KEGG   Escherichia coli K-12 MG1655: b3368
Entry
b3368             CDS       T00007                                 
Symbol
cysG
Name
(RefSeq) siroheme synthase
  KO
K02302  uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4]
Organism
eco  Escherichia coli K-12 MG1655
Pathway
eco00860  Porphyrin metabolism
eco01100  Metabolic pathways
eco01110  Biosynthesis of secondary metabolites
eco01120  Microbial metabolism in diverse environments
eco01240  Biosynthesis of cofactors
Module
eco_M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
Brite
KEGG Orthology (KO) [BR:eco00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    b3368 (cysG)
Enzymes [BR:eco01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.76  precorrin-2 dehydrogenase
     b3368 (cysG)
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.107  uroporphyrinogen-III C-methyltransferase
     b3368 (cysG)
 4. Lyases
  4.99  Other lyases
   4.99.1  Sole sub-subclass for lyases that do not belong in the other subclasses
    4.99.1.4  sirohydrochlorin ferrochelatase
     b3368 (cysG)
SSDB
Motif
Pfam: TP_methylase NAD_binding_7 CysG_dimeriser Sirohm_synth_M Col-Pyo_DNase Radical_SAM
Other DBs
NCBI-GeneID: 947880
NCBI-ProteinID: NP_417827
Pasteur: cysG
RegulonDB: ECK120000183
ECOCYC: EG10188
ASAP: ABE-0011010
UniProt: P0AEA8
Position
3497828..3499201
AA seq 457 aa
MDHLPIFCQLRDRDCLIVGGGDVAERKARLLLDAGARLTVNALAFIPQFTAWADAGMLTL
VEGPFDESLLDTCWLAIAATDDDALNQRVSEAAEARRIFCNVVDAPKAASFIMPSIIDRS
PLMVAVSSGGTSPVLARLLREKLESLLPLHLGQVAKYAGQLRGRVKQQFATMGERRRFWE
KLFVNDRLAQSLANNDQKAITETTEQLINEPLDHRGEVVLVGAGPGDAGLLTLKGLQQIQ
QADVVVYDRLVSDDIMNLVRRDADRVFVGKRAGYHCVPQEEINQILLREAQKGKRVVRLK
GGDPFIFGRGGEELETLCNAGIPFSVVPGITAASGCSAYSGIPLTHRDYAQSVRLITGHL
KTGGELDWENLAAEKQTLVFYMGLNQAATIQQKLIEHGMPGEMPVAIVENGTAVTQRVID
GTLTQLGELAQQMNSPSLIIIGRVVGLRDKLNWFSNH
NT seq 1374 nt   +upstreamnt  +downstreamnt
gtggatcatttgcctatattttgccaattacgcgatcgcgactgtctgattgtcggcggt
ggtgatgtcgcggaacgcaaagcaaggttgctgttagacgcaggcgctcgcttaacggtg
aatgcattagcgtttattccacagttcaccgcatgggcagatgcaggcatgttaaccctc
gtcgaagggccatttgatgaaagccttctcgacacctgctggctggcgattgcagcgacg
gatgatgacgcgcttaaccagcgcgtcagcgaagccgctgaagctcgtcgcatcttctgt
aacgtggtcgatgcgccgaaagccgccagctttattatgccgtcgattattgaccgctca
ccgctcatggtagcggtctcctctggcggcacctctccggttctggcacgcctgttgcgc
gaaaaacttgaatcactgctgccgttacatctgggccaggtagcgaaatacgccgggcaa
ttacgcgggcgagtgaaacaacagttcgccacgatgggtgagcgtcgccgtttctgggag
aaattgttcgttaacgaccgcctggcgcagtcgctggcaaacaacgatcagaaagccatt
actgaaacgaccgaacagttaatcaacgaaccgctcgaccatcgcggtgaagtggtgctg
gttggtgcaggtccgggcgatgccgggctgctgacactgaaaggactgcaacaaattcag
caggcagatgtggtggtctacgaccgtctggtttctgacgatattatgaatctggtacgc
cgcgatgcggaccgtgttttcgtcggcaaacgcgcgggataccactgcgtaccccaggaa
gagattaaccagatcctgctgcgggaagcgcaaaaaggcaaacgcgtggtgcggctgaaa
ggtggcgatccgtttatttttggccgtggtggcgaagagctggaaacactgtgcaacgcg
ggtattccgttctcggtggttccgggtattaccgcagcttctggttgctctgcctattcg
ggtattccactcacgcatcgcgattatgcccagagcgtacgcttaattaccggacactta
aaaaccggtggcgagctggactgggaaaacctggcggcagaaaaacagacgctggtgttc
tatatggggttgaatcaggccgcgactattcagcaaaagctgattgaacacggaatgcca
ggcgaaatgccggtggcaattgtcgaaaacggtacggcagtcacgcagcgcgtgattgac
ggtacgctcacacagctgggagaactggcgcagcaaatgaacagtccatcgctaattatt
attggtcgggttgttggcctgcgcgataaactgaactggttctccaaccattaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (5)   
   KEGG MODULE (2)   
Chemical substance (10)   
   KEGG COMPOUND (10)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   ASAP (1)   
   ECOCYC (1)   
   OC (1)   
   PASTEUR (1)   
   REGULONDB (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
Protein domain (6)   
   Pfam (6)   
All databases (51)   

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