| Entry |
|
|---|
| Name |
isocitrate dehydrogenase (NAD+);
isocitric dehydrogenase;
beta-ketoglutaric-isocitric carboxylase;
isocitric acid dehydrogenase;
NAD dependent isocitrate dehydrogenase;
NAD isocitrate dehydrogenase;
NAD-linked isocitrate dehydrogenase;
NAD-specific isocitrate dehydrogenase;
NAD isocitric dehydrogenase;
isocitrate dehydrogenase (NAD);
IDH (ambiguous);
nicotinamide adenine dinucleotide isocitrate dehydrogenase |
|---|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
|---|
| Sysname |
isocitrate:NAD+ oxidoreductase (decarboxylating) |
|---|
| Reaction(IUBMB) |
isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709] |
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| Reaction(KEGG) |
R00709
 |
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| Substrate |
isocitrate [CPD:C00311];
NAD+ [CPD:C00003] |
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| Product |
2-oxoglutarate [CPD:C00026];
CO2 [CPD:C00011];
NADH [CPD:C00004] |
|---|
| Comment |
Requires Mn2+ or Mg2+ for activity. Unlike EC 1.1.1.42, isocitrate
dehydrogenase (NADP+), oxalosuccinate cannot be used as a substrate.
In eukaryotes, isocitrate dehydrogenase exists in two forms: an
NAD+-linked enzyme found only in mitochondria and displaying
allosteric properties, and a non-allosteric, NADP+-linked enzyme
that is found in both mitochondria and cytoplasm [7]. The enzyme
from some species can also use NADP+ but much more slowly [9]. |
|---|
| Pathway |
PATH: ec00020 Citrate cycle (TCA cycle)
PATH: ec01062 Biosynthesis of terpenoids and steroids
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid
PATH: ec01065 Biosynthesis of alkaloids derived from histidine and
purine
PATH: ec01066 Biosynthesis of alkaloids derived from terpenoid and
polyketide
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00030 isocitrate dehydrogenase (NAD+) |
|---|
| Genes |
HSA: 3419(IDH3A) 3420(IDH3B) 3421(IDH3G)
PTR: 453565(IDH3A) 458048(IDH3B)
MCC: 677715(IDH3A) 698558(IDH3G) 716726
MMU: 15929(Idh3g) 170718(Idh3b) 67834(Idh3a)
RNO: 114096(Idh3a) 25179(Idh3g) 94173(Idh3B)
CFA: 477177(IDH3B) 479066(IDH3A) 481081(IDH3G)
BTA: 282446(IDH3A) 613338(IDH3B) 614145(IDH3G)
SSC: 100157242 733641(IDH3B)
ECB: 100052969 100057896 100060114
MDO: 100012825 100027983
OAA: 100080286 100082669
GGA: 415362(IDH3A) 426573(RCJMB04_9n20)
TGU: 100190682 100224627
XLA: 443821 444419 444551
XTR: 100144949 394979(idh3a) 594985(idh3g)
DRE: 393926(idh3a) 415247 550579
SPU: 578131 587700
DME: Dmel_CG12233(l(1)G0156) Dmel_CG32026 Dmel_CG3483 Dmel_CG5028
Dmel_CG6439
DPO: Dpse_GA11495 Dpse_GA16620 Dpse_GA17474 Dpse_GA18606
Dpse_GA19594
AGA: AgaP_AGAP002192 AgaP_AGAP002728 AgaP_AGAP007786
AAG: AaeL_AAEL000454 AaeL_AAEL010143 AaeL_AAEL010814
AME: 409292 410396
TCA: 657626 658559 662783 662903
CEL: C30F12.7 C37E2.1 F35G12.2 F43G9.1
CBR: CBG03937 CBG12504 CBG16309 CBG18040
BMY: Bm1_13415 Bm1_14945 Bm1_37675
NVE: NEMVE_v1g173016 NEMVE_v1g245762
TAD: TRIADDRAFT_54615 TRIADDRAFT_63943
ATH: AT1G32480 AT2G17130(IDH2) AT3G09810 AT4G35260(IDH1) AT4G35650
AT5G03290
OSA: 4324442(Os01g0276100) 4329858(Os02g0595500)
4336169(Os04g0479200)
PPP: PHYPADRAFT_129687 PHYPADRAFT_133156 PHYPADRAFT_144112
PHYPADRAFT_185348 PHYPADRAFT_193492 PHYPADRAFT_59205
CRE: CHLREDRAFT_196042(IDH1) CHLREDRAFT_196044(IDH2)
CME: CMS272C CMT412C
SCE: YNL037C(IDH1) YOR136W(IDH2)
AGO: AGOS_ADL223W AGOS_AFR137C
KLA: KLLA0E03058g KLLA0F04103g
DHA: DEHA0C11770g DEHA0G06435g
PIC: PICST_42313(IDH2) PICST_91057(IDH1)
VPO: Kpol_1039p35 Kpol_440p12 Kpol_543p8
CAL: CaO19.12289(IDH1) CaO19.13213(IDH2) CaO19.4826(IDH1)
CaO19.5791(IDH2)
CGR: CAGL0G02673g CAGL0I07227g
YLI: YALI0D06303g YALI0E05137g
SPO: SPAC11G7.03(glu3) SPBC902.05c(glu2)
NCR: NCU00775 NCU07697
PAN: PODANSg09844 PODANSg7259
MGR: MGG_01712 MGG_01995
FGR: FG05733.1 FG09580.1
ANI: AN1003.2 AN5790.2
AFM: AFUA_1G12800 AFUA_6G06370
AOR: AO090003000008 AO090012000629
ANG: An08g05580 An18g06760
NFI: NFIA_012760 NFIA_052000
SSL: SS1G_04160 SS1G_09958
BFU: BC1G_00206 BC1G_07285
CNE: CNA04610 CNJ02060
CNB: CNBA4420 CNBJ1400
LBC: LACBIDRAFT_311842 LACBIDRAFT_311861
UMA: UM01328.1 UM01329.1
MGL: MGL_0301 MGL_0302
MBR: MONBRDRAFT_19354 MONBRDRAFT_37916 MONBRDRAFT_6048
DDI: DDB_0231288(idhA) DDB_0231294(idhB)
TET: TTHERM_00344030 TTHERM_00723390
PTM: GSPATT00012691001 GSPATT00013309001 GSPATT00017313001
GSPATT00023050001 GSPATT00025896001
XFA: XF2596
XFT: PD1973
XFM: Xfasm12_2166
XFN: XfasM23_2077
XCC: XCC0967(icd)
XCB: XC_3268
XCA: xccb100_3384(icd1)
XCV: XCV1076
XAC: XAC1046(icd)
XOO: XOO1024(icd)
XOM: XOO_0926
XOP: PXO_02485
SML: Smlt0982
SMT: Smal_0828
SON: SO_1538
SDN: Sden_2561
SFR: Sfri_2779
SAZ: Sama_2423
SBL: Sbal_1368
SBM: Shew185_1354
SBN: Sbal195_1393
SBP: Sbal223_2992
SLO: Shew_2760
SPC: Sputcn32_1286
SSE: Ssed_3318
SPL: Spea_2980
SHE: Shewmr4_2720
SHM: Shewmr7_2791
SHN: Shewana3_2890
SHW: Sputw3181_2820
SHL: Shal_3069
SWD: Swoo_3466
SWP: swp_3606
ILO: IL0861
CPS: CPS_3540
PHA: PSHAb0465
PAT: Patl_3197
AMC: MADE_03050
MCA: MCA3071
AEH: Mlg_0664
CSA: Csal_1434
ABO: ABO_0296(icd)
AHA: AHA_1152
ASA: ASA_3183
REH: H16_B1016(icd3)
BXE: Bxe_C0665
RFR: Rfer_2380 Rfer_2411
VAP: Vapar_4079
HAR: HEAR3270
MMS: mma_3499(idh)
LCH: Lcho_4250
BBA: Bd1264(leuB)
DPS: DP0778
MXA: MXAN_6337
SCL: sce5773(icd1) sce6432(leuB2)
SAT: SYN_01410
MET: M446_0777
GBE: GbCGDNIH1_2050
GDI: GDI_1991
GDJ: Gdia_0214
BHA: BH3159(citC)
BCE: BC4593
BCA: BCE_4724(citC)
BCZ: BCZK4334(citC)
BTK: BT9727_4322(citC)
BTL: BALH_4177(citC)
BCL: ABC2714(citC)
OIH: OB2167(citC)
GKA: GK2735
GTN: GTNG_2659
SAR: SAR1773(citC)
SAS: SAS1622
SAC: SACOL1741(icd)
SAB: SAB1553c(citC)
SAA: SAUSA300_1640(icd)
SAO: SAOUHSC_01801
SAJ: SaurJH9_1751
SAH: SaurJH1_1785
SAE: NWMN_1587(citC)
SER: SERP1257(icd)
LWE: lwe1579(citC)
CAC: CAC0972(citC)
CNO: NT01CX_0139
CDF: CD0834
CBO: CBO0419
CBA: CLB_0452
CBH: CLC_0485
CBL: CLK_3621
CBB: CLD_0324
CBF: CLI_0504
AMT: Amet_1319
ATE: Athe_0525
PTH: PTH_2517(leuB)
DAU: Daud_1038
CHY: CHY_1107
MTA: Moth_0993
CSC: Csac_0751
HOR: Hore_08060
RXY: Rxyl_1297
LIL: LA4067(icd1)
LBJ: LBJ_0210(icdA)
ABA: Acid345_4042
SUS: Acid_7350
SRU: SRU_1677
GAU: GAU_2477(icd)
EMI: Emin_0404
SYW: SYNW0166(icd)
SYG: sync_0214(icd)
CYA: CYA_1467
CYB: CYB_1678
TEL: tlr0302
GVI: gvip428(icd)
PMA: Pro1752(icd)
PMM: PMM1596(icd)
PMT: PMT1935(icd)
PMB: A9601_18051(icd)
PMC: P9515_17831(icd)
PMF: P9303_25761(icd)
PMG: P9301_17881(icd)
PME: NATL1_20451(icd)
CTS: Ctha_2161
DET: DET0450
DEH: cbdb_A408
DEB: DehaBAV1_0427
TPT: Tpet_1602
PMO: Pmob_1706
TYE: THEYE_A1278
MTP: Mthe_0549
 |
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| Structures |
PDB: 3BLV 3BLW 3BLX |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14063317]
HATHAWAY JA, ATKINSON DE.
THE EFFECT OF ADENYLIC ACID ON YEAST NICOTINAMIDE ADENINE
DINUCLEOTIDE ISOCITRATE DEHYDROGENASE, A POSSIBLE METABOLIC CONTROL
MECHANISM.
J. Biol. Chem. 238 (1963) 2875-81.
Acetobacter peroxydans |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14832224]
KORNBERG A, PRICER WE Jr.
Di- and triphosphopyridine nucleotide isocitric dehydrogenases in
yeast.
J. Biol. Chem. 189 (1951) 123-36.
Saccharomyces cerevisiae [GN:sce] |
|---|
Reference
Authors
Title
Journal
|
3
Plaut, G.W.E.
Isocitrate dehydrogenases.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 7, Academic Press, New York, 1963, p. 105-126. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:13152105]
PLAUT GW, SUNG SC.
Diphosphopyridine nucleotide isocitric dehydrogenase from animal
tissues.
J. Biol. Chem. 207 (1954) 305-14.
Cavia porcellus |
|---|
Reference
Authors
Title
Journal
|
5
Ramakrishnan, C.V. and Martin, S.M.
Isocitric dehydrogenase in Aspergillus niger.
Arch. Biochem. Biophys. 55 (1955) 403-407. |
|---|
Reference
Authors
Title
Journal
|
6 [PMID:13925783]
VICKERY HB.
A suggested new nomenclature for the isomers of isocitric acid.
J. Biol. Chem. 237 (1962) 1739-41. |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:8593959]
Camacho ML, Brown RA, Bonete MJ, Danson MJ, Hough DW.
Isocitrate dehydrogenases from Haloferax volcanii and Sulfolobus
solfataricus: enzyme purification, characterisation and N-terminal
sequence.
FEMS. Microbiol. Lett. 134 (1995) 85-90.
Sulfolobus solfataricus [GN:sso], Haloferax volcanii |
|---|
Reference
Authors
Title
Journal
Organism
|
8 [PMID:10601238]
Kim YO, Koh HJ, Kim SH, Jo SH, Huh JW, Jeong KS, Lee IJ, Song BJ,
Huh TL.
Identification and functional characterization of a novel,
tissue-specific NAD(+)-dependent isocitrate dehydrogenase beta
subunit isoform.
J. Biol. Chem. 274 (1999) 36866-75.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
9 [PMID:12204383]
Inoue H, Tamura T, Ehara N, Nishito A, Nakayama Y, Maekawa M, Imada
K, Tanaka H, Inagaki K.
Biochemical and molecular characterization of the NAD(+)-dependent
isocitrate dehydrogenase from the chemolithotroph Acidithiobacillus
thiooxidans.
FEMS. Microbiol. Lett. 214 (2002) 127-32.
Acidithiobacillus thiooxidans |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.1.1.41
IUBMB Enzyme Nomenclature: 1.1.1.41
ExPASy - ENZYME nomenclature database: 1.1.1.41
BRENDA, the Enzyme Database: 1.1.1.41
CAS: 9001-58-5 |
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