KEGG   ENZYME: 1.16.3.1Help
Entry
EC 1.16.3.1                 Enzyme                                 
Name ferroxidase;
ceruloplasmin;
ferroxidase I;
iron(II): oxygen oxidoreductase;
caeruloplasmin;
ferro:O2 oxidoreductase;
ferroxidase, iron II:oxygen oxidoreductase
Class Oxidoreductases;
Oxidizing metal ions;
With oxygen as acceptor
BRITE hierarchy
Sysname Fe(II):oxygen oxidoreductase
Reaction(IUBMB) 4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O [RN:R00078]
Reaction(KEGG) R00078
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Substrate Fe(II) [CPD:C14818];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product Fe(III) [CPD:C14819];
H2O [CPD:C00001]
Cofactor Copper [CPD:C00070]
Comment A multi-copper protein: ceruloplasmin from animals, rusticyanin in
Thiobacillus ferroxidans.
Pathway PATH: ec00860  Porphyrin and chlorophyll metabolism
Orthology KO: K00522  ferroxidase
Genes HSA: 1356(CP) 2495(FTH1) 94033(FTMT)
PTR: 471613(FTMT) 738986(FTH1)
MCC: 699743 707011(FTH1) 712210(CP) 714576(FTH1) 718612
MMU: 12870(Cp) 14319(Fth1) 67634(Ftmt)
RNO: 24268(Cp) 25319(Fth1) 291470(Ftmt)
CFA: 403631(FTH1) 442963(CP)
BTA: 281173(FTH1) 514194(CP) 539838(FTMT)
SSC: 100155179 397030(FTH1)
ECB: 100051036(FT) 100058573
MDO: 100017675
OAA: 100077298 100090297
GGA: 395970(FTH1) 771940(CP)
TGU: 100190515 100218872
XLA: 379339 379618(MGC68606) 398724(MGC64558)
XTR: 394820 448718
DRE: 58108(fth1) 84702(cp)
SPU: 586705 591499
DME: Dmel_CG5959
AME: 408663
CEL: D1037.3(ftn-2)
NVE: NEMVE_v1g191126 NEMVE_v1g235103
OLU: OSTLU_6922 OSTLU_7252
NOC: Noc_2612
NET: Neut_0710
NMU: Nmul_A2394
GUR: Gura_2910
GEM: GM21_1700
DVM: DvMF_0183
DSA: Desal_0081
DBA: Dbac_2466
DRT: Dret_0514
FJO: Fjoh_0866
AMU: Amuc_1703
PAA: Paes_0556
RRS: RoseRS_1855
RCA: Rcas_3287
CAU: Caur_3918
CAG: Cagg_3808
CHL: Chy400_4235
TPT: Tpet_1617
TRQ: TRQ2_1683
TME: Tmel_1199
FNO: Fnod_1381
PMO: Pmob_0136
MAE: Maeo_0328
Taxonomy
Structures PDB: 1KCW  2CEI  2CHI  2CIH  2CLU  2CN6  2CN7  2HTN  2IU2  2J5W  
     2WLU  2Z6M  3A68  3A9Q  3BVE  3BVF  3BVI  3BVK  3BVL  3E2C  
     3E6R  3E6S  3EGM  3ERZ  3ES3  
Reference
  Authors
  Title


  Journal
 1
Cox, J.C. and Boxer, D.H.
The role of rusticyanin, a blue copper protein, in the electron
transport chain of Thiobacillus ferrooxidans grown on iron or
thiosulfate.
Biotechnol. Appl. Biochem. 8 (1986) 269-275.
Reference
  Authors
  Title

  Journal
  Organism
 2  [PMID:5925868]
Osaki S.
Kinetic studies of ferrous ion oxidation with crystalline human
ferroxidase (ceruloplasmin).
J. Biol. Chem. 241 (1966) 5053-9.
Homo sapiens [GN:hsa]
Reference
  Authors
  Title


  Journal
  Organism
 3  [PMID:6027241]
Osaki S, Walaas O.
Kinetic studies of ferrous ion oxidation with crystalline human
ferroxidase. II. Rate constants at various steps and formation of a
possible enzyme-substrate complex.
J. Biol. Chem. 242 (1967) 2653-7.
Homo sapiens [GN:hsa]
Other DBs ExplorEnz - The Enzyme Database: 1.16.3.1
IUBMB Enzyme Nomenclature: 1.16.3.1
ExPASy - ENZYME nomenclature database: 1.16.3.1
BRENDA, the Enzyme Database: 1.16.3.1
CAS: 9031-37-2 104404-69-5
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