KEGG   ENZYME: 2.7.1.154Help
Entry
EC 2.7.1.154                Enzyme                                 
Name
phosphatidylinositol-4-phosphate 3-kinase;
type II phosphoinositide 3-kinase;
C2-domain-containing phosphoinositide 3-kinase;
phosphoinositide 3-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase
Reaction(IUBMB)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [RN:R05795]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
1-phosphatidyl-1D-myo-inositol 4-phosphate [CPD:C01277]
Product
ADP [CPD:C00008];
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate [CPD:C11554]
Comment
This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.
Pathway
Inositol phosphate metabolism
Metabolic pathways
Orthology
K00923  
phosphatidylinositol-4-phosphate 3-kinase
Genes
HSA: 
5286(PIK3C2A) 5287(PIK3C2B) 5288(PIK3C2G)
PTR: 
451052(PIK3C2A) 457657(PIK3C2B) 465321(PIK3C2G)
PPS: 
100977462(PIK3C2A) 100982135(PIK3C2B) 100986428(PIK3C2G)
GGO: 
101127796(PIK3C2A) 101132724(PIK3C2B) 101153676(PIK3C2G)
PON: 
100441714(PIK3C2G) 100457125(PIK3C2A) 100461668(PIK3C2B)
MCC: 
697202 701974(PIK3C2B) 702929(PIK3C2G)
MMU: 
18704(Pik3c2a) 18705(Pik3c2g) 240752(Pik3c2b)
RNO: 
116720(Pik3c2g) 289021(Pik3c2b) 361632(Pik3c2a)
CFA: 
477681(PIK3C2G) 478938(PIK3C2B) 485399(PIK3C2A)
AML: 
100465834(PIK3C2B) 100470614(PIK3C2G) 100481616(PIK3C2A)
FCA: 
101082204(PIK3C2B) 101084293(PIK3C2G) 101096512(PIK3C2A)
BTA: 
513301(PIK3C2G) 537396(PIK3C2B) 537790(PIK3C2A)
SSC: 
100512551(PIK3C2B) 100523844(PIK3C2G)
ECB: 
100054391(PIK3C2B) 100056431(PIK3C2A) 100064130(PIK3C2G)
MDO: 
100017523(PIK3C2B) 100028742(PIK3C2A)
SHR: 
100913785(PIK3C2B) 100930379(PIK3C2A)
OAA: 
100075377 100079037(PIK3C2A)
GGA: 
418181(PIK3C2G) 419822(PIK3C2B) 423070(PIK3C2A)
MGP: 
100544264 100548137(PIK3C2A)
TGU: 
100219236(PIK3C2G) 100219982(PIK3C2A)
ACS: 
100557407(pik3c2a) 100567393(pik3c2b)
XTR: 
100038240(pik3c2a)
DRE: 
100330514 567938(pik3c2b) 571356(pik3c2a)
TRU: 
101065977 101074574
OLA: 
101155105 101162831
BFO: 
BRAFLDRAFT_233446
CIN: 
100175620
SPU: 
586734(pik3c2a)
DME: 
Dmel_CG11621(Pi3K68D)
DPO: 
Dpse_GA11104
DAN: 
Dana_GF24513
DER: 
Dere_GG13889
DPE: 
Dper_GL20824
DSE: 
Dsec_GM24713
DSI: 
Dsim_GD12776
DWI: 
Dwil_GK12371
DYA: 
Dyak_GE20180
DGR: 
Dgri_GH16381
DMO: 
Dmoj_GI11573
DVI: 
Dvir_GJ11253
AGA: 
AgaP_AGAP011036
AAG: 
AaeL_AAEL000386
CQU: 
CpipJ_CPIJ003365
AME: 
413425
NVI: 
100121969(NV13341)
TCA: 
655501
API: 
100160780
PHU: 
Phum_PHUM060620
ISC: 
IscW_ISCW022811
CEL: 
CELE_F39B1.1(piki-1)
CBR: 
CBG07670
BMY: 
Bm1_05655
SMM: 
Smp_172400
NVE: 
NEMVE_v1g90881
HMG: 
100211167
AQU: 
100639364
DDI: 
DDB_G0282625(pikG)
DPP: 
DICPUDRAFT_35373
EDI: 
EDI_083720
 » show all
Taxonomy
Reference
1  [PMID:11395417]
  Authors
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD.
  Title
Synthesis and function of 3-phosphorylated inositol lipids.
  Journal
Annu. Rev. Biochem. 70 (2001) 535-602.
  Organism
Drosophila melanogaster [GN:dme], Caenorhabditis elegans [GN:cel], mammalian
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
141176-94-5
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