KEGG   ENZYME: 2.4.2.36Help
Entry
EC 2.4.2.36                 Enzyme                                 
Name
NAD+---diphthamide ADP-ribosyltransferase;
ADP-ribosyltransferase;
mono(ADPribosyl)transferase;
NAD---diphthamide ADP-ribosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase
Reaction(IUBMB)
NAD+ + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide [RN:R04074]
Reaction(KEGG)
Substrate
NAD+ [CPD:C00003];
peptide diphthamide [CPD:C02872]
Product
nicotinamide [CPD:C00153];
peptide N-(ADP-D-ribosyl)diphthamide [CPD:C04339]
Comment
Diphtheria toxin and some other bacterial toxins catalyse this reaction. The acceptor is a diphthamide residue in elongation factor 2. cf. EC 2.4.2.31 NAD(P)+---protein-arginine ADP-ribosyltransferase.
Orthology
K00776  
NAD-diphthamide ADP-ribosyltransferase
K10928  
cholera enterotoxin subunit A
Genes
ECW: 
ELH: 
EUN: 
VCH: 
VCE: 
VCJ: 
VCO: 
VCR: 
VCI: 
CDI: 
DIP0222(tox)
CDZ: 
CD31A_0221(tox)
CDS: 
CDC7B_0178(tox)
CDD: 
CDCE8392_0179(tox)
CDW: 
CDPW8_0179(tox1) CDPW8_0220(tox2)
COP: 
Cp31_0135(tox)
CUE: 
CULC0102_0213(tox)
 » show all
Taxonomy
Reference
1  [PMID:6326138]
  Authors
Lee H, Iglewski WJ.
  Title
Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 81 (1984) 2703-7.
  Organism
Pseudomonas aeruginosa
Reference
2  [PMID:3927821]
  Authors
Ueda K, Hayaishi O.
  Title
ADP-ribosylation.
  Journal
Annu. Rev. Biochem. 54 (1985) 73-100.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52933-21-8
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