KEGG   ENZYME: 6.3.2.37Help
Entry
EC 6.3.2.37                 Enzyme                                 

Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---D-lysine ligase;
UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase;
D-lysine-adding enzyme
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:D-lysine alpha-ligase (ADP-forming)
Reaction(IUBMB)
ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-D-lysine [RN:R09596]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate [CPD:C00692];
D-lysine [CPD:C00739]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-D-lysine [CPD:C19720]
Comment
The enzyme from Thermotoga maritima also performs the reaction of EC 6.3.2.7, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase. Involved in the synthesis of cell-wall peptidoglycan.
History
EC 6.3.2.37 created 2011
Reference
1  [PMID:16595662]
  Authors
Boniface A, Bouhss A, Mengin-Lecreulx D, Blanot D
  Title
The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine  adding activity.
  Journal
J. Biol. Chem. 281 (2006) 15680-6.
  Sequence
[tma:TM0237]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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