KEGG ENZYME: 6.3.5.9

ENZYME: 6.3.5.9

Entry

EC 6.3.5.9 Enzyme

Name

hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing);
CobB

Class

Ligases;
Forming carbon-nitrogen bonds;
Carbon-nitrogen ligases with glutamine as amido-N-donor

Sysname

hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming)

Reaction(IUBMB)

2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H2O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate [RN:R05224]

Reaction(KEGG)

R05224

Substrate

ATP [CPD:C00002];
hydrogenobyrinic acid [CPD:C06399];
L-glutamine [CPD:C00064];
H2O [CPD:C00001]

Product

ADP [CPD:C00008];
phosphate [CPD:C00009];
hydrogenobyrinic acid a,c-diamide [CPD:C06503];
L-glutamate [CPD:C00025]

Comment

This step in the aerobic biosynthesis of cobalamin generates hydrogenobyrinic acid a,c-diamide, the substrate required by EC 6.6.1.2, cobaltochelatase, which adds cobalt to the macrocycle.

Pathway

ec00860	Porphyrin and chlorophyll metabolism
ec01100	Metabolic pathways

Orthology

K02224

cobyrinic acid a,c-diamide synthase

Genes

EBT:	EBL_c14760(cbiA)
STY:	STY2240(cbiA)
STT:	t0840(cbiA)
SEX:	STBHUCCB_8940
STM:	STM2035(cbiA)
SEO:	STM14_2523(cbiA)
SEV:	STMMW_20661
SEY:	SL1344_2011(cbiA)
SEM:	STMDT12_C20570
SEJ:	STMUK_2065(cbiA)
SEB:	STM474_2120(cbiA)
SEF:	UMN798_2200(cbiA)
SETU:	STU288_06565
SPQ:	SPAB_01070
SEI:	SPC_1680(cbiA)
SEC:	SC2043(cbiA)
SEH:	SeHA_C2257(cobB)
SHB:	SU5_02629
SEE:	SNSL254_A2211(cobB)
SEW:	SeSA_A2204(cobB)
SEA:	SeAg_B2157(cobB)
SED:	SeD_A2370(cobB)
SEG:	SG2061(cbiA)
SEL:	SPUL_0865(cbiA)
SET:	SEN2033(cbiA)
SENJ:	CFSAN001992_01260
SES:	SARI_00853
YEN:	YE2725(cbiA)
YEP:	YE105_C1560
YEY:	Y11_16111
PLU:	plu2999(cbiA)
PAY:	PAU_01601(cbiA)
ESC:	Entcl_1762
KPN:	KPN_03200(cbiA)
KPU:	KP1_4466
KPM:	KPHS_42640
KPP:	A79E_0910
KPE:	KPK_0916(cobB)
KPO:	KPN2242_18950
KVA:	Kvar_0870
KOX:	KOX_01430
CKO:	CKO_00802
CRO:	ROD_21201(cbiA)
EIC:	NT01EI_2193
ETR:	ETAE_2004(cbiA)
ETD:	ETAF_1813
ETC:	ETAC_09170
XBO:	XBJ1_0852
XNE:	XNC1_1149
MMK:	MU9_1015
EBF:	D782_1620
XCC:	XCC3063(cobB)
XCB:	XC_1095
XCA:	xccb100_1131(cobB)
XCP:	XCR_3401
FAU:	Fraau_1298
VSP:	VS_2671
PAE:	PA1273(cobB)
PAU:	PA14_47760(cobB)
PAP:	PSPA7_4117(cobB)
PAG:	PLES_40391(cobB)
PAF:	PAM18_3756(cobB)
PNC:	NCGM2_2157(cobB)
PDK:	PADK2_19280
PSG:	G655_18800
PPU:	PP_1673(cobB)
PPF:	Pput_4046
PPG:	PputGB1_1272
PPW:	PputW619_1232
PPT:	PPS_1324
PPB:	PPUBIRD1_3944(cobB)
PPI:	YSA_02433
PPX:	T1E_3649(cobB)
PPUH:	B479_06400
PPUU:	PputUW4_03774(cobB)
PST:	PSPTO_1709
PSB:	Psyr_3680
PSP:	PSPPH_3701
PFL:	PFL_4430(cobB)
PFO:	Pfl01_1642
PFS:	PFLU4490
PFE:	PSF113_4409
PFC:	PflA506_3795(cobB)
PPZ:	H045_13370
PEN:	PSEEN1379
PMY:	Pmen_1751
PMK:	MDS_3111
PSA:	PST_1292(cobB)
PSZ:	PSTAB_1285(cobB)
PSR:	PSTAA_1324(cobB)
PSC:	A458_07180
PSJ:	PSJM300_09260
PSH:	Psest_3013
PBA:	PSEBR_a4244
PFV:	Psefu_1875
PDR:	H681_18010
AVN:	Avin_33120(cbiA)
AVL:	AvCA_33120(cbiA)
AVD:	AvCA6_33120(cbiA)
SSE:	Ssed_2156
CPS:	CPS_1147(cobB)
MAQ:	Maqu_0277
MHC:	MARHY0220(cobB)
MBS:	MRBBS_0217
MCA:	MCA2290(cobB)
MMT:	Metme_3023
MAH:	MEALZ_1521(cobB)
MEJ:	Q7A_2234
ALV:	Alvin_1263(dsrN) Alvin_1817
TVI:	Thivi_0556 Thivi_1697
TMB:	Thimo_0155 Thimo_0500
AEH:	Mlg_1666 Mlg_2813
HHA:	Hhal_1909 Hhal_1963
TGR:	Tgr7_2197
TKM:	TK90_0796
TNI:	TVNIR_0848(cobB_[H])
HCH:	HCH_06468(cbiA)
HEL:	HELO_1830(cobB)
ABO:	ABO_2367
ADI:	B5T_04139
MMW:	Mmwyl1_3379
MME:	Marme_1236
MPC:	Mar181_0873
TAU:	Tola_1681 Tola_3116
RMA:	Rmag_0858
VOK:	COSY_0783(dsrN)
GPB:	HDN1F_26270(cobB)
CVI:	CV_1556(cobB)
PSE:	NH8B_1829(cobB)
RSO:	RSp0615(cobB)
RSL:	RPSI07_mp0499(cobB)
RSN:	RSPO_m00963(cobB)
RME:	Rmet_3938(cobB)
BMA:	BMA1176(cobB)
BMV:	BMASAVP1_A1620(cobB)
BML:	BMA10229_A0282(cobB)
BMN:	BMA10247_0878(cobB)
BPS:	BPSL1773(cobB)
BPM:	BURPS1710b_2093(cobB)
BPL:	BURPS1106A_1948(cobB)
BPD:	BURPS668_1932(cobB)
BPR:	GBP346_A1971
BPZ:	BP1026B_I1730(cobB)
BPQ:	BPC006_I2000
BTE:	BTH_I2412
BVI:	Bcep1808_1596
BUR:	Bcep18194_A4799
BCN:	Bcen_1171
BCH:	Bcen2424_1651
BCM:	Bcenmc03_1625
BCJ:	BCAL1705(cobB)
BAM:	Bamb_1551
BAC:	BamMC406_1570
BMU:	Bmul_1588
BMJ:	BMULJ_01655(cobB)
BCT:	GEM_1763
BXE:	Bxe_B1656
BPH:	Bphy_3157
BPY:	Bphyt_4996
BGL:	bglu_1g18560
BUG:	BC1001_5802
BGE:	BC1002_3796
BGF:	BC1003_5839
BGD:	bgla_1g19210
BYI:	BYI23_B004030(cobB_cobQ)
BUK:	MYA_1475
BPX:	BUPH_05994
RFR:	Rfer_2624
POL:	Bpro_2785
PNA:	Pnap_2367
AAV:	Aave_1538
AJS:	Ajs_1097
DIA:	Dtpsy_1013
AAA:	Acav_1578
ACK:	C380_15495
DAC:	Daci_2790
DEL:	DelCs14_3967
VAP:	Vapar_2548
VPE:	Varpa_3378
CTT:	CtCNB1_1843
ADN:	Alide_3313
ADK:	Alide2_1134
RTA:	Rta_16380
MPT:	Mpe_B0437(cobB) Mpe_B0472(cobB) Mpe_B0510(cobB)
HAR:	HEAR0965
MMS:	mma_1096(cobB)
HSE:	Hsero_2646(cobB)
RGE:	RGE_18800(cobB)
EBA:	ebA4027(cobB)
AZO:	azo3550(cobB)
AZA:	AZKH_0617(cbiA_cobB)
DAR:	Daro_4034
TMZ:	Tmz1t_3750
DSU:	Dsui_0533
TBD:	Tbd_2473
MFA:	Mfla_0119
MMB:	Mmol_0277
MEH:	M301_0172
MEI:	Msip34_0151
MEP:	MPQ_0162(cobB)
APP:	CAP2UW1_2620
SLT:	Slit_1674
ANT:	Arnit_1845
SBA:	Sulba_2131
GSU:	GSU3006(cbiA)
GSK:	KN400_2949(cobB)
GME:	Gmet_0470(cbiA)
GUR:	Gura_4184
GLO:	Glov_3655
GBM:	Gbem_3810(cobB)
GEO:	Geob_0542
GEM:	GM21_3894
GEB:	GM18_4240
PCA:	Pcar_0481(cbiA)
PPD:	Ppro_2890
DVU:	DVU0405(cobB-1) DVU3086(cobB-2)
DVL:	Dvul_0293 Dvul_2529
DVM:	DvMF_1556 DvMF_2254
DVG:	Deval_0367 Deval_2850
DDE:	Dde_0343 Dde_0529
DDS:	Ddes_0028 Ddes_2263
DDN:	DND132_2058 DND132_2812
DMA:	DMR_03630 DMR_11850(cbiA)
DSA:	Desal_0269 Desal_0790
DAS:	Daes_0734 Daes_2982
DAF:	Desaf_1373 Desaf_1831
DHY:	DESAM_20114 DESAM_20464(cobB)
DPI:	BN4_11946(cobB) BN4_12631(cobB)
DBA:	Dbac_0282 Dbac_1715
DRT:	Dret_0247
DPS:	DP0218 DP2763
DAK:	DaAHT2_1581 DaAHT2_1671
DPR:	Despr_2263 Despr_3025
DSF:	UWK_02639 UWK_02952
DOL:	Dole_2672
DAL:	Dalk_0444 Dalk_4298
DAT:	HRM2_00190(cbiA1) HRM2_42370(cbiA2)
DTO:	TOL2_C00080(cbiA) TOL2_C05600(cobB)
SCL:	sce0213(cbiA)
DAO:	Desac_1620 Desac_2242
DTI:	Desti_1640 Desti_5593
SFU:	Sfum_1740 Sfum_4044
DBR:	Deba_0958 Deba_2456
HMR:	Hipma_1600
MLO:	mlr1387
MCI:	Mesci_3270
MOP:	Mesop_3666
MAM:	Mesau_03541
SME:	SMc04282(cobB)
SMK:	Sinme_1916
SMQ:	SinmeB_1757
SMX:	SM11_chr1385(cobB)
SMI:	BN406_01674(cobB)
SMEG:	C770_GR4Chr1999
SMEL:	SM2011_c04282(cobB)
SMD:	Smed_1745
RHI:	NGR_c18140(cobB)
SFH:	SFHH103_01742(cobB)
SFD:	USDA257_c42250(cobB)
ATU:	Atu2793(cobB)
ARA:	Arad_2785(cobB)
AVI:	Avi_2623(cobB)
AGR:	AGROH133_09245(cobB)
RET:	RHE_CH02483(cobB)
REC:	RHECIAT_CH0002586(cobB)
RLE:	RL2823(cobB)
RLT:	Rleg2_2123
RLG:	Rleg_2365
RTR:	RTCIAT899_CH10565(cobB)
BME:	BMEI0705
BMI:	BMEA_A1343(cobB)
BMZ:	BM28_A1309(cobB)
BMG:	BM590_A1300
BMW:	BMNI_I1259
BMF:	BAB1_1316
BMB:	BruAb1_1297(cobB)
BMC:	BAbS19_I12290
BAA:	BAA13334_I01909
BMS:	BR1296(cobB)
BSI:	BS1330_I1292(cobB)
BMT:	BSUIS_A1346(cobB)
BSV:	BSVBI22_A1292(cobB)
BOV:	BOV_1259(cobB)
BCS:	BCAN_A1319(cobB)
BSK:	BCA52141_I3115
BMR:	BMI_I1309(cobB)
BPP:	BPI_I1348(cobB)
OAN:	Oant_1889
BJA:	blr3272(cobB)
BJU:	BJ6T_64780
BRA:	BRADO4897(cobB)
BBT:	BBta_3154(cobB)
BRS:	S23_47320(cobB)
RPA:	RPA2083(cobB)
RPB:	RPB_3185
RPC:	RPC_1881
RPD:	RPD_2313
RPE:	RPE_2218
RPT:	Rpal_2373
RPX:	Rpdx1_3431
AOL:	S58_27930
XAU:	Xaut_3276
AZC:	AZC_3946(cbiA)
SNO:	Snov_2562
MEX:	Mext_1040
MEA:	Mex_1p0805(cobB)
MDI:	METDI1519(cobB)
MCH:	Mchl_1167
MRD:	Mrad2831_3124
MET:	M446_2455
MPO:	Mpop_0970
MNO:	Mnod_2159
BID:	Bind_3518
MSL:	Msil_3259
HDN:	Hden_2690
HMC:	HYPMC_0696(cobB)
RVA:	Rvan_0588 Rvan_3654
PHL:	KKY_3943
MSC:	BN69_3114
SIL:	SPO2872(cobB)
SIT:	TM1040_2219
RSP:	RSP_3185(cobB)
RSH:	Rsph17029_3922
RSQ:	Rsph17025_4334
RSK:	RSKD131_3359
RCP:	RCAP_rcc02032(cobB)
JAN:	Jann_2922
RDE:	RD1_3818(cobB)
RLI:	RLO149_c006260(cobB)
PDE:	Pden_2541
DSH:	Dshi_1693(cobB)
PSF:	PSE_0829
PGA:	PGA1_c08080(cobB)
PGL:	PGA2_c07860(cobB)
OAT:	OAN307_c22640(cobB)
OAR:	OA238_c22140(cobB)
NAR:	Saro_0333
NPP:	PP1Y_AT19877
SJP:	SJA_C2-03180(cobB)
SCH:	Sphch_3757
GOH:	B932_2904
GBE:	GbCGDNIH1_0667
AMV:	ACMV_P1_00540(cobB)
GXY:	GLX_19900
APT:	APA01_22510(cbiA)
APW:	APA42C_22510(cbiA)
APF:	APA03_22510(cbiA)
APU:	APA07_22510(cbiA)
APG:	APA12_22510(cbiA)
APQ:	APA22_22510(cbiA)
APX:	APA26_22510(cbiA)
APZ:	APA32_22510(cbiA)
RRU:	Rru_A3359
RRF:	F11_17220
RPM:	RSPPHO_00758
MAG:	amb3622
AZL:	AZL_d03390(cobB)
ALI:	AZOLI_p40237(cobB)
ABS:	AZOBR_p140043(cobB)
TMO:	TMO_2767(cobB)
APB:	SAR116_0560
PGV:	SL003B_3905
MGM:	Mmc1_1703 Mmc1_3137
DIN:	Selin_1689
BSUB:	BEST7613_1805(cbiA)
BHA:	BH1898
BPF:	BpOF4_01250(cobB)
BMQ:	BMQ_2610(cbiA)
BMD:	BMD_2597(cbiA)
GKA:	GK1796
GTN:	GTNG_1685(cbiA)
GTH:	Geoth_2170
GTE:	GTCCBUS3UF5_20920
GWC:	GWCH70_1559
GYC:	GYMC61_2607
GYA:	GYMC52_1739
GCT:	GC56T3_1744
GMC:	GY4MC1_2084
GGH:	GHH_c18390(cobB3)
AFL:	Aflv_2171
LMO:	lmo1191(cbiA)
LMF:	LMOf2365_1200(cobB)
LMH:	LMHCC_1460(cbiA)
LMC:	Lm4b_01195(cbiA)
LMN:	LM5578_1264(cbiA)
LMY:	LM5923_1217(cbiA)
LMT:	LMRG_00637
LMG:	LMKG_01737
LMS:	LMLG_1070
LMJ:	LMOG_00534
LMQ:	LMM7_1196(cbiA)
LML:	lmo4a_1173(cobB)
LMP:	MUO_06145
LMW:	LMOSLCC2755_1184(cobB)
LMX:	LMOSLCC2372_1188(cobB)
LMZ:	LMOSLCC2482_1232(cobB)
LMON:	LMOSLCC2376_1142(cobB)
LMOC:	LMOSLCC5850_1181(cobB)
LMOS:	LMOSLCC7179_1159(cobB)
LMOO:	LMOSLCC2378_1197(cobB)
LMOY:	LMOSLCC2479_1189(cobB)
LMOT:	LMOSLCC2540_1170(cobB)
LMOA:	LMOATCC19117_1191(cobB)
LMOL:	LMOL312_1179(cobB)
LMOG:	BN389_12090(cobB)
LMOE:	BN418_1397
LMOB:	BN419_1395
LIN:	lin1154
LWE:	lwe1148(cbiA)
LSG:	lse_1070(cbiA)
LIV:	LIV_1122(cbiA)
LSP:	Bsph_3436
BBE:	BBR47_12540(cobB)
PPY:	PPE_04539(cobB)
PPM:	PPSC2_c5041
PMS:	KNP414_06826(cobB)
PMQ:	PM3016_6442
PMW:	B2K_32585
PTA:	HPL003_05195
BTS:	Btus_0411
SIV:	SSIL_2485
SSA:	SSA_0463
LRE:	Lreu_1722
LRF:	LAR_1610
LRU:	HMPREF0538_20909(cobB)
PCE:	PECL_1403(cbiA)
AUR:	HMPREF9243_1742(cobB)
CAC:	CA_C1375(cobB)
CAE:	SMB_G1398
CAY:	CEA_G1389
CTC:	CTC00731
CNO:	NT01CX_0583(cobB)
CBO:	CBO0924(cbiA)
CBA:	CLB_0965(cobB)
CBH:	CLC_0979(cobB)
CBY:	CLM_1072(cobB)
CBL:	CLK_0361(cobB)
CBK:	CLL_A2938(cobB)
CBB:	CLD_3635(cobB)
CBI:	CLJ_B0975(cobB)
CBN:	CbC4_2316(cobB)
CBT:	CLH_2684(cobB)
CBF:	CLI_1011(cobB)
CBM:	CBF_0983(cobB)
CBJ:	H04402_00995
CBE:	Cbei_2310
CKL:	CKL_0722(cbiB)
CKR:	CKR_0644
CPY:	Cphy_1380
CCE:	Ccel_1283
CLJ:	CLJU_c31950(cbiA)
CSH:	Closa_2411
CSO:	CLS_23930
CCB:	Clocel_2223
CLS:	CXIVA_12220
CLB:	Clo1100_0963
CCL:	Clocl_3583 Clocl_3810
CSR:	Cspa_c36260(cobB1)
CDC:	CD196_3210(cbiA)
CDL:	CDR20291_3256(cbiA)
CDG:	CDBI1_16680
CST:	CLOST_0981(cobB)
AMT:	Amet_0065
AOE:	Clos_0862
SLP:	Slip_0934
DSY:	DSY0318(cobB) DSY4060(cobB)
DHD:	Dhaf_0262 Dhaf_1306
DDH:	Desde_0276 Desde_1238
DDL:	Desdi_0252 Desdi_1029
DRM:	Dred_2715 Dred_3196
DAE:	Dtox_0078 Dtox_3091
DCA:	Desca_0578 Desca_2676
DKU:	Desku_2368 Desku_3484
DRU:	Desru_0898 Desru_3733
PTH:	PTH_0959(CobB)
DAU:	Daud_1850 Daud_2189
TJR:	TherJR_1309
SGY:	Sgly_2884
DOR:	Desor_2795 Desor_3300
DAI:	Desaci_2444 Desaci_3002
DMI:	Desmer_2198 Desmer_2564
DED:	DHBDCA_p750(cobB)
DEC:	DCF50_p63 DCF50_p808(cobB)
HMO:	HM1_2399(cbiA)
EEL:	EUBELI_20180
ERE:	EUBREC_1912
ERT:	EUR_15580
ERA:	ERE_29260
ELM:	ELI_0755
AWO:	Awo_c30520(cbiB)
BFI:	CIY_15520
CLE:	Clole_3424
RHO:	RHOM_09000
RIX:	RO1_08400
RIM:	ROI_19970
CCT:	CC1_11760
ROB:	CK5_24030
RTO:	RTO_03990
FPR:	FP2_02840
FPA:	FPR_29150
SAY:	TPY_1374(cobB-cbiA)
SAP:	Sulac_2282
BPRM:	CL3_26590
BPRS:	CK3_28480
TTE:	TTE0375(CobB)
TEX:	Teth514_0299
THX:	Thet_0342
TPD:	Teth39_1901
TIT:	Thit_0342
TMT:	Tmath_0412
TBO:	Thebr_1949
TWI:	Thewi_0432
CHY:	CHY_0771(cobB1) CHY_2399(cobB2)
TEP:	TepRe1_0450
TAE:	TEPIRE1_5010
MTA:	Moth_1100 Moth_1628
ADG:	Adeg_0036 Adeg_0183
TPZ:	Tph_c08600(cobB)
TOC:	Toce_0308
TTM:	Tthe_2263
TTO:	Thethe_02344
TXY:	Thexy_1962
TSH:	Tsac_0065
TNR:	Thena_0633
MAS:	Mahau_1224
NTH:	Nther_0926
HAS:	Halsa_2194
HPK:	Hprae_1520
AAR:	Acear_0843
HHL:	Halha_1703
VPR:	Vpar_1129
SSG:	Selsp_0926
SRI:	SELR_20700(cbiA)
MED:	MELS_1571
MHG:	MHY_21720
MTU:	Rv2848c(cobB)
MTV:	RVBD_2848c
MTC:	MT2914(cobB)
MRA:	MRA_2871(cobB)
MTF:	TBFG_12863
MTB:	TBMG_01124
MTK:	TBSG_01133
MTZ:	TBXG_001114
MTI:	MRGA423_17635
MTO:	MTCTRI2_2905(cobB)
MTD:	UDA_2848c(cobB)
MTN:	ERDMAN_3123(cobB)
MTUB:	MT7199_2880
MBO:	Mb2873c(cobB)
MBB:	BCG_2868c(cobB)
MBT:	JTY_2863(cobB)
MBM:	BCGMEX_2862c(cobB)
MBK:	K60_029470
MAF:	MAF_28530(cobB)
MCE:	MCAN_28701(cobB)
MCQ:	BN44_60315(cobB)
MCV:	BN43_40538(cobB)
MCX:	BN42_40835(cobB)
MCZ:	BN45_51244(cobB)
MPA:	MAP2917c(cobB)
MAV:	MAV_3704(cobB)
MIT:	OCO_35310
MIR:	OCQ_36520
MIA:	OCU_35360
MID:	MIP_05314
MSM:	MSMEG_2617(cobB)
MSG:	MSMEI_2555(cobB)
MSA:	Mycsm_02468
MUL:	MUL_2113(cobB)
MVA:	Mvan_2304
MGI:	Mflv_4048
MSP:	Mspyr1_33930
MAB:	MAB_3155c
MMV:	MYCMA_1731(cobB)
MMC:	Mmcs_2073
MKM:	Mkms_2119
MJL:	Mjls_2056
MJD:	JDM601_3169(cobB)
MMI:	MMAR_1885(cobB)
MRH:	MycrhN_5683
MMM:	W7S_17660
MCB:	Mycch_2038
MLI:	MULP_02054(cobB)
ASD:	AS9A_1611(cobB)
CDI:	DIP1488
CDP:	CD241_1433
CDH:	CDB402_1397
CDT:	CDHC01_1432
CDE:	CDHC02_1385
CDR:	CDHC03_1409
CDA:	CDHC04_1409
CDZ:	CD31A_1505
CDB:	CDBH8_1482
CDS:	CDC7B_1490
CDD:	CDCE8392_1407
CDW:	CDPW8_1478
CDV:	CDVA01_1371
CKP:	ckrop_1151(cobB)
CPU:	cpfrc_01292(cobB)
CPL:	Cp3995_1323(cobB)
CPG:	Cp316_1340(cobB)
CPP:	CpP54B96_1311(cobB)
CPK:	Cp1002_1288(cobB)
CPQ:	CpC231_1287(cobB)
CPX:	CpI19_1294(cobB)
CPZ:	CpPAT10_1286(cobB)
COR:	Cp267_1345(cobB)
COP:	Cp31_1306(cobB)
COD:	Cp106_1268(cobB)
COS:	Cp4202_1278(cobB)
COI:	CpCIP5297_1311(cobB)
COE:	Cp258_1308(cobB)
COU:	Cp162_1287(cobB)
CUL:	CULC22_01398(cobB)
CUC:	CULC809_01385(cobB)
CUE:	CULC0102_1515(cobB)
NFA:	nfa40810(cobB)
NCY:	NOCYR_3803
NBR:	O3I_030680
RHA:	RHA1_ro06616(cobB)
RER:	RER_26080(cobB)
ROP:	ROP_66510(cobB)
REQ:	REQ_18750(cobB)
GBR:	Gbro_2136
GPO:	GPOL_c20360(cobB)
GOR:	KTR9_2063
TPR:	Tpau_1702
SCO:	SCO1852(cobB)
SMA:	SAV_6412(cobB)
SGR:	SGR_5641
SCB:	SCAB_70841(cobB)
SSX:	SACTE_1278
SVL:	Strvi_6942
SCT:	SCAT_1051(cobB)
SCY:	SCATT_10450
SFA:	Sfla_4964
SBH:	SBI_08141(cobB)
SHY:	SHJG_3310
SHO:	SHJGH_3075
SVE:	SVEN_1498
SALB:	XNR_4969
STRP:	F750_1714
KSK:	KSE_56380(cobB)
ICA:	Intca_0803
PAC:	PPA0438
PAK:	HMPREF0675_3472(cobB)
PAV:	TIA2EST22_02160
PAX:	TIA2EST36_02135
PAZ:	TIA2EST2_02080
PAW:	PAZ_c04500(cobB)
PAD:	TIIST44_06930
PCN:	TIB1ST10_02230
PACC:	PAC1_02225
PACH:	PAGK_0453
PFR:	PFREUD_12220(cbiA)
PPC:	HMPREF9154_1256(cobB)
PBO:	PACID_08930(cobB)
PRA:	PALO_08455
MPH:	MLP_03180(cobBC)
NCA:	Noca_2887
KFL:	Kfla_3127
TFU:	Tfu_0311
NDA:	Ndas_1619
NAL:	B005_0628(cobB)
TCU:	Tcur_1311
SRO:	Sros_5883
FRA:	Francci3_2297
FRE:	Franean1_4160
FRI:	FraEuI1c_0475
FAL:	FRAAL3729(cobB)
FSY:	FsymDg_2351
NML:	Namu_0161
GOB:	Gobs_0544
BSD:	BLASA_1254(cobB)
MMAR:	MODMU_0624(cobB)
SEN:	SACE_5963(cobB)
SVI:	Svir_17740
TBI:	Tbis_2491 Tbis_3370
AMD:	AMED_7052(cobB)
AMN:	RAM_36185
AMM:	AMES_6944(cobB)
PDX:	Psed_2725
AMI:	Amir_5859
SESP:	BN6_70190
STP:	Strop_2525
SAQ:	Sare_2707
MAU:	Micau_4963
MIL:	ML5_3332 ML5_4305
VMA:	VAB18032_28871
AMS:	AMIS_54290
ASE:	ACPL_5302(cobB)
CAI:	Caci_6037
SNA:	Snas_3350
RXY:	Rxyl_0638
AFO:	Afer_0805
SHI:	Shel_21180
TDE:	TDE2658
TPI:	TREPR_0526(cobB_2) TREPR_3603(cobB_1)
SSM:	Spirs_0183
LIL:	LB_154(cbiA)
LIE:	LIF_B126(cobB)
LIC:	LIC20124(cobB)
LBJ:	LBJ_4188(cobB)
LBL:	LBL_4203(cobB)
ACM:	AciX9_2036
GMA:	AciX8_3089
CTM:	Cabther_B0286
BFR:	BF2503
BFS:	BF2534(cobB)
BFG:	BF638R_2496(cobB)
BVU:	BVU_3113
BHL:	Bache_2233
BSA:	Bacsa_0560
PGI:	PG1163(cbiA)
PGN:	PGN_1262
PGT:	PGTDC60_1052(cbiA)
PAH:	Poras_0018
PDI:	BDI_0814
PPN:	Palpr_2564
OSP:	Odosp_2448
TFO:	BFO_0026(cobB)
PRU:	PRU_1086(cobB)
CPI:	Cpin_4466
DFE:	Dfer_5366
FCO:	FCOL_02485
FNU:	FN0972
LBA:	Lebu_0095
STR:	Sterm_1007
IPO:	Ilyop_2363
CAA:	Caka_2428
PSL:	Psta_3042
IPA:	Isop_3350
SACI:	Sinac_5979 Sinac_6645
TAI:	Taci_1676
AMO:	Anamo_1796
SBR:	SY1_20430
SYN:	sll1501(cbiA)
SYZ:	MYO_14520(cbiA)
SYY:	SYNGTS_0446(cbiA)
SYT:	SYNGTI_0446(cbiA)
SYS:	SYNPCCN_0446(cbiA)
SYQ:	SYNPCCP_0446(cbiA)
SYW:	SYNW0748(cbiA)
SYC:	syc2239_c(cobB)
SYF:	Synpcc7942_1855
SYD:	Syncc9605_1920
SYE:	Syncc9902_0746
SYG:	sync_1000(cobB)
SYR:	SynRCC307_0757(cobB)
SYX:	SynWH7803_1563(cobB)
CYA:	CYA_1189(cobB)
CYB:	CYB_2586(cobB)
SYNE:	Syn6312_1268
SYNP:	Syn7502_00505
TEL:	tlr1848(cobB)
MAR:	MAE_06120(cobB)
CYT:	cce_4641(cbiA)
CYP:	PCC8801_0431
CYC:	PCC7424_1500
CYN:	Cyan7425_2994
CYH:	Cyan8802_0442
CYJ:	Cyan7822_4175
AMR:	AM1_2881(cobB)
CGC:	Cyagr_0310
CAN:	Cyan10605_0604
CSN:	Cyast_2283
DSL:	Dacsa_2566
HAO:	PCC7418_2175
GLP:	Glo7428_1667
CMP:	Cha6605_0155
CYU:	UCYN_12680
GVI:	gvip500(cobB)
ANA:	alr3934
NPU:	Npun_R4057
NOS:	Nos7107_2748
NOP:	Nos7524_0673
AVA:	Ava_1768
ANB:	ANA_C12458(cobB)
ACY:	Anacy_1026
NAZ:	Aazo_1956
CSG:	Cylst_4211
CALO:	Cal7507_4563
CALT:	Cal6303_1787
RIV:	Riv7116_1241
PMA:	Pro1126(cobB)
PMM:	PMM1072(cbiA)
PMT:	PMT1104(cbiA)
PMN:	PMN2A_0678
PMI:	PMT9312_1083
PMB:	A9601_11771(cobB)
PMC:	P9515_11621(cobB)
PMF:	P9303_09381(cobB)
PMG:	P9301_11781(cobB)
PMH:	P9215_12071(cobB)
PMJ:	P9211_11161(cobB)
PME:	NATL1_15121(cobB)
TER:	Tery_0517
GEI:	GEI7407_0732
OAC:	Oscil6304_1005
ONI:	Osc7112_2821
PSEU:	Pse7367_1918
CEP:	Cri9333_3603
MIC:	Mic7113_5213
ARP:	NIES39_A00780(cobB)
CTHE:	Chro_0753
PLP:	Ple7327_0087
SCS:	Sta7437_3428
CTE:	CT0929(cbiA-1) CT2251(dsrN)
CPC:	Cpar_0026 Cpar_1191
CCH:	Cag_1429 Cag_1958
CPH:	Cpha266_0126 Cpha266_0312
CPB:	Cphamn1_0353 Cphamn1_1859
CLI:	Clim_0252 Clim_0692
PVI:	Cvib_0037 Cvib_0809
PLT:	Plut_0034 Plut_1935
PPH:	Ppha_1761 Ppha_2323
PAA:	Paes_0027 Paes_0327
CTS:	Ctha_0796
DET:	DET0128(cobB)
DEH:	cbdb_A149(cobB)
DEB:	DehaBAV1_0243
DEV:	DhcVS_135(cbiA)
DEG:	DehalGT_0156
DMC:	btf_87(cbiA)
DMD:	dcmb_150(cbiA)
DLY:	Dehly_0610
RRS:	RoseRS_0574
RCA:	Rcas_0635
CAU:	Caur_2563
CAG:	Cagg_1262
CHL:	Chy400_2770
HAU:	Haur_2329
CAP:	CLDAP_16560(cobB)
DRA:	DR_B0009
DGE:	Dgeo_2349
DDR:	Deide_2p01690(cobB)
DMR:	Deima_2092
DPT:	Deipr_2604
DGO:	DGo_CA0586
DPD:	Deipe_2316
TTH:	TT_P0001
TTJ:	TTHB043
TTS:	Ththe16_2328
TTL:	TtJL18_2212
TSC:	TSC_c11720(cobB)
THC:	TCCBUS3UF1_2230
TOS:	Theos_2306
OPR:	Ocepr_0399
MHD:	Marky_1996
TYE:	THEYE_A0001(cobB)
NDE:	NIDE2105(cobB) NIDE2670(cbiA)
LFC:	LFE_1457(cbiA)
LFI:	LFML04_1209(cbiA)
DDF:	DEFDS_2061(cbiA1)
DAP:	Dacet_0156
CNI:	Calni_2110
TID:	Thein_1554 Thein_1896
TOP:	TOPB45_1205
MJA:	MJ_1421
MFE:	Mefer_0145
MVU:	Metvu_0761
MFS:	MFS40622_0633
MIF:	Metin_1439
MIG:	Metig_0804
MMP:	MMP1477(cbiA) MMP1478(cbiA)
MMQ:	MmarC5_0100
MMX:	MmarC6_1196
MMZ:	MmarC7_0722
MMD:	GYY_08225
MAE:	Maeo_0309
MVN:	Mevan_0787
MVO:	Mvol_1625
MOK:	Metok_0060
MAC:	MA0106(cbiA1) MA3626(cbiA2)
MBA:	Mbar_A0348 Mbar_A1187 Mbar_A2158
MMA:	MM_0513 MM_1394
MMAZ:	MmTuc01_1452
MBU:	Mbur_1039 Mbur_2191
MMH:	Mmah_0378 Mmah_1414
MEV:	Metev_0554 Metev_1126
MZH:	Mzhil_0467 Mzhil_1676
MPY:	Mpsy_0957 Mpsy_2334
MHZ:	Metho_0464 Metho_0541
MTP:	Mthe_1001 Mthe_1179
MCJ:	MCON_0502(cobB1) MCON_2971(cobB2)
MHI:	Mhar_0046 Mhar_1505
MHU:	Mhun_0671 Mhun_1157
MLA:	Mlab_0521 Mlab_1072
MEM:	Memar_0532 Memar_1734
MBG:	BN140_0717(cobB) BN140_2447
MPI:	Mpet_1003 Mpet_1766
MBN:	Mboo_0220 Mboo_1420
MFO:	Metfor_0921 Metfor_1658 Metfor_1747
MPL:	Mpal_0678 Mpal_0741
MPD:	MCP_0365(cobB)
MEZ:	Mtc_0065(cbiA-1) Mtc_1819(cbiA-2)
RCI:	RCIX2001(cbiA-1) RCIX825(cbiA-2)
MTH:	MTH1460
MMG:	MTBMA_c00460(cbiA)
MST:	Msp_0162(cbiA)
MSI:	Msm_1215
MRU:	mru_0893(cbiA3) mru_2151(cbiA4)
MEL:	Metbo_0082
MEW:	MSWAN_0006
MFV:	Mfer_0846
MKA:	MK1573(CobB_1) MK1643(CobB_2)
AFU:	AF2229(cbiA)
APO:	Arcpr_1725
AVE:	Arcve_1693
FPL:	Ferp_1878
HAL:	VNG1573G(cbiA)
HSL:	OE3243F(cbiA)
HMA:	rrnAC1102(cbiA2)
HHI:	HAH_1712(cbiA2)
HWA:	HQ1829A(cbiA)
HWC:	Hqrw_1969(cbiA)
NPH:	NP0738A(cbiA)
NMO:	Nmlp_1039(cbiA)
HLA:	Hlac_0231
HMU:	Hmuk_1855
HTU:	Htur_0999
NMG:	Nmag_3175
HVO:	HVO_A0487(cobB)
HME:	HFX_5051(cbiA)
HJE:	HacjB3_12905
HBO:	Hbor_03360
HXA:	Halxa_2785
NAT:	NJ7G_3573
NPE:	Natpe_2705
NGE:	Natgr_0537
HRU:	Halru_0647
NOU:	Natoc_1096
TAC:	Ta1200
TVO:	TVN0409
PTO:	PTO0108
TAR:	TALC_01230 TALC_01250
MAX:	MMALV_12740 MMALV_13200
SSO:	SSO0404
SOL:	Ssol_1382
STO:	ST0389
SAI:	Saci_0825
SACN:	SacN8_04000
SACR:	SacRon12I_03990
SIS:	LS215_1827
SIA:	M1425_1699
SIM:	M1627_1815
SID:	M164_1746
SIY:	YG5714_1815
SIN:	YN1551_1111
SII:	LD85_1956
SIH:	SiH_1674
SIR:	SiRe_1595
SIC:	SiL_1587
MSE:	Msed_0043
MCN:	Mcup_0043
AHO:	Ahos_0721
PAI:	PAE2587
PIS:	Pisl_0178
PCL:	Pcal_1441
PAS:	Pars_1220
PYR:	P186_1808
POG:	Pogu_1018
CMA:	Cmaq_1228
TNE:	Tneu_0337
TUZ:	TUZN_1066
TTN:	TTX_0412(cbiA) TTX_1195(cbiA)
VDI:	Vdis_2083
VMO:	VMUT_0487
NMR:	Nmar_0079
NIR:	NSED_00090
NKR:	NKOR_00140
CSY:	CENSYa_1944
NGA:	Ngar_c17980(cobB)

» show all

Reference

1 [PMID:2172209]

Authors

Debussche L, Thibaut D, Cameron B, Crouzet J, Blanche F.

Title

Purification and characterization of cobyrinic acid a,c-diamide synthase from Pseudomonas denitrificans.

Journal

J. Bacteriol. 172 (1990) 6239-44.

Organism

Pseudomonas denitrificans

Reference

2 [PMID:12195810]

Authors

Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.

Title

The biosynthesis of adenosylcobalamin (vitamin B12).

Journal

Nat. Prod. Rep. 19 (2002) 390-412.

Organism

Pseudomonas denitrificans

Other DBs

ExplorEnz - The Enzyme Database:

6.3.5.9

IUBMB Enzyme Nomenclature:

6.3.5.9

ExPASy - ENZYME nomenclature database:

6.3.5.9

BRENDA, the Enzyme Database:

6.3.5.9

CAS:

132053-22-6

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