KEGG   ENZYME: 6.3.4.16Help
Entry
EC 6.3.4.16                 Enzyme                                 
Name
carbamoyl-phosphate synthase (ammonia);
carbon-dioxide---ammonia ligase;
carbamoylphosphate synthase;
carbamylphosphate synthetase;
carbamoylphosphate synthase (ammonia);
carbamoylphosphate synthetase;
carbamylphosphate synthetase I
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
Reaction(IUBMB)
2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate [RN:R00149]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
NH3 [CPD:C00014];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
carbamoyl phosphate [CPD:C00169]
Pathway
Alanine, aspartate and glutamate metabolism
Arginine and proline metabolism
Nitrogen metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K01948  
carbamoyl-phosphate synthase (ammonia)
Genes
HSA: 
1373(CPS1)
PTR: 
738670(CPS1)
PPS: 
100984596(CPS1)
GGO: 
101130709(CPS1)
PON: 
100442727(CPS1)
MCC: 
711806(CPS1)
MMU: 
227231(Cps1)
RNO: 
497840(Cps1)
CFA: 
488506(CPS1)
AML: 
100466842(CPS1)
FCA: 
101099824(CPS1)
BTA: 
510506(CPS1)
SSC: 
100156131 100157716(CPS1)
ECB: 
100050116(CPS1)
MDO: 
100015090
SHR: 
100929825(CPS1)
OAA: 
100077228
GGA: 
428994(CPS1)
MGP: 
100539661
TGU: 
100221389(CPS1)
ACS: 
100562333
XLA: 
733340(cps1)
DRE: 
555623(cps1)
TRU: 
101074466
OLA: 
101164854
BFO: 
BRAFLDRAFT_67029
SPU: 
584369
PTI: 
PHATRDRAFT_24195
TPS: 
THAPSDRAFT_40323
PIF: 
PITG_03098
 » show all
Taxonomy
Reference
1  [PMID:14213379]
  Authors
FAHIEN LA, COHEN PP.
  Title
A KINETIC STUDY OF CARBAMYL PHOSPHATE SYNTHETASE.
  Journal
J. Biol. Chem. 239 (1964) 1925-34.
  Organism
frog
Reference
2  [PMID:13790558]
  Authors
JONES ME, SPECTOR L.
  Title
The pathway of carbonate in the biosynthesis of carbamyl phosphate.
  Journal
J. Biol. Chem. 235 (1960) 2897-901.
  Organism
frog
Reference
3  [PMID:13563449]
  Authors
METZENBERG RL, MARSHALL M, COHEN PP.
  Title
Purification of carbamyl phosphate synthetase from frog liver.
  Journal
J. Biol. Chem. 233 (1958) 102-5.
  Organism
frog
Reference
4
  Authors
Marshall, M., Metzenberg, R.L. and Cohen, P.P.
  Title
Physical and kinetic properties of carbamyl phosphate synthetase from frog liver.
  Journal
J. Biol. Chem. 236 (1961) 2229-2237.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9026-23-7
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