Entry
Name
5-(carboxyamino)imidazole ribonucleotide synthase;
N5-CAIR synthetase;
N5-carboxyaminoimidazole ribonucleotide synthetase;
PurK
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming)
Reaction(IUBMB)
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole [RN:
R07404 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
5-amino-1-(5-phospho-D-ribosyl)imidazole [CPD:
C03373 ];
HCO3- [CPD:
C00288 ]
Product
ADP [CPD:
C00008 ];
phosphate [CPD:
C00009 ];
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole [CPD:
C15667 ]
Comment
In Escherichia coli, this enzyme, along with EC
5.4.99.18 , 5-(carboxyamino)imidazole ribonucleotide mutase, is required to carry out the single reaction catalysed by EC
4.1.1.21 , phosphoribosylaminoimidazole carboxylase, in vertebrates. Belongs to the ATP grasp protein superfamily [3]. Carboxyphosphate is the putative acyl phosphate intermediate. Involved in the late stages of purine biosynthesis.
History
EC 6.3.4.18 created 2006
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K01589 5-(carboxyamino)imidazole ribonucleotide synthase
Genes
ECOO : ECRM13514_0315(purK)
ECOH : ECRM13516_0510(purK)
ECW : EcE24377A_0560(purK)
EDJ : ECDH1ME8569_0507(purK)
ECOI : ECOPMV1_00510(purK)
REE : electrica_03826(purK)
RTG : NCTC13098_05677(purK_2)
CLAP : NCTC11466_01125(purK)
KIE : NCTC12125_02511(purK)
AHN : NCTC12129_03737(purK_1)
METY : MRY16398_43200(purK)
PSHI : SAMEA2665130_0947(purK)
YPG : YpAngola_A1274(purK)
YPI : YpsIP31758_3018(purK)
SMW : SMWW4_v1c11310(purK)
SFJ : SAMEA4384070_1191(purK)
SOF : NCTC11214_00327(purK)
PAQU : DMB82_0006870(purK)
DIC : Dpoa569_000996(purK)
EHD : ERCIPSTX3056_333(purK)
TPTY : NCTC11468_01117(purK)
PHEI : NCTC12003_01100(purK)
PRJ : NCTC6933_02938(purK)
LRI : NCTC12151_02296(purK_1)
HIC : NTHIC486_01492(purK)
HPIT : NCTC13334_01612(purK)
HHZ : NCTC10839_01602(purK)
HAEG : NCTC8502_01378(purK_1) NCTC8502_01379(purK_2)
PDAG : 4362423_00758(purK)
ALIG : NCTC10568_00780(purK)
ASEG : NCTC10977_01433(purK)
AVT : NCTC3438_01191(purK)
RPNE : NCTC8284_02239(purK_1)
PAET : NCTC13378_00989(purK)
XFU : XFF4834R_chr26740(purK)
XPH : XppCFBP6546_22515(XppCFBP6546P_22515)
XHD : LMG31886_16680(purK)
LLZ : LYB30171_00888(purK)
VAU : VANGNB10_cI0061c(purK)
VPL : SA104470976_00068(purK)
PAEB : NCGM1900_6276(purK)
PVD : CFBP1590__5363(purK)
PPRC : PFLCHA0_c60860(purK)
PMUD : NCTC8068_05335(purK)
PFW : PF1751_v1c54640(purK)
PPUU : PputUW4_05370(purK)
PTW : TUM18999_60510(purK)
PTAE : NCTC10697_04433(purK)
MSHE : MAALD49_14010(purK)
PSYC : DABAL43B_0354(purK)
MCAT : MC25239_00429(purK)
MCUN : NCTC10297_00925(purK_1)
SCAA : TUM17387_27110(purK)
SALH : HMF8227_00372(purK)
LCJ : NCTC11976_00429(purK)
LWA : SAMEA4504053_2455(purK)
LSS : NCTC12082_01256(purK)
MISZ : MishRS11D_29410(purK)
THIO : AYJ59_03130 AYJ59_04100
TIB : THMIRHAM_18820(purK)
TSE : THMIRHAS_21210(purK)
TZO : THMIRHAT_05470(purK)
TFRI : Thiofri_03051(purK)
TNI : TVNIR_0348(purK_[H])
GAI : IMCC3135_07495(purK)
THIC : TspCOW1_22350(purK)
ALCA : ASALC70_02212(purK)
CHJ : NCTC10426_02032(purK)
CDIZ : CEDIAZO_00432(purK)
NMQ : NMBM04240196_1141(purK)
NMZ : NMBNZ0533_1072(purK)
NMX : NMA510612_1382(purK)
NWE : SAMEA3174300_0940(purK)
NZO : SAMEA4504057_1608(purK)
NCI : NCTC10296_01694(purK)
NCZ : NCTC10294_00791(purK)
NANI : NCTC12227_01029(purK)
ECOR : SAMEA4412678_0643(purK)
BMV : BMASAVP1_A0597(purK)
BML : BMA10229_A2431(purK)
BPM : BURPS1710b_1001(purK)
BPL : BURPS1106A_0844(purK)
PLG : NCTC10937_05198(purK)
LMIR : NCTC12852_02349(purK)
BUO : BRPE64_ACDS04960(purK)
VTR : MYVALT_G_01830(purK)
BTRM : SAMEA390648702215(purK)
AXX : ERS451415_04905(purK)
LIM : L103DPR2_00161(purK)
LIH : L63ED372_00167(purK)
URU : DSM104443_02616(purK)
UPL : DSM104440_02339(purK)
FPHO : SHINM1_015500(purK)
ERW : ERWE_CDS_08400(purK)
ERG : ERGA_CDS_08290(purK)
RBS : RHODOSMS8_02254(purK)
SMEL : SM2011_c04002(purK)
SFD : USDA257_c52520(purK)
SAME : SAMCFNEI73_Ch3207(purK)
AVV : RvVAT039_10030(purK)
AVF : RvVAR031_29950(purK)
REC : RHECIAT_CH0003782(purK)
REL : REMIM1_CH03603(purK)
REP : IE4803_CH03904(purK)
REI : IE4771_CH03842(purK)
RTR : RTCIAT899_CH14915(purK)
RGA : RGR602_CH03426(purK)
RPHA : AMC79_CH03706(purK)
NEN : NCHU2750_27410(purK)
LAS : CLIBASIA_00205(purk)
BIO : BR141012304_10960(purK)
VGO : GJW-30_1_02535(purK)
BHS : BM1374165_01479(purK)
BBK : BARBAKC583_0208(purK)
BTX : BM1374166_01876(purK)
BEZ : NCTC12898_01294(purK)
MAQU : Maq22A_c14745(purK)
MTUN : MTUNDRAET4_2594(purK)
FIL : BN1229_v1_0096(purK)
FIY : BN1229_v1_0099(purK)
BVY : NCTC9239_00862(purK)
TSV : DSM104635_00931(purK)
RLI : RLO149_c027140(purK)
PHP : PhaeoP97_02358(purK)
PPIC : PhaeoP14_02273(purK)
SINL : DSM14862_00691(purK)
SPSE : SULPSESMR1_02395(purK)
RMM : ROSMUCSMR3_01747(purK)
AHT : ANTHELSMS3_01489(purK)
LALG : LentiSH36_00389(purK)
LVS : LOKVESSMR4R_00639(purK)
SBIN : SBA_ch1_18350(purK)
SFLA : SPHFLASMR4Y_01533(purT)
BDQ : CIK05_05455 CIK05_07840
BAZ : BAMTA208_02985(purK)
BSON : S101395_00889(purK)
BFD : NCTC4823_03299(purK)
PARG : PspKH34_35420(purK)
BLEN : NCTC4824_00904(purK)
SAX : USA300HOU_1010(purK)
SUQ : HMPREF0772_12168(purK)
SUX : SAEMRSA15_08960(purK)
SUF : SARLGA251_09790(purK)
SAUV : SAI7S6_1007550(purK)
SAUW : SAI5S5_1007510(purK)
SAUX : SAI6T6_1007520(purK)
SAUY : SAI8T7_1007550(purK)
SDP : NCTC12225_01968(purK)
SPIC : SAMEA4384060_1878(purK)
SSH : NCTC13712_01011(purK)
SSIM : SAMEA4384339_0977(purK)
SSTE : SAMEA4384403_1773(purK)
LMOC : LMOSLCC5850_1836(purK)
LMW : LMOSLCC2755_1832(purK)
LMX : LMOSLCC2372_1840(purK)
LMZ : LMOSLCC2482_1835(purK)
LMON : LMOSLCC2376_1732(purK)
LMOS : LMOSLCC7179_1746(purK)
LMOO : LMOSLCC2378_1795(purK)
LMOY : LMOSLCC2479_1838(purK)
LMOT : LMOSLCC2540_1854(purK)
LMOA : LMOATCC19117_1789(purK)
LGZ : NCTC10812_01067(purK)
GMO : NCTC11323_00808(purK)
GHA : NCTC10459_00794(purK)
BAYD : BSPP4475_18280(purK)
PPQ : PPSQR21_008230(purK)
PNK : AASFL403_15875(purK)
COHN : KCTCHS21_51100(purK)
SPYM : M1GAS476_0053(purK)
SPH : MGAS10270_Spy0032(purK)
SPI : MGAS10750_Spy0032(purK)
SPJ : MGAS2096_Spy0032(purK)
SPK : MGAS9429_Spy0031(purK)
STG : MGAS15252_0052(purK)
STZ : SPYALAB49_000060(purK)
SNV : SPNINV200_00530(purK)
SNC : HMPREF0837_10343(purK)
SPNG : HMPREF1038_00119(purK)
SPNE : SPN034156_11600(purK)
SPNU : SPN034183_00980(purK)
SPNM : SPN994038_00980(purK)
SPNO : SPN994039_00980(purK)
SMC : SmuNN2025_0045(purK)
SGG : SGGBAA2069_c00350(purK)
SCP : HMPREF0833_11512(purK)
SVB : NCTC12167_00060(purK)
SMEN : SAMEA4412692_2024(purK)
SFER : NCTC12278_00056(purK)
SCAI : NCTC12191_00531(purK)
SAUP : NCTC3168_00716(purK)
SURN : NCTC13766_02225(purK)
SVF : NCTC3166_00057(purK)
SMIE : NCTC11169_00057(purK)
LCZ : LCAZH_1099 LCAZH_1746
LCS : LCBD_1260(purK) LCBD_1952
LCE : LC2W_1282(purK) LC2W_1931
LCW : BN194_12510(purK) BN194_19370(purK_2)
LCL : LOCK919_1275 LOCK919_1928
LPQ : AF91_05100 AF91_08290
LPI : LBPG_00700 LBPG_01031
LPAP : LBPC_1046 LBPC_1674
LCB : LCABL_12790(purK2) LCABL_19740(purK1)
LCX : LCA12A_0087 LCA12A_0965
LRH : LGG_01078(purK) LGG_01813(purK)
LRL : LC705_01155(purK) LC705_01795(purK)
LRA : LRHK_1121 LRHK_1789(purK)
LRO : LOCK900_1044 LOCK900_1755
LRC : LOCK908_1178 LOCK908_1849
LCHI : KG086_04760 KG086_07775(purK)
LZE : KG087_05430 KG087_08430(purK)
LHN : LHUE1_002200 LHUE1_002792(purK)
LPL : lp_1141(purK2) lp_2728(purK1)
LPJ : JDM1_0938(purK2) JDM1_2187(purK1)
LPT : zj316_1171(purK2) zj316_2619(purK1)
LPS : LPST_C0915(purK2) LPST_C2241(purK1)
LPR : LBP_cg0905 LBP_cg2233
LPB : SH83_04735 SH83_11480
LPX : ASU28_00600 ASU28_11480
LPG : BB562_04130 BB562_11655
LARG : LPA65_04615 LPA65_11790(purK)
LRU : HMPREF0538_20553 HMPREF0538_21287(purK)
LRR : N134_00715 N134_07950
LMU : LBLM1_01695 LBLM1_10270
LOR : AYI71_01510 AYI71_03780 AYI71_08755 AYI71_11400
LVA : LV515_00565(purK) LV515_07410
LFN : LF145_00455(purK) LF145_06880
LPON : LP475_00595(purK) LP475_06540
LGAS : LG045_00590(purK) LG045_02255
LPAS : KZE55_00985(purK) KZE55_07560
LPOR : PRK60_00100(purK) PRK60_01625
LNG : BSQ50_01530 BSQ50_07690
LHW : BSQ49_01890 BSQ49_03455
LMAL : LM596_02060 LM596_03710(purK)
LLE : AYR59_03565 AYR59_03925
FCLI : M3M38_05960(purK) M3M38_06330
LBN : LBUCD034_0404(purk1) LBUCD034_1760(purk3)
LPAR : FAM21731_00596 FAM21731_01741
LCU : PL11_003405 PL11_006670
LKF : DNL43_00885 DNL43_03420
LHIL : G8J22_00323(purK_1) G8J22_01980(purK_2)
LSL : LSL_0516(purK) LSL_1350(purK)
LSI : HN6_00472(purK) HN6_01126(purK)
LSJ : LSJ_0564(purK) LSJ_1378c(purK)
LRM : LRC_05000(purK) LRC_11380(purK)
LAGL : BEN83_02175 BEN83_07565
LANI : FAX13_06590(purK) FAX13_07455
LMUR : CPS94_01020 CPS94_02095
LFD : QFX10_06885 QFX10_07645(purK)
LBT : AYR52_07545 AYR52_10710
LCY : LC20004_06810 LC20004_12090
LHO : LOOC260_106160 LOOC260_110820
LOL : LACOL_0295(purK) LACOL_0527
LNN : F0161_02210(purK) F0161_03805
LPD : AYR62_07485 AYR62_08085
PPEN : T256_06790 T256_07245
PACI : A4V11_01990 A4V11_04060
LGN : ABM34_03330 ABM34_11435
LHI : JP39_06710 JP39_08975
LCT : BI355_0877 BI355_1723
LALW : BTM29_05930 BTM29_08630
LALI : LA20249_03915 LA20249_05875
LFM : LF20184_02895 LF20184_05520
LZH : D1B17_07440(purK) D1B17_09835
LFT : FG051_02750 FG051_05095(purK)
CPAB : G6534_01460 G6534_06510(purK)
LSA : LCA_0653(purK1) LCA_1556(purK2)
LCV : FBA2_03375 FBA2_07820
LHB : D1010_11745 D1010_13935(purK)
LDX : LH506_00985 LH506_07305(purK)
WTR : KHQ32_01505 KHQ32_03685(purK)
WCI : WS105_0256 WS105_0747
WCB : AO080_05380 AO080_05565
WJO : FOL01_0284 FOL01_1454
WPA : CO680_01600 CO680_06900
WCF : C6P13_02970 C6P13_03155
WSO : WSWS_00392(purK) WSWS_01168
WDI : H9L19_01405 H9L19_05605(purK)
WVR : IE337_02580 IE337_03980(purK)
WEI : EQG49_03005(purK) EQG49_04855
LBE : MOO44_05550 MOO44_07660(purK)
EFA : EF1786(purK-1) EF2362(purK-2)
EFL : EF62_2160(purK) EF62_2551
EFI : OG1RF_11498(purK) OG1RF_11796(purK2)
EFD : EFD32_1519 EFD32_1985
EFS : EFS1_1596(purK-1) EFS1_1895(purK-2)
EFN : DENG_01970(purK) DENG_02309(purK)
EFQ : DR75_1093 DR75_782(purK)
EFU : HMPREF0351_11203(purK)
ECEC : NCTC12421_01130(purK)
VTE : BHY08_06670 BHY08_07510
VPI : BW732_02830 BW732_08960
VAC : E4Z98_05560(purK) E4Z98_07015
VCP : H9L18_05615 H9L18_10650(purK)
VHY : G7082_00540 G7082_10165(purK)
VFV : K5K99_07005(purK) K5K99_11900
VLC : G314FT_12900(purK_1) G314FT_20200(purK_2)
AUR : HMPREF9243_0933(purK)
AMIT : DBT49_0005855(purK)
ADC : FOC79_00850 FOC79_01705
ABAE : CL176_01515 CL176_01580
IRU : M0R79_05850 M0R79_08275(purK)
FCT : NRE15_05090(purK) NRE15_13175
FHM : R0V13_01820 R0V13_07355(purK)
CRN : CAR_c16450(purK1) CAR_c23850(purK2)
CAW : Q783_07450 Q783_10715
CVD : LHA31_07810(purK) LHA31_11070(purK)
MARR : BKP56_04340 BKP56_06300
JEP : BW721_03590 BW721_06650
JEH : EJN90_08330 EJN90_12245(purK)
JAR : G7057_07310 G7057_10625(purK)
CBAR : PATL70BA_0596(purK)
CDIA : CaldiYA01_13290(purK)
SLL : SLITO_v1c09690(purK)
SCOU : SCORR_v1c09070(purK)
STAB : STABA_v1c09120(purK)
SGQ : SGLAD_v1c08540(purK)
MBO : BQ2027_MB3304C(purK)
MMAE : MMARE11_12280(purK)
MBAI : MB901379_01156(purK)
MHEK : JMUB5695_03682(purK)
MKY : IWGMT90018_13000(purK)
MPHL : MPHLCCUG_01616(purK)
MTHN : 4412656_01177(purK)
MAUU : NCTC10437_01418(purK)
MFLV : NCTC10271_03874(purK)
MSAL : DSM43276_03415(purK)
MTER : 4434518_03023(purK)
CDIP : ERS451417_00599(purK)
CUN : Cul210932_0569(purK)
CUQ : Cul210931_0547(purK)
CUJ : CUL131002_0549(purK)
CMIN : NCTC10288_01975(purK)
CRL : NCTC7448_01368(purK)
CCYS : SAMEA4530656_1789(purK)
NFR : ERS450000_03116(purK)
NAD : NCTC11293_01851(purK)
NWL : NWFMUON74_60430(purK)
NSPU : IFM12276_52660(purK)
RCR : NCTC10994_03895(purK)
TPUL : TPB0596_13290(purK)
SAMB : SAM23877_3112(purK)
SLE : sle_42150(sle_42150)
SGM : GCM10017557_31680(purK)
STUI : GCM10017668_27690(purK)
SXT : KPP03845_103165(purK)
MOY : CVS54_02389(purK_1) CVS54_02417(purK_3)
MSUW : GCM10025863_14270(purK)
FSB : GCM10025867_38080(purK)
AMAU : DSM26151_08850(purK)
MALK : MalAC0309_2312(purK)
PSEV : USB125703_01030(purK)
AAGI : NCTC2676_1_00773(purK)
GCR : GcLGCM259_0612(purK)
RDN : HMPREF0733_11396(purK)
DCO : SAMEA4475696_0784(purK)
DSS : GCM25873_00100(purK_1) GCM25873_27880(purK_2)
PAK : HMPREF0675_4754(purK)
CGRN : 4412665_01708(purK)
PAUS : NCTC13651_01695(purK)
PPC : HMPREF9154_0948(purK)
NAQU : ENKNEFLB_01244(purK)
MSAG : GCM10017556_34930(purK)
ACTR : Asp14428_36120(purK)
MCU : HMPREF0573_11036(purK)
ANE : ATCC27039_16650(purK)
AHW : NCTC11636_02336(purK)
AIR : NCTC12972_00175(purK)
ASLA : NCTC11923_02588(purK)
AVC : NCTC10951_01544(purK)
ACAP : MANAM107_05530(purK)
BBV : HMPREF9228_1327(purK)
GVG : HMPREF0421_20882(purK)
GVA : HMPREF0424_1039(purK)
GVH : HMPREF9231_0686(purK)
SYR : SynRCC307_1417(purK)
SYX : SynWH7803_1206(purK)
SYH : Syncc8109_1222(purK)
SYNW : SynWH8103_01451(purK)
TVN : NIES2134_113980(purK)
LET : O77CONTIG1_00630(purK)
SYP : SYNPCC7002_A0606(purK)
SYNN : NIES970_07980(purK)
MVZ : myaer102_37240(purK)
PAGH : NIES204_37440(purK)
PRUN : PCC7821_00273(purK)
NSPH : BDGGKGIB_00875(purK)
GLT : GlitD10_0134(purK-1)
DEIN : DAAJ005_05205(purK)
OBG : Verru16b_00860(purK)
LCRE : Pla8534_01100(purK)
ACOU : A5CBH24_14980(purK)
ADA : A5CPEGH6_17650(purK)
SMIZ : 4412673_00688(purK)
SDJ : NCTC13534_00771(purK)
STHA : NCTC11429_00720(purK)
PSEZ : HME7025_00486(purK)
FOK : KK2020170_11400(purK)
PHG : KCTC32516_01128(purK)
AALG : AREALGSMS7_00397(purK)
KOS : KORDIASMS9_00125(purK)
KAN : IMCC3317_19990(purK)
SPON : HME9304_00838(purK)
CGLE : NCTC11432_01943(purK)
CTAI : NCTC12078_03300(purK)
CTAK : 4412677_00861(purK)
CHRJ : CHRYMOREF3P_1608(purK)
CJG : NCTC13459_01278(purK)
CANT : NCTC13489_02908(purK)
PTAN : CRYO30217_01229(purK)
TVO : TVG0442698(TVG0442698)
» show all
Taxonomy
Reference
Authors
Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM
Title
Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway.
Journal
Sequence
Reference
Authors
Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J
Title
N5-carboxyaminoimidazole ribonucleotide: evidence for a new intermediate and two new enzymatic activities in the de novo purine biosynthetic pathway of Escherichia coli.
Journal
Sequence
Reference
Authors
Thoden JB, Kappock TJ, Stubbe J, Holden HM
Title
Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.18
ExPASy - ENZYME nomenclature database: 6.3.4.18