| Entry |
|
|---|
| Name |
inositol-polyphosphate 5-phosphatase;
type I inositol-polyphosphate phosphatase;
inositol trisphosphate phosphomonoesterase;
InsP3/Ins(1,3,4,5)P4 5-phosphatase;
inosine triphosphatase;
D-myo-inositol 1,4,5-triphosphate 5-phosphatase;
D-myo-inositol 1,4,5-trisphosphate 5-phosphatase;
L-myo-inositol 1,4,5-trisphosphate-monoesterase;
inositol phosphate 5-phosphomonoesterase;
inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate
5-phosphatase;
Ins(1,4,5)P3 5-phosphatase;
D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase;
inositol 1,4,5-trisphosphate phosphatase;
inositol polyphosphate-5-phosphatase;
myo-inositol-1,4,5-trisphosphate 5-phosphatase;
inositol-1,4,5-trisphosphate 5-phosphatase |
|---|
| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
 |
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| Sysname |
1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase |
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| Reaction(IUBMB) |
(1) D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol
1,4-bisphosphate + phosphate [RN:R03394];
(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O =
1D-myo-inositol 1,3,4-trisphosphate + phosphate [RN:R03430] |
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| Reaction(KEGG) |
R03394 R03430
 |
|---|
| Substrate |
D-myo-inositol 1,4,5-trisphosphate [CPD:C01245];
H2O [CPD:C00001];
1D-myo-inositol 1,3,4,5-tetrakisphosphate [CPD:C01272] |
|---|
| Product |
myo-inositol 1,4-bisphosphate [CPD:C01220];
phosphate [CPD:C00009];
1D-myo-inositol 1,3,4-trisphosphate [CPD:C01243] |
|---|
| Comment |
One mammalian isoform is known. This enzyme is distinguished from
the family of enzymes classified under EC 3.1.3.36, phosphoinositide
5-phosphatase, by its inability to dephosphorylate inositol lipids. |
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| Pathway |
PATH: ec00562 Inositol phosphate metabolism
PATH: ec01100 Metabolic pathways
PATH: ec04070 Phosphatidylinositol signaling system |
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| Orthology |
KO: K01106 inositol-1,4,5-trisphosphate 5-phosphatase |
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| Genes |
HSA: 27124(INPP5J) 3632(INPP5A) 3636(INPPL1) 51763(INPP5K)
PTR: 451403(INPPL1) 454410(INPP5K) 458767(INPP5J) 747128(INPP5A)
MCC: 718308(INPP5J) 718421 719508 721222
MMU: 16330(Inpp5b) 16332(Inppl1) 170835(Inpp5j) 19062(Inpp5k)
212111(Inpp5a)
RNO: 171088(Inpp5j) 287533(Inpp5k) 365382(Inpp5a) 65038(Inppl1)
CFA: 403937(INPP5A) 480647(INPP5K) 485209(INPPL1) 486360
BTA: 514123(INPP5K) 514307 615232(INPP5A) 783833(INPPL1)
SSC: 100153326 100153509
ECB: 100051027(INPP5A) 100058547(INPP5J) 100066037 100072370
MDO: 100015500 100028528
OAA: 100075999
GGA: 416996(PIB5PA) 423973(INPP5A) 428692(INPPL1) 771549(INPP5K)
TGU: 100231908
XLA: 447532
XTR: 100127685(inpp5k) 548959
DRE: 100037338 325179 368433(inppl1) 569568 641571
CIN: 100178482
SPU: 575498 576800
DME: Dmel_CG6562(synj) Dmel_CG9784
AGA: AgaP_AGAP000203 AgaP_AGAP011644
AAG: AaeL_AAEL000840
AME: 406096 408730
TCA: 659746 662279
CEL: C09B8.1(ipp-5)
CBR: CBG14816
NVE: NEMVE_v1g196982
TAD: TRIADDRAFT_31282
SCE: YNL106C(INP52) YOL065C(INP54) YOR109W(INP53)
KLA: KLLA0D13860g
PIC: PICST_58872(INP51) PICST_82710(INP52)
CGR: CAGL0C05269g
UMA: UM02595.1
MBR: MONBRDRAFT_33207
CPV: cgd2_230
TBR: Tb09.160.4180 Tb11.02.4140
TCR: 506297.200 510101.130
LMA: LmjF11.1010
 |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:6285891]
Downes CP, Mussat MC, Michell RH.
The inositol trisphosphate phosphomonoesterase of the human
erythrocyte membrane.
Biochem. J. 203 (1982) 169-77.
Homo sapiens [GN:hsa] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2540972]
Erneux C, Lemos M, Verjans B, Vanderhaeghen P, Delvaux A, Dumont JE.
Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in
bovine brain.
Eur. J. Biochem. 181 (1989) 317-22.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
|
3
Woscholski, R. and Parker, P.J.
Inositol phosphatases: constructive destruction of phosphoinositides
and inositol phosphates.
In: Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of
Phosphoinositides, Oxford, 2000, p. 320-338. |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:8198557]
Verjans B, De Smedt F, Lecocq R, Vanweyenberg V, Moreau C, Erneux C.
Cloning and expression in Escherichia coli of a dog thyroid cDNA
encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase.
Biochem. J. 300 ( Pt 1) (1994) 85-90.
Bos taurus [GN:bta] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.1.3.56
IUBMB Enzyme Nomenclature: 3.1.3.56
ExPASy - ENZYME nomenclature database: 3.1.3.56
BRENDA, the Enzyme Database: 3.1.3.56
CAS: 106283-14-1 |
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