KEGG   ENZYME: 1.1.1.112Help
Entry
EC 1.1.1.112                Enzyme                                 

Name
indanol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
indan-1-ol:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+ [RN:R03582 R03583]
Reaction(KEGG)
Substrate
indan-1-ol [CPD:C01710];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
indanone [CPD:C01504];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
3(20)alpha-Hydroxysteroids are also oxidized, more slowly.
History
EC 1.1.1.112 created 1972
Reference
1  [PMID:4397102]
  Authors
Billings RE, Sullivan HR, McMahon RE.
  Title
The dehydrogenation of 1-indanol by a soluble oxidoreductase from bovine liver.
  Journal
J. Biol. Chem. 246 (1971) 3512-7.
Reference
2  [PMID:2559080]
  Authors
Hara A, Nakagawa M, Taniguchi H, Sawada H.
  Title
3(20)alpha-hydroxysteroid dehydrogenase activity of monkey liver indanol dehydrogenase.
  Journal
J. Biochem. (Tokyo). 106 (1989) 900-3.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-43-4

KEGG   ENZYME: 1.1.1.149Help
Entry
EC 1.1.1.149                Enzyme                                 

Name
20alpha-hydroxysteroid dehydrogenase;
20alpha-hydroxy steroid dehydrogenase;
20alpha-HSD;
20alpha-HSDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase
Reaction(IUBMB)
17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+ = 17alpha-hydroxyprogesterone + NAD(P)H + H+ [RN:R03325]
Reaction(KEGG)
Substrate
17alpha,20alpha-dihydroxypregn-4-en-3-one [CPD:C04518];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
17alpha-hydroxyprogesterone [CPD:C01176];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Re-specific with respect to NAD(P)+ (cf. EC 1.1.1.62 17beta-estradiol 17-dehydrogenase).
History
EC 1.1.1.149 created 1972, deleted 1983, reinstated 1986
Pathway
Steroid hormone biosynthesis
Orthology
K05295  
20alpha-hydroxysteroid dehydrogenase
Genes
MMU: 
105349(Akr1c18)
RNO: 
171516(Akr1c3)
Taxonomy
Reference
1  [PMID:4382486]
  Authors
Shikita M, Inano H, Tamaoki B.
  Title
Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes.
  Journal
Biochemistry. 6 (1967) 1760-4.
Reference
2  [PMID:6935192]
  Authors
Strickler RC, Tobias B, Covey DF.
  Title
Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site.
  Journal
J. Biol. Chem. 256 (1981) 316-21.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9040-08-8

KEGG   ENZYME: 1.3.1.20Help
Entry
EC 1.3.1.20                 Enzyme                                 

Name
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase;
dihydrodiol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase
Reaction(IUBMB)
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ [RN:R00814]
Reaction(KEGG)
R00814;
(other) R07015 R09420
Show
Substrate
trans-1,2-dihydrobenzene-1,2-diol [CPD:C04221];
NADP+ [CPD:C00006]
Product
catechol [CPD:C00090];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.3.1.20 created 1972
Pathway
Metabolism of xenobiotics by cytochrome P450
Orthology
K00078  
dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP)
K00212  
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Genes
HSA: 
1109(AKR1C4) 1645(AKR1C1) 1646(AKR1C2) 27294(DHDH)
PTR: 
450274(AKR1C4) 456194(DHDH)
PPS: 
100991467(DHDH)
GGO: 
101152398(DHDH)
PON: 
100174691(DHDH)
NLE: 
100591778(DHDH)
MCC: 
MCF: 
102133381(DHDH)
CJC: 
100390604(DHDH)
MMU: 
71755(Dhdh)
RNO: 
691002(Dhdh)
CGE: 
100753544(Dhdh)
HGL: 
101713222(Dhdh)
TUP: 
102470508(DHDH)
CFA: 
403786(DHDH)
AML: 
UMR: 
103657108(DHDH)
FCA: 
101101272(DHDH)
PTG: 
102948867(DHDH)
BTA: 
617564(DHDH)
BOM: 
102280401(DHDH)
PHD: 
102323268(DHDH)
CHX: 
102188075(DHDH)
OAS: 
101103175(DHDH)
SSC: 
397337(SUS2DD)
CFR: 
102512639(DHDH)
BACU: 
103008204(DHDH)
ECB: 
100051521(DHDH)
MYB: 
102262437(DHDH)
MYD: 
102770117(DHDH)
PALE: 
102885391(DHDH)
MDO: 
100030403(DHDH)
GGA: 
777348(DHDH)
PHI: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
444539(dhdh)
XTR: 
100145807(dhdh) 448579(dhdh)
DRE: 
406433(dhdhl) 449558(dhdh)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103189533(dhdh)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
412231(GB13821)
NVI: 
TCA: 
BMOR: 
API: 
ISC: 
HRO: 
LGI: 
NVE: 
HMG: 
AQU: 
PTI: 
TPS: 
PIF: 
EHX: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:13651190]
  Authors
AYENGAR PK, HAYAISHI O, NAKAJIMA M, TOMIDA I.
  Title
Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol.
  Journal
Biochim. Biophys. Acta. 33 (1959) 111-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37255-32-6

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