KEGG   ENZYME: 3.1.1.34Help
Entry
EC 3.1.1.34                 Enzyme                                 
Name
lipoprotein lipase;
clearing factor lipase;
diglyceride lipase;
diacylglycerol lipase;
postheparin esterase;
diglyceride lipase;
postheparin lipase;
diacylglycerol hydrolase;
lipemia-clearing factor
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
triacylglycero-protein acylhydrolase
Reaction(IUBMB)
triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Reaction(KEGG)
R01369;
(other) R01350
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Substrate
triacylglycerol [CPD:C00422];
H2O [CPD:C00001]
Product
diacylglycerol [CPD:C00165];
carboxylate [CPD:C00060]
Comment
Hydrolyses triacylglycerols in chylomicrons and low-density lipoproteins. Also hydrolyses diacylglycerol.
Pathway
Glycerolipid metabolism
Orthology
K01059  
lipoprotein lipase
Genes
HSA: 
4023(LPL)
PTR: 
464031(LPL)
PPS: 
GGO: 
PON: 
MCC: 
712887(LPL)
MMU: 
16956(Lpl)
RNO: 
24539(Lpl)
CFA: 
403626(LPL)
AML: 
FCA: 
727696(LPL)
BTA: 
280843(LPL)
SSC: 
397537(LPL)
ECB: 
100055358(LPL)
MDO: 
100033067
SHR: 
100933361(LPL)
OAA: 
100077350
GGA: 
396219(LPL)
MGP: 
100544844
TGU: 
100223817
XTR: 
100127862(lpl)
DRE: 
30354(lpl)
TRU: 
101062428
OLA: 
101160547
DME: 
Dmel_CG1986 Dmel_CG4582 Dmel_CG5665
DPO: 
Dpse_GA15172 Dpse_GA18274 Dpse_GA19044
 » show all
Taxonomy
Reference
1  [PMID:4703566]
  Authors
Egelrud T, Olivecrona T.
  Title
Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors.
  Journal
Biochim. Biophys. Acta. 306 (1973) 115-27.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:5441398]
  Authors
Fielding CJ.
  Title
Human lipoprotein lipase. I. Purification and substrate specificity.
  Journal
Biochim. Biophys. Acta. 206 (1970) 109-17.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:5466051]
  Authors
Greten H, Levy RI, Fales H, Fredrickson DS.
  Title
Hydrolysis of diglyceride and glyceryl monoester diethers with "lipoprotein lipase".
  Journal
Biochim. Biophys. Acta. 210 (1970) 39-45.
  Organism
Rattus norvegicus [GN:rno]
Reference
4  [PMID:5076762]
  Authors
Morley N, Kuksis A.
  Title
Positional specificity of lipoprotein lipase.
  Journal
J. Biol. Chem. 247 (1972) 6389-93.
  Organism
Rattus norvegicus [GN:rno], Bos taurus [GN:bta]
Reference
5  [PMID:5168777]
  Authors
Nilsson-Ehle P, Belfrage P, Borgstrom B.
  Title
Purified human lipoprotein lipase: positional specificity.
  Journal
Biochim. Biophys. Acta. 248 (1971) 114-20.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9004-02-8
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