| Entry |
|
|---|
| Name |
glucuronosyltransferase;
1-naphthol glucuronyltransferase;
1-naphthol-UDP-glucuronosyltransferase;
17beta-hydroxysteroid UDP-glucuronosyltransferase;
3alpha-hydroxysteroid UDP-glucuronosyltransferase;
4-hydroxybiphenyl UDP-glucuronosyltransferase;
4-methylumbelliferone UDP-glucuronosyltransferase;
4-nitrophenol UDP-glucuronyltransferase;
4-nitrophenol UDPGT;
17-OH steroid UDPGT;
3-OH androgenic UDPGT;
bilirubin uridine diphosphoglucuronyltransferase;
bilirubin UDP-glucuronosyltransferase;
bilirubin monoglucuronide glucuronyltransferase;
bilirubin UDPGT;
bilirubin glucuronyltransferase;
ciramadol UDP-glucuronyltransferase;
estriol UDP-glucuronosyltransferase;
estrone UDP-glucuronosyltransferase;
uridine diphosphoglucuronosyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronoside
glucuronosyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase;
uridine diphosphoglucuronate-estriol glucuronosyltransferase;
uridine diphosphoglucuronate-estradiol glucuronosyltransferase;
uridine diphosphoglucuronate-4-hydroxybiphenyl
glucuronosyltransferase;
uridine diphosphoglucuronate-1,2-diacylglycerol
glucuronosyltransferase;
uridine diphosphoglucuronate-estriol
16alpha-glucuronosyltransferase;
uridine diphosphoglucuronosyltransferase;
GT;
morphine glucuronyltransferase;
p-hydroxybiphenyl UDP glucuronyltransferase;
p-nitrophenol UDP-glucuronosyltransferase;
p-nitrophenol UDP-glucuronyltransferase;
p-nitrophenylglucuronosyltransferase;
p-phenylphenol glucuronyltransferase;
phenyl-UDP-glucuronosyltransferase;
PNP-UDPGT;
UDP glucuronate-estradiol-glucuronosyltransferase;
UDP glucuronosyltransferase;
UDP glucuronate-estriol glucuronosyltransferase;
UDP glucuronic acid transferase;
UDP glucuronyltransferase;
UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase;
UDP-glucuronate-bilirubin glucuronyltransferase;
UDP-glucuronosyltransferase;
UDP-glucuronyltransferase;
UDPGA transferase;
UDPGA-glucuronyltransferase;
UDPGT;
uridine diphosphoglucuronyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase;
uridine diphosphate glucuronyltransferase;
uridine 5'-diphosphoglucuronyltransferase;
uridine diphosphoglucuronosyltransferase |
|---|
| Class |
Transferases;
Glycosyltransferases;
Hexosyltransferases
 |
|---|
| Sysname |
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) |
|---|
| Reaction(IUBMB) |
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside
[RN:R01383] |
|---|
| Reaction(KEGG) |
R01383 > R02358 R02389 R02478 R02502 R02902 R03091 R04352 R04353
R04354 R04683 R07106 R08259 R08261 R08262 R08263;
(other) R08615
 |
|---|
| Substrate |
UDP-glucuronate [CPD:C00167];
acceptor [CPD:C00028] |
|---|
| Product |
UDP [CPD:C00015];
acceptor beta-D-glucuronoside [CPD:C03033] |
|---|
| Comment |
This entry denotes a family of enzymes accepting a wide range of
substrates, including phenols, alcohols, amines and fatty acids.
Some of the activities catalysed were previously listed separately
as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77,
EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature
for the various forms, whose delineation is in a state of flux, is
suggested in Ref. 1. |
|---|
| Pathway |
PATH: ec00040 Pentose and glucuronate interconversions
PATH: ec00053 Ascorbate and aldarate metabolism
PATH: ec00140 Steroid hormone biosynthesis
PATH: ec00500 Starch and sucrose metabolism
PATH: ec00830 Retinol metabolism
PATH: ec00860 Porphyrin and chlorophyll metabolism
PATH: ec00980 Metabolism of xenobiotics by cytochrome P450
PATH: ec00982 Drug metabolism - cytochrome P450
PATH: ec00983 Drug metabolism - other enzymes
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K00699 glucuronosyltransferase |
|---|
| Genes |
HSA: 10720(UGT2B11) 10941(UGT2A1) 54490(UGT2B28) 54575(UGT1A10)
54576(UGT1A8) 54577(UGT1A7) 54578(UGT1A6) 54579(UGT1A5)
54600(UGT1A9) 54657(UGT1A4) 54658(UGT1A1) 54659(UGT1A3)
7363(UGT2B4) 7364(UGT2B7) 7365(UGT2B10) 7366(UGT2B15)
7367(UGT2B17) 79799(UGT2A3)
PTR: 461285(UGT2B4) 461289(UGT2B15) 471217(UGT2B11) 471218(UGT2B7)
471220(UGT2A3) 739942(UGT1A6) 742890(UGT2A1)
MCC: 574147 574210(UGT1A1) 613249(UGT2B9*2) 709234(UGT2B4) 709420
709669(UGT2B7) 710412(UGT2B15)
MMU: 100727(Ugt2b34) 22236(Ugt1a2) 22238(Ugt2b5) 231396(Ugt2b36)
394430(Ugt1a10) 394432(Ugt1a7c) 394433(Ugt1a5) 394434(Ugt1a9)
394435(Ugt1a6b) 394436(Ugt1a1) 552899(Ugt2a2) 71773(Ugt2b1)
72094(Ugt2a3) 94215(Ugt2a1) 94284(Ugt1a6a)
RNO: 113992(Ugt1a6) 154516(Ugt1a7c) 24861(Ugt1a1) 24862(Ugt2b)
266685(Ugt2b5) 286954(Ugt2b17) 289533(Ugt2a3) 29623(Ugt2b37)
301595(Ugt1a8) 305264(Ugt2b34) 396527(Ugt1a2) 396551(Ugt1a3)
396552(Ugt1a9) 574523(Ugt1a5) 63867(Ugt2a1) 83808(Ugt2b36)
CFA: 403629(UGT1A6) 442984(UGT2B31) 475163(UGT2A1) 480777 608760
BTA: 286792(UGT1A6) 511743(UGT2A3) 515638(MGC152010) 533587(UGT2B10)
540615(UGT2B17) 615303(UGT2B4) 751790(UGT1A1)
SSC: 100152603
ECB: 100065342 100066444 100068176(UGT2A2)
MDO: 100010818 100025642
OAA: 100079726
GGA: 422660(UGT2A3) 424028(UGT1A1)
TGU: 100226418 100229734
XTR: 100135191 100145362 100145398
DRE: 100002369 100148803 406731(ugt1ab) 550352 553952 570913 641488
792506
SPU: 578573 592958 593427
DME: Dmel_CG10178 Dmel_CG11012(Ugt37a1) Dmel_CG11289
Dmel_CG13270(Ugt36Ba) Dmel_CG13271(Ugt36Bb) Dmel_CG15661
Dmel_CG15902(Ugt86Dj) Dmel_CG17200(Ugt86Dg) Dmel_CG17323
Dmel_CG17932(Ugt36Bc) Dmel_CG31002 Dmel_CG3797
Dmel_CG3881(GlcAT-S) Dmel_CG4302 Dmel_CG4414(Ugt58Fa)
Dmel_CG4739(Ugt86Dc) Dmel_CG4772(Ugt86Dh) Dmel_CG5999
Dmel_CG6207(GlcAT-P) Dmel_CG6475 Dmel_CG6633(Ugt86Dd)
Dmel_CG6644(Ugt35a) Dmel_CG6649(Ugt35b) Dmel_CG6653(Ugt86De)
Dmel_CG6658(Ugt86Di) Dmel_CG8652(Ugt37c1) Dmel_CG9481(Ugt37b1)
DPO: Dpse_GA10135 Dpse_GA12161 Dpse_GA13878 Dpse_GA14014
Dpse_GA18094 Dpse_GA18421 Dpse_GA19741 Dpse_GA19751
Dpse_GA19758 Dpse_GA21820(Dpse_Ugt37b1)
AME: 408788 409304
CEL: B0310.5(ugt-46) C18C4.3(ugt-48) F35H8.6(ugt-58) F39G3.1(ugt-61)
T04H1.7(ugt-55) T04H1.8(ugt-56) T07C5.1(ugt-50)
NVE: NEMVE_v1g122091
 |
|---|
| Structures |
PDB: 2HY7 2O6L 2Q6V 3CUY 3CV3 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6404284]
Bock KW, Burchell B, Dutton GJ, Hanninen O, Mulder GJ, Owens IS,
Siest G, Tephly TR.
UDP-glucuronosyltransferase activities. Guidelines for consistent
interim terminology and assay conditions.
Biochem. Pharmacol. 32 (1983) 953-5.
Rattus norvegicus [GN:rno], Oryctolagus cuniculus |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:111930]
Bock KW, Josting D, Lilienblum W, Pfeil H.
Purification of rat-liver microsomal UDP-glucuronyltransferase.
Separation of two enzyme forms inducible by 3-methylcholanthrene or
phenobarbital.
Eur. J. Biochem. 98 (1979) 19-26.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
|
3
Burchell, B.
Identification and purification of multiple forms of
UDP-glucuronosyltransferase.
Rev. Biochem. Toxicol. 3 (1981) 1-32. |
|---|
Reference
Authors
Title
|
4
Dutton, G.J.
Glucuronidation of Drugs and Other Compounds, C.R.C. Press, Boca
Raton, Florida, 1980. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:3931633]
Green MD, Falany CN, Kirkpatrick RB, Tephly TR.
Strain differences in purified rat hepatic 3 alpha-hydroxysteroid
UDP-glucuronosyltransferase.
Biochem. J. 230 (1985) 403-9.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
|
6
Jansen, P.L.M.
The enzyme-catalyzed formation of bilirubin diglucuronide by a
solublized preparation from cat liver microsomes.
Biochim. Biophys. Acta 338 (1974) 170-182. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.4.1.17
IUBMB Enzyme Nomenclature: 2.4.1.17
ExPASy - ENZYME nomenclature database: 2.4.1.17
BRENDA, the Enzyme Database: 2.4.1.17
CAS: 9030-08-4 |
|---|
