| Entry |
|
|---|
| Name |
hexokinase;
hexokinase type IV glucokinase;
hexokinase D;
hexokinase type IV;
hexokinase (phosphorylating);
ATP-dependent hexokinase;
glucose ATP phosphotransferase |
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
 |
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| Sysname |
ATP:D-hexose 6-phosphotransferase |
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| Reaction(IUBMB) |
ATP + D-hexose = ADP + D-hexose 6-phosphate [RN:R02848] |
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| Reaction(KEGG) |
R02848 > R00299 R00760 R00867 R01326 R01600 R01786 R01961 R02865
R03920;
(other) R00725 R00876 R01139 R01140 R01327 R01330 R01964 R01965
R02849 R02850 R02867 R02868
 |
|---|
| Substrate |
ATP [CPD:C00002];
D-hexose [CPD:C00738] |
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| Product |
ADP [CPD:C00008];
D-hexose 6-phosphate [CPD:C02965] |
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| Comment |
D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act
as acceptors; ITP and dATP can act as donors. The liver isoenzyme
has sometimes been called glucokinase. |
|---|
| Pathway |
PATH: ec00010 Glycolysis / Gluconeogenesis
PATH: ec00051 Fructose and mannose metabolism
PATH: ec00052 Galactose metabolism
PATH: ec00500 Starch and sucrose metabolism
PATH: ec00520 Amino sugar and nucleotide sugar metabolism
PATH: ec00521 Streptomycin biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01062 Biosynthesis of terpenoids and steroids
PATH: ec01063 Biosynthesis of alkaloids derived from shikimate
pathway
PATH: ec01064 Biosynthesis of alkaloids derived from ornithine,
lysine and nicotinic acid
PATH: ec01065 Biosynthesis of alkaloids derived from histidine and
purine
PATH: ec01066 Biosynthesis of alkaloids derived from terpenoid and
polyketide
PATH: ec01070 Biosynthesis of plant hormones
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K00844 hexokinase |
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| Genes |
HSA: 3098(HK1) 3099(HK2) 3101(HK3)
PTR: 450505(HK1) 462298(HK3) 741291(HK2)
MCC: 698120(HK3) 710479 711922
MMU: 15275(Hk1) 15277(Hk2) 212032(Hk3)
RNO: 25058(Hk1) 25059(Hk2) 25060(Hk3)
CFA: 475781(HK2) 479234(HK1) 489096(HK3)
BTA: 280817(HK1) 281771(HK1) 788926(HK2)
SSC: 100152344 494561(HK2)
ECB: 100009677(HKII) 100068725 100072687
MDO: 100031311 100031793 100032849
GGA: 373889(HK1) 374044(HK2)
TGU: 100226456
XLA: 394323(hk1-A)
XTR: 100124752(hk1)
DRE: 406339(hk2) 406791(hk1)
BFO: BRAFLDRAFT_126138
CIN: 100180240
SPU: 594105
DME: Dmel_CG3001(Hex-A) Dmel_CG32849(Hex-t2) Dmel_CG33102(Hex-t1)
Dmel_CG8094(Hex-C)
DPO: Dpse_GA15574 Dpse_GA17282 Dpse_GA20820
DAN: Dana_GF12622 Dana_GF20727 Dana_GF20735 Dana_GF22320
DER: Dere_GG11476 Dere_GG11478 Dere_GG18317 Dere_GG22367
DPE: Dper_GL11018 Dper_GL15877 Dper_GL21847 Dper_GL21996
DSE: Dsec_GM10320 Dsec_GM10321 Dsec_GM11376 Dsec_GM20151
DSI: Dsim_GD21281(Dsim_Hex-t1) Dsim_GD21282(Dsim_Hex-t2)
Dsim_GD25630
DYA: Dyak_GE12255(Dyak_Hex-C) Dyak_GE17799(Dyak_Hex-A)
Dyak_GE23668(Dyak_Hex-t1) Dyak_GE23669(Dyak_Hex-t2)
DGR: Dgri_GH12375 Dgri_GH19418 Dgri_GH19419 Dgri_GH21465
DMO: Dmoj_GI14754 Dmoj_GI19942 Dmoj_GI22622 Dmoj_GI22624
AGA: AgaP_AGAP011208
AAG: AaeL_AAEL009387
CQU: CpipJ_CPIJ008049
AME: 551005
NVI: 100121683
TCA: 657694 659227
API: 100169524
ISC: IscW_ISCW012387
CEL: F14B4.2(hexokinase)
CBR: CBG13890
BMY: Bm1_41805
SMM: Smp_043030
NVE: NEMVE_v1g229061
TAD: TRIADDRAFT_50939
ATH: AT1G47840(HXK3) AT2G19860(HXK2) AT4G29130(HXK1) AT4G37840(HKL3)
POP: POPTR_764893 POPTR_797614 POPTR_815248 POPTR_818799
POPTR_825877
RCU: RCOM_0189410 RCOM_1049540 RCOM_1488780 RCOM_1597800
VVI: 100242358 100244595(GSVIVT00034293001)
100255753(GSVIVT00014427001) 100262786
OSA: 4326547(Os01g0742500) 4326776(Os01g0190400)
4339361(Os05g0522500) 4339420(Os05g0532600)
4342654(Os07g0197100) 4343113(Os07g0446800)
SBI: SORBI_03g003190(SORBIDRAFT_03g003190)
SORBI_03g034230(SORBIDRAFT_03g034230)
SORBI_03g045420(SORBIDRAFT_03g045420)
SORBI_09g005840(SORBIDRAFT_09g005840)
SORBI_09g026080(SORBIDRAFT_09g026080)
ZMA: 100170246 100192075(si946063f09) 100279587 100283735
542510(pco074668)
PPP: PHYPADRAFT_228844(hxk1) PHYPADRAFT_228857(hxk2)
PHYPADRAFT_228859(hxk4) PHYPADRAFT_228860(hxk5)
PHYPADRAFT_228861(hxk6) PHYPADRAFT_228862(hxk7)
PHYPADRAFT_228864(hxk9) PHYPADRAFT_235449(hxk8)
CRE: CHLREDRAFT_21582(HXK1)
SCE: YCL040W(GLK1) YFR053C(HXK1) YGL253W(HXK2)
AGO: AGOS_AFR279C AGOS_AFR716C
KLA: KLLA0C01155g KLLA0D11352g
LTH: KLTH0F01144g KLTH0G00440g
DHA: DEHA0E07007g DEHA0F15169g DEHA0F26092g
PIC: PICST_32526(NAG5) PICST_73701(GLK1) PICST_85453(HXK1)
PPA: PAS_chr1-4_0447 PAS_chr3_1192 PAS_chr4_0624
VPO: Kpol_2000p103 Kpol_2002p32 Kpol_507p3
LEL: LELG_03126 LELG_03305 LELG_03676
ZRO: ZYRO0E09878g ZYRO0F17864g
CAL: CaO19.13(GLK2) CaO19.1408(GLK3) CaO19.542(HXK2) CaO19.734(GLK1)
CTP: CTRG_00414 CTRG_03132 CTRG_03726
CDU: CD36_29870 CD36_32740 CD36_65510(NAG5)
CGR: CAGL0A04829g CAGL0F00605g CAGL0H07579g
YLI: YALI0B22308g YALI0E15488g YALI0E20207g
SPO: SPAC24H6.04(hxk1) SPAC4F8.07c(hxk2)
NCR: NCU00575 NCU02542 NCU04728
PAN: PODANSg09944 PODANSg2983 PODANSg3980
MGR: MGCH7_ch7g833 MGG_00623 MGG_03041 MGG_09289
FGR: FG00500.1 FG08399.1
ANI: AN7459.2 AN8689.2
AFM: AFUA_2G00450 AFUA_2G05910 AFUA_2G16330 AFUA_6G02230
AFUA_6G03980 AFUA_7G04040
AOR: AO090001000710 AO090120000109
ANG: An02g14380(hxk) An12g08610(GlkA) An13g00510
AFV: AFLA_073260 AFLA_130070
PCS: Pc20g13040 Pc22g08480 Pc22g23550
NFI: NFIA_025000 NFIA_032670 NFIA_048520 NFIA_050510 NFIA_082630
NFIA_091590
CIM: CIMG_00997 CIMG_04401 CIMG_05829
URE: UREG_00948 UREG_04499
SSL: SS1G_01273 SS1G_05407 SS1G_12834
BFU: BC1G_05322 BC1G_12086 BC1G_12178
CNE: CNB02660 CNH01400
CNB: CNBB3020 CNBL1350
LBC: LACBIDRAFT_184098 LACBIDRAFT_312018
MPR: MPER_06863 MPER_13256
UMA: UM02173.1 UM03093.1
MGL: MGL_1289
EHI: EHI_098290 EHI_098560
EDI: EDI_295250
PFA: PFF1155w
PFD: PFDG_04244
PFH: PFHG_01142
PYO: PY02030
PBE: PB000727.00.0
PKN: PKH_112550
PVX: PVX_114315
TAN: TA19800 TA19810
TPV: TP01_0043 TP01_0045
BBO: BBOV_I000860
CPV: cgd6_3800
CHO: Chro.60435
TGO: TGME49_065450
TBR: Tb10.70.5800 Tb10.70.5820
TCR: 508951.20 510121.20
LMA: LmjF21.0240 LmjF21.0250
LIF: LinJ21.0140 LinJ21.0150
LBZ: LbrM21_V2.0310
CCE: Ccel_3221
DRM: Dred_1810
DAE: Dtox_3946
HMO: HM1_0763
TPA: TP0505
TPP: TPASS_0505(hxk)
TDE: TDE2469
 |
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| Structures |
PDB: 1BDG 1BG3 1CZA 1DGK 1HKB 1HKC 1HKG 1IG8 1QHA 1V4S
1V4T 2E2N 2E2O 2E2P 2E2Q 2NZT 2VTA 2YHX 3B8A 3HM8 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:16748250]
Bailey K, Webb EC.
Purification of yeast hexokinase and its reaction with
betabeta'-dichlorodiethyl sulphide.
Biochem. J. 42 (1948) 60-8.
Saccharomyces cerevisiae [GN:sce] |
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Reference
Authors
Title
Journal
|
2
Berger, L., Slein, M.W., Colowick, S.P. and Cori, C.F.
Isolation of hexokinase from baker's yeast.
J. Gen. Physiol. 29 (1946) 379-391. |
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Reference
Authors
Title
Journal
|
3
Kunitz, M. and McDonald, M.R.
Crystalline hexokinase (heterophosphatase). Method of isolation and
properties.
J. Gen. Physiol. 29 (1946) 393-412. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:7048063]
Pollard-Knight D, Cornish-Bowden A.
Mechanism of liver glucokinase.
Mol. Cell. Biochem. 44 (1982) 71-80.
Rattus norvegicus [GN:rno], Bos taurus [GN:bta] |
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Reference
Authors
Title
Journal
|
5 [PMID:233226]
Ureta T, Radojkovic J, Lagos R, Guixe V, Nunez L.
Phylogenetic and ontogenetic studies of glucose phosphorylating
isozymes of vertebrates.
Arch. Biol. Med. Exp. (Santiago). 12 (1979) 587-604. |
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Reference
Authors
Title
Journal
Organism
|
6 [PMID:6477520]
Cardenas ML, Rabajille E, Niemeyer H.
Fructose is a good substrate for rat liver 'glucokinase' (hexokinase
D).
Biochem. J. 222 (1984) 363-70.
Rattus norvegicus [GN:rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 2.7.1.1
IUBMB Enzyme Nomenclature: 2.7.1.1
ExPASy - ENZYME nomenclature database: 2.7.1.1
BRENDA, the Enzyme Database: 2.7.1.1
CAS: 9001-51-8 |
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