| Entry |
|
|---|
| Name |
monophenol monooxygenase;
tyrosinase;
phenolase;
monophenol oxidase;
cresolase;
catechol oxidase;
polyphenolase;
pyrocatechol oxidase;
dopa oxidase;
chlorogenic oxidase;
catecholase;
polyphenol oxidase;
monophenolase;
o-diphenol oxidase;
chlorogenic acid oxidase;
diphenol oxidase;
o-diphenolase;
tyrosine-dopa oxidase;
o-diphenol:oxygen oxidoreductase;
polyaromatic oxidase;
monophenol monooxidase;
o-diphenol oxidoreductase;
monophenol dihydroxyphenylalanine:oxygen oxidoreductase;
N-acetyl-6-hydroxytryptophan oxidase;
monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase;
o-diphenol:O2 oxidoreductase;
phenol oxidase |
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or
reduction of oxygen. The oxygen incorporated need not be derived
from O2;
With another compound as one donor, and incorporation of one atom of
oxygen into the other donor
 |
|---|
| Sysname |
monophenol,L-dopa:oxygen oxidoreductase |
|---|
| Reaction(IUBMB) |
L-tyrosine + L-dopa + O2 = L-dopa + dopaquinone + H2O [RN:R02078] |
|---|
| Reaction(KEGG) |
R02078;
(other) R00058 R00731 R02363 R02383 R02950 R04693 R04884
 |
|---|
| Substrate |
L-tyrosine [CPD:C00082];
L-dopa [CPD:C00355];
O2 [CPD:C00007] |
|---|
| Product |
L-dopa [CPD:C00355];
dopaquinone [CPD:C00822];
H2O [CPD:C00001] |
|---|
| Cofactor |
Copper [CPD:C00070] |
|---|
| Comment |
A group of copper proteins that also catalyse the reaction of EC
1.10.3.1 catechol oxidase, if only 1,2-benzenediols are available as
substrate. |
|---|
| Pathway |
PATH: ec00350 Tyrosine metabolism
PATH: ec00740 Riboflavin metabolism
PATH: ec00950 Isoquinoline alkaloid biosynthesis
PATH: ec00965 Betalain biosynthesis
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00505 tyrosinase |
|---|
| Genes |
HSA: 7299(TYR)
PTR: 451473(TYR)
MCC: 705792(TYR)
MMU: 22173(Tyr)
RNO: 308800(Tyr)
CFA: 403405(TYR)
BTA: 280951(TYR)
SSC: 407745(TYR)
ECB: 100060227
OAA: 100080574
GGA: 373971(TYR)
TGU: 100225893
XTR: 100125152
DRE: 30207(tyr)
DME: Dmel_CG2952(Dox-A3) Dmel_CG5779(Bc)
DPO: Dpse_GA19121
DER: Dere_GG22822(Dere_Dox-A3)
DYA: Dyak_GE14257
CEL: C34G6.2(tyr-4)
NCR: NCU11382
MGR: MGG_06169 MGG_10585
ANI: AN2799.2 AN5311.2
AFM: AFUA_1G17430 AFUA_3G01070
AOR: AO090001000383 AO090010000557 AO090023000424
ANG: An01g09220 An03g00280 An15g07670
PFO: Pfl01_3461
CVI: CV_3262
RSO: RSc1501(mel)
BPM: BURPS1710b_A0806
BTE: BTH_II0649
BUR: Bcep18194_C6986
NEU: NE1241
NMU: Nmul_A2156
RET: RHE_PD00076(melA)
RPB: RPB_2167
NWI: Nwi_0968
NHA: Nham_2941
BCA: BCE_A0211
CEF: CE1756
SCO: SCO2700(melC2)
SMA: SAV_5362(melC1-2)
FRA: Francci3_0237
FAL: FRAAL0531
RXY: Rxyl_1947
SUS: Acid_5081
 |
|---|
| Structures |
PDB: 1WX2 1WX4 1WX5 1WXC 2AHK 2AHL 2ZMX 2ZMY 2ZMZ 2ZWD
2ZWE 2ZWF 2ZWG 3HHS |
|---|
Reference
Authors
Title
Journal
|
1
Dawson, C.R. and Tarpley, W.B.
The copper oxidases.
In: Sumner, J.B. and Myrback, K. (Eds.), The Enzymes, 1st ed., vol.
2, Academic Press, New York, 1951, p. 454-498. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:151279]
Lerch K.
Amino acid sequence of tyrosinase from Neurospora crassa.
Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 3635-9.
Neurospora crassa [GN:ncr] |
|---|
Reference
Authors
Title
Journal
|
3
Malmstrom, B.G., Andreasson, L.-E. and Reinhammar, B.
Copper-containing oxidases and superoxide dismutase.
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 12, Academic
Press, New York, 1975, p. 507-579. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:170916]
McIntyre RJ, Vaughan PF.
Kinetic studies on the hydroxylation of p-coumaric acid to caffeic
acid by spinach-beet phenolase.
Biochem. J. 149 (1975) 447-61.
Beta vulgaris |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:5842066]
Patil SS, Zucker M.
Potato phenolases. Purification and properties.
J. Biol. Chem. 240 (1965) 3938-43.
Solanum tuberosum |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:13972077]
POMERANTZ SH.
Separation, purification, and properties of two tyrosinases from
hamster melanoma.
J. Biol. Chem. 238 (1963) 2351-7.
hamster |
|---|
Reference
Authors
Title
Journal
|
7
Robb, D.A.
`Tyrosinase.
In: Lontie, R. (Ed.), Copper Proteins and Copper Enzymes, vol. 2,
CRC Press, Boca Raton, FL, 1984, p. 207-240. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 1.14.18.1
IUBMB Enzyme Nomenclature: 1.14.18.1
ExPASy - ENZYME nomenclature database: 1.14.18.1
BRENDA, the Enzyme Database: 1.14.18.1
CAS: 9002-10-2 |
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