| Entry |
|
|---|
| Name |
exo-alpha-sialidase;
neuraminidase;
sialidase;
alpha-neuraminidase;
acetylneuraminidase |
|---|
| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
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| Sysname |
acetylneuraminyl hydrolase |
|---|
| Reaction(IUBMB) |
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic
linkages of terminal sialic acid residues in oligosaccharides,
glycoproteins, glycolipids, colominic acid and synthetic substrates |
|---|
| Reaction(KEGG) |
(other) R03491 R04018 R04634 R04650 R05115 R05117 R05996(G)
R05998(G) R05999(G) R06012(G) R06147(G) R06253(G)
 |
|---|
| Inhibitor |
2-Deoxy-2,3-dehydro-N-acetylneuraminic acid [CPD:C04580] |
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| Comment |
The enzyme does not act on 4-O-acetylated sialic acids.
endo-alpha-Sialidase activity is listed as EC 3.2.1.129,
endo-alpha-sialidase. See also EC 4.2.2.15 anhydrosialidase. |
|---|
| Pathway |
PATH: ec00511 Other glycan degradation
PATH: ec00600 Sphingolipid metabolism |
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| Orthology |
KO: K01186 sialidase-1
KO: K12357 sialidase-2/3/4 |
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| Genes |
HSA: 10825(NEU3) 129807(NEU4) 4758(NEU1) 4759(NEU2)
PTR: 471968(NEU1)
MCC: 702264(NEU4) 713979(NEU2) 716740(NEU1)
MMU: 18010(Neu1) 23956(Neu2) 241159(Neu4) 50877(Neu3)
RNO: 117185(Neu3) 24591(Neu1) 29204(Neu2) 316642(Neu4)
CFA: 481717(NEU1) 485195(NEU3) 486166(NEU2) 609668(NEU4)
BTA: 281349(NEU3) 505554(NEU1) 528030(NEU4)
SSC: 100124381(SBAB-707F1.8)
ECB: 100057378 100059083 100064871(NEU3)
MDO: 100012303 100012630 100021389 100025319
OAA: 100082341 100092279
GGA: 430542(NEU3) 768823(NEU2)
TGU: 100220481 100224381
XLA: 444511
XTR: 100145410
DRE: 100000684(neu3.5) 445250(neu3.2) 553569(neu4) 555206(neu3.3)
559850(neu1) 780844(neu3.1) 793046(neu3.4)
BFO: BRAFLDRAFT_249134
SPU: 583431 585449 764416
NVE: NEMVE_v1g210903
PIC: PICST_3402(HYR6.2) PICST_3529(HYR6.3) PICST_61722(HYR6.4)
FGR: FG00251.1
AFM: AFUA_4G13800
MBR: MONBRDRAFT_22854
TBR: Tb927.7.6850 Tb927.7.7480
STM: STM0928(nanH)
PMU: PM0663 PM1000
VCH: VC1784
VCO: VC0395_A1381(nanH)
ABM: ABSDF1049
PHA: PSHAb0159
BXE: Bxe_B2278
BBA: Bd2821 Bd3647
SPN: SP_1326 SP_1687
SPD: SPD_1499(nanB) SPD_1504(nanA)
SPR: spr1531(nanB) spr1536(nanA)
SPW: SPCG_0853(nanC) SPCG_1660(nanB) SPCG_1665(nanA)
SPV: SPH_1468 SPH_1797
SAG: SAG1932
SAN: gbs1919
SAK: SAK_1891
SEZ: Sez_1425(nanA)
CPE: CPE0553(nanJ) CPE0725(nanI)
CPF: CPF_0532 CPF_0721
CPR: CPR_0877
CTC: CTC00453
CGL: NCgl1495(cgl1556)
CGB: cg1756(nanH)
CGT: cgR_1608
CDI: DIP0330
SCO: SCO6557(SC4B5.07c)
SMA: SAV_1842(nanH) SAV_5934
SGR: SGR_6429
ART: Arth_0189 Arth_0543
AAU: AAur_0636 AAur_3540
PAC: PPA0684 PPA0685 PPA1560
SEN: SACE_1663 SACE_5159(nanH)
BLN: Blon_2348
TDE: TDE0471
SUS: Acid_0193
BTH: BT_0455
BFR: BF1729 BF3936 BF4242
BFS: BF3709 BF4051(nanH2)
BVU: BVU_4143
PGI: PG0352
PGN: PGN_1608
PDI: BDI_2946
COC: Coch_0016
AMU: Amuc_0625 Amuc_1835
RBA: RB3353
HMA: pNG5066
 |
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| Structures |
PDB: 1A14 1A4G 1A4Q 1B9S 1B9T 1B9V 1BJI 1DIL 1DIM 1E8T
1E8U 1E8V 1EUR 1EUS 1EUT 1EUU 1F8B 1F8C 1F8D 1F8E
1INF 1ING 1INH 1INV 1INW 1INX 1INY 1IVB 1IVC 1IVD
1IVE 1IVF 1IVG 1KIT 1L7F 1L7G 1L7H 1MR5 1MS0 1MS1
1MS3 1MS4 1MS5 1MS8 1MS9 1MWE 1MZ5 1MZ6 1N1S 1N1T
1N1V 1N1Y 1NCA 1NCB 1NCC 1NCD 1NMA 1NMB 1NMC 1NN2
1NNA 1NNB 1NNC 1NSB 1NSC 1NSD 1S0I 1S0J 1SLI 1SLL
1SNT 1SO7 1USR 1USX 1V0Z 1V2I 1V3B 1V3C 1V3D 1V3E
1VCJ 1VCU 1W0O 1W0P 1W1X 1W20 1W21 1W8N 1W8O 1WCQ
1WCS 1XOE 1XOG 1Z4V 1Z4W 1Z4X 1Z4Y 1Z4Z 1Z50 2A75
2AEP 2AGS 2AH2 2B8H 2BAT 2BER 2BF6 2BZD 2C4A 2C4L
2CML 2F0Z 2F10 2F11 2F12 2F13 2F24 2F25 2F26 2F27
2F28 2F29 2FHR 2HT5 2HT7 2HT8 2HTQ 2HTR 2HTU 2QWA
2QWB 2QWC 2QWD 2QWE 2QWF 2QWG 2QWH 2QWI 2QWJ 2QWK
2SIL 2SIM 2SLI 2VK5 2VK6 2VK7 2VSK 2VSM 2VVZ 2VW0
2VW1 2VW2 2W20 2W68 3B69 3B7E 3BEQ 3CKZ 3CL0 3CL2
3CYE 3D11 3D12 3H71 3H72 3H73 3NN9 3SIL 3SLI 4NN9
4SLI 5NN9 6NN9 7NN9 |
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Reference
Authors
Title
Journal
|
1 [PMID:6762816]
Schauer R.
Chemistry, metabolism, and biological functions of sialic acids.
Adv. Carbohydr. Chem. Biochem. 40 (1982) 131-234. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:1883340]
Cabezas JA.
Some questions and suggestions on the type references of the
official nomenclature (IUB) for sialidase(s) and endosialidase.
Biochem. J. 278 ( Pt 1) (1991) 311-2.
Homo sapiens [GN:hsa] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.18
IUBMB Enzyme Nomenclature: 3.2.1.18
ExPASy - ENZYME nomenclature database: 3.2.1.18
BRENDA, the Enzyme Database: 3.2.1.18
CAS: 9001-67-6 |
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