KEGG   ENZYME: 6.3.2.7Help
Entry
EC 6.3.2.7                  Enzyme                                 

Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase;
MurE synthetase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase;
uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase;
UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine [RN:R02786]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [CPD:C00692];
L-lysine [CPD:C00047]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine [CPD:C05892]
Comment
Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase) adds 2,6-diaminopimelate instead.
History
EC 6.3.2.7 created 1961, modified 2002
Pathway
Peptidoglycan biosynthesis
Metabolic pathways
Orthology
K05362  
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
Genes
BACO: 
LSP: 
LFU: 
VIR: 
SAU: 
SA0876(murE)
SAV: 
SAV1018(murE)
SAW: 
SAHV_1012(murE)
SAH: 
SAJ: 
SAM: 
MW0899(murE)
SAS: 
SAR: 
SAR0988(murE)
SAC: 
SACOL1023(murE)
SAX: 
SAA: 
SAO: 
SAE: 
NWMN_0888(murE)
SAD: 
SUU: 
SUV: 
SUE: 
SUJ: 
SUK: 
SUC: 
ECTR2_873(murE)
SUT: 
SUQ: 
SUZ: 
MS7_0974(murE)
SUD: 
SUX: 
SUW: 
SUG: 
SUF: 
SAUA: 
SAUE: 
SAUN: 
SAUS: 
SA40_0888(murE)
SAUU: 
SAUG: 
SAUZ: 
SAUT: 
SAUJ: 
SAUK: 
SAUQ: 
SAUV: 
SAUW: 
SAUX: 
SAUY: 
SAB: 
SAB0884(murE)
SUY: 
SAUB: 
C248_1042(murE)
SAUM: 
SAUC: 
CA347_935(murE)
SAUR: 
SAUI: 
SAUD: 
SAUF: 
X998_1016(murE)
SUH: 
SEP: 
SER: 
SERP0607(murE)
SEPP: 
SEPS: 
DP17_2003(murE)
SHA: 
SH1941(murE)
SHH: 
SSP: 
SCA: 
SCA_0621(murE)
SLG: 
SLN: 
SSD: 
SDT: 
SPSE_1819(murE)
SWA: 
SPAS: 
SXY: 
SXL: 
SXO: 
SHU: 
SHYC_09250(murE-2)
SCAP: 
SSCH: 
SAGQ: 
SEQO: 
SSIF: 
MCL: 
MCCL_0631(murE)
SHV: 
GOT: 
SIV: 
PLN: 
PKU: 
PRT: 
PLL: 
PANA: 
JEO: 
KUR: 
SPSY: 
RST: 
LLK: 
LLKF_1979(murE)
LLT: 
LLS: 
lilo_1789(murE)
LLD: 
LLX: 
LLR: 
LLN: 
LLI: 
LLW: 
kw2_1860(murE)
LLJ: 
LG36_1762(murE)
LGR: 
LGV: 
LPK: 
SPY: 
SPy_0388(murE)
SPZ: 
SPYM: 
SPM: 
SPG: 
SPS: 
SPH: 
SPI: 
SPJ: 
SPK: 
SPF: 
SpyM51533(murE)
SPA: 
SPB: 
STG: 
SOZ: 
STZ: 
STX: 
SPYA: 
A20_0373c(murE)
SPYH: 
SPN: 
SP_1530(murE)
SPD: 
SPD_1359(murE)
SPR: 
spr1384(murE)
SPW: 
SPCG_1517(murE)
SPX: 
SPG_1456(murE)
SNE: 
SPV: 
SNM: 
SJJ: 
SPP: 
SNT: 
SNC: 
SNB: 
SNP: 
SNI: 
SNV: 
SNX: 
SND: 
SNU: 
SPNG: 
SPNE: 
SPNU: 
SPNM: 
SPNO: 
SPNN: 
SAG: 
SAG1391(murE)
SAN: 
SAK: 
SAK_1424(murE)
SGC: 
A964_1305(murE)
SAGS: 
SAGL: 
SAGM: 
SAGI: 
SAGR: 
SAGP: 
SAGC: 
SAGT: 
SAGE: 
SAGG: 
SAGN: 
W903_1407(murE)
SMU: 
SMU_1677(murE)
SMC: 
SMJ: 
SMUT: 
SMUA: 
STC: 
str0349(murE)
STL: 
stu0349(murE)
STE: 
STN: 
STU: 
STW: 
STHE: 
SSA: 
SSA_1739(murE)
SSB: 
SSU: 
SSV: 
SSI: 
SSU0608(murE)
SSS: 
SST: 
SSF: 
SSK: 
SSW: 
SUI: 
SUO: 
SRP: 
SUP: 
SSUS: 
SSUT: 
TL13_1126(murE)
SSUI: 
T15_1332(murE)
SSUY: 
SGO: 
SGO_1638(murE)
SEQ: 
SEZ: 
Sez_1617(murE)
SEZO: 
SEQU: 
SEU: 
SUB: 
SUB0425(murE)
SDS: 
SDEG_0435(murE)
SDG: 
SDA: 
GGS_0424(murE)
SDC: 
SDSE_0454(murE)
SDQ: 
SGA: 
SGG: 
SGT: 
SGGB_1757(murE)
SMB: 
smi_1512(murE)
SOR: 
SOR_0659(murE)
STK: 
STB: 
SGPB_1578(murE.2)
SCP: 
SCF: 
Spaf_1551(murE2)
SSR: 
STF: 
STJ: 
STRS: 
STD: 
SMN: 
SMA_1676(murE)
SIF: 
Sinf_1499(murE)
SIE: 
SCIM_0429(murE)
SIB: 
SIR_1231(murE)
SIU: 
SII_1255(murE)
SANG: 
SAIN_0463(murE)
SANC: 
SANR_0481(murE)
SANS: 
SCG: 
SCI_0511(murE)
SCON: 
SCRE_0491(murE)
SCOS: 
SCR2_0491(murE)
SOI: 
SIK: 
SIQ: 
SIO: 
SIZ: 
SLU: 
SIG: 
SIP: 
STV: 
EFA: 
EF0668(murE)
EFL: 
EF62_1038(murE)
EFI: 
EFD: 
EFS: 
EFS1_0515(murE)
EFN: 
EFQ: 
DR75_2617(murE)
EFC: 
EFAU: 
EFU: 
EFM: 
EFT: 
EHR: 
ECAS: 
EMU: 
EDU: 
EGA: 
ESS: 
MPS: 
MPX: 
CML: 
BN424_209(murE)
 » show all
Taxonomy
Reference
1
  Authors
Ito, E. and Strominger, J.L.
  Title
Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine.
  Journal
J. Biol. Chem. 237 (1962) 2689-2695.
Reference
2  [PMID:11699883]
  Authors
van Heijenoort J.
  Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
  Journal
Nat. Prod. Rep. 18 (2001) 503-19.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9023-51-2

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