| Entry |
|
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| Name |
beta-glucuronidase;
beta-glucuronide glucuronohydrolase glucuronidase;
exo-beta-D-glucuronidase;
ketodase |
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| Class |
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl
compounds
 |
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| Sysname |
beta-D-glucuronoside glucuronosohydrolase |
|---|
| Reaction(IUBMB) |
a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol
[RN:R01478] |
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| Reaction(KEGG) |
R01478 > R07818(G) R08260;
(other) R04979 R08127
 |
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| Substrate |
beta-D-glucuronoside [CPD:C03033];
H2O [CPD:C00001] |
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| Product |
D-glucuronate [CPD:C00191];
alcohol [CPD:C00069] |
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| Pathway |
PATH: ec00040 Pentose and glucuronate interconversions
PATH: ec00500 Starch and sucrose metabolism
PATH: ec00531 Glycosaminoglycan degradation
PATH: ec00860 Porphyrin and chlorophyll metabolism
PATH: ec00944 Flavone and flavonol biosynthesis
PATH: ec00983 Drug metabolism - other enzymes
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01195 beta-glucuronidase |
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| Genes |
HSA: 2990(GUSB)
PTR: 463443(GUSB)
MCC: 677692(GUSB) 697348(GUSB) 720924
MMU: 110006(Gusb)
RNO: 24434(Gusb)
CFA: 403831(GUSB)
BTA: 515687(GUSB)
SSC: 100144519(GUSB)
ECB: 100037416(GUSB)
MDO: 100010196
OAA: 100074325 100089771
GGA: 427823(RCJMB04_28l23)
DRE: 571441
BFO: BRAFLDRAFT_59392
CIN: 100179958
SPU: 575689 752070 765286
DME: Dmel_CG15117 Dmel_CG2135
DPO: Dpse_GA13505 Dpse_GA24063
DAN: Dana_GF11492 Dana_GF11493 Dana_GF11494
DER: Dere_GG11851 Dere_GG20922
DPE: Dper_GL11760 Dper_GL11761
DSE: Dsec_GM16415 Dsec_GM19850
DSI: Dsim_GD25338
DYA: Dyak_GE13860 Dyak_GE23298
DGR: Dgri_GH22627 Dgri_GH22628
DMO: Dmoj_GI20626 Dmoj_GI20627
AGA: AgaP_AGAP011859
CQU: CpipJ_CPIJ001433
AME: 409814
NVI: 100123886 100123893
TCA: 657744 657825 657903
API: 100165307 100168343
ISC: IscW_ISCW004513 IscW_ISCW013666
CEL: Y105E8B.9
CBR: CBG19804
BMY: Bm1_53975
NVE: NEMVE_v1g163145 NEMVE_v1g30997
HMG: 100200074
FGR: FG07593.1
ANI: AN5361.2
AOR: AO090038000009
ANG: An01g01260
AFV: AFLA_124740
PCS: Pc16g06900
ECO: b1617(uidA)
ECJ: JW1609(uidA)
ECD: ECDH10B_1750(uidA)
EBW: BWG_1431(uidA)
ECE: Z2621m(uidA)
ECG: E2348C_1702(uidA)
ECC: c2009(uidA)
ECI: UTI89_C1805(uidA)
ECP: ECP_1561
ECV: APECO1_700(uidA)
ECW: EcE24377A_1825(uidA)
ECX: EcHS_A1692(uidA)
ECM: EcSMS35_1582(uidA)
ECY: ECSE_1738
ECL: EcolC_2013
ECK: EC55989_1783(uidA)
ECQ: ECED1_1816(uidA)
ECR: ECIAI1_1668(uidA)
ECT: ECIAI39_1441(uidA)
ECZ: ECS88_1663(uidA)
EUM: ECUMN_1906(uidA)
ELF: LF82_2368(uidA)
EBL: B21_01576(uidA)
EBD: ECBD_2028
EBR: ECB_01586(uidA)
EOH: ECO103_1757(gusA)
EOI: ECO111_2086(gusA)
EOJ: ECO26_2345(gusA)
SEW: SeSA_A3313
SFL: SF1640(uidA)
SFX: S1771(uidA)
SFV: SFV_1633(uidA)
SSN: SSON_1543(uidA)
SBC: SbBS512_E1804(uidA)
EIC: NT01EI_3431
ETR: ETAE_3023(uidA)
HSO: HS_1330(uidA)
HSM: HSM_0285
SDE: Sde_2632
TAU: Tola_2896
SIT: TM1040_3871
SHA: SH2645
PJD: Pjdr2_2995
SPH: MGAS10270_Spy1174
SNM: SP70585_2241
SAG: SAG0698
SAN: gbs0671
SAK: SAK_0824
SSU: SSU05_1163
SSV: SSU98_1179 SSU98_1180
SSB: SSUBM407_0780(uidA)
SSI: SSU1006(uidA)
SSS: SSUSC84_1044(uidA)
SEQ: SZO_13150
SEZ: Sez_0686
SEU: SEQ_0713
SUB: SUB1206(uidA)
SDS: SDEG_1367
LBR: LVIS_0138
LRH: LGG_00050(uidA)
LRL: LC705_00042(uidA)
CPE: CPE0147(bglR)
CPY: Cphy_0530
CCE: Ccel_1670
ATE: Athe_2086
EEL: EUBELI_20590
CEF: CE2379
AAU: AAur_0068
PAC: PPA2333
FRE: Franean1_3255
BLJ: BLD_0829(lacZ2)
BHY: BHWA1_02243(uidA)
ABA: Acid345_0579
SUS: Acid_7301
RMR: Rmar_1185
DFE: Dfer_2609
FJO: Fjoh_2082 Fjoh_4198
SMF: Smon_1310
OTE: Oter_3352
TMA: TM1062
TPT: Tpet_0490 Tpet_1689
TNA: CTN_1505
TNP: Tnap_1703
DTH: DICTH_1429
DTU: Dtur_1539
TTR: Tter_2447
HUT: Huta_2842
SSO: SSO3036(gusB)
SIS: LS215_2491
SIA: M1425_2319
SIM: M1627_2398
SID: M164_2321
SIY: YG5714_2459
SIN: YN1551_0450
CMA: Cmaq_1386
 |
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| Structures |
PDB: 1BHG 3HN3 |
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Reference
Authors
Title
Journal
|
1
Diez, T. and Cabezas, J.A.
Properties of two molecular forms of beta-glucuronidase from the
mollusc Littorina littorea L.
Eur. J. Biochem. 93 (1978) 301-311. |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:13271452]
DOYLE ML, KATZMAN PA, DOISY EA.
Production and properties of bacterial beta-glucuronidase.
J. Biol. Chem. 217 (1955) 921-30.
Escherichia coli [GN:eco] |
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Reference
Authors
Title
Journal
|
3 [PMID:14376216]
FISHMAN WH.
Not Available
Adv. Enzymol. Relat. Subj. Biochem. 16 (1955) 361-409. |
|---|
Reference
Authors
Title
Journal
|
4
Levvy, G.A. and Marsh, C.A.
beta-Glucuronidase.
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd
ed., vol. 4, Academic Press, New York, 1960, p. 397-407. |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:13782588]
WAKABAYASHI M, FISHMAN WH.
The comparative ability of beta-glucuronidase preparations (liver,
Escherichia coli, Helix pomatia, and Patella vulgata) to hydrolyze
certain steroid glucosiduronic acids.
J. Biol. Chem. 236 (1961) 996-1001.
Bos taurus [GN:bta], Escherichia coli [GN:eco], Helix pomatia,
Patella vulgata |
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| Other DBs |
ExplorEnz - The Enzyme Database: 3.2.1.31
IUBMB Enzyme Nomenclature: 3.2.1.31
ExPASy - ENZYME nomenclature database: 3.2.1.31
BRENDA, the Enzyme Database: 3.2.1.31
CAS: 9001-45-0 |
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