folC_2)
HNI : W911_06245 W911_17200
TSV : DSM104635_01809(fgs_1) DSM104635_03511(fgs_2)
PHP : PhaeoP97_00115(folC)
PPIC : PhaeoP14_00080(folC)
SINL : DSM14862_03130(fpgS)
SPSE : SULPSESMR1_03326(folC)
RMM : ROSMUCSMR3_01000(folC)
AHT : ANTHELSMS3_01241(folC)
LALG : LentiSH36_02458(folC)
LVS : LOKVESSMR4R_02943(fgs)
MMR : Mmar10_0088 Mmar10_1137
CBOT : ATE48_12380 ATE48_18530
SBIN : SBA_ch1_29110(folC)
SFLA : SPHFLASMR4Y_01207(folC)
SPHJ : BSL82_14665 BSL82_17245
HPO : HMPREF4655_20166(folC)
HPX : HMPREF0462_1569(folC)
HCL : NCTC13205_00917(folC)
HSH : NHP194022_13180(folC)
HPUL : NCTC13154_00814(folC)
CJV : MTVDSCj20_1092(folC)
CFV : CFVI03293_0701(folC)
CAMP : CFT03427_0724(folC)
CCOC : CCON33237_0725(folC)
CLR : UPTC16701_1011(folC)
CLM : UPTC16712_1041(folC)
CAMR : CAQ16704_1029(folC)
CHV : CHELV3228_1297(folC)
CPIN : CPIN18020_1673(folC)
CAMZ : CVIC12175_0510(folC)
GBN : GEOBRER4_08610(folC)
BAZ : BAMTA208_13775(folC)
BSON : S101395_01552(folC)
BHK : B4U37_16090 B4U37_16115
BKW : BkAM31D_01765(fgs_1) BkAM31D_18125(fgs_2)
LSP : Bsph_3961(folC) Bsph_3962
LGY : T479_16470 T479_16475
LFU : HR49_07120 HR49_07125
LYS : LBYS11_15750 LBYS11_15755
LYB : C3943_11320 C3943_11325
LYZ : DCE79_12600 DCE79_12605
LYG : C1N55_12980 C1N55_12985
LPAK : GDS87_17110 GDS87_17115
LAGR : FJQ98_20665 FJQ98_20670
LMAC : I6G82_03825 I6G82_03830
LCAP : ICJ70_07940 ICJ70_07945
LYP : MTP04_25700(folC_1) MTP04_25710(folC_2)
LIU : OU989_15710 OU989_15715
LLB : R6U77_12985 R6U77_12990
AIA : AWH56_014820 AWH56_014825
BLEN : NCTC4824_01540(fgs)
BVJ : I5776_07315 I5776_17745
BOU : I5818_08630 I5818_22145
ALKL : MM271_19360 MM271_20815
HYI : K2M58_03870 K2M58_04935
SAX : USA300HOU_1654(folC)
SUQ : HMPREF0772_11487(folC)
SUX : SAEMRSA15_15730(folC)
SUF : SARLGA251_15560(folC)
SAUT : SAI1T1_2012050(folC)
SAUJ : SAI2T2_1012070(folC)
SAUK : SAI3T3_1012050(folC)
SAUQ : SAI4T8_1012060(folC)
SAUV : SAI7S6_1012070(folC)
SAUW : SAI5S5_1012020(folC)
SAUX : SAI6T6_1012030(folC)
SAUY : SAI8T7_1012060(folC)
SCA : SCA_1267(folC'') SCA_1268(folC')
SDP : NCTC12225_01350(folC)
SPIC : SAMEA4384060_1299(fgs)
SSH : NCTC13712_01651(fgs)
SSIM : SAMEA4384339_1544(folC)
SSTE : SAMEA4384403_1100(folC)
LMOC : LMOSLCC5850_1615(folC)
LMW : LMOSLCC2755_1559(folC)
LMX : LMOSLCC2372_1614(folC)
LMON : LMOSLCC2376_1507(folC)
LMOS : LMOSLCC7179_1525(folC)
LMOO : LMOSLCC2378_1569(folC)
LMOY : LMOSLCC2479_1613(folC)
LMOT : LMOSLCC2540_1631(folC)
LMOA : LMOATCC19117_1562(folC)
LGZ : NCTC10812_01539(fgs)
GMO : NCTC11323_01540(fgs)
GHA : NCTC10459_01572(fgs)
PPM : PPSC2_19430(folC) PPSC2_27935
PPQ : PPSQR21_039150(folC)
POD : PODO_01240 PODO_24585
PDH : B9T62_25145 B9T62_33335
COHN : KCTCHS21_19250(folC)
AAD : TC41_1926(folC) TC41_2349
AFX : JZ786_15420 JZ786_18130
AACO : K1I37_12520 K1I37_17030
ACUR : JZ785_05290 JZ785_26820
ACYC : JI721_11805 JI721_15285
KYR : CVV65_04765 CVV65_15425
SSIL : SOLI23_11470 SOLI23_11475
SOB : CSE16_15125 CSE16_15130
PANC : E2636_06305 E2636_06310
VIJ : JNUCC6_08965 JNUCC6_08970
UTH : DKZ56_11320 DKZ56_11325
NTR : B0W44_04710 B0W44_10980
SPY : SPy_0814(folC.2) SPy_1096(folC.1)
SPZ : M5005_Spy0628(folC.2) M5005_Spy0820(folC.1)
SPYM : M1GAS476_0687(folC.2) M1GAS476_0875(folC.1)
SPYA : A20_0672c(folC) A20_0859(folC)
SPM : spyM18_0876(folC) spyM18_1058(folC)
SPG : SpyM3_0547(folC.2) SpyM3_0758(folC.1)
SPH : MGAS10270_Spy0684(folC2) MGAS10270_Spy0936(folC1)
SPI : MGAS10750_Spy0716(folC2) MGAS10750_Spy0971(folC1)
SPJ : MGAS2096_Spy0693(folC2) MGAS2096_Spy0894(folC1)
SPK : MGAS9429_Spy0683(folC2) MGAS9429_Spy0939(folC1)
SPF : SpyM50968(folC1) SpyM51179(folC2)
SPA : M6_Spy0645 M6_Spy0818
SPB : M28_Spy0608(folC.2) M28_Spy0797(folC.1)
STG : MGAS15252_0656(folC.1) MGAS15252_0822(folC.2)
STX : MGAS1882_0652(folC.1) MGAS1882_0818(folC.2)
SOZ : Spy49_0638c(folC.2) Spy49_0851(folC1)
STZ : SPYALAB49_000657 SPYALAB49_000818
SPN : SP_0197 SP_0290(folC)
SPD : SPD_0183(folC) SPD_0270
SPR : spr0178(folC) spr0267(sulB)
SPW : SPCG_0208(folC) SPCG_0303(sulB)
SNV : SPNINV200_01820 SPNINV200_02720(folC)
SPX : SPG_0184 SPG_0275(sulB)
SPNN : T308_00970 T308_01435
SNE : SPN23F01890 SPN23F02790(folC)
SNC : HMPREF0837_10510(folC) HMPREF0837_10606(folC)
SNM : SP70585_0255 SP70585_0349
SNI : INV104_01610 INV104_02480(folC)
SPNG : HMPREF1038_00255 HMPREF1038_00346(sulB)
SNB : SP670_0272 SP670_0364
SNX : SPNOXC02220 SPNOXC03080(folC)
SNU : SPNA45_01748(folC) SPNA45_01832
SPNE : SPN034156_12780 SPN034156_13640(folC)
SPNU : SPN034183_02280 SPN034183_03140(folC)
SPNM : SPN994038_02160 SPN994038_03020(folC)
SPNO : SPN994039_02170 SPN994039_03030(folC)
SMU : SMU_839(fol) SMU_967(folC)
SMC : SmuNN2025_1054(folC) SmuNN2025_1175(fol)
SMUT : SMUGS5_03720 SMUGS5_04270
SMJ : SMULJ23_1062(folC) SMULJ23_1172(fol)
SMUA : SMUFR_0729(folC) SMUFR_0841(folC)
STC : str0409(folC1) str1546(folC2)
STL : stu0409(folC1) stu1546(folC2)
STU : STH8232_0511(folC1) STH8232_1770(hk01-1)
STHE : T303_03170 T303_08550
STHS : AVT04_02835 AVT04_07285
SSB : SSUBM407_0050 SSUBM407_0133(folC)
SSU : SSU05_0056 SSU05_0137
SSV : SSU98_0056 SSU98_0139
SSI : SSU0054 SSU0136(folC)
SSS : SSUSC84_0050 SSUSC84_0131(folC)
SSF : SSUA7_0053 SSUA7_0133
SSW : SSGZ1_0051 SSGZ1_0130
SSUS : NJAUSS_0068 NJAUSS_0155
SST : SSUST3_0058 SSUST3_0145
SSUY : YB51_0290 YB51_0700
SSK : SSUD12_0059 SSUD12_0133(folC)
SSQ : SSUD9_0059 SSUD9_0145(folC)
SUI : SSUJS14_0053 SSUJS14_0137
SUO : SSU12_0053 SSU12_0137
SRP : SSUST1_0066 SSUST1_0149
SSUT : TL13_0069 TL13_0182
SSUI : T15_0054(folC) T15_0127
SDS : SDEG_0779 SDEG_0860(folC1)
SDG : SDE12394_04200 SDE12394_04865
SDA : GGS_0750(folC) GGS_0838(folC1)
SDC : SDSE_0818 SDSE_0896(folC)
SDQ : SDSE167_0845 SDSE167_0956(folC1)
SGA : GALLO_1233(folC) GALLO_1349
SGG : SGGBAA2069_c12240(folC) SGGBAA2069_c13380(fol)
SGT : SGGB_1227(folC) SGGB_1344(fpgs)
SMB : smi_0280(sulB) smi_1917
SOR : SOR_0227(folC) SOR_1796
STK : STP_0550 STP_0628(folC)
STB : SGPB_1087(folC) SGPB_1271(fpgs)
SCP : HMPREF0833_11396(folC) HMPREF0833_11666(folC)
SSR : SALIVB_0405(folC) SALIVB_1636
STF : Ssal_00519(folC) Ssal_01788(folC)
STJ : SALIVA_0386(folC1) SALIVA_1593(folC)
STRS : SSAL8618_02200 SSAL8618_07845
SSAH : HSISS4_00326(folC1) HSISS4_01442(folC2)
STD : SPPN_01715 SPPN_02415
SMN : SMA_1137(folC) SMA_1276(folC)
SIF : Sinf_1067(folC) Sinf_1166
SIB : SIR_1643 SIR_1797(folC)
SIU : SII_1628 SII_1764(folC)
SANG : SAIN_0212 SAIN_1740(folC)
SANC : SANR_0252 SANR_2008(folC)
SANS : DK43_00740 DK43_08995
SCG : SCI_1706 SCI_1834(folC)
SCON : SCRE_1662 SCRE_1790(folC)
SCOS : SCR2_1662 SCR2_1790(folC)
SOI : I872_00735 I872_09890
SIQ : DQ08_05200 DQ08_06310
SIO : DW64_05195 DW64_06305
SIZ : SI82_05385 SI82_06460
SIG : N596_06845 N596_08385
SIP : N597_00300 N597_08750
STV : V470_01035 V470_09025
SPAT : A0O21_03605 A0O21_03970
STRA : ATM98_06525 ATM98_07995
STRN : SNAG_0294(fgs_1) SNAG_1720(fgs_2)
SSOB : DK181_04850 DK181_05415
SRQ : SR187_0395 SR187_0865
SEQI : A6J79_00200 A6J79_04915
SKI : D7D50_01990 D7D50_03520
SPEI : EHW89_01145 EHW89_08720
SRAT : FY406_07845 FY406_08545
SGW : D7D53_07805 D7D53_09850
STRG : SRT_11290(folC) SRT_13020(fol)
SVB : NCTC12167_00453(folC) NCTC12167_01483(fgs)
SMEN : SAMEA4412692_0611(fgs)
SFER : NCTC12278_01004(fgs)
SCAI : NCTC12191_01520(folC.1) NCTC12191_01859(fgs)
SPSU : NCTC13786_00147(folC1)
SCHJ : DDV21_006635 DDV21_007205
SPOC : NCTC10925_01026(folC1)
SPAB : KQ224_06345 KQ224_07660
SLAT : J4854_01185 J4854_09925
SAUP : NCTC3168_00546(fgs_1) NCTC3168_00852(fgs_2)
SURN : NCTC13766_01014(fgs)
SVF : NCTC3166_00227(fgs_1) NCTC3166_01896(fgs_2)
SOS : INT76_06180 INT76_06900
STOY : STYK_02380(sulB) STYK_18270(folC)
SRUM : GPZ88_00155 GPZ88_09540
SACY : O6R09_03970 O6R09_05790
SMIE : NCTC11169_00213(fgs) NCTC11169_01798(folC)
SRUN : LPB404_00420 LPB404_01955
LDB : Ldb0248(folC2) Ldb0728(folC1)
LDE : LDBND_0662 LDBND_0876
LGL : AO203_06950 AO203_08775
LPW : LpgJCM5343_12190(folC)
LZE : KG087_06040 KG087_09100
LHN : LHUE1_000067 LHUE1_002324
LPL : lp_2321(folC1) lp_3296(folC2)
LPJ : JDM1_1941(folC1) JDM1_2648(folC2)
LPT : zj316_2298(folC1) zj316_3132(folC2)
LPS : LPST_C1922(folC1) LPST_C2716(folC2)
LPR : LBP_cg1903 LBP_cg2691
LPB : SH83_09950 SH83_13735
LPX : ASU28_02950 ASU28_10050
LPG : BB562_05925 BB562_15050
LARG : LPA65_09425 LPA65_14195
LRU : HMPREF0538_20290(folC) HMPREF0538_21738(folC)
LRR : N134_02680 N134_07130
LMU : LBLM1_02590 LBLM1_08430
LOR : AYI71_06825 AYI71_12215
LFN : LF145_02670 LF145_05795
LBN : LBUCD034_1034(folc1) LBUCD034_1229(folc3)
LPAR : FAM21731_02366 FAM21731_02568
LCU : PL11_009005 PL11_009960
LKF : DNL43_08970 DNL43_09965
LHIL : G8J22_01184(fpgS_1) G8J22_01460(fpgS_2)
LCY : LC20004_06375 LC20004_09945
LHO : LOOC260_112900 LOOC260_115570
LOL : LACOL_0681 LACOL_1275
LNN : F0161_04775 F0161_08345
LPD : AYR62_04010 AYR62_12710
PCE : PECL_1085(folC) PECL_695(folC)
PDM : ADU72_1330 ADU72_1776
PACI : A4V11_01760 A4V11_03385
PIO : PI20285_06305 PI20285_08530
LROS : LROSL1_0993 LROSL1_1779
LGN : ABM34_01765 ABM34_08290
LHI : JP39_04575 JP39_08400
CPAB : G6534_03850 G6534_04955
LSA : LCA_0850(folC1) LCA_1099(folC2)
OEN : DSM07_00635 DSM07_02750
LCI : LCK_00367(folC1) LCK_00966(folC2) LCK_01016(folC3)
LKI : LKI_01045 LKI_05535 LKI_09380
LEC : LGMK_01640 LGMK_02735 LGMK_06605
LCN : C270_03385 C270_06185
LGS : LEGAS_0854(folC2) LEGAS_1438(folC1)
LGE : C269_04205 C269_07180
LLF : BCR17_02320 BCR17_07360 BCR17_07665
LGC : A9176_00820 A9176_07200 A9176_07475
LSU : A6B45_02200 A6B45_03545
LPSE : FGL85_04695 FGL85_09015
WTR : KHQ32_04590 KHQ32_05225
WCI : WS105_0877 WS105_0992
WCB : AO080_04925 AO080_09625 AO080_11160
WJO : FOL01_0669 FOL01_1498
WPA : CO680_01290 CO680_04995
WCF : C6P13_02590 C6P13_06995
WSO : WSWS_00414(folC) WSWS_00539
WHE : EFA59_03310 EFA59_06910
WVR : IE337_02280 IE337_04365 IE337_05595
WCO : G7084_03210 G7084_04600
WEI : EQG49_03360 EQG49_09650
EFU : HMPREF0351_12184(folC)
ESG : EsVE80_01040(folC_1) EsVE80_06090(folC_2)
ECEC : NCTC12421_00710(fgs)
EMS : P3T75_09910 P3T75_13150
AUR : HMPREF9243_0662(folC)
AUI : APT62_03720 APT62_07115
AVS : AWM76_03100 AWM76_06640
ABAE : CL176_09285 CL176_10065
IRU : M0R79_02180 M0R79_06695
FCT : NRE15_11820 NRE15_14265
FHM : R0V13_04185 R0V13_05530
CARN : FPV25_04920 FPV25_07950
DPM : FNV33_00190 FNV33_00730
CLS : CXIVA_02720 CXIVA_13810
CCOH : SAMEA4530647_1976(fgs)
CGEL : psyc5s11_20810(folC)
CLO : HMPREF0868_0498(folC)
RAL : Rumal_1336 Rumal_2417
FPRA : CG447_05850 CG447_11025
FDU : GXM22_03085 GXM22_12930
SMAN : C12CBH8_02010(folC)
CFEM : HCR03_04875 HCR03_18760
ACAE : HYG86_02155 HYG86_02965
CCOM : I6K69_13620 I6K69_14260
CEV : LK421_02230 LK421_11460
BYL : A4V09_14760 A4V09_15895
BHAN : CGC63_06850 CGC63_12930
BLAU : DQQ01_02335 DQQ01_06690
BPRO : PMF13cell1_01875(fgs_1) PMF13cell1_02143(fgs_2)
BLAB : EYS05_00595 EYS05_10455
BMAS : LK422_05270 LK422_13170
BLAR : LC508_13285 LC508_14505
BLUI : Blut17040_09250 Blut17040_25750
BCOC : BLCOC_09310(fpgS_1) BLCOC_12300(fpgS_2)
BHV : BLHYD_13280(fpgS) BLHYD_26560(murE_1)
CSCI : HDCHBGLK_00579(fpgS_1) HDCHBGLK_03406(fpgS_2)
CHYL : CE91St63_29210(folC)
CSH : Closa_1140 Closa_1556
BPRL : CL2_10160 CL2_27030
ARF : AR1Y2_0769 AR1Y2_2806
ACAC : EYQ97_04275 EYQ97_13150
PXV : FXF36_02330 FXF36_14345
ACEL : acsn021_33060(folC)
ACHT : bsdcttw_35900(folC)
CBOL : CGC65_10760 CGC65_13200
DLO : K5I24_11770 K5I24_12520
WCP : H9Q76_04830 H9Q76_10525
SSUN : H9Q77_00150 H9Q77_03905 H9Q77_05635
QDO : H9Q78_06685 H9Q78_12125
WHJ : H9Q79_03550 H9Q79_11750
KIB : RBB56_13895 RBB56_15015
CEW : EKH84_00750 EKH84_09815
CBAR : PATL70BA_0950 PATL70BA_1548
VPY : HZI73_06460 HZI73_15235
MDV : C5Q96_02290 C5Q96_03915
MNL : QU661_03900 QU661_05500
AMIC : Ami3637_03170 Ami3637_03175
ETM : CE91St48_21610(folC)
CSPO : QNI18_05290 QNI18_07935
PDF : CD630DERM_32530(folC)
PHX : KGNDJEFE_00527(fpgS)
FAA : HMPREF0389_00099(folC) HMPREF0389_00289(folC)
CDIA : CaldiYA01_10280(folC)
PED : ING2D1G_0069 ING2D1G_0836
PHAR : NCTC13077_00580(fgs_1) NCTC13077_01277(fgs_2)
MHAP : JFY71_07840 JFY71_11040 JFY71_11645
ECOU : M1R54_06950 M1R54_07040
VDN : NCTC11831_00624(fgs)
DHO : Dia5BBH33_06700(folC)
PFAC : PFJ30894_00893(fgs)
FRO : AALO17_23800 AALO17_23830
AARG : Aargi30884_21940(folC)
ABSI : A9CBEGH2_19730(folC)
EBM : SG0102_06900 SG0102_18510
FIT : Fi14EGH31_21050(folC) Fi14EGH31_25030
ERM : EYR00_09860 EYR00_13430
TSF : NQ543_04345 NQ543_11000
MMYI : mycmycITA_00996(fgs)
MCAR : MCCPILRI181_00908(fgs)
MPUT : MPUT9231_6480(folC)
MBP : MBSPM3_v1c0100(folC)
AHK : NCTC10172_00295(fgs)
AAXA : NCTC10138_01125(fgs)
MTAB : MTABA_v1c00610(folC)
MCOL : MCOLE_v1c00710(folC)
EML : EMELA_v1c00840(folC)
EFR : EFREU_v1c06410(folC)
ELJ : ELUMI_v1c00870(folC)
ESX : ESOMN_v1c06510(folC)
SCR : SCHRY_v1c01390(folC)
SSYR : SSYRP_v1c01590(folC)
SDI : SDIMI_v3c00660(folC)
STAI : STAIW_v1c00660(folC)
SAPI : SAPIS_v1c00610(folC)
SCQ : SCULI_v1c00760(folC)
SSAB : SSABA_v1c00620(folC)
SATR : SATRI_v1c10760(folC)
SERI : SERIO_v1c10500(folC)
SLL : SLITO_v1c00570(folC)
SCJ : SCANT_v1c00670(folC)
SHJ : SHELI_v1c00780(folC)
SFZ : SFLOR_v1c00660(folC)
SCOU : SCORR_v1c00580(folC)
SCLA : SCLARK_001871(folC)
SPRN : S100390_v1c01430(folC)
SPIT : STU14_v1c01430(folC)
STAB : STABA_v1c01480(folC)
SMOO : SMONO_v1c00630(folC)
SALX : SALLE_v1c00700(folC)
SGQ : SGLAD_v1c00860(folC)
SCHI : SCHIN_v1c00990(folC)
SPLT : SPLAT_v1c06360(folC)
PCAT : Pcatena_06120(folC)
RTS : CE91St31_06790(folC)
ERZ : ER308_03225 ER308_06625
MBO : BQ2027_MB2474C(folC)
MMAE : MMARE11_36780(folC)
MDX : BTO20_00780 BTO20_11930
MBAI : MB901379_03354(fgs)
MHEK : JMUB5695_01920(folC)
MKY : IWGMT90018_20350(folC)
MPHL : MPHLCCUG_03601(fgs)
MAUU : NCTC10437_03729(fgs)
MALV : MALV_00140 MALV_00150(folC) MALV_54900
MMAT : MMAGJ_50830 MMAGJ_76700(folC)
MFLV : NCTC10271_01700(fgs)
MSAL : DSM43276_01465(fgs)
MTER : 4434518_01357(folC)
ASD : AS9A_0972 AS9A_1119(folC)
CDIP : ERS451417_01801(folC)
CUN : Cul210932_1769(folC)
CUQ : Cul210931_1667(folC)
CUJ : CUL131002_1691c(folC)
CMIN : NCTC10288_00563(folC)
CCYS : SAMEA4530656_0430(fgs)
NFR : ERS450000_02758(fgs)
NTP : CRH09_10075 CRH09_31990
NAD : NCTC11293_02334(fgs)
RCR : NCTC10994_01042(folC)
RKO : JWS14_06810 JWS14_16810
STRE : GZL_05798 GZL_08302
SLE : sle_46250(sle_46250)
SNR : SNOUR_27275 SNOUR_37305
SALL : SAZ_01195 SAZ_16720
SDX : C4B68_00270 C4B68_26680
SAOV : G3H79_24940 G3H79_35710
SXT : KPP03845_102777(folC)
SYUN : MOV08_27350 MOV08_38525
KSK : KSE_04510(folC2) KSE_26190(folC1)
AMAU : DSM26151_15620(folC)
MALK : MalAC0309_2058(folC)
MHUM : NNL39_09855 NNL39_11450
PSEV : USB125703_00064(folC)
AAGI : NCTC2676_1_01603(fgs)
RDN : HMPREF0733_12077(folC)
RAJ : RA11412_2010 RA11412_2011
RKR : I6G21_09795 I6G21_09805
DVA : DAD186_15180 DAD186_17010
DJJ : COP05_02645 COP05_03600
DHM : CYJ49_008200 CYJ49_009095
HMM : R3I40_01375 R3I40_02575
DCO : SAMEA4475696_1421(fgs)
DSS : GCM25873_12770 GCM25873_12800
PAK : HMPREF0675_3886(folC)
PAUS : NCTC13651_01549(fgs)
PPC : HMPREF9154_1830(folC)
NAQU : ENKNEFLB_03372(folC)
NAL : B005_0496(folC) B005_0497
NGV : CDO52_20310 CDO52_20315
NEX : NE857_25505 NE857_25510
NAKE : KGD83_08120 KGD83_08125
NCG : KGD84_07965 KGD84_07970
STRR : EKD16_08640(fgs1) EKD16_17895(fgs2)
SNAH : OUQ99_06885 OUQ99_06890
ACTW : F7P10_07925 F7P10_07930
AGRA : AGRA3207_001718 AGRA3207_001719
ACIR : OG979_28975 OG979_28980
SPIQ : OHA34_12970 OHA34_12975
ACTQ : OG417_41960 OG417_41965
FRA : Francci3_1208 Francci3_1209
FAL : FRAAL1913(folC) FRAAL1914
AAB : A4R43_24740 A4R43_39185
PAUT : Pdca_23770 Pdca_48430
MCU : HMPREF0573_10184(folC)
TBW : NCTC13354_00393(fgs)
AHW : NCTC11636_00819(fgs)
AIR : NCTC12972_01200(fgs)
ASLA : NCTC11923_02320(fgs)
AVC : NCTC10951_01191(fgs)
FSL : EJO69_04275 EJO69_05035
FLH : EJ997_05330 EJ997_06120
BBV : HMPREF9228_0626(folC)
GVG : HMPREF0421_21186(folC)
GVA : HMPREF0424_0464(folC)
GVH : HMPREF9231_0353(folC)
BALA : DSM104299_03751(fpgS)
IAM : HC251_02830 HC251_08710
SYR : SynRCC307_0610(folC)
SYX : SynWH7803_1748(folC)
SYH : Syncc8109_1868(folC)
SYNW : SynWH8103_01865(folC)
TVN : NIES2134_104730(folC)
LET : O77CONTIG1_03354(fgs)
CHON : NIES4102_21910(folC)
SYP : SYNPCC7002_A0401(folC)
SYNN : NIES970_02700(folC)
MVZ : myaer102_49570(folC)
CYP : PCC8801_0207 PCC8801_2807
CYH : Cyan8802_0203 Cyan8802_3293
PRUN : PCC7821_03562(fol3)
GLJ : GKIL_0381 GKIL_2772(folC)
NSPH : BDGGKGIB_03541(fpgS)
DRA : DR_0340 DR_2575(folC)
DDR : Deide_02860 Deide_20591
DMR : Deima_0557 Deima_3173
DPT : Deipr_0091 Deipr_1878
DGO : DGo_CA0308(folC2) DGo_CA2761(folC)
DPD : Deipe_1114 Deipe_1842
DSW : QR90_00380 QR90_12545
DCH : SY84_06870 SY84_08045
DPU : SU48_01775 SU48_13345
DEZ : DKM44_12405 DKM44_13485
DWU : DVJ83_10685 DVJ83_12845
DEIN : DAAJ005_02545 DAAJ005_05215
DGA : DEGR_27710 DEGR_30100(folC)
DPH : EHF33_07010 EHF33_13015
DRD : LMT64_09120 LMT64_10355
DRB : N0D28_12925 N0D28_14040
DAH : DAETH_00840(folC) DAETH_31080
DAQU : M8445_03450 M8445_07435
DTAE : LAJ19_00205 LAJ19_00980
TTJ : TTHA0343(TTHA0343) TTHA1340(TTHA1340)
TTS : Ththe16_0034 Ththe16_1351
TTL : TtJL18_0038 TtJL18_0709
TSC : TSC_c01240 TSC_c05000
THC : TCCBUS3UF1_2720 TCCBUS3UF1_6650
TOS : Theos_0505 Theos_2185
TANT : KNN15_04750 KNN15_07130
MTAI : Mtai_v1c22380 Mtai_v1c28510
MSV : Mesil_0351 Mesil_2502
OPR : Ocepr_0875 Ocepr_1874
MHD : Marky_0288 Marky_1009
CSUI : Chls_964(alternative_Folylglutamate_Synthase)
SCOR : J3U87_05420 J3U87_14775
FPOL : ERS445057_01202(fgs)
LHF : JCM16775_1051 JCM16775_1307
LHG : JMUB5056_1126 JMUB5056_1905
LTE : JMUB4039_0656 JMUB4039_1353
STR : Sterm_1883 Sterm_2622
BTHO : Btheta7330_01886(fgs)
BCEL : BcellWH2_05074(fgs)
BFIN : BFINE_30680 BFINE_30690
PCRE : NCTC12858_01308(folC)
PCAG : NCTC12856_01983(folC)
PMZ : HMPREF0659_A7254(folC)
PDN : HMPREF9137_1865(folC)
POC : NCTC13071_01649(fgs)
SDJ : NCTC13534_04530(fgs)
STHA : NCTC11429_02313(fgs)
PSEZ : HME7025_01610(folC)
FOK : KK2020170_11090(folC)
PHG : KCTC32516_01441(folC)
AALG : AREALGSMS7_00459(fgs)
KOS : KORDIASMS9_00179(fgs)
SPON : HME9304_00880(folC)
OHM : MSHRCOH1_02905(folC)
CGLE : NCTC11432_03349(fgs)
CTAI : NCTC12078_02370(folC)
CJG : NCTC13459_02188(fgs)
CANT : NCTC13489_02073(fgs)
PTAN : CRYO30217_01318(folC)
PROC : Ptc2401_00407(folC)
CPO : COPRO5265_0578 COPRO5265_1231
NMV : NITMOv2_1442(folC) NITMOv2_2962 NITMOv2_3290
NTI : DNFV4_00264 DNFV4_01938
HMA : pNG7379(folP2) rrnAC0184(folP)
HHI : HAH_0935(folP1) HAH_5188(folP3)
HHN : HISP_04810 HISP_19115
HAB : SG26_12495 SG26_17135
HTA : BVU17_04560 BVU17_16805
HALJ : G9465_08000(folP) G9465_20140(folP) G9465_23475(folP)
HSIN : KDQ40_08855(folP) KDQ40_19450(folP)
HALA : Hrd1104_06245(folP)
HARC : HARCEL1_06305(folP)
SSAI : N0B31_01885(folP) N0B31_21090(folP)
HAAD : MW046_11535(folP) MW046_16050(folP)
HALB : EKH57_10060(folP) EKH57_15400(folP)
HALQ : Hrr1229_004725(folP)
HACB : Hbl1158_07635(folP)
HSAL : JMJ58_12025(folP) JMJ58_23985(folP)
NOU : Natoc_1904 Natoc_2214
HLR : HALLA_02055 HALLA_16265
NAJ : B1756_14735 B1756_16635
NAG : AArcMg_0494 AArcMg_1552
NAN : AArc1_0506 AArc1_2091
TVO : TVG0771612(TVG0771612)
MARC : AR505_0729 AR505_1304
» show all
Taxonomy
Reference
Authors
GRIFFIN MJ, BROWN GM.
Title
THE BIOSYNTHESIS OF FOLIC ACID. III. ENZYMATIC FORMATION OF DIHYDROFOLIC ACID FROM DIHYDROPTEROIC ACID AND OF TETRAHYDROPTEROYLPOLYGLUTAMIC ACID COMPOUNDS FROM TETRAHYDROFOLIC ACID.
Journal
J Biol Chem 239:310-6 (1964)
Reference
Authors
Bognar AL, Osborne C, Shane B, Singer SC, Ferone R.
Title
Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product.
Journal
J Biol Chem 260:5625-30 (1985)
Reference
Authors
Ravanel S, Cherest H, Jabrin S, Grunwald D, Surdin-Kerjan Y, Douce R, Rebeille F
Title
Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana.
Journal
Sequence
Reference
Authors
Cherest H, Thomas D, Surdin-Kerjan Y
Title
Polyglutamylation of folate coenzymes is necessary for methionine biosynthesis and maintenance of intact mitochondrial genome in Saccharomyces cerevisiae.
Journal
Sequence
Reference
Authors
Cossins EA, Chen L.
Title
Folates and one-carbon metabolism in plants and fungi.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.12
ExPASy - ENZYME nomenclature database: 6.3.2.12