KEGG   Equus caballus (horse): 100052122
Entry
100052122         CDS       T01058                                 
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ecb  Equus caballus (horse)
Pathway
ecb01521  EGFR tyrosine kinase inhibitor resistance
ecb01522  Endocrine resistance
ecb01524  Platinum drug resistance
ecb04012  ErbB signaling pathway
ecb04014  Ras signaling pathway
ecb04015  Rap1 signaling pathway
ecb04024  cAMP signaling pathway
ecb04062  Chemokine signaling pathway
ecb04066  HIF-1 signaling pathway
ecb04068  FoxO signaling pathway
ecb04070  Phosphatidylinositol signaling system
ecb04071  Sphingolipid signaling pathway
ecb04072  Phospholipase D signaling pathway
ecb04140  Autophagy - animal
ecb04150  mTOR signaling pathway
ecb04151  PI3K-Akt signaling pathway
ecb04152  AMPK signaling pathway
ecb04210  Apoptosis
ecb04211  Longevity regulating pathway
ecb04213  Longevity regulating pathway - multiple species
ecb04218  Cellular senescence
ecb04360  Axon guidance
ecb04370  VEGF signaling pathway
ecb04380  Osteoclast differentiation
ecb04510  Focal adhesion
ecb04550  Signaling pathways regulating pluripotency of stem cells
ecb04611  Platelet activation
ecb04613  Neutrophil extracellular trap formation
ecb04620  Toll-like receptor signaling pathway
ecb04625  C-type lectin receptor signaling pathway
ecb04630  JAK-STAT signaling pathway
ecb04650  Natural killer cell mediated cytotoxicity
ecb04660  T cell receptor signaling pathway
ecb04662  B cell receptor signaling pathway
ecb04664  Fc epsilon RI signaling pathway
ecb04666  Fc gamma R-mediated phagocytosis
ecb04668  TNF signaling pathway
ecb04670  Leukocyte transendothelial migration
ecb04722  Neurotrophin signaling pathway
ecb04725  Cholinergic synapse
ecb04750  Inflammatory mediator regulation of TRP channels
ecb04810  Regulation of actin cytoskeleton
ecb04910  Insulin signaling pathway
ecb04914  Progesterone-mediated oocyte maturation
ecb04915  Estrogen signaling pathway
ecb04917  Prolactin signaling pathway
ecb04919  Thyroid hormone signaling pathway
ecb04923  Regulation of lipolysis in adipocytes
ecb04926  Relaxin signaling pathway
ecb04929  GnRH secretion
ecb04930  Type II diabetes mellitus
ecb04931  Insulin resistance
ecb04932  Non-alcoholic fatty liver disease
ecb04933  AGE-RAGE signaling pathway in diabetic complications
ecb04935  Growth hormone synthesis, secretion and action
ecb04960  Aldosterone-regulated sodium reabsorption
ecb04973  Carbohydrate digestion and absorption
ecb05010  Alzheimer disease
ecb05017  Spinocerebellar ataxia
ecb05020  Prion disease
ecb05100  Bacterial invasion of epithelial cells
ecb05135  Yersinia infection
ecb05142  Chagas disease
ecb05146  Amoebiasis
ecb05160  Hepatitis C
ecb05161  Hepatitis B
ecb05162  Measles
ecb05163  Human cytomegalovirus infection
ecb05164  Influenza A
ecb05165  Human papillomavirus infection
ecb05166  Human T-cell leukemia virus 1 infection
ecb05167  Kaposi sarcoma-associated herpesvirus infection
ecb05168  Herpes simplex virus 1 infection
ecb05169  Epstein-Barr virus infection
ecb05170  Human immunodeficiency virus 1 infection
ecb05171  Coronavirus disease - COVID-19
ecb05200  Pathways in cancer
ecb05203  Viral carcinogenesis
ecb05205  Proteoglycans in cancer
ecb05206  MicroRNAs in cancer
ecb05207  Chemical carcinogenesis - receptor activation
ecb05208  Chemical carcinogenesis - reactive oxygen species
ecb05210  Colorectal cancer
ecb05211  Renal cell carcinoma
ecb05212  Pancreatic cancer
ecb05213  Endometrial cancer
ecb05214  Glioma
ecb05215  Prostate cancer
ecb05218  Melanoma
ecb05220  Chronic myeloid leukemia
ecb05221  Acute myeloid leukemia
ecb05222  Small cell lung cancer
ecb05223  Non-small cell lung cancer
ecb05224  Breast cancer
ecb05225  Hepatocellular carcinoma
ecb05226  Gastric cancer
ecb05230  Central carbon metabolism in cancer
ecb05231  Choline metabolism in cancer
ecb05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ecb05415  Diabetic cardiomyopathy
ecb05417  Lipid and atherosclerosis
ecb05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ecb00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100052122
   04014 Ras signaling pathway
    100052122
   04015 Rap1 signaling pathway
    100052122
   04370 VEGF signaling pathway
    100052122
   04630 JAK-STAT signaling pathway
    100052122
   04668 TNF signaling pathway
    100052122
   04066 HIF-1 signaling pathway
    100052122
   04068 FoxO signaling pathway
    100052122
   04070 Phosphatidylinositol signaling system
    100052122
   04072 Phospholipase D signaling pathway
    100052122
   04071 Sphingolipid signaling pathway
    100052122
   04024 cAMP signaling pathway
    100052122
   04151 PI3K-Akt signaling pathway
    100052122
   04152 AMPK signaling pathway
    100052122
   04150 mTOR signaling pathway
    100052122
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100052122
  09143 Cell growth and death
   04210 Apoptosis
    100052122
   04218 Cellular senescence
    100052122
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100052122
   04550 Signaling pathways regulating pluripotency of stem cells
    100052122
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100052122
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100052122
   04613 Neutrophil extracellular trap formation
    100052122
   04620 Toll-like receptor signaling pathway
    100052122
   04625 C-type lectin receptor signaling pathway
    100052122
   04650 Natural killer cell mediated cytotoxicity
    100052122
   04660 T cell receptor signaling pathway
    100052122
   04662 B cell receptor signaling pathway
    100052122
   04664 Fc epsilon RI signaling pathway
    100052122
   04666 Fc gamma R-mediated phagocytosis
    100052122
   04670 Leukocyte transendothelial migration
    100052122
   04062 Chemokine signaling pathway
    100052122
  09152 Endocrine system
   04910 Insulin signaling pathway
    100052122
   04923 Regulation of lipolysis in adipocytes
    100052122
   04929 GnRH secretion
    100052122
   04915 Estrogen signaling pathway
    100052122
   04914 Progesterone-mediated oocyte maturation
    100052122
   04917 Prolactin signaling pathway
    100052122
   04926 Relaxin signaling pathway
    100052122
   04935 Growth hormone synthesis, secretion and action
    100052122
   04919 Thyroid hormone signaling pathway
    100052122
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100052122
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100052122
  09156 Nervous system
   04725 Cholinergic synapse
    100052122
   04722 Neurotrophin signaling pathway
    100052122
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100052122
  09158 Development and regeneration
   04360 Axon guidance
    100052122
   04380 Osteoclast differentiation
    100052122
  09149 Aging
   04211 Longevity regulating pathway
    100052122
   04213 Longevity regulating pathway - multiple species
    100052122
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100052122
   05206 MicroRNAs in cancer
    100052122
   05205 Proteoglycans in cancer
    100052122
   05207 Chemical carcinogenesis - receptor activation
    100052122
   05208 Chemical carcinogenesis - reactive oxygen species
    100052122
   05203 Viral carcinogenesis
    100052122
   05230 Central carbon metabolism in cancer
    100052122
   05231 Choline metabolism in cancer
    100052122
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100052122
  09162 Cancer: specific types
   05210 Colorectal cancer
    100052122
   05212 Pancreatic cancer
    100052122
   05225 Hepatocellular carcinoma
    100052122
   05226 Gastric cancer
    100052122
   05214 Glioma
    100052122
   05221 Acute myeloid leukemia
    100052122
   05220 Chronic myeloid leukemia
    100052122
   05218 Melanoma
    100052122
   05211 Renal cell carcinoma
    100052122
   05215 Prostate cancer
    100052122
   05213 Endometrial cancer
    100052122
   05224 Breast cancer
    100052122
   05222 Small cell lung cancer
    100052122
   05223 Non-small cell lung cancer
    100052122
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100052122
   05170 Human immunodeficiency virus 1 infection
    100052122
   05161 Hepatitis B
    100052122
   05160 Hepatitis C
    100052122
   05171 Coronavirus disease - COVID-19
    100052122
   05164 Influenza A
    100052122
   05162 Measles
    100052122
   05168 Herpes simplex virus 1 infection
    100052122
   05163 Human cytomegalovirus infection
    100052122
   05167 Kaposi sarcoma-associated herpesvirus infection
    100052122
   05169 Epstein-Barr virus infection
    100052122
   05165 Human papillomavirus infection
    100052122
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100052122
   05100 Bacterial invasion of epithelial cells
    100052122
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100052122
   05142 Chagas disease
    100052122
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100052122
   05017 Spinocerebellar ataxia
    100052122
   05020 Prion disease
    100052122
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100052122
   05418 Fluid shear stress and atherosclerosis
    100052122
   05415 Diabetic cardiomyopathy
    100052122
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100052122
   04932 Non-alcoholic fatty liver disease
    100052122
   04931 Insulin resistance
    100052122
   04933 AGE-RAGE signaling pathway in diabetic complications
    100052122
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100052122
   01524 Platinum drug resistance
    100052122
   01522 Endocrine resistance
    100052122
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ecb04131]
    100052122
Membrane trafficking [BR:ecb04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100052122
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 Transcrip_act Cupin_8 Exonuc_VII_L
Other DBs
NCBI-GeneID: 100052122
NCBI-ProteinID: XP_023486548
Position
2:12392962..12499508
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSGISNGIKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLTYPVSRYQQDQLVKEDNIDAVGKK
LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDESLPHYDEKTWFV
EDINRVQAEDLLCGKPDGAFLIRESSKEGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcaggcatttcaaatggaataaaggacagttctgtttctctt
caggatgcagaatggtactggggggatatttcaagggaggaggtaaatgacaaattacga
gacatgccagatggtaccttcttggtcagagatgcctcaacaaaaatgcagggagattac
actttgactttgcggaagggaggcaataataagttaataaagatctatcatcgagatggt
aaatatggcttttctgatcctctgacctttaattctgtggtggagctcattaaccactat
catcacgaatctctggctcagtacaatcccaaacttgatgtgaagctgacgtacccggtg
tccaggtaccaacaggatcagttggtaaaagaagataacattgatgcagtaggtaaaaaa
ctgcaagagtaccactctcagtatcaggaaaagagtaaagagtatgacaggctatatgaa
gaatataccagaacatcccaggaaatacagatgaagaggactgcaattgaagcttttaat
gaaacaattaaaatatttgaagagcagtgtcacacacaagaacaacatagcaaagaatat
attgagcgatttcgcagagaggggaatgaaaaggaaattgaacgaattatgatgaattat
gacaaattgaaatcacgtctgggtgagattcatgatagtaaaatgcgtctagagcaggat
ttgaagaaacaagctttggacaaccgggaaatagataaaaaaatgaacagtatcaaacct
gacctgatccagctgcgcaagatccgagatcagcaccttgtatggctcaatcacaaagga
gtgagacagaagcgcctaaatgcctggctgggaatcaagaatgaggatgctgatgagacc
tattttatcaatgaggaagatgaaagcctgccccattatgatgagaaaacctggtttgtt
gaggatatcaatcgagtacaagcagaggacttgctttgtgggaagcctgatggcgcattc
ttaatccgtgagagcagcaaggaaggatgctatgcttgctctgtggttgccgatggggaa
gtgaagcactgtgtgatctacagcactgctcggggctatggctttgcggagccctacaac
ctgtacagctcactgaaggagctggtgctccattaccagcagacatcgctcgttcagcac
aacgactcgctcaacgtcaggcttgcctaccctgtccacgcacagatgccctcactctgc
agataa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (102)   
   KEGG PATHWAY (102)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (6)   
   RefSeq(pep) (6)   
DNA sequence (6)   
   RefSeq(nuc) (6)   
Protein domain (5)   
   Pfam (5)   
All databases (143)   

Download RDF
DBGET integrated database retrieval system