Entry
Name
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Preferential cleavage: Leu!, Tyr!, Phe!, Met!, Trp!, Gln!, Asn!
Comment
Formed from pig chymotrypsinogen C, and from cattle subunit II of procarboxypeptidase A. Reacts more readily with Tos-Leu-CH2Cl than Tos-Phe-CH2Cl in contrast to chymotrypsin. In peptidase family S1 (trypsin family)
History
EC 3.4.21.2 created 1972
Orthology
Genes
MTHB : 126959451 126959986
CATY : 105587355 105593653(CTRC) 105593656
PANU : 101008888 101027045 116271818
LMUT : 125703491 125703494
PMOA : 120498997 120499435
PRUF : 121351341 121351382 121351397
GFR : 102039202 102039374 102039552
ZAB : 102065082 102067097 102073038
ASN : 102384487 102386144 102386393 102386635
AMJ : 102574442 102574676 102575846
CPOO : 109314379 109314516 109314543
GGN : 109293559 109293560 109293788 109293791
ZVI : 118079002 118079003 118086814 118087165
RTEM : 120916258 120916260
CSEM : 103384948 107989142
ACOZ : 120949877 120950135
AALB : 109409749 109417827 109426733 109426788
CQU : CpipJ_CPIJ002139 CpipJ_CPIJ011616
TPRE : 106649093 106649500 106649502 106651994 106651995 111693485 111693486 111693565 111694337
OSN : 115224509 115224512 115224554 115224560
ATEN : 116297736 116297737 116305518 116305520 116308478
PDAM : 113674894 113674914 113682978
» show all
Taxonomy
Reference
Authors
Peanasky RJ, Gratecos D, Baratti J, Rovery M.
Title
Mode of activation of N-terminal sequence of subunit II in bovine procarboxypeptidase A and of porcine chymotrypsinogen C.
Journal
Reference
2
Authors
Folk, J.E.
Title
Chymotrypsin C (porcine pancreas).
Journal
Methods Enzymol 19:109-112 (1970)
Reference
3
Authors
Wilcox, P.E.
Title
Chymotrypsinogens - chymotrypsins.
Journal
Methods Enzymol 19:64-108 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.2
ExPASy - ENZYME nomenclature database: 3.4.21.2