| Entry |
|
|---|
| Name |
L-lactate dehydrogenase;
lactic acid dehydrogenase;
L(+)-nLDH;
L-(+)-lactate dehydrogenase;
L-lactic dehydrogenase;
L-lactic acid dehydrogenase;
lactate dehydrogenase;
lactate dehydrogenase NAD+-dependent;
lactic dehydrogenase;
NAD+-lactate dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
(S)-lactate:NAD+ oxidoreductase |
|---|
| Reaction(IUBMB) |
(S)-lactate + NAD+ = pyruvate + NADH + H+ [RN:R00703] |
|---|
| Reaction(KEGG) |
R00703;
(other) R01000 R03104
 |
|---|
| Substrate |
(S)-lactate [CPD:C00186];
NAD+ [CPD:C00003] |
|---|
| Product |
pyruvate [CPD:C00022];
NADH [CPD:C00004];
H+ [CPD:C00080] |
|---|
| Comment |
Also oxidizes other (S)-2-hydroxymonocarboxylic acids. NADP+ also
acts, more slowly, with the animal, but not the bacterial, enzyme. |
|---|
| Pathway |
PATH: ec00010 Glycolysis / Gluconeogenesis
PATH: ec00270 Cysteine and methionine metabolism
PATH: ec00620 Pyruvate metabolism
PATH: ec00640 Propanoate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00016 L-lactate dehydrogenase |
|---|
| Genes |
HSA: 160287(LDHAL6A) 3939(LDHA) 3945(LDHB) 3948(LDHC) 92483(LDHAL6B)
PTR: 451063(LDHA) 451064(LDHC) 464999 465337(LDHB) 466460(LDHAL6A)
747141(LDHAL6B)
MCC: 693731 693802(LDHB) 693907 694309(LDHA) 696854(LDHA)
696935(LDHB) 702403 706110(LDHB) 716800(LDHB) 718082(LDHB)
MMU: 106557(Ldhal6b) 16828(Ldha) 16832(Ldhb) 16833(Ldhc)
433229(Gm5514)
RNO: 24533(Ldha) 24534(Ldhb) 29634(Ldhc) 369018(Ldhal6b)
500965(RGD1562690)
CFA: 475101 476213 476882(LDHA) 476883(LDHC) 477675(LDHB) 477883
479371 481004 482405 484048(LDHAL6B) 485449 490690 609013
610330 611702
BTA: 281274(LDHA) 281275(LDHB) 509519(LDHAL6B) 784938(LDHA)
SSC: 100153697 407246(LDHB)
ECB: 100033997(LDHB) 100057016(LDHA) 100057054 100059970
MDO: 100012604 100016009 100023295 100028279 100028290 503513(LDHA)
554182(LDHB)
OAA: 100086588 791112(LDHA)
GGA: 373997(LDHB) 396221(LDHA)
TGU: 100190454 100223914
XLA: 380394(ldhaa) 380546(ldhba) 394355(ldhbb) 398121(ldhab)
XTR: 394477(ldhb) 394758(ldha)
DRE: 100149316 100150938 30496(ldha) 30497(ldhb) 436747
CIN: 100174998
SPU: 586683
DME: Dmel_CG10160(ImpL3) Dmel_CG13334
DPO: Dpse_GA10121
DAN: Dana_GF10902 Dana_GF13705
DER: Dere_GG14061 Dere_GG20393
DPE: Dper_GL17466
DSE: Dsec_GM13843 Dsec_GM21480
DSI: Dsim_GD10977 Dsim_GD13128
DYA: Dyak_GE12554 Dyak_GE20486
DGR: Dgri_GH16279
DMO: Dmoj_GI13222
AGA: AgaP_AGAP004880
AAG: AaeL_AAEL012014
CQU: CpipJ_CPIJ014454 CpipJ_CPIJ016131
AME: 411188
NVI: 100118743
TCA: 656589
CEL: F13D12.2(ldh-1)
CBR: CBG03136
BMY: Bm1_43730
SMM: Smp_038950 Smp_038960
ATH: AT4G17260
POP: POPTR_554197
RCU: RCOM_0540790
VVI: 100250615(GSVIVT00009618001)
OSA: 4328012(Os02g0105400) 4339856(Os06g0104900)
SBI: SORBI_04g000580(SORBIDRAFT_04g000580)
ZMA: 100193279 100282503(cl2158_1)
PPP: PHYPADRAFT_146489 PHYPADRAFT_195311 PHYPADRAFT_55784
CME: CMA145C CMC188C CMI306C CMJ002C CMK006C
LTH: KLTH0D00440g KLTH0G19558g
SPO: SPAC186.08c
NCR: NCU00720
PAN: PODANSg09793 PODANSg866
MGR: MGG_10453
FGR: FG10444.1
ANI: AN5842.2
AFM: AFUA_5G14800
ANG: An04g08220
MBR: MONBRDRAFT_32392
PFA: PF13_0141
ECG: E2348C_4376
ECC: c5039
ECI: UTI89_C4637
ECP: ECP_4280
ECV: APECO1_2404
ECZ: ECS88_4540
ELF: LF82_p646
EFE: EFER_4154
ENT: Ent638_2002
ESA: ESA_01812
CTU: Ctu_21690(ldh2)
KPN: KPN_01632
KPE: KPK_2747
KPU: KP1_2672
CKO: CKO_01547 CKO_03848
VVU: VV2_1457
VVY: VVA0276
VPA: VPA0147
VEX: VEA_000852
TTU: TERTU_0352
TGR: Tgr7_1919
TAU: Tola_1750
REH: H16_A0666(ldh)
RME: Rmet_0559
BGL: bglu_2g19240
BPE: BP0379(ldh)
BPA: BPP4051(ldh)
BBR: BB4524(ldh) BB4684
BAV: BAV3171(ldh)
VEI: Veis_4538
CJE: Cj1167(ldh)
CJR: CJE1301(ldh)
CJJ: CJJ81176_1182(ldh)
CJU: C8J_1111(ldh)
CJD: JJD26997_0565
SDL: Sdel_0325
GEO: Geob_0424
DVU: DVU0600(ldh)
DVL: Dvul_2352
SCL: sce5245(ldh)
AVI: Avi_4103(mdh)
RLE: pRL120231
RCE: RC1_3506
BSU: BSU03050(ldh)
BHA: BH3937(lctE)
BAN: BA1923(ldh) BA5125(ldh) BA5240(ldh)
BAR: GBAA1923(ldh) GBAA5125(ldh) GBAA5240(ldh)
BAA: BA_0106 BA_2427
BAT: BAS1784(ldh) BAS4762(ldh) BAS4869(ldh)
BAH: BAMEG_2667(ldh1) BAMEG_5157(ldh2) BAMEG_5294(ldh3)
BAI: BAA_1993(ldh1) BAA_5136(ldh2) BAA_5272(ldh3)
BCE: BC1924(ldh) BC4870(ldh) BC4996(ldh)
BCA: BCE_2007(ldh) BCE_5032(ldh) BCE_5135(ldh)
BCZ: BCZK1741(ldh) BCZK4624(ldh) BCZK4723(ldh)
BCR: BCAH187_A2028(ldh) BCAH187_A5012(ldh) BCAH187_A5142(ldh)
BCB: BCB4264_A1927(ldh) BCB4264_A5002(ldh) BCB4264_A5140(ldh)
BCU: BCAH820_1959(ldh) BCAH820_4981(ldh) BCAH820_5106(ldh)
BCG: BCG9842_B0100(ldh) BCG9842_B0236(ldh) BCG9842_B3415(ldh)
BCQ: BCQ_4689(ldhP) BCQ_4814(ldhB)
BCX: BCA_1989(ldh1) BCA_5005(ldh2) BCA_5136(ldh3)
BCY: Bcer98_1484(ldh) Bcer98_3505(ldh) Bcer98_3591(ldh)
BTK: BT9727_1763(ldh) BT9727_4600(ldh) BT9727_4708(ldh)
BTL: BALH_1702(ldh) BALH_4435(ldh) BALH_4532(ldh)
BWE: BcerKBAB4_1798(ldh) BcerKBAB4_4713(ldh) BcerKBAB4_4826(ldh)
BLI: BL01703(ldh)
BLD: BLi00366(ldh)
BCL: ABC2872(ldh)
BAY: RBAM_003290(ldh)
BPU: BPUM_0277(ldh)
OIH: OB3279
GKA: GK0475(ldh)
GTN: GTNG_0487(ldh)
GWC: GWCH70_0489
GYM: GYMC10_3602
GYC: GYMC61_1361
AFL: Aflv_0889(ldh)
SAU: SA0232(lctE) SA2395
SAV: SAV0241(lctE) SAV2602
SAW: SAHV_0240(lctE) SAHV_2586
SAM: MW0217(lctE) MW2521
SAR: SAR0234(ldh1) SAR2680(ldh2)
SAS: SAS0217 SAS2487
SAC: SACOL0222(ldh1) SACOL2618(ldh2)
SAB: SAB0180 SAB2475c(ldh)
SAA: SAUSA300_0235 SAUSA300_2537
SAX: USA300HOU_0251(ldh)
SAO: SAOUHSC_00206 SAOUHSC_02922
SAJ: SaurJH9_0225 SaurJH9_2624
SAH: SaurJH1_0231 SaurJH1_2678
SAE: NWMN_0176(ldh1) NWMN_2499(ldh)
SAD: SAAV_0206(ldh1) SAAV_2668(ldh2)
SEP: SE2145
SER: SERP2156(ldh)
SHA: SH0525
SSP: SSP0249 SSP1001
SCA: Sca_0343(ldh) Sca_1369(ldh)
LMO: lmo0210(ldh) lmo1534 lmo1667
LMF: LMOf2365_0221(ldh) LMOf2365_1553(ldh-2) LMOf2365_1691
LMH: LMHCC_0899 LMHCC_1035 LMHCC_2433(ldh)
LMC: Lm4b_00208(ldh) Lm4b_01544 Lm4b_01680
LIN: lin0242(ldh) lin1569 lin1775
LWE: lwe0172(ldh) lwe1034 lwe1547(ldhB) lwe1685
ESI: Exig_0870
EAT: EAT1b_0554
MCL: MCCL_0163(lctD) MCCL_0255
PJD: Pjdr2_5353
AAC: Aaci_0520
LLA: L0017(ldh) L0018(ldhB) L142159(ldhX)
LLK: LLKF_0427(ldhB) LLKF_0494 LLKF_1154(ldhX) LLKF_1422(ldhL)
LLC: LACR_0421 LACR_1239 LACR_1455(ldh)
LLM: llmg_0392(ldhB) llmg_1120(ldh) llmg_1429(ldhX)
SPY: SPy_1151(ldh)
SPZ: M5005_Spy_0873(ldh)
SPM: spyM18_1111(ldh)
SPG: SpyM3_0809(ldh)
SPS: SPs1008(ldh)
SPH: MGAS10270_Spy0987(ldh)
SPI: MGAS10750_Spy1022(ldh)
SPJ: MGAS2096_Spy0947(ldh)
SPK: MGAS9429_Spy0991(ldh)
SPF: SpyM50917(ldh)
SPA: M6_Spy0869(ldh)
SPB: M28_Spy0847(ldh)
SOZ: Spy49_0904c(ldh)
SPN: SP_1220(ldh)
SPD: SPD_1078(ldh)
SPR: spr1100(ldh)
SPW: SPCG_1081(ldh)
SPX: SPG_1112(ldh)
SNE: SPN23F_11170(ldh)
SPV: SPH_1335(ldh)
SNM: SP70585_1267
SJJ: SPJ_1135
SPP: SPP_1258
SNT: SPT_1008
SAG: SAG0128 SAG0959(ldh)
SAN: gbs0126 gbs0947(ldh)
SAK: SAK_0179 SAK_1054(ldh)
SMU: SMU.1115(ldh)
STC: str0644(hdhL) str1280(ldh)
STL: stu0644(hdhL) stu1280(ldh)
STE: STER_0694 STER_1257(ldh)
SSA: SSA_1221(ldh)
SSU: SSU05_1076(ldh)
SSV: SSU98_1087(ldh)
SSB: SSUBM407_0854(ldh)
SSI: SSU0927(ldh)
SSS: SSUSC84_0970(ldh)
SGO: SGO_1232(ldh) SGO_1369
SEQ: SZO_09420
SEZ: Sez_1022(ldh)
SEU: SEQ_1169
SUB: SUB0879(ldh)
SDS: SDEG_0911(ldh)
LPL: lp_0537(ldhL1) lp_1101(ldh) lp_1245(hicD2) lp_2349(hicD3)
LPJ: JDM1_0436(ldhL1) JDM1_0908(ldh) JDM1_1054(hicD2)
JDM1_1964(hicD3)
LJO: LJ0274 LJ1403(ldh)
LJF: FI9785_1528(hicD) FI9785_337(ldh) FI9785_863(ldh)
LAC: LBA0271 LBA0910(ldh) LBA1516
LSA: LSA1606(ldh)
LSL: LSL_1362(ldh)
LDB: Ldb0120(ldh)
LBU: LBUL_0100(ldh)
LBR: LVIS_0514
LCA: LSEI_0634 LSEI_2549 LSEI_2607
LCB: LCABL_06930(ldh) LCABL_27160(ldh) LCABL_27730(hicD3)
LGA: LGAS_0269 LGAS_0849(ldh)
LRE: Lreu_0194 Lreu_0716 Lreu_0907 Lreu_1272
LRF: LAR_0185 LAR_0688 LAR_0853 LAR_1206
LHE: lhv_0289 lhv_0978(ldh) lhv_1578
LFE: LAF_0348 LAF_0806
LRH: LGG_00606(ldh) LGG_02523(L-LDH) LGG_02591(hicD2)
LRL: LC705_00585(ldh) LC705_02527(L-LDH) LC705_02599(hicD2)
PPE: PEPE_1554
EFA: EF0255(ldh) EF0641(ldh-2)
LCI: LCK_01655
CAC: CAC0267(ldh) CAC3552
CPE: CPE0103(ldh)
CPF: CPF_0098(ldh)
CPR: CPR_0102(ldh)
CTC: CTC01998(ldh)
CNO: NT01CX_0236(ldh)
CTH: Cthe_1053(ldh)
CDF: CD2164(ldh)
CDC: CD196_2027(ldh)
CDL: CDR20291_2070(ldh)
CBO: CBO1519(ldh)
CBA: CLB_1540(ldh)
CBH: CLC_1552(ldh)
CBY: CLM_1754(ldh)
CBL: CLK_0997(ldh)
CBK: CLL_A2569 CLL_A3511
CBB: CLD_3035(ldh)
CBI: CLJ_B1617(ldh)
CBT: CLH_2335 CLH_3305
CBF: CLI_1599(ldh)
CBE: Cbei_1014 Cbei_2789 Cbei_4903
CKL: CKL_1381
CKR: CKR_1277
CPY: Cphy_1117 Cphy_1232
CCE: Ccel_2485
AOE: Clos_2712
VPR: Vpar_0498
ATE: Athe_1918
DRM: Dred_2797
PTH: PTH_0747(mdh)
DAU: Daud_1522
HMO: HM1_2756(ldh)
APR: Apre_1065
EEL: EUBELI_20026
ERE: EUBREC_2331
TEX: Teth514_0216
TPD: Teth39_1997
MTA: Moth_1826
ADG: Adeg_1582
CSC: Csac_1027
HOR: Hore_16140
MGE: MG_460(ldh)
MPN: MPN674(ldh)
MPU: MYPU_7590(ldh)
MPE: MYPE9640
MGA: MGA_0746(mdh)
MMY: MSC_0532(ldh)
MMO: MMOB0410(ldh)
MHY: mhp245(ictD) mhp469(ldh)
MHJ: MHJ_0133(ldh) MHJ_0468
MHP: MHP7448_0137(ldh) MHP7448_0471
MSY: MS53_0461(ldh)
MCP: MCAP_0439(ldh)
MAA: MAG_4900(ldh)
MAT: MARTH_orf109(ldh)
MCO: MCJ_001000 MCJ_006130(ldh)
MHO: MHO_3580(ldh)
ACL: ACL_1028(ldh)
MFL: Mfl596
MVA: Mvan_0439
MGI: Mflv_0307
MMC: Mmcs_0382
MKM: Mkms_0391
MJL: Mjls_0370
CGL: NCgl2810(ldh)
CGB: cg3219(ldh)
CGT: cgR_2812(ldh)
CEF: CE2753(ldh)
CDI: DIP0427 DIP2255(ldh)
CJK: jk0113(ldh)
CAR: cauri_2403(ldh)
CKP: ckrop_0111(ldh) ckrop_1700
RER: RER_42180(ldh)
GBR: Gbro_1116
SMA: SAV_339(ldhA)
ART: Arth_3978
KRH: KRH_05010(ldh)
MLU: Mlut_21510
BCV: Bcav_2434
JDE: Jden_1053
XCE: Xcel_1257
PAC: PPA0012 PPA0887 PPA1952
NML: Namu_0206
BLO: BL0710(ldh1) BL1308(ldh2)
BLJ: BLD_0165(ldh) BLD_0435
BLN: Blon_0840 Blon_1090
BAD: BAD_1117(ldh2)
BLA: BLA_0305(ldh) BLA_0792
BLC: Balac_0321 Balac_1214
BLT: Balat_0321 Balat_1214
APV: Apar_0054
ELE: Elen_2253
BBU: BB0087
BBZ: BbuZS7_0087
BGA: BG0088(ldh)
BAF: BAPKO_0088(ldh)
BTU: BT0087
BHR: BH0087
BDU: BDU_90(ldh)
BRE: BRE_89(ldh)
TDE: TDE0351(ldh)
LIL: LA1488
BHY: BHWA1_01750(ldh)
ABA: Acid345_1483
SRU: SRU_0681
RMR: Rmar_0132
FNU: FN1169
STR: Sterm_2675
SMF: Smon_0985
OTE: Oter_1299
RBA: RB2566(ldh) RB856(ldh)
CYA: CYA_2670
CYB: CYB_2165
MAR: MAE_05340
CYT: cce_5187(ldh)
CYC: PCC7424_3778
GVI: gll3324
NPU: Npun_R1983
AMR: AM1_5026(ldh)
CTS: Ctha_2381
CAU: Caur_1675
CAG: Cagg_2397
CHL: Chy400_1816
DRA: DR_2364
DDR: Deide_22290(ldh)
TTH: TTC0748
TTJ: TTHA1113
TMA: TM1867
TPT: Tpet_0930
TLE: Tlet_1246
TRQ: TRQ2_0952
TNA: CTN_0802
TNP: Tnap_0624
TAF: THA_1478
FNO: Fnod_1175
PMO: Pmob_1893
KOL: Kole_0912
DTH: DICTH_0539
DTU: Dtur_0700
HLA: Hlac_2649
HUT: Huta_0463
HMU: Hmuk_0803
TSI: TSIB_1633
 |
|---|
| Structures |
PDB: 1A5Z 1CEQ 1CET 1EZ4 1HYE 1HYG 1HYH 1I0Z 1I10 1LDB
1LDG 1LDM 1LDN 1LLC 1LLD 1LTH 1OC4 1PZE 1PZF 1PZG
1PZH 1SOV 1SOW 1T24 1T25 1T26 1T2C 1T2D 1T2E 1T2F
1U4O 1U4S 1U5A 1U5C 1V6A 1VBI 1X0A 1XIV 1Y6J 2A92
2A94 2AA3 2E37 2EWD 2FM3 2FN7 2FNZ 2FRM 2LDB 2LDX
2V65 2V6B 2V6M 2V7P 2ZQY 2ZQZ 3CZM 3D0O 3D4P 3H3F
3LDH 5LDH 6LDH 8LDH 9LDB 9LDT |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13815938]
DENNIS D, KAPLAN NO.
D- and L-lactic acid dehydrogenases in Lactobacillus plantarum.
J. Biol. Chem. 235 (1960) 810-8.
Lactobacillus plantarum [GN:lpl] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:4146647]
Adams MJ, Buehner M, Chandrasekhar K, Ford GC, Hackert ML, Liljas A,
Rossmann MG, Smiley IE, Allison WS, Everse J, Kaplan NO, Taylor SS.
Structure-function relationships in lactate dehydrogenase.
Proc. Natl. Acad. Sci. U. S. A. 70 (1973) 1968-72.
Squalus acanthius |
|---|
Reference
Authors
Title
Journal
|
3
Holbrook, J.J., Liljas, A., Steindel, S.J. and Rossmann, M.G.
Lactate dehydrogenase.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 11, Academic
Press, New York, 1975, p. 191-292. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:114469]
Schar HP, Zuber H.
Structure and function of L-lactate dehydrogenases from thermophilic
and mesophilic bacteria. I) Isolation and characterization of
lactate dehydrogenases from thermophilic and mesophilic bacilli.
Hoppe. Seylers. Z. Physiol. Chem. 360 (1979) 795-807.
Bacillus subtilis [GN:bsu], Bacillus stearothermophilus, Bacillus
caldotenax |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.27
IUBMB Enzyme Nomenclature: 1.1.1.27
ExPASy - ENZYME nomenclature database: 1.1.1.27
BRENDA, the Enzyme Database: 1.1.1.27
CAS: 9001-60-9 |
|---|
