KEGG   ENZYME: 2.3.3.10Help
Entry
EC 2.3.3.10                 Enzyme                                 
Name hydroxymethylglutaryl-CoA synthase;
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase
(CoA-acetylating);
3-hydroxy-3-methylglutaryl CoA synthetase;
3-hydroxy-3-methylglutaryl coenzyme A synthase;
3-hydroxy-3-methylglutaryl coenzyme A synthetase;
3-hydroxy-3-methylglutaryl-CoA synthase;
3-hydroxy-3-methylglutaryl-coenzyme A synthase;
beta-hydroxy-beta-methylglutaryl-CoA synthase;
HMG-CoA synthase;
acetoacetyl coenzyme A transacetase;
hydroxymethylglutaryl coenzyme A synthase;
hydroxymethylglutaryl coenzyme A-condensing enzyme
Class Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname acetyl-CoA:acetoacetyl-CoA C-acetyltransferase
(thioester-hydrolysing, carboxymethyl-forming)
Reaction(IUBMB) acetyl-CoA + H2O + acetoacetyl-CoA =
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA [RN:R01978]
Reaction(KEGG) R01978
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Substrate acetyl-CoA [CPD:C00024];
H2O [CPD:C00001];
acetoacetyl-CoA [CPD:C00332]
Product (S)-3-hydroxy-3-methylglutaryl-CoA [CPD:C00356];
CoA [CPD:C00010]
Pathway PATH: ec00072  Synthesis and degradation of ketone bodies
PATH: ec00280  Valine, leucine and isoleucine degradation
PATH: ec00650  Butanoate metabolism
PATH: ec00900  Terpenoid backbone biosynthesis
PATH: ec01062  Biosynthesis of terpenoids and steroids
PATH: ec01066  Biosynthesis of alkaloids derived from terpenoid and
               polyketide
PATH: ec01070  Biosynthesis of plant hormones
PATH: ec01100  Metabolic pathways
Orthology KO: K01641  hydroxymethylglutaryl-CoA synthase
Genes HSA: 3157(HMGCS1) 3158(HMGCS2)
PTR: 457169(HMGCS2) 461892(HMGCS1)
MCC: 702553(HMGCS1) 713541(HMGCS2)
MMU: 100040592 15360(Hmgcs2) 208715(Hmgcs1)
RNO: 24450(Hmgcs2) 29637(Hmgcs1)
CFA: 479344(HMGCS1) 607923(HMGCS2)
BTA: 407767(HMGCS1) 503684(HMGCS2)
SSC: 397673(CH242-38B5.1)
ECB: 100059971 100065037(HMGCS1)
MDO: 100012956
OAA: 100075498 100092884
GGA: 396379(HMGCS1) 424380(HMGCS2)
TGU: 100218910 100221293
XLA: 380091(hmgcs1) 447204
XTR: 100145212(hmgcs1)
DRE: 394060(hmgcs1)
CIN: 100175295
SPU: 578259
DME: Dmel_CG4311(Hmgs)
DPO: Dpse_GA18098
DAN: Dana_GF13593
DER: Dere_GG20599
DPE: Dper_GL10732
DSE: Dsec_GM21690
DSI: Dsim_GD11187(Dsim_Hmgs)
DYA: Dyak_GE11785
DGR: Dgri_GH19963
DMO: Dmoj_GI19921
AGA: AgaP_AGAP005847
AAG: AaeL_AAEL005201
CQU: CpipJ_CPIJ002065
AME: 413763
NVI: 100116401
TCA: 662232
API: 100162980
ISC: IscW_ISCW002615
CEL: F25B4.6
CBR: CBG09344
SMM: Smp_195010
NVE: NEMVE_v1g120697
HMG: 100205655
TAD: TRIADDRAFT_27878
ATH: AT4G11820(MVA1)
POP: POPTR_548531 POPTR_646543
RCU: RCOM_1683050
VVI: 100244379(GSVIVT00001077001)
OSA: 4331418(Os03g0118800) 4347614(Os09g0521400)
SBI: SORBI_01g049310(SORBIDRAFT_01g049310)
     SORBI_07g025240(SORBIDRAFT_07g025240)
ZMA: 100272824(pco130633) 100285783
PPP: PHYPADRAFT_107354 PHYPADRAFT_219750
CRE: CHLREDRAFT_118594
CME: CMM189C
SCE: YML126C(ERG13)
AGO: AGOS_ADL356C
KLA: KLLA0D10505g
LTH: KLTH0E16192g
DHA: DEHA0A03399g
PIC: PICST_83020
PPA: PAS_chr2-1_0191
VPO: Kpol_541p22
LEL: LELG_05375
ZRO: ZYRO0A00770g
CAL: CaO19.7312(ERG13)
CTP: CTRG_05936
CDU: CD36_34550
CGR: CAGL0H04081g
YLI: YALI0F30481g
SPO: SPAC4F8.14c(hcs)
NCR: NCU03922
PAN: PODANSg3027
MGR: MGG_01026
FGR: FG09266.1
ANI: AN4923.2
AFM: AFUA_3G10660 AFUA_8G07210
AOR: AO090003000611 AO090010000487
ANG: An02g06320
AFV: AFLA_032030 AFLA_119710
PCS: Pc12g01730 Pc18g01450
NFI: NFIA_066630 NFIA_100020
CIM: CIMG_03635
URE: UREG_07400
SSL: SS1G_14433
BFU: BC1G_09652
CNE: CNC05080 CNG02670
CNB: CNBC2090 CNBG2100
LBC: LACBIDRAFT_182480 LACBIDRAFT_239957 LACBIDRAFT_254737
MPR: MPER_08619
UMA: UM05362.1
MGL: MGL_2838
ECU: ECU10_0510
MBR: MONBRDRAFT_11388
DDI: DDBDRAFT_0217522 DDB_0219924(hgsA)
TET: TTHERM_00691190
TBR: Tb927.8.6110
GLA: GL50803_13962
TVA: TVAG_304570 TVAG_438940
PTI: PHATRDRAFT_16649
TPS: THAPSDRAFT_260768(HMCS1)
YPE: YPO1457
YPK: y2712(pksG)
YPM: YP_1349(pksG)
YPA: YPA_0750
YPN: YPN_2521
YPG: YpAngola_A2969
YPP: YPDSF_1517
YPS: YPTB1475
YPI: YpsIP31758_2518
YPY: YPK_2608
YPB: YPTS_1582
DDA: Dd703_1418
TTU: TERTU_3251
CBD: CBUD_1931
TCX: Tcr_1719
DNO: DNO_0799
BMA: BMAA1212
BPS: BPSS1002
BPM: BURPS1710b_A2613
BPL: BURPS1106A_A1384
BPD: BURPS668_A1470
BTE: BTH_II1670
MXA: MXAN_3948(tac) MXAN_4267(mvaS)
SCL: sce3181 sce6394
HOH: Hoch_1179 Hoch_4396
LAS: CLIBASIA_04605
MNO: Mnod_8252
BSU: BSU17150(pksG)
BAY: RBAM_016950(baeG)
OIH: OB2248
SAU: SA2334(mvaS)
SAV: SAV2546(mvaS)
SAW: SAHV_2530(mvaS)
SAM: MW2467(mvaS)
SAR: SAR2626(mvaS)
SAS: SAS2432
SAC: SACOL2561
SAB: SAB2420(mvaS)
SAA: SAUSA300_2484
SAX: USA300HOU_2540(mvaS)
SAO: SAOUHSC_02860
SAJ: SaurJH9_2569
SAH: SaurJH1_2622
SAE: NWMN_2446(mvaS)
SAD: SAAV_2612
SEP: SE2110
SER: SERP2122
SHA: SH0508(mvaS)
SSP: SSP0324
SCA: Sca_1885(mvaS)
LMO: lmo1415
LMF: LMOf2365_1434(mvaS)
LMH: LMHCC_1153
LMC: Lm4b_01424
LIN: lin1454
LWE: lwe1432(mvaS)
LLA: L13187(hmcM)
LLK: LLKF_1696(hmcM)
LLC: LACR_1666
LLM: llmg_0929(hmcM)
SPY: SPy_0881(mvaS.2)
SPZ: M5005_Spy_0687(mvaS.1)
SPM: spyM18_0942(mvaS2)
SPG: SpyM3_0600(mvaS.2)
SPS: SPs1253
SPH: MGAS10270_Spy0745(mvaS1)
SPI: MGAS10750_Spy0779(mvaS1)
SPJ: MGAS2096_Spy0759(mvaS1)
SPK: MGAS9429_Spy0743(mvaS1)
SPF: SpyM51121(mvaS)
SPA: M6_Spy0704
SPB: M28_Spy0667(mvaS.1)
SOZ: Spy49_0695c(mvaS2)
SPN: SP_1727
SPD: SPD_1537(mvaS)
SPR: spr1571(mvaS)
SPW: SPCG_1699(mvaS)
SPX: SPG_1632(mvaS)
SNE: SPN23F_17280(mvaS)
SPV: SPH_1836
SNM: SP70585_1766
SJJ: SPJ_1622
SPP: SPP_1744
SNT: SPT_1665
SAG: SAG1316
SAN: gbs1386
SAK: SAK_1347
SMU: SMU.943c
STC: str0577(mvaS)
STL: stu0577(mvaS)
STE: STER_0621
SSA: SSA_0338(mvaS)
SSU: SSU05_1641
SSV: SSU98_1652
SSB: SSUBM407_1529(mvaS)
SSI: SSU1453(mvaS)
SSS: SSUSC84_1482(mvaS)
SGO: SGO_0244
SEQ: SZO_08880
SEZ: Sez_1079
SEU: SEQ_1109
SUB: SUB0770(mvaS)
SDS: SDEG_0843(mvaS2)
LPL: lp_2067(mvaS)
LPJ: JDM1_1727(mvaS)
LJO: LJ1607
LJF: FI9785_1398(mvaS)
LAC: LBA0628(hmcS)
LSA: LSA1484(mvaS)
LSL: LSL_0526
LDB: Ldb0881(mvaS)
LBU: LBUL_0806
LBR: LVIS_1363
LCA: LSEI_1785
LCB: LCABL_20030(mvaS)
LGA: LGAS_1372
LRE: Lreu_0676
LRF: LAR_0649
LHE: lhv_0663
LFE: LAF_0707
LRH: LGG_01837(mvaS)
LRL: LC705_01820(mvaS)
PPE: PEPE_0868
EFA: EF1363
OOE: OEOE_0968
LME: LEUM_1184
LCI: LCK_00976(mvaS)
ACL: ACL_0224(pksG)
MMI: MMAR_3213(pksG)
CKP: ckrop_0032(mvaS)
NFA: nfa22120
SEN: SACE_4570(pksG)
CAI: Caci_2595
BBU: BB0683
BBZ: BbuZS7_0703
BGA: BG0706
BAF: BAPKO_0727
BTU: BT0683
BHR: BH0683
BDU: BDU_686
BRE: BRE_689
CPI: Cpin_5295
FJO: Fjoh_0678
LBA: Lebu_0852
SMF: Smon_1291
CYN: Cyan7425_2884
NPU: Npun_F3165
HAL: VNG1615G(mvaB)
HSL: OE3296F(mvaB)
HMA: rrnAC1740(mvaS)
HWA: HQ2868A(mvaB)
NPH: NP2608A(mvaB_1) NP4836A(mvaB_2)
HLA: Hlac_2313
HUT: Huta_2766
HMU: Hmuk_1739
NMR: Nmar_0828
Taxonomy
Structures PDB: 1XPK  1XPL  1XPM  2P8U  2WYA  
Reference
  Authors
  Title
  Journal
  Organism
 1  [PMID:13449080]
RUDNEY H.
The biosynthesis of beta-hydroxy-beta-methylglutaric acid.
J. Biol. Chem. 227 (1957) 363-77.
Rattus norvegicus [GN:rno]
Other DBs ExplorEnz - The Enzyme Database: 2.3.3.10
IUBMB Enzyme Nomenclature: 2.3.3.10
ExPASy - ENZYME nomenclature database: 2.3.3.10
BRENDA, the Enzyme Database: 2.3.3.10
CAS: 9027-44-5
DBGET integrated database retrieval system