KEGG   ENZYME: 6.3.2.7Help
Entry
EC 6.3.2.7                  Enzyme                                 

Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase;
MurE synthetase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase;
uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase;
UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine [RN:R02786]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [CPD:C00692];
L-lysine [CPD:C00047]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine [CPD:C05892]
Comment
Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase) adds 2,6-diaminopimelate instead.
History
EC 6.3.2.7 created 1961, modified 2002
Pathway
ec00550  Peptidoglycan biosynthesis
ec01100  Metabolic pathways
Orthology
K05362  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
Genes
BACO: OXB_1857
LSP: Bsph_1281
LFU: HR49_19765
LYS: LBYS11_03725
LYB: C3943_04735
VIR: X953_06650
SAU: SA0876(murE)
SAV: SAV1018(murE)
SAW: SAHV_1012(murE)
SAH: SaurJH1_1035
SAM: MW0899(murE)
SAS: SAS0887
SAR: SAR0988(murE)
SAC: SACOL1023(murE)
SAX: USA300HOU_0976(murE1)
SAA: SAUSA300_0919(murE)
SAE: NWMN_0888(murE)
SAD: SAAV_0980
SUE: SAOV_0963
SUJ: SAA6159_00874(murE)
SUK: SAA6008_00973(murE)
SUC: ECTR2_873(murE)
SUQ: HMPREF0772_12216(murE)
SUZ: MS7_0974(murE)
SUX: SAEMRSA15_08480(murE)
SUW: SATW20_10150(murE)
SUG: SAPIG1014
SUF: SARLGA251_09330(murE)
SAUA: SAAG_02127
SAUE: RSAU_000903(murE)
SAUS: SA40_0888(murE)
SAUU: SA957_0903(murE)
SAUG: SA268_0905(murE)
SAUZ: SAZ172_0959(murE)
SAUV: SAI7S6_1007210(murE)
SAUW: SAI5S5_1007170(murE)
SAUX: SAI6T6_1007180(murE)
SAUY: SAI8T7_1007210(murE)
SAUF: X998_1016
SAB: SAB0884(murE)
SUY: SA2981_0972(murE)
SAUB: C248_1042(murE)
SAUM: BN843_9230
SAUC: CA347_935(murE)
SAUR: SABB_00986(murE)
SAUI: AZ30_04840
SAUD: CH52_00795
SAMS: NI36_04845
SEP: SE0718
SER: SERP0607(murE)
SEPP: SEB_00697
SEPS: DP17_2003(murE)
SHA: SH1941(murE)
SHH: ShL2_01803(murE)
SSP: SSP1767
SCA: SCA_0621(murE)
SLN: SLUG_18440(murE)
SDT: SPSE_1819(murE)
SPAS: STP1_2087
SXO: SXYL_01914(murE)
SHU: SHYC_09250(murE-2)
SCAP: AYP1020_0275(murE)
SSCH: LH95_08705
SSCZ: RN70_09185
SAGQ: EP23_00740
MCL: MCCL_0631(murE)
MCAK: MCCS_08580(murE)
SIV: SSIL_3199
JEO: JMA_14530
KUR: ASO14_2324(murE)
LLK: LLKF_1979(murE)
LLT: CVCAS_1739(murE)
LLS: lilo_1789(murE)
LLX: NCDO2118_1912(murE)
LLR: llh_3110
LLN: LLNZ_10265(murE)
LLI: uc509_1759(murE)
LLW: kw2_1860(murE)
LLJ: LG36_1762(murE)
LGR: LCGT_0383
LGV: LCGL_0383
LPK: LACPI_2096(murE)
SPY: SPy_0388(murE)
SPZ: M5005_Spy0325(murE)
SPYM: M1GAS476_0392(murE)
SPM: spyM18_0440(murE)
SPG: SpyM3_0284(murE)
SPS: SPs1575
SPH: MGAS10270_Spy0320(murE)
SPI: MGAS10750_Spy0321(murE)
SPK: MGAS9429_Spy0324(murE)
SPF: SpyM51533(murE)
SPB: M28_Spy0314(murE)
STG: MGAS15252_0351(murE.1)
SOZ: Spy49_0319c(murE)
STZ: SPYALAB49_000354(murE)
STX: MGAS1882_0351(murE.1)
SPYA: A20_0373c(murE)
SPYH: L897_01765
SPN: SP_1530(murE)
SPD: SPD_1359(murE)
SPR: spr1384(murE)
SPW: SPCG_1517(murE)
SPX: SPG_1456(murE)
SNE: SPN23F14930(murE)
SPV: SPH_1643
SJJ: SPJ_1434
SPP: SPP_1552
SNT: SPT_1468
SNC: HMPREF0837_11764(murE)
SNP: SPAP_1552
SNI: INV104_13020(murE)
SNV: SPNINV200_13670(murE)
SNX: SPNOXC13410(murE)
SND: MYY_1460
SNU: SPNA45_00691(murE)
SPNE: SPN034156_04290(murE)
SPNU: SPN034183_13400(murE)
SPNM: SPN994038_13290(murE)
SPNO: SPN994039_13300(murE)
SPNN: T308_06950
SAG: SAG1391(murE)
SAN: gbs1461
SAK: SAK_1424(murE)
SGC: A964_1305(murE)
SAGS: SaSA20_1131(murE)
SAGL: GBS222_1144(murE)
SAGM: BSA_14720
SAGI: MSA_15140
SAGR: SAIL_14460
SAGP: V193_06190
SAGC: DN94_06190
SAGE: EN72_07725
SAGG: EN73_06915
SAGN: W903_1407(murE)
SMU: SMU_1677(murE)
SMC: SmuNN2025_0440(murE)
SMJ: SMULJ23_0456(murE)
SMUA: SMUFR_1459
STC: str0349(murE)
STL: stu0349(murE)
STE: STER_0387
STN: STND_0341
STU: STH8232_0447(mure)
STW: Y1U_C0334
STHE: T303_02880
SSA: SSA_1739(murE)
SSB: SSUBM407_1216(murE)
SSI: SSU0608(murE)
SSS: SSUSC84_0581(murE)
SST: SSUST3_0812(murE)
SSF: SSUA7_0606(murE)
SSK: SSUD12_1217(murE)
SUI: SSUJS14_0741(murE)
SUO: SSU12_0607(murE)
SRP: SSUST1_1159(murE)
SUP: YYK_02890
SSUT: TL13_1126(murE)
SSUI: T15_1332(murE)
SSUY: YB51_4025
SGO: SGO_1638(murE)
SEZ: Sez_1617(murE)
SEQ: SZO_03550
SEZO: SeseC_02166(murE)
SEQU: Q426_00770
SEU: SEQ_1835
SUB: SUB0425(murE)
SDS: SDEG_0435(murE)
SDA: GGS_0424(murE)
SDC: SDSE_0454(murE)
SDQ: SDSE167_0474(murE)
SGA: GALLO_1770(murE)
SGG: SGGBAA2069_c17290(murE)
SGT: SGGB_1757(murE)
SMB: smi_1512(murE)
SOR: SOR_0659(murE)
STK: STP_1332
STB: SGPB_1578(murE.2)
SCP: HMPREF0833_10974(murE)
SCF: Spaf_1551(murE2)
SSR: SALIVB_0346(murE)
STF: Ssal_01844(murE)
STJ: SALIVA_0324(murE)
SSAH: HSISS4_00276(murE)
SMN: SMA_1676(murE)
SIF: Sinf_1499(murE)
SIE: SCIM_0429(murE)
SIB: SIR_1231(murE)
SIU: SII_1255(murE)
SANG: SAIN_0463(murE)
SANC: SANR_0481(murE)
SANS: DK43_07865
SCG: SCI_0511(murE)
SCON: SCRE_0491(murE)
SCOS: SCR2_0491(murE)
SIK: K710_1552
SLU: KE3_1632
EFA: EF0668(murE)
EFL: EF62_1038(murE)
EFI: OG1RF_10399(murE)
EFS: EFS1_0515(murE)
EFN: DENG_00697(murE)
EFQ: DR75_2617(murE)
EFU: HMPREF0351_12511(murE2)
EFM: M7W_2527
EHR: EHR_05945
ECAS: ECBG_02266
EMU: EMQU_2676
EDU: LIU_02615
MPS: MPTP_1715
MPX: MPD5_0348
CML: BN424_209(murE)
 » show all
Taxonomy
Reference
1
  Authors
Ito, E. and Strominger, J.L.
  Title
Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine.
  Journal
J. Biol. Chem. 237 (1962) 2689-2695.
Reference
2  [PMID:11699883]
  Authors
van Heijenoort J.
  Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
  Journal
Nat. Prod. Rep. 18 (2001) 503-19.
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.7
IUBMB Enzyme Nomenclature: 6.3.2.7
ExPASy - ENZYME nomenclature database: 6.3.2.7
BRENDA, the Enzyme Database: 6.3.2.7
CAS: 9023-51-2

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