KEGG   Equus caballus (horse): 100057177
Entry
100057177         CDS       T01058                                 
Symbol
DPYD
Name
(RefSeq) dihydropyrimidine dehydrogenase [NADP(+)] isoform X1
  KO
K00207  dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2]
Organism
ecb  Equus caballus (horse)
Pathway
ecb00240  Pyrimidine metabolism
ecb00410  beta-Alanine metabolism
ecb00770  Pantothenate and CoA biosynthesis
ecb00983  Drug metabolism - other enzymes
ecb01100  Metabolic pathways
Module
ecb_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Brite
KEGG Orthology (KO) [BR:ecb00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    100057177 (DPYD)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    100057177 (DPYD)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    100057177 (DPYD)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    100057177 (DPYD)
Enzymes [BR:ecb01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.2  dihydropyrimidine dehydrogenase (NADP+)
     100057177 (DPYD)
SSDB
Motif
Pfam: Fer4_20 Pyr_redox_2 NAD_binding_8 Pyr_redox_3 Pyr_redox FAD_oxidored DAO
Other DBs
NCBI-GeneID: 100057177
NCBI-ProteinID: XP_023497338
Ensembl: ENSECAG00000010881
VGNC: 17302
Position
5:64578209..65408755
AA seq 589 aa
MAPVLSKDPADIESILALNPRTQTHAVLRSTSAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGSAKTIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFSTEVFKAMNIPQIRNPSLPPPE
KMPEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNEMTLSTVKEEGYKAVFIGIGLPEPKKDQIFQGLTQD
QGFYTSKDFLPLVAKGSKPGMCACHSPLPSIRGAVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVVVRGGRIVAMQFVRTEQDEAGNWS
EDEDQIVQLKADVIISAFGSVLSDPKVKEALSPIKFNKWGLPEVDPETMQTSEPWVFAGG
DIVGTANTTVESVNDGKQASWFIHKYIQSQHGASVAAKPELPLFYTPIDLVDISVEMAGL
KFVNPFGLASATPATSASMIRRAFEAGWGFALTKTFSLDKAVISHLLIS
NT seq 1770 nt   +upstreamnt  +downstreamnt
atggcccctgtgctgagcaaggacccggccgacatcgagagtatcctggctttaaatcct
cgaacacaaactcatgcagttctgcgttccacttcggccaagaaattagacaagaaacat
tggaaaagaaatcctgataagaactgctttaattgcgagaagctggagaataattttgat
gacatcaagcacacgactcttggtgaacgaggagctctccgagaagcaatgagatgcctg
aaatgtgccgatgccccctgtcagaaaagctgtccaacaaatctggatatcaagtcattc
atcacaagtatcgcaaacaagaactattatggatctgctaagacgattttttctgacaac
ccacttggtttgacctgtggaatggtatgtccaacctctgatctttgtgtcggtggatgc
aatttgtatgccactgaggagggaccaattaatattggtggattgcagcagttttctact
gaggtgttcaaagcaatgaatatcccacaaatcagaaatccttctctgcctcctccagaa
aaaatgcctgaagcctattctgcaaagattgctctttttggtgctgggcctgcaagtatc
agttgcgcttcctttttggctcgattaggctactctgacatcactatatttgaaaaacaa
gaatacgttggtggtttaagtacttctgaaatccctcagttccggctgccatatgatgta
gtgaattttgagattgagcttatgaaggaccttggtgtaaagataatttgtggtaaaagc
ctttcagtgaatgaaatgactcttagcactgtgaaagaagaagggtacaaagctgttttc
attgggataggtttaccagaacccaaaaaagaccaaatcttccaaggcctgacgcaggac
caggggttttacacatccaaggactttttgccacttgtagccaaaggcagtaaaccagga
atgtgcgcctgtcactctccattgccatcgatacggggagccgtgattgtactcggggct
ggagacactgctttcgactgtgcaacatccgctttacgttgtggagcccgccgcgtgttc
atcgtcttcagaaaaggctttgttaatataagagctgtccctgaggagatggagcttgct
aaggaagaaaagtgtgaatttttgcctttcctgtccccacggaaggttgtcgtaagaggt
gggagaattgttgctatgcagtttgttcggacagagcaagatgaagctggaaactggagt
gaagatgaagatcagatcgtccagctgaaagccgatgtgatcatcagcgcctttggttca
gttctgagtgatcctaaagtaaaagaagctttgagccctataaaatttaacaaatggggt
ctcccagaagtagatccagaaactatgcaaaccagtgaaccatgggtgtttgcaggtggt
gatattgttggtacggctaacaccacagtggaatcagtgaatgatggcaagcaagcttct
tggttcattcacaaatatatacagtcacaacatggagcttcagttgctgccaagcctgaa
ctacccctcttttacactcctattgatcttgtggacattagtgtggaaatggctggattg
aagtttgtaaacccttttggtcttgctagtgcgactccagctaccagtgcatcaatgatt
cgaagagcttttgaagctggatggggttttgccctgaccaaaactttctctcttgataag
gctgtgatttcacacttgttaattagttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (5)   
   RefSeq(pep) (5)   
DNA sequence (7)   
   RefSeq(nuc) (5)   
   GenBank (1)   
   EMBL (1)   
Protein domain (7)   
   Pfam (7)   
All databases (51)   

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