KEGG   ENZYME: 2.4.1.17Help
Entry
EC 2.4.1.17                 Enzyme                                 
Name
glucuronosyltransferase;
1-naphthol glucuronyltransferase;
1-naphthol-UDP-glucuronosyltransferase;
17beta-hydroxysteroid UDP-glucuronosyltransferase;
3alpha-hydroxysteroid UDP-glucuronosyltransferase;
4-hydroxybiphenyl UDP-glucuronosyltransferase;
4-methylumbelliferone UDP-glucuronosyltransferase;
4-nitrophenol UDP-glucuronyltransferase;
4-nitrophenol UDPGT;
17-OH steroid UDPGT;
3-OH androgenic UDPGT;
bilirubin uridine diphosphoglucuronyltransferase;
bilirubin UDP-glucuronosyltransferase;
bilirubin monoglucuronide glucuronyltransferase;
bilirubin UDPGT;
bilirubin glucuronyltransferase;
ciramadol UDP-glucuronyltransferase;
estriol UDP-glucuronosyltransferase;
estrone UDP-glucuronosyltransferase;
uridine diphosphoglucuronosyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase;
uridine diphosphoglucuronate-estriol glucuronosyltransferase;
uridine diphosphoglucuronate-estradiol glucuronosyltransferase;
uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase;
uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase;
uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase;
uridine diphosphoglucuronosyltransferase;
GT;
morphine glucuronyltransferase;
p-hydroxybiphenyl UDP glucuronyltransferase;
p-nitrophenol UDP-glucuronosyltransferase;
p-nitrophenol UDP-glucuronyltransferase;
p-nitrophenylglucuronosyltransferase;
p-phenylphenol glucuronyltransferase;
phenyl-UDP-glucuronosyltransferase;
PNP-UDPGT;
UDP glucuronate-estradiol-glucuronosyltransferase;
UDP glucuronosyltransferase;
UDP glucuronate-estriol glucuronosyltransferase;
UDP glucuronic acid transferase;
UDP glucuronyltransferase;
UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase;
UDP-glucuronate-bilirubin glucuronyltransferase;
UDP-glucuronosyltransferase;
UDP-glucuronyltransferase;
UDPGA transferase;
UDPGA-glucuronyltransferase;
UDPGT;
uridine diphosphoglucuronyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase;
uridine diphosphate glucuronyltransferase;
uridine 5'-diphosphoglucuronyltransferase;
uridine diphosphoglucuronosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
Reaction(IUBMB)
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside [RN:R09428]
Reaction(KEGG)
Substrate
UDP-glucuronate [CPD:C00167];
acceptor [CPD:C00028]
Product
UDP [CPD:C00015];
acceptor beta-D-glucuronoside [CPD:C19646]
Comment
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
Pathway
Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Steroid hormone biosynthesis
Starch and sucrose metabolism
Retinol metabolism
Porphyrin and chlorophyll metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Orthology
K00699  
glucuronosyltransferase
Genes
HSA: 
10720(UGT2B11) 10941(UGT2A1) 54490(UGT2B28) 54575(UGT1A10) 54576(UGT1A8) 54577(UGT1A7) 54578(UGT1A6) 54579(UGT1A5) 54600(UGT1A9) 54657(UGT1A4) 54658(UGT1A1) 54659(UGT1A3) 574537(UGT2A2) 7363(UGT2B4) 7364(UGT2B7) 7365(UGT2B10) 7366(UGT2B15) 7367(UGT2B17) 79799(UGT2A3)
PTR: 
100611992(UGT2B11) 461285(UGT2B4) 461287(UGT2B10) 461289(UGT2B15) 471217(UGT2B28) 471218(UGT2B7) 471219(UGT2B28) 471220(UGT2A3) 739942(UGT1A6) 742890(UGT2A1) 743607(UGT2B17)
PPS: 
GGO: 
PON: 
100171521(UGT2B7) 100172533(UGT1A3) 100172560(UGT1A6) 100173720(UGT1A9) 100174202(UGT2A3) 100441531(UGT2B10) 100444573 100445423 100446928(UGT2B4) 100447782(UGT2A1) 100460599(UGT2B17)
MCC: 
100427327 574147(UGT2B33) 574210(UGT1A1) 613249(UGT2B9*2) 709132(UGT2B4) 709234(UGT2B4) 709420(UGT2A3) 710412(UGT2B15)
MMU: 
100559(Ugt2b38) 100727(Ugt2b34) 112417(Ugt2b37) 22236(Ugt1a2) 22238(Ugt2b5) 231396(Ugt2b36) 243085(Ugt2b35) 394430(Ugt1a10) 394432(Ugt1a7c) 394433(Ugt1a5) 394434(Ugt1a9) 394435(Ugt1a6b) 394436(Ugt1a1) 552899(Ugt2a2) 71773(Ugt2b1) 72094(Ugt2a3) 94215(Ugt2a1) 94284(Ugt1a6a)
RNO: 
113992(Ugt1a6) 154516(Ugt1a7c) 24861(Ugt1a1) 24862(Ugt2b) 266685(Ugt2b17) 286954(Ugt2b1) 286989(Ugt2b7) 289533(Ugt2a3) 29623(Ugt2b37) 301595(Ugt1a8) 305264(Ugt2b10) 396527(Ugt1a2) 396551(Ugt1a3) 396552(Ugt1a9) 501907(RGD1559459) 574523(Ugt1a5) 63867(Ugt2a1) 83808(Ugt2b15)
CFA: 
100686607 100856068 100856129 403629(UGT1A6) 442984(UGT2B31) 475163(UGT2A2) 480777(UGT2B4) 482178 608760(UGT2B4)
AML: 
FCA: 
101087059(UGT2A2) 101087662 101098790 493955(UGT1A1) 494146(UGT1A)
BTA: 
100138004(UGT2B11) 100138908 100140261 100296421 286792(UGT1A6) 511743(UGT2A3) 515638(MGC152010) 530553 533587(UGT2B10) 540615(UGT2B17) 615303(UGT2B4) 751790(UGT1A1)
SSC: 
100152603 100511479(UGT1A1) 100511841(UGT1A3) 100513872(UGT2B4) 100514063(UGT2B31) 100515394 100515741 100516628 100623255 100624700 100624788(UGT2A1) 100738495
ECB: 
100065342(UGT1A1) 100066444 100066472 100068122 100068176(UGT2A2) 100146977
MDO: 
100010818(UGT2B17) 100025642
SHR: 
100914496 100919527
OAA: 
100079726 100081856
GGA: 
100857136 422660(UGT2A3) 424028(UGT1A1)
MGP: 
100549312
TGU: 
100226418 100229734(UGT1A1)
ACS: 
100552049 100566309
XTR: 
100135191(ugt1a6) 100489505 447975(ugt2a1)
DRE: 
100002369 100006320(ugt2a1) 100148803 406731(ugt1ab) 553952(ugt2a2) 570913(ugt5g1) 641488(ugt1a1) 792506
TRU: 
101071470 101071697 101076616 101079875
OLA: 
100125517 101159946 101172907
BFO: 
BRAFLDRAFT_124872 BRAFLDRAFT_220053 BRAFLDRAFT_63761 BRAFLDRAFT_63938 BRAFLDRAFT_79157 BRAFLDRAFT_83810
SPU: 
578573 578628 592078 592958 593427 764059
DME: 
Dmel_CG10178 Dmel_CG11012(Ugt37a1) Dmel_CG11289 Dmel_CG13270(Ugt36Ba) Dmel_CG13271(Ugt36Bb) Dmel_CG15661 Dmel_CG15902(Ugt86Dj) Dmel_CG17200(Ugt86Dg) Dmel_CG17323 Dmel_CG17932(Ugt36Bc) Dmel_CG31002 Dmel_CG3797 Dmel_CG4302 Dmel_CG4414(Ugt58Fa) Dmel_CG4772(Ugt86Dh) Dmel_CG5724 Dmel_CG5999 Dmel_CG6475 Dmel_CG6633(Ugt86Dd) Dmel_CG6644(Ugt35a) Dmel_CG6649(Ugt35b) Dmel_CG6653(Ugt86De) Dmel_CG6658(Ugt86Di) Dmel_CG8652(Ugt37c1) Dmel_CG9481(Ugt37b1)
DPO: 
Dpse_GA10135 Dpse_GA12161 Dpse_GA12162 Dpse_GA13878 Dpse_GA14014 Dpse_GA14457 Dpse_GA17692 Dpse_GA18094 Dpse_GA18421 Dpse_GA19741 Dpse_GA19749 Dpse_GA19751 Dpse_GA19758 Dpse_GA21820(Dpse_Ugt37b1) Dpse_GA25796 Dpse_GA26099 Dpse_GA26172 Dpse_GA27741 Dpse_GA28017
DAN: 
Dana_GF10786 Dana_GF12115 Dana_GF12116 Dana_GF13005 Dana_GF14965 Dana_GF15058 Dana_GF15362 Dana_GF15363 Dana_GF15366 Dana_GF15420 Dana_GF15747 Dana_GF16729 Dana_GF16734 Dana_GF18259 Dana_GF18260 Dana_GF18261 Dana_GF18262 Dana_GF19938 Dana_GF20787
DER: 
Dere_GG10462 Dere_GG11869 Dere_GG13430 Dere_GG14517 Dere_GG17242 Dere_GG17243 Dere_GG17244 Dere_GG17245 Dere_GG17248 Dere_GG17925 Dere_GG19225 Dere_GG20794 Dere_GG20795 Dere_GG21117 Dere_GG21135 Dere_GG21777 Dere_GG22773 Dere_GG22774
DPE: 
Dper_GL10763 Dper_GL12042 Dper_GL12043 Dper_GL12044 Dper_GL12045 Dper_GL12048 Dper_GL12561 Dper_GL14109 Dper_GL14477 Dper_GL18787 Dper_GL18788 Dper_GL18789 Dper_GL19444 Dper_GL19446 Dper_GL21944 Dper_GL25510 Dper_GL26283
DSE: 
Dsec_GM11008 Dsec_GM12089 Dsec_GM14898 Dsec_GM15628 Dsec_GM15739 Dsec_GM15740 Dsec_GM16333 Dsec_GM17207 Dsec_GM17209 Dsec_GM17278 Dsec_GM17296 Dsec_GM18614 Dsec_GM20028 Dsec_GM23331 Dsec_GM23921 Dsec_GM26122 Dsec_GM26123 Dsec_GM26124 Dsec_GM26133
DSI: 
Dsim_GD12307 Dsim_GD16447 Dsim_GD18734 Dsim_GD20543 Dsim_GD20680 Dsim_GD20681 Dsim_GD20682 Dsim_GD20684 Dsim_GD20686 Dsim_GD21706 Dsim_GD23396 Dsim_GD23454 Dsim_GD24083 Dsim_GD24084 Dsim_GD24159 Dsim_GD25117 Dsim_GD25217 Dsim_GD25218 Dsim_GD25513
DWI: 
Dwil_GK12526 Dwil_GK13275 Dwil_GK13276 Dwil_GK13277 Dwil_GK13278 Dwil_GK13279 Dwil_GK14001 Dwil_GK14003 Dwil_GK14004 Dwil_GK14592 Dwil_GK14593 Dwil_GK14742 Dwil_GK14743 Dwil_GK15553 Dwil_GK15803 Dwil_GK15804 Dwil_GK18234 Dwil_GK18235 Dwil_GK18237 Dwil_GK21429 Dwil_GK24294
DYA: 
Dyak_GE11852 Dyak_GE12597 Dyak_GE12767 Dyak_GE12768 Dyak_GE12769 Dyak_GE13191 Dyak_GE13209(Dyak_lola) Dyak_GE13731 Dyak_GE13732 Dyak_GE13734 Dyak_GE13736 Dyak_GE14033 Dyak_GE14406 Dyak_GE22527 Dyak_GE23318 Dyak_GE24489 Dyak_GE24642 Dyak_GE24644 Dyak_GE24645 Dyak_GE24646 Dyak_GE24647 Dyak_GE24648 Dyak_GE24650 Dyak_GE24978 Dyak_GE26074 Dyak_GE26221
DGR: 
Dgri_GH10101 Dgri_GH10546 Dgri_GH10731 Dgri_GH11213 Dgri_GH11566 Dgri_GH11567 Dgri_GH11568 Dgri_GH16953 Dgri_GH18172 Dgri_GH18173 Dgri_GH18740 Dgri_GH19421 Dgri_GH19422 Dgri_GH19423 Dgri_GH20035 Dgri_GH20036 Dgri_GH20037 Dgri_GH20333 Dgri_GH20997
DMO: 
Dmoj_GI10122 Dmoj_GI10820 Dmoj_GI11811 Dmoj_GI14134 Dmoj_GI14390 Dmoj_GI17057 Dmoj_GI17058 Dmoj_GI17059 Dmoj_GI17523 Dmoj_GI19212 Dmoj_GI19214 Dmoj_GI20004 Dmoj_GI20943 Dmoj_GI20954 Dmoj_GI20965 Dmoj_GI22626 Dmoj_GI22627 Dmoj_GI22628 Dmoj_GI22630
DVI: 
Dvir_GJ12718 Dvir_GJ13515 Dvir_GJ14419 Dvir_GJ15376 Dvir_GJ16260 Dvir_GJ17307 Dvir_GJ17308 Dvir_GJ17311 Dvir_GJ17764 Dvir_GJ19920 Dvir_GJ19931 Dvir_GJ20282 Dvir_GJ20283 Dvir_GJ21253 Dvir_GJ23344 Dvir_GJ23345 Dvir_GJ23872 Dvir_GJ23873 Dvir_GJ23874 Dvir_GJ23875
AGA: 
AgaP_AGAP007374 AgaP_AGAP007920 AgaP_AGAP008401
AAG: 
AaeL_AAEL001804 AaeL_AAEL002688 AaeL_AAEL014244 AaeL_AAEL014246
CQU: 
CpipJ_CPIJ000351 CpipJ_CPIJ004369 CpipJ_CPIJ010762
AME: 
408788 409304 411021
NVI: 
100119652(NV18225) 100120053(NV18591) 100121977(NV14936) 100123458(NV12051)
TCA: 
658932 660290 660678 661117 661172 661391
API: 
100160142 100160202 100160324 100160380 100160783 100161224 100161787 100163870 100164169 100166729 100169323 100169551
PHU: 
Phum_PHUM177490 Phum_PHUM313730
CEL: 
CELE_B0310.5(ugt-46) CELE_C17G1.3(ugt-23) CELE_C18C4.3(ugt-48) CELE_F35H8.6(ugt-58) CELE_F39G3.1(ugt-61) CELE_M88.1(ugt-62) CELE_T04H1.7(ugt-55) CELE_T04H1.8(ugt-56) CELE_T07C5.1(ugt-50)
CBR: 
CBG00090(Cbr-ugt-50) CBG00954(Cbr-ugt-58) CBG09373(Cbr-ugt-48) CBG17190(Cbr-ugt-46) CBG18047(Cbr-ugt-62) CBG23424(Cbr-ugt-56)
BMY: 
Bm1_13480
TSP: 
Tsp_08871
NVE: 
NEMVE_v1g122091
TAD: 
TRIADDRAFT_54143 TRIADDRAFT_54724 TRIADDRAFT_54725
 » show all
Taxonomy
Reference
1  [PMID:6404284]
  Authors
Bock KW, Burchell B, Dutton GJ, Hanninen O, Mulder GJ, Owens IS, Siest G, Tephly TR.
  Title
UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions.
  Journal
Biochem. Pharmacol. 32 (1983) 953-5.
  Organism
Rattus norvegicus [GN:rno], Oryctolagus cuniculus
Reference
2  [PMID:111930]
  Authors
Bock KW, Josting D, Lilienblum W, Pfeil H.
  Title
Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital.
  Journal
Eur. J. Biochem. 98 (1979) 19-26.
  Organism
Rattus norvegicus [GN:rno]
Reference
3
  Authors
Burchell, B.
  Title
Identification and purification of multiple forms of UDP-glucuronosyltransferase.
  Journal
Rev. Biochem. Toxicol. 3 (1981) 1-32.
Reference
4
  Authors
Dutton, G.J.
  Title
Glucuronidation of Drugs and Other Compounds, C.R.C. Press, Boca Raton, Florida, 1980.
Reference
5  [PMID:3931633]
  Authors
Green MD, Falany CN, Kirkpatrick RB, Tephly TR.
  Title
Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase.
  Journal
Biochem. J. 230 (1985) 403-9.
  Organism
Rattus norvegicus [GN:rno]
Reference
6
  Authors
Jansen, P.L.M.
  Title
The enzyme-catalyzed formation of bilirubin diglucuronide by a solublized preparation from cat liver microsomes.
  Journal
Biochim. Biophys. Acta 338 (1974) 170-182.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-08-4
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