KEGG   Equus caballus (horse): 100066282Help
Entry
100066282         CDS       T01058                                 

Gene name
SOS2
Definition
(RefSeq) SOS Ras/Rho guanine nucleotide exchange factor 2
  KO
K03099  
son of sevenless
Organism
ecb  Equus caballus (horse)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ecb00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100066282 (SOS2)
   04010 MAPK signaling pathway
    100066282 (SOS2)
   04012 ErbB signaling pathway
    100066282 (SOS2)
   04630 Jak-STAT signaling pathway
    100066282 (SOS2)
   04068 FoxO signaling pathway
    100066282 (SOS2)
   04072 Phospholipase D signaling pathway
    100066282 (SOS2)
   04151 PI3K-Akt signaling pathway
    100066282 (SOS2)
   04150 mTOR signaling pathway
    100066282 (SOS2)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    100066282 (SOS2)
  Cellular community
   04510 Focal adhesion
    100066282 (SOS2)
   04540 Gap junction
    100066282 (SOS2)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    100066282 (SOS2)
   04660 T cell receptor signaling pathway
    100066282 (SOS2)
   04662 B cell receptor signaling pathway
    100066282 (SOS2)
   04664 Fc epsilon RI signaling pathway
    100066282 (SOS2)
   04062 Chemokine signaling pathway
    100066282 (SOS2)
  Endocrine system
   04910 Insulin signaling pathway
    100066282 (SOS2)
   04912 GnRH signaling pathway
    100066282 (SOS2)
   04915 Estrogen signaling pathway
    100066282 (SOS2)
   04917 Prolactin signaling pathway
    100066282 (SOS2)
  Nervous system
   04722 Neurotrophin signaling pathway
    100066282 (SOS2)
  Development
   04320 Dorso-ventral axis formation
    100066282 (SOS2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    100066282 (SOS2)
   05231 Choline metabolism in cancer
    100066282 (SOS2)
   05206 MicroRNAs in cancer
    100066282 (SOS2)
   05205 Proteoglycans in cancer
    100066282 (SOS2)
   05214 Glioma
    100066282 (SOS2)
   05221 Acute myeloid leukemia
    100066282 (SOS2)
   05220 Chronic myeloid leukemia
    100066282 (SOS2)
   05211 Renal cell carcinoma
    100066282 (SOS2)
   05215 Prostate cancer
    100066282 (SOS2)
   05213 Endometrial cancer
    100066282 (SOS2)
   05223 Non-small cell lung cancer
    100066282 (SOS2)
  Substance dependence
   05034 Alcoholism
    100066282 (SOS2)
  Infectious diseases
   05160 Hepatitis C
    100066282 (SOS2)
  Antineoplastic resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    100066282 (SOS2)
   01522 Endocrine resistance
    100066282 (SOS2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
1
AA seq 1340 aa AA seqDB search
MLLPALQSSVAEELNEPAADGLLREQFESPVTVSDRASPHLTGEPCSLVRLSPSRRGCHG
SRGRLPDGALRDSLRELQLERVQKTFPHPIDKWAIADAQSAIEKRKRRHPLLLPVDKIHP
SLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVL
MDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDR
KLFKPSDIEKIFSNILDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDP
YETLSQDILSPKFNEHFSKLMARPAVALHFQSIADGFREAVRYVLPRLMLVPVYHCWHYF
ELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPVCPFYNRQLRS
KHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTKIGAKHERHIFLFDGLMISCKPN
HSQSRLPGYSSAEYRLKEKFVMRKIQICDKEDTCECRHAFELVSKDENSITFAAKSAEEK
NNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEMYRFVVKDSEENIVFEDSLQS
RSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPE
PTEADKLAVEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERL
ESFISSVRGKAMKKWVESIAKIIKRKKQTQANGISHNITFESPPPPIEWHISRPGQFETF
DLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLW
FEKCIVEAENFEERVAVLSRVIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQ
ERKRRILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKD
LINFSKRRKVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGSSSEKEFTDYLFNKSL
EIEPRNCKQPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIA
EAELGSAVSAPTSPNTPSTPPASAASDLSVFPDVDLSASCGSNSIFAPVLLPHSKSFFSS
CGSLHKLSDEPLIPPPLPPRKKFDHDASNPKGNMKSDDDPPAIPPRQPPPPKVKPRVPAP
SGAFEGSLHSPPPPPPREPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDPDWFRDV
STRPDSPNTPPSTPSPRVPRRCCVLSSSHSNLTYPQAPPVPPRQNSSPHLPKLPPKTYKR
ELSHPPMYRLSLLENAETPQ
NT seq 4023 nt NT seq  +upstreamnt  +downstreamnt
atgctgctgcccgcccttcagtcttctgtggctgaggagctgaacgaacctgcagctgat
gggcttttacgagaacagtttgagagtcctgtcactgtctcggaccgggcgtcgccgcac
ctaacgggcgagccctgctccctggtgcgcctgtctccttctcggcgggggtgtcacggc
agccggggccgcctcccggacggtgcgctccgggactcgctcagagagctgcagctcgaa
cgagttcaaaagacctttccgcatccaattgataaatgggctattgctgatgcacaatcc
gccatagagaaacgaaaacgaagacaccctctcttactgcctgtggacaaaatccatcct
tcattgaaggaggttttagggtacaaagtggactaccatgtgtccctgtatattgtggct
gtactggagtatatctcagctgatattttaaaattggctggtaattatgtttttaatatt
cgacattatgaaatatctcagcaggacattaaagtgtcaatgtgtgcagataaggttttg
atggacatgtttgatcaggatgacataggtttggtttctctctgtgaagatgagccgagt
tcttcaggtgaattgaattactatgaccttgtcagaactgaaattgcagaagaaagacag
tatctccgggaactaaatatgatcataaaagtatttcgagaagcctttctttctgacaga
aagctgtttaaaccttctgatattgagaagattttcagtaacattttagatatacatgaa
ttgactgtgaaacttctaggtttgattgaggacacagttgagatgactgatgaaagcagt
cctcatcccttagctggcagctgtttcgaagatttggcagaagagcaggcttttgatcct
tatgaaacattatcacaggacatcctttcaccaaaattcaatgaacatttcagtaagttg
atggccagacctgcagtggctctacactttcagtccattgctgatgggttcagagaggcg
gttcgttatgtccttccacgcctgatgcttgtgccagtgtatcattgttggcactacttc
gaattattaaagcaattgaaagcatgtagtgaagaacaagaagacagagaatgtttgaac
caagctattactgctctcatgaatctccagggtagtatggaccgaatttataagcagtat
tcgcctagacgtcgacctggggatcctgtttgccctttttataatcgtcaattaagaagc
aagcacctggctattaaaaaaatgaatgaaattcagaaaaacatagatggatgggaaggc
aaagacatcggacagtgttgtaatgaattcattatggaaggtcctttgacaaaaattggt
gctaaacatgaacggcatatttttctctttgatggcttaatgattagctgcaaacccaat
catagccagtcgcggcttccagggtacagtagtgcagaatacagactgaaagagaagttt
gtcatgaggaaaatacaaatatgtgataaagaagacacttgcgagtgcagacatgctttt
gaattagtctccaaagatgaaaacagcatcacatttgctgccaagtctgccgaagagaag
aataactggatggcagcactcatttctcttcattaccgtagcacactggaccgaatgctg
gactcagtgttactgaaggaagaaaatgagcagccactgaggttaccaagtcctgagatg
tatcgtttcgtggtgaaagactctgaggaaaacatagtttttgaagacagcttgcaaagt
agaagtggaatccccattattaaaggaggaactgtggtgaaattaattgaaaggttgaca
tatcatatgtatgcagatcccaattttgttcgtacttttcttactacatatcgttcattt
tgtaaaccacaggaattgctaagcttactaattgaacgatttgaaattccagagccagaa
cctactgaagcagataaattggcagtagagaaaggcgagcagcccatcagtgcagacctt
aaaaggtttcgcaaggaatacgtccaaccagtacaacttaggatcttaaatgtgtttcgg
cactgggttgaacaccatttttatgattttgaaagagatttggagttgcttgaacggcta
gaatccttcatttcaagtgtaagagggaaagctatgaagaaatgggtagagtcaattgct
aagatcatcaagaggaagaaacagactcaggcaaacggaataagccataatatcaccttt
gaaagcccaccccccccgattgaatggcacatcagcagacccgggcagttcgagaccttt
gatctcatgacacttcatccaatagaaattgcacgccagctgacgcttttggaatctgat
ctctataggaaagtccagccttctgaacttgtagggagtgtgtggaccaaagaagataaa
gaaataaattctccaaatttattaaaaatgattcgccacaccacaaatctcaccctctgg
tttgaaaagtgcattgtggaagcagaaaactttgaggaacgagtggcagtactaagtaga
gttatagaaattctgcaagtttttcaagatttgaataatttcaatggcgtactggagata
gtcagtgcagtgaattcagtgtcagtgtacagactagaccataccttcgaggcattgcag
gaaagaaaaaggagaattttggatgaagctgtggaattaagtcaagatcactttaaaaaa
tacctagtaaaacttaagtcaatcaatccaccttgtgtgcctttttttggaatatattta
acaaatattctgaagactgaagaagggaataatgattttttaaaaaagaaagggaaagat
ttaatcaatttcagtaagaggaggaaagtagctgaaattactggagaaattcagcagtat
cagaatcaaccttactgtttacggatagaaccagagatgaggcggttctttgaaaacctt
aaccccatgggaagttcttctgaaaaagagtttacggattatttgttcaacaaatcacta
gaaattgaaccccgcaactgcaaacagccacctcgatttcctaggaaatcaactttctct
ttaaaatctcctggaataaggcctaacacgggccgacatggctctacctcaggcacttta
cgaggtcatcccaccccgttagaaagagaaccgtgtaaaatcagctttagtcggattgct
gaggctgagctgggatcagcagtgtcggcaccaacctctcccaacacgccgtccaccccg
ccggcgtctgctgcttcagacctcagtgtgttcccagacgtggacctcagcgcttcctgt
ggcagcaatagcatctttgctccagtcctcttgccacactcaaagtccttcttcagttca
tgcggtagtttacataaactaagtgacgagcccctgattcctcctccgcttcctcctcgg
aagaagtttgatcacgatgcttcgaatcccaagggaaatatgaaatctgatgatgaccct
cctgctattccaccaagacaacctcctcctccaaaggtgaaacccagagttcccgctcct
tctggtgcatttgaggggtctctgcacagcccacctccaccgccgcccagagagcctctt
cctgacacgcctccaccggttccccttcggcctccagaacactttataaactgtccgttt
aatcttcagccacctcccctgggacatcttcacagagatccagactggttcagagacgtt
agcacacgaccagattcgcccaacactcctcccagcacaccgtctccacgggtgccacgt
cgatgctgtgtgctcagttctagtcacagtaatctcacttatcctcaagctccccctgtt
ccaccaaggcagaattcaagccctcacctaccaaaactgccaccaaagacttacaaacgg
gagctttcgcaccccccaatgtacagactgtctttgctagaaaacgcggaaactcctcaa
tga

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