KEGG   ENZYME: 2.4.1.17Help
Entry
EC 2.4.1.17                 Enzyme                                 

Name
glucuronosyltransferase;
1-naphthol glucuronyltransferase;
1-naphthol-UDP-glucuronosyltransferase;
17beta-hydroxysteroid UDP-glucuronosyltransferase;
3alpha-hydroxysteroid UDP-glucuronosyltransferase;
4-hydroxybiphenyl UDP-glucuronosyltransferase;
4-methylumbelliferone UDP-glucuronosyltransferase;
4-nitrophenol UDP-glucuronyltransferase;
4-nitrophenol UDPGT;
17-OH steroid UDPGT;
3-OH androgenic UDPGT;
bilirubin uridine diphosphoglucuronyltransferase;
bilirubin UDP-glucuronosyltransferase;
bilirubin monoglucuronide glucuronyltransferase;
bilirubin UDPGT;
bilirubin glucuronyltransferase;
ciramadol UDP-glucuronyltransferase;
estriol UDP-glucuronosyltransferase;
estrone UDP-glucuronosyltransferase;
uridine diphosphoglucuronosyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase;
uridine diphosphoglucuronate-estriol glucuronosyltransferase;
uridine diphosphoglucuronate-estradiol glucuronosyltransferase;
uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase;
uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase;
uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase;
uridine diphosphoglucuronosyltransferase;
GT;
morphine glucuronyltransferase;
p-hydroxybiphenyl UDP glucuronyltransferase;
p-nitrophenol UDP-glucuronosyltransferase;
p-nitrophenol UDP-glucuronyltransferase;
p-nitrophenylglucuronosyltransferase;
p-phenylphenol glucuronyltransferase;
phenyl-UDP-glucuronosyltransferase;
PNP-UDPGT;
UDP glucuronate-estradiol-glucuronosyltransferase;
UDP glucuronosyltransferase;
UDP glucuronate-estriol glucuronosyltransferase;
UDP glucuronic acid transferase;
UDP glucuronyltransferase;
UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase;
UDP-glucuronate-bilirubin glucuronyltransferase;
UDP-glucuronosyltransferase;
UDP-glucuronyltransferase;
UDPGA transferase;
UDPGA-glucuronyltransferase;
UDPGT;
uridine diphosphoglucuronyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase;
uridine diphosphate glucuronyltransferase;
uridine 5'-diphosphoglucuronyltransferase;
uridine diphosphoglucuronosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
Reaction(IUBMB)
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside [RN:R09428]
Reaction(KEGG)
Substrate
UDP-glucuronate [CPD:C00167];
acceptor [CPD:C00028]
Product
UDP [CPD:C00015];
acceptor beta-D-glucuronoside [CPD:C19646]
Comment
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
History
EC 2.4.1.17 created 1961 (EC 2.4.1.42, EC 2.4.1.59 and EC 2.4.1.61 all created 1972; EC 2.4.1.76, EC 2.4.1.77 and EC 2.4.1.84 all created 1976; EC 2.4.1.107 and EC 2.4.1.108 both created 1983, all incorporated 1984)
Pathway
Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Steroid hormone biosynthesis
Starch and sucrose metabolism
Retinol metabolism
Porphyrin and chlorophyll metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Orthology
K00699  
glucuronosyltransferase
Genes
HSA: 
10720(UGT2B11) 10941(UGT2A1) 54490(UGT2B28) 54575(UGT1A10) 54576(UGT1A8) 54577(UGT1A7) 54578(UGT1A6) 54579(UGT1A5) 54600(UGT1A9) 54657(UGT1A4) 54658(UGT1A1) 54659(UGT1A3) 574537(UGT2A2) 7363(UGT2B4) 7364(UGT2B7) 7365(UGT2B10) 7366(UGT2B15) 7367(UGT2B17) 79799(UGT2A3)
PTR: 
100611992(UGT2B11) 461285(UGT2B4) 461287(UGT2B10) 461289(UGT2B15) 471217(UGT2B28) 471218(UGT2B7) 471219(UGT2B28) 471220(UGT2A3) 739942(UGT1A6) 742890(UGT2A1) 743607(UGT2B17)
PPS: 
GGO: 
PON: 
100171521(UGT2B7) 100172533(UGT1A3) 100172560(UGT1A6) 100173720(UGT1A9) 100174202(UGT2A3) 100441531(UGT2B10) 100444573 100445423 100446928(UGT2B4) 100447782(UGT2A1) 100460599(UGT2B17)
MCC: 
100427327 574147(UGT2B33) 574210(UGT1A1) 613249(UGT2B9*2) 709132(UGT2B4) 709234(UGT2B4) 709420(UGT2A3) 710412(UGT2B15)
MCF: 
102121904(UGT2A1) 102122035(UGT1A9) 102123935 102124844(UGT2A3) 102125239(UGT2B23) 102126139(mfUGT2B33) 102127013 102127901(UGT2B9) 102128580(UGT2B20)
MMU: 
100559(Ugt2b38) 100727(Ugt2b34) 112417(Ugt2b37) 22236(Ugt1a2) 22238(Ugt2b5) 231396(Ugt2b36) 243085(Ugt2b35) 394430(Ugt1a10) 394432(Ugt1a7c) 394433(Ugt1a5) 394434(Ugt1a9) 394435(Ugt1a6b) 394436(Ugt1a1) 552899(Ugt2a2) 71773(Ugt2b1) 72094(Ugt2a3) 94215(Ugt2a1) 94284(Ugt1a6a)
RNO: 
113992(Ugt1a6) 154516(Ugt1a7c) 24861(Ugt1a1) 24862(Ugt2b) 266685(Ugt2b17) 286954(Ugt2b1) 286989(Ugt2b7) 289533(Ugt2a3) 29623(Ugt2b37) 301595(Ugt1a8) 305264(Ugt2b10) 396527(Ugt1a2) 396551(Ugt1a3) 396552(Ugt1a9) 501907(RGD1559459) 574523(Ugt1a5) 63867(Ugt2a1) 83808(Ugt2b15)
CGE: 
HGL: 
TUP: 
CFA: 
100686607 100856068 100856129 403629(UGT1A6) 442984(UGT2B31) 475163(UGT2A1) 480777(UGT2B4) 482178 608760(UGT2B4)
AML: 
FCA: 
101087059(UGT2A2) 101087662 101098790 493955(UGT1A1) 494146(UGT1A)
PTG: 
BTA: 
100138004(UGT2B11) 100138908 100140261 100296421 286792(UGT1A6) 511743(UGT2A3) 515638(MGC152010) 530553 533587(UGT2B10) 540615(UGT2B17) 615303(UGT2B4) 751790(UGT1A1) 781478
BOM: 
PHD: 
CHX: 
SSC: 
CFR: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
100857136 422660(UGT2A3) 424028(UGT1A1)
MGP: 
TGU: 
FAB: 
PHI: 
APLA: 
FPG: 
101923845(UGT1A1) 101924619(UGT2A1)
FCH: 
CLV: 
102089270(UGT2A1) 102092009(UGT1A8) 102095474
ASN: 
PSS: 
102443979(UGT1A6) 102460451(UGT2A1)
CMY: 
ACS: 
XTR: 
100135191(ugt1a6) 100489505 447975(ugt2a1)
DRE: 
100002369 100006320(ugt2a1) 100148803 406731(ugt1ab) 553952(ugt2a2) 570913(ugt5g1) 571561 641488(ugt1a1) 792506
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
BFO: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408788(GB16747) 411021(GB12751)
NVI: 
TCA: 
BMOR: 
100862804(UGT33D6) 100862817(UGT42A1) 100862818(UGT42A2) 100862823(UGT47A1) 100862830(UGT39B1) 100862832(UGT46A1) 100862841(UGT33D7) 101739741(UGT42B1)
API: 
PHU: 
CEL: 
CELE_B0310.5(ugt-46) CELE_C17G1.3(ugt-23) CELE_C18C4.3(ugt-48) CELE_F35H8.6(ugt-58) CELE_F39G3.1(ugt-61) CELE_M88.1(ugt-62) CELE_T04H1.7(ugt-55) CELE_T04H1.8(ugt-56) CELE_T07C5.1(ugt-50)
CBR: 
CBG00090(Cbr-ugt-50) CBG00954(Cbr-ugt-58) CBG09373(Cbr-ugt-48) CBG17190(Cbr-ugt-46) CBG18047(Cbr-ugt-62) CBG23424(Cbr-ugt-56)
BMY: 
LOA: 
TSP: 
NVE: 
TAD: 
SLY: 
CSL: 
 » show all
Taxonomy
Reference
1  [PMID:6404284]
  Authors
Bock KW, Burchell B, Dutton GJ, Hanninen O, Mulder GJ, Owens IS, Siest G, Tephly TR.
  Title
UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions.
  Journal
Biochem. Pharmacol. 32 (1983) 953-5.
  Organism
Rattus norvegicus, Oryctolagus cuniculus
Reference
2  [PMID:111930]
  Authors
Bock KW, Josting D, Lilienblum W, Pfeil H.
  Title
Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital.
  Journal
Eur. J. Biochem. 98 (1979) 19-26.
  Organism
Rattus norvegicus
Reference
3
  Authors
Burchell, B.
  Title
Identification and purification of multiple forms of UDP-glucuronosyltransferase.
  Journal
Rev. Biochem. Toxicol. 3 (1981) 1-32.
Reference
4
  Authors
Dutton, G.J.
  Title
Glucuronidation of Drugs and Other Compounds, C.R.C. Press, Boca Raton, Florida, 1980.
Reference
5  [PMID:3931633]
  Authors
Green MD, Falany CN, Kirkpatrick RB, Tephly TR.
  Title
Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase.
  Journal
Biochem. J. 230 (1985) 403-9.
  Organism
Rattus norvegicus
Reference
6
  Authors
Jansen, P.L.M.
  Title
The enzyme-catalyzed formation of bilirubin diglucuronide by a solublized preparation from cat liver microsomes.
  Journal
Biochim. Biophys. Acta 338 (1974) 170-182.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-08-4

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