KEGG   ENZYME: 3.4.21.1Help
Entry
EC 3.4.21.1                 Enzyme                                 
Name
chymotrypsin;
chymotrypsins A and B;
alpha-chymar ophth;
avazyme;
chymar;
chymotest;
enzeon;
quimar;
quimotrase;
alpha-chymar;
alpha-chymotrypsin A;
alpha-chymotrypsin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Tyr!, Trp!, Phe!, Leu!
Comment
Chymotrypsin A is formed from cattle and pig chymotrypsinogen A, several iso-forms being produced according to the number of bonds hydrolysed in the precursor. Chymotrypsin B (formerly listed as EC 3.4.4.6), formed from chymotrypsinogen B, is homologous with chymotrypsin A. Enzymes with specificity similar to that of chymotrypsins A and B have been isolated from many species. In peptidase family S1 (trypsin family)
Orthology
K01310  
chymotrypsin
Genes
HSA: 
1504(CTRB1) 440387(CTRB2)
PTR: 
736467(CTRB1)
PPS: 
100979112(CTRB2) 100979449(CTRB1)
GGO: 
101134917(CTRB2)
PON: 
MCC: 
711100(CTRB1) 713851(CTRB2)
MMU: 
66473(Ctrb1)
RNO: 
24291(Ctrb1)
CFA: 
479649 479650(CTRB2) 610373(CTRB1)
AML: 
FCA: 
101091168 101096125 101096371(CTRB1)
BTA: 
100848132 100851201 504241(CTRB1) 618826
SSC: 
100621642 100621820
ECB: 
100068875 100146723
MDO: 
100023625
SHR: 
100915387
OAA: 
100082597 100082620
GGA: 
431235
MGP: 
100544825
TGU: 
100221838
ACS: 
100565667
XLA: 
379495(ctrl) 379607(ctrb1) 444360(ctrb2)
XTR: 
496968(ctrb2) 548358(ctrl)
DRE: 
322451(ctrb1) 562139
TRU: 
101074582
OLA: 
101170410
DME: 
Dmel_CG18179 Dmel_CG31362(Jon99Ciii) Dmel_CG6298(Jon74E)
DPO: 
Dpse_GA19618 Dpse_GA21380
NVE: 
NEMVE_v1g140545
 » show all
Taxonomy
Reference
1
  Authors
Wilcox, P.E.
  Title
Chymotrypsinogens - chymotrypsins.
  Journal
Methods Enzymol. 19 (1970) 64-108.
Reference
2
  Authors
Blow, D.M.
  Title
Structure and mechanism of chymotrypsin.
  Journal
Acc. Chem. Res. 9 (1976) 145-152.
Reference
3  [PMID:6768556]
  Authors
Bauer CA.
  Title
Active centers of alpha-chymotrypsin and of Streptomyces griseus proteases 1 and 3. S2-P2 enzyme-substrate interactions.
  Journal
Eur. J. Biochem. 105 (1980) 565-70.
  Organism
Streptomyces griseus [GN:sgr]
Reference
4
  Authors
Polgar, L.
  Title
Structure and function of serine proteases.
  Journal
In: Neuberger, A. and Brocklehurst, K. (Eds.), New Comprehensive Biochemistry: Hydrolytic Enzymes, vol. 16, Elsevier, Amsterdam, 1987, p. 159-200.
Reference
5  [PMID:2917002]
  Authors
Tomita N, Izumoto Y, Horii A, Doi S, Yokouchi H, Ogawa M, Mori T, Matsubara K.
  Title
Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.
  Journal
Biochem. Biophys. Res. Commun. 158 (1989) 569-75.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9004-07-3
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